Pub Date : 2022-01-01Epub Date: 2022-09-20DOI: 10.26502/fjsrs0047
Thomas Theis, Carlos Ayala, Monica Tschang, Michele Philip, Vini Nagaraj, Anil Shrirao, Gregory Voronin, Wise Young, Melitta Schachner
CHL1 is a close homolog of L1, a cell adhesion molecule that plays major roles in neural and tumor cell functions. We had found that young adult female mice deficient in CHL1 recovered better than their wild-type female littermates after thoracic Spinal Cord Injury (SCI). This observation was surprising, because CHL1 increases neurite outgrowth in vitro. Injury of adult mouse central and peripheral nervous systems upregulate CHL1 expression in neurons and astrocytes, consistent with CHL1's pro-active, homophilic interaction between CHL1 surface molecules in wild-type mice. After SCI, CHL1 expression was observed to increase in the glial scar, areas of axonal regrowth and remodeling of neural circuits. These observations were made only in females, and we therefore sought to analyze SCI in CHL1-deficient male mice. We now show that CHL1-deficient males did not recover better or worse than their male wild-type littermates. Primary and secondary lesion volumes were similar in the two genotypes, as seen in female mice which were studied in parallel with male mice. Assessment of peripheral leukocytes showed a significant increase in numbers of blood neutrophils at 24 h after SCI in males, but not in females. Lymphocyte numbers in mutant males increased slightly, but numbers of lymphocytes or monocytes did not differ significantly between males or females. These results indicate that CHL1-deficient males and females differ in the number of neutrophils but not lymphocytes or monocytes, suggesting that the difference between males and females is unlikely due to differences in leukocytes.
{"title":"CHL1-Deficient and Wild-Type Male Mice do Not Differ in Locomotor Recovery from Spinal Cord Injury.","authors":"Thomas Theis, Carlos Ayala, Monica Tschang, Michele Philip, Vini Nagaraj, Anil Shrirao, Gregory Voronin, Wise Young, Melitta Schachner","doi":"10.26502/fjsrs0047","DOIUrl":"https://doi.org/10.26502/fjsrs0047","url":null,"abstract":"<p><p>CHL1 is a close homolog of L1, a cell adhesion molecule that plays major roles in neural and tumor cell functions. We had found that young adult female mice deficient in CHL1 recovered better than their wild-type female littermates after thoracic Spinal Cord Injury (SCI). This observation was surprising, because CHL1 increases neurite outgrowth in vitro. Injury of adult mouse central and peripheral nervous systems upregulate CHL1 expression in neurons and astrocytes, consistent with CHL1's pro-active, homophilic interaction between CHL1 surface molecules in wild-type mice. After SCI, CHL1 expression was observed to increase in the glial scar, areas of axonal regrowth and remodeling of neural circuits. These observations were made only in females, and we therefore sought to analyze SCI in CHL1-deficient male mice. We now show that CHL1-deficient males did not recover better or worse than their male wild-type littermates. Primary and secondary lesion volumes were similar in the two genotypes, as seen in female mice which were studied in parallel with male mice. Assessment of peripheral leukocytes showed a significant increase in numbers of blood neutrophils at 24 h after SCI in males, but not in females. Lymphocyte numbers in mutant males increased slightly, but numbers of lymphocytes or monocytes did not differ significantly between males or females. These results indicate that CHL1-deficient males and females differ in the number of neutrophils but not lymphocytes or monocytes, suggesting that the difference between males and females is unlikely due to differences in leukocytes.</p>","PeriodicalId":73951,"journal":{"name":"Journal of spine research and surgery","volume":"4 3","pages":"96-103"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40718990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Ainur Nishad Rhajib, Md. Waliul Islam, Md Zakir Hossain, E. Rahman
Evidence based Physiotherapy Management of a Cervical Radiculopathy Patient using Clinical Reasoning Process. Journal Abstract Introduction: Neck pain is one of the most common musculoskeletal disorder in the general population, second only to low back pain. Cervical radiculopathy is a dysfunction of a nerve root in the cervical spine resulting in producing radicular symptom such as pain, paresthesia, weakness, numbness in the upper extremity. Case Report: The aim of this study is evidence-based physiotherapy management of a single case of cervical radiculopathy. This single case was solved by using hypothetico deductive reasoning. Result: After 6 th week of intervention improvement was, found in pain reduction both in resting and during movement and improve range of motion. In addition, disability status also progressed from 60% to 20% Journal of Spine Research and Surgery Conclusion: Clinical reasoning is the foundation in our clinical practice. Mckenzie MDT for cervical spine, neural mobilization, manual cervical traction along with cervical stabilization exercise was effective for cervical radiculopathy patient.
{"title":"Evidence based Physiotherapy Management of a Cervical Radiculopathy Patient by using Clinical Reasoning Process","authors":"Mohammad Ainur Nishad Rhajib, Md. Waliul Islam, Md Zakir Hossain, E. Rahman","doi":"10.26502/fjsrs0041","DOIUrl":"https://doi.org/10.26502/fjsrs0041","url":null,"abstract":"Evidence based Physiotherapy Management of a Cervical Radiculopathy Patient using Clinical Reasoning Process. Journal Abstract Introduction: Neck pain is one of the most common musculoskeletal disorder in the general population, second only to low back pain. Cervical radiculopathy is a dysfunction of a nerve root in the cervical spine resulting in producing radicular symptom such as pain, paresthesia, weakness, numbness in the upper extremity. Case Report: The aim of this study is evidence-based physiotherapy management of a single case of cervical radiculopathy. This single case was solved by using hypothetico deductive reasoning. Result: After 6 th week of intervention improvement was, found in pain reduction both in resting and during movement and improve range of motion. In addition, disability status also progressed from 60% to 20% Journal of Spine Research and Surgery Conclusion: Clinical reasoning is the foundation in our clinical practice. Mckenzie MDT for cervical spine, neural mobilization, manual cervical traction along with cervical stabilization exercise was effective for cervical radiculopathy patient.","PeriodicalId":73951,"journal":{"name":"Journal of spine research and surgery","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. G., Gyra A, A. c, Masedu F, M. E., Franchi D, Introzzi L, Lucchelli M, Molesi A, Marinangeli F, B. V.
{"title":"Videolaringoscopy beyond Conventional Endotracheal Intubation in HEMS: A Real Flight Simulation","authors":"F. G., Gyra A, A. c, Masedu F, M. E., Franchi D, Introzzi L, Lucchelli M, Molesi A, Marinangeli F, B. V.","doi":"10.26502/fjsrs0044","DOIUrl":"https://doi.org/10.26502/fjsrs0044","url":null,"abstract":"","PeriodicalId":73951,"journal":{"name":"Journal of spine research and surgery","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: We have previously reported ten effective serological indicators of surgical site infection (SSI) in the perioperative period after spinal surgery. However, the false-positive fractions of these markers were 0.15-0.39 which frequencies were not negligible. These mean the delays of surgical inflammatory recoveries without SSI. This study aimed to identify and classify the factors associated with these delays. Methods: This retrospective study enrolled 320 patients who underwent spinal surgery for causes other than infectious spondylitis without surgical site infection. Demographic data, preoperative serological data, operative times, and operative methods were examined by multivariate regression for each SSI indicator and classified into related groups. Results: Nine significantly associated factors, age, malignancy, preoperative total protein, albumin, J Spine Res Surg 2022; 4 (1): 029-039 DOI: 10.26502/fjsrs0039 Journal of Spine Research and Surgery 30 white blood cell count, albumin/globulin ratio, Creactive protein, operation time, and use of spinal instrumentation were found. We classified the patients into three groups according to their preoperative nutritional status, immune-inflammation status, and surgical procedure. Malnutrition, high CRP and WBC, older age, and malignancy might be related to delays in surgical recovery without SSI; therefore, a single indicator may have limited capability in detecting SSI. Conclusions: We have to recognize the several causes to retard surgical inflammatory recovery. Improved preoperative conditions and less invasive surgery may decrease delays and improve the accuracy of SSI indicators.
{"title":"Factors Associated with Delayed Inflammatory Recovery after Spinal Surgery without Surgical Site Infection: A Retrospective Study","authors":"Hideaki Imabayashi, Atsushi Miyake, K. Chiba","doi":"10.26502/fjsrs0039","DOIUrl":"https://doi.org/10.26502/fjsrs0039","url":null,"abstract":"Background: We have previously reported ten effective serological indicators of surgical site infection (SSI) in the perioperative period after spinal surgery. However, the false-positive fractions of these markers were 0.15-0.39 which frequencies were not negligible. These mean the delays of surgical inflammatory recoveries without SSI. This study aimed to identify and classify the factors associated with these delays. Methods: This retrospective study enrolled 320 patients who underwent spinal surgery for causes other than infectious spondylitis without surgical site infection. Demographic data, preoperative serological data, operative times, and operative methods were examined by multivariate regression for each SSI indicator and classified into related groups. Results: Nine significantly associated factors, age, malignancy, preoperative total protein, albumin, J Spine Res Surg 2022; 4 (1): 029-039 DOI: 10.26502/fjsrs0039 Journal of Spine Research and Surgery 30 white blood cell count, albumin/globulin ratio, Creactive protein, operation time, and use of spinal instrumentation were found. We classified the patients into three groups according to their preoperative nutritional status, immune-inflammation status, and surgical procedure. Malnutrition, high CRP and WBC, older age, and malignancy might be related to delays in surgical recovery without SSI; therefore, a single indicator may have limited capability in detecting SSI. Conclusions: We have to recognize the several causes to retard surgical inflammatory recovery. Improved preoperative conditions and less invasive surgery may decrease delays and improve the accuracy of SSI indicators.","PeriodicalId":73951,"journal":{"name":"Journal of spine research and surgery","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md Nazmul Hassan, Parvin Akter, Mohammad Anwar Hossain, Koushik Ahmed, F. Sharmin, Md Shahoriar Ahmed, Kumar Amitav, Md Ashif Ikbal khan, Shazal Kumar Das, L. Walton, M. Habibur Rahman
Objective: This study aims to evaluate the effectiveness of Dynamic Back Strengthening exercise along with conventional physiotherapy for chronic non-specific low back pain (LBP) patients over a conventional rehabilitation protocol for chronic non-specific LBP patients. Methods: Between October to December 2021 to a total of 8 patients with nonspecific LBP (5 males, 3 females; mean age: 41.12± years; ranged, 25 to 55 years) were included in this randomized - controlled pilot study. The patients were randomly assigned to experimental (n=4) and control (n=4) group. The treatment period was 3 days in a week for four consecutive weeks where pre & post assessment were done. Data were collected by using structured questionnaires related to CLBP and disability, socio-demographic data were collected through a semi-structured questionnaire including the Dallas Pain Questionnaire & Oswestry disability index (ODI). Results: In Mann Whitney 'U', the level of significance is greater than p = > 0.05, and there is no significant difference in between group analysis for all traits of the Dallas pain questionnaire and the Oswestry disability questionnaire. Conclusion: Effectiveness of Dynamic Strengthening Exercise along with conventional physiotherapy was the same in comparison to the conventional physiotherapy treatment for patients with CLBP. In these limited sessions, it has been found that the strengthening program could be started earlier but not for all kinds of patients. As the disability level has been improved by both groups, so it can be introduced earlier with the patients. A complete study should be done with a larger sample size to find out the effectiveness of the dynamic strengthening exercise along with the conventional physiotherapy treatment approach for CLBP patients.
{"title":"Manual Therapy Followed by Dynamic Strengthening Exercise Along With Conventional Physiotherapy Versus Manual Therapy Along With Conventional Physiotherapy on The Improvement of Pain and Functional Disability In Patients With Chronic Non-Specific Low Back Pain: A Randomized-Controlled Pilot Study","authors":"Md Nazmul Hassan, Parvin Akter, Mohammad Anwar Hossain, Koushik Ahmed, F. Sharmin, Md Shahoriar Ahmed, Kumar Amitav, Md Ashif Ikbal khan, Shazal Kumar Das, L. Walton, M. Habibur Rahman","doi":"10.26502/fjsrs0048","DOIUrl":"https://doi.org/10.26502/fjsrs0048","url":null,"abstract":"Objective: This study aims to evaluate the effectiveness of Dynamic Back Strengthening exercise along with conventional physiotherapy for chronic non-specific low back pain (LBP) patients over a conventional rehabilitation protocol for chronic non-specific LBP patients. Methods: Between October to December 2021 to a total of 8 patients with nonspecific LBP (5 males, 3 females; mean age: 41.12± years; ranged, 25 to 55 years) were included in this randomized - controlled pilot study. The patients were randomly assigned to experimental (n=4) and control (n=4) group. The treatment period was 3 days in a week for four consecutive weeks where pre & post assessment were done. Data were collected by using structured questionnaires related to CLBP and disability, socio-demographic data were collected through a semi-structured questionnaire including the Dallas Pain Questionnaire & Oswestry disability index (ODI). Results: In Mann Whitney 'U', the level of significance is greater than p = > 0.05, and there is no significant difference in between group analysis for all traits of the Dallas pain questionnaire and the Oswestry disability questionnaire. Conclusion: Effectiveness of Dynamic Strengthening Exercise along with conventional physiotherapy was the same in comparison to the conventional physiotherapy treatment for patients with CLBP. In these limited sessions, it has been found that the strengthening program could be started earlier but not for all kinds of patients. As the disability level has been improved by both groups, so it can be introduced earlier with the patients. A complete study should be done with a larger sample size to find out the effectiveness of the dynamic strengthening exercise along with the conventional physiotherapy treatment approach for CLBP patients.","PeriodicalId":73951,"journal":{"name":"Journal of spine research and surgery","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69348142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-20DOI: 10.34371/JSPINERES.2021-0052
寧 大島
{"title":"「コロナ禍」に思うこと（まさかの第2章）","authors":"寧 大島","doi":"10.34371/JSPINERES.2021-0052","DOIUrl":"https://doi.org/10.34371/JSPINERES.2021-0052","url":null,"abstract":"","PeriodicalId":73951,"journal":{"name":"Journal of spine research and surgery","volume":"57 1","pages":"1086-1086"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74568115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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