Pub Date : 2022-09-01Epub Date: 2022-06-03DOI: 10.1007/s00424-022-02707-6
Maximilian Zeidler, Kai K Kummer, Michaela Kress
Despite numerous studies which have explored the pathogenesis of pain disorders in preclinical models, there is a pronounced translational gap, which is at least partially caused by differences between the human and rodent nociceptive system. An elegant way to bridge this divide is the exploitation of human-induced pluripotent stem cell (iPSC) reprogramming into human iPSC-derived nociceptors (iDNs). Several protocols were developed and optimized to model nociceptive processes in health and disease. Here we provide an overview of the different approaches and summarize the knowledge obtained from such models on pain pathologies associated with monogenetic sensory disorders so far. In addition, novel perspectives offered by increasing the complexity of the model systems further to better reflect the natural environment of nociceptive neurons by involving other cell types in 3D model systems are described.
{"title":"Towards bridging the translational gap by improved modeling of human nociception in health and disease.","authors":"Maximilian Zeidler, Kai K Kummer, Michaela Kress","doi":"10.1007/s00424-022-02707-6","DOIUrl":"10.1007/s00424-022-02707-6","url":null,"abstract":"<p><p>Despite numerous studies which have explored the pathogenesis of pain disorders in preclinical models, there is a pronounced translational gap, which is at least partially caused by differences between the human and rodent nociceptive system. An elegant way to bridge this divide is the exploitation of human-induced pluripotent stem cell (iPSC) reprogramming into human iPSC-derived nociceptors (iDNs). Several protocols were developed and optimized to model nociceptive processes in health and disease. Here we provide an overview of the different approaches and summarize the knowledge obtained from such models on pain pathologies associated with monogenetic sensory disorders so far. In addition, novel perspectives offered by increasing the complexity of the model systems further to better reflect the natural environment of nociceptive neurons by involving other cell types in 3D model systems are described.</p>","PeriodicalId":73971,"journal":{"name":"Journal of the American Medical Women's Association","volume":"1 1","pages":"965-978"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72979674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Plastic surgery.","authors":"D. Bowles","doi":"10.32388/aiv3xm","DOIUrl":"https://doi.org/10.32388/aiv3xm","url":null,"abstract":"","PeriodicalId":73971,"journal":{"name":"Journal of the American Medical Women's Association","volume":"3 7 1","pages":"280-8"},"PeriodicalIF":0.0,"publicationDate":"2020-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42747600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Supply.","authors":"V. Storrie","doi":"10.2307/j.ctvhn0bwn.14","DOIUrl":"https://doi.org/10.2307/j.ctvhn0bwn.14","url":null,"abstract":"","PeriodicalId":73971,"journal":{"name":"Journal of the American Medical Women's Association","volume":"21 10 1","pages":"837-9"},"PeriodicalIF":0.0,"publicationDate":"2020-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47737187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.1079/9781789242232.0343
A. Chappell
{"title":"Artificial insemination.","authors":"A. Chappell","doi":"10.1079/9781789242232.0343","DOIUrl":"https://doi.org/10.1079/9781789242232.0343","url":null,"abstract":"","PeriodicalId":73971,"journal":{"name":"Journal of the American Medical Women's Association","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58628535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.20902/ijctr.2018.110213
J. Bauman, J. Elenbaas, S. Hamburger
Cimetidine has been extensively used in the treatment of diverse gastrointestinal disorders. This drug is a selective, competitive histamine H2 receptor antagonist. An extensive survey of literature has been published that includes various analytical, pharmacokinetic, clinical, analytical aspects, drug interactions and adverse effects of the drug.
{"title":"Cimetidine--a review.","authors":"J. Bauman, J. Elenbaas, S. Hamburger","doi":"10.20902/ijctr.2018.110213","DOIUrl":"https://doi.org/10.20902/ijctr.2018.110213","url":null,"abstract":"Cimetidine has been extensively used in the treatment of diverse gastrointestinal disorders. This drug is a selective, competitive histamine H2 receptor antagonist. An extensive survey of literature has been published that includes various analytical, pharmacokinetic, clinical, analytical aspects, drug interactions and adverse effects of the drug.","PeriodicalId":73971,"journal":{"name":"Journal of the American Medical Women's Association","volume":"35 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67619980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-11-04DOI: 10.4159/harvard.9780674333574.c5
B. VAN HOOSEN
In his introduction , Bellamy explains that while to his readers (supposedly in the year 2000, it may seem impossible to believe, that in the time from whence he came (over a hundred years before) America was an industrialized nation operating according to the principles of capitalism and a certain amount of Social Darwinism. He promises to tell them the truth of what it was like back then, as unbelievable as he’s sure it will seem to their 21st Century minds. Things in the 21st Century, of course, were MUCH better, and all men work for the common good of those around them. The government’s primary job is to coordinate all of this goodwill.
{"title":"Looking backward.","authors":"B. VAN HOOSEN","doi":"10.4159/harvard.9780674333574.c5","DOIUrl":"https://doi.org/10.4159/harvard.9780674333574.c5","url":null,"abstract":"In his introduction , Bellamy explains that while to his readers (supposedly in the year 2000, it may seem impossible to believe, that in the time from whence he came (over a hundred years before) America was an industrialized nation operating according to the principles of capitalism and a certain amount of Social Darwinism. He promises to tell them the truth of what it was like back then, as unbelievable as he’s sure it will seem to their 21st Century minds. Things in the 21st Century, of course, were MUCH better, and all men work for the common good of those around them. The government’s primary job is to coordinate all of this goodwill.","PeriodicalId":73971,"journal":{"name":"Journal of the American Medical Women's Association","volume":"5 10 1","pages":"406-8"},"PeriodicalIF":0.0,"publicationDate":"2014-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70539969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The gift.","authors":"J. van Dis","doi":"10.7312/enns17896-024","DOIUrl":"https://doi.org/10.7312/enns17896-024","url":null,"abstract":"","PeriodicalId":73971,"journal":{"name":"Journal of the American Medical Women's Association","volume":"58 4 1","pages":"285-6"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71147016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1999-01-01DOI: 10.3109/9781841849126.006
J. Gibbs
{"title":"Emergency contraception.","authors":"J. Gibbs","doi":"10.3109/9781841849126.006","DOIUrl":"https://doi.org/10.3109/9781841849126.006","url":null,"abstract":"","PeriodicalId":73971,"journal":{"name":"Journal of the American Medical Women's Association","volume":"54 2 1","pages":"101-2"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69466851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1996-02-21DOI: 10.1001/JAMA.1996.03530310078046
H. Nickens
AFFIRMATIVE ACTION is under increasing attack, particularly so since the 1994 off-year elections produced a much more conservative Congress. Affirmative action describes a broad spectrum of activities ranging from aggressive advertising of opportunities at one end, to outright quotas and set-asides at the other. Moreover, affirmative action programs targeted to help women are different from those targeted to help racial and ethnic minorities, and those designed to remedy inequities in education differ from those addressing occupational opportunities or the awarding of contracts. While the affirmative action debate is intense, it remains remarkably ill defined, acting like a societal Rorschach upon which a wide spectrum of individuals can project their fears, grievances, and frustrations. As a "wedge issue," affirmative action has been welded selectively to activities yielding preferences for minorities, ignoring preferences for women, for small businesses, for veterans, and (in college admissions) for the children of alumni and athletes. While
{"title":"Affirmative action.","authors":"H. Nickens","doi":"10.1001/JAMA.1996.03530310078046","DOIUrl":"https://doi.org/10.1001/JAMA.1996.03530310078046","url":null,"abstract":"AFFIRMATIVE ACTION is under increasing attack, particularly so since the 1994 off-year elections produced a much more conservative Congress. Affirmative action describes a broad spectrum of activities ranging from aggressive advertising of opportunities at one end, to outright quotas and set-asides at the other. Moreover, affirmative action programs targeted to help women are different from those targeted to help racial and ethnic minorities, and those designed to remedy inequities in education differ from those addressing occupational opportunities or the awarding of contracts. While the affirmative action debate is intense, it remains remarkably ill defined, acting like a societal Rorschach upon which a wide spectrum of individuals can project their fears, grievances, and frustrations. As a \"wedge issue,\" affirmative action has been welded selectively to activities yielding preferences for minorities, ignoring preferences for women, for small businesses, for veterans, and (in college admissions) for the children of alumni and athletes. While","PeriodicalId":73971,"journal":{"name":"Journal of the American Medical Women's Association","volume":"47 5","pages":"171"},"PeriodicalIF":0.0,"publicationDate":"1996-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/JAMA.1996.03530310078046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50830632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiovascular disease in women.","authors":"Judelson Dr","doi":"10.1201/9780367804299","DOIUrl":"https://doi.org/10.1201/9780367804299","url":null,"abstract":"","PeriodicalId":73971,"journal":{"name":"Journal of the American Medical Women's Association","volume":"49 1","pages":"180"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65944194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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