MalariaWorld journal最新文献

A controversy has arisen over whether or not the replacement of PFAS compounds as a binder between insecticides and nets by other compounds has affected the nets' efficacy in preventing malaria transmission. Robert Bos places this matter in a broader and historical context and concludes that now is the time to revisit earlier concepts and provide sustainable malaria prevention and control with a broader foundation aiming for truly resilient results. The need to promote institutional arrangements conducive to inter-sectoral action is as great in WHO Member States as it is within the structure of the World Health Organization itself. Robert Bos is former Executive Secretary, WHO/FAO/UNEP/UN-Habitat Panel of Experts on Environmental Management for Vector Control, WHO, Geneva (1983-1995) former Scientist, Division of Environmental Health, later Department of Sustainable Development and Healthy Environments, later Department of Public Health and Environment, WHO, Geneva (1995-2009) and former Coordinator, Water, Sanitation and Health, WHO, Geneva (2009-2013).

Introduction: Malaria remains a major public health problem in children in endemic areas. This study aimed to determine its prevalence, intensity, and assess how biological parameters like RBC count, haemoglobin, haematocrit, glycaemia, platelet count and WBC count vary with respect to parasitaemia in children <16 years attending the Nkwen District Hospital, northwest Cameroon.

Materials and methods: The study was a hospital-based cross-sectional study conducted between March-May 2023. Structured, closed-ended questionnaires were administered to obtain information. Patients' temperature was measured using an infrared forehead digital thermometer. Malaria was diagnosed by RDT and positive samples Giemsa-stained for parasitaemia. Full blood count was performed using a haemolyser and glycaemia measured using a glucometer.

Results: In total, 321 children were examined. Overall prevalence of malaria (all P. falciparum) was 22.7% (73/321), with 24.7% (18/73), 34.2% (25/73) and 41.1% (30/73) having low, moderate and high parasitaemias, respectively. Overall GMPD was 2.670.8±179.9/μL; children aged 6-10 years were hit hardest (5.377.7 ± 3.2/μL). Malaria-positive children had significantly lower RBC count, Hb concentration, Hct, blood sugar, WBC and platelet counts (p<0.05) compared to those that were negative. Among positive children, RBC count, Hct, Hb, lymphocyte and platelet count each showed a significant (p<0.05) decrease while total WBC and granulocyte count each showed a significant (p<0.05) increase with increasing levels of parasitaemia.

Conclusions: Changes in biological parameters during malaria are sensitive but poor specific indicators of malaria because they may overlap with symptoms of other infections. More attention should be given to children aged 6-10 years during strategic planning and design of malaria control programmes.

Introduction: In the current study we assessed clinical laboratories' staff ability across the city of Kinshasa with particular focus on their practices and performance regarding malaria microscopy.

Materials and methods: This was a non-random cross-sectional study included clinical laboratories in Kinshasa and focused on cross-checking of blood slides, a questionnaire and checklist according to standardised analytic malaria microscopy procedures. Regarding the cross-checking of slides, participant responses were considered 'corrects' in cases of complete congruence with the reference; 'acceptable' for malaria-positive slides but no identification of Plasmodium species, stage of development, parasite density and/or reported as P. falciparum instead of 'P. non falciparum'; and 'incorrect' if 'false positive' and 'false negative' cases.

Results: Eighty-eight among the 90 targeted clinical laboratories (participation 97.8%) took part in the investigation from February to July 2019. The ability assessment revealed that individuals qualified to perform thick blood films (TBF) according to the national malaria control program (NMCP) procedures ranged from 48.6% to 100.0%. Overall cross-checking performance of 167 eligible routine slides was relatively low: 37.7%; 25.8% and 36.5% of correct, acceptable and incorrect responses, respectively. The first routine slide was correctly and acceptably scored respectively by 35.3% and 28.2% of participating laboratories (n = 85); and the second, by 40.2% and 23.2% respectively (n = 82). The sensitivity and specificity were found to be 79.4% and 53.8%, respectively. However, the relative high scores reported in relation with the ability needed to perform TBF based on NMCP standards contrasted with the poor performance from cross-checking slides. Consecutively, only one-third of the 88 participating laboratories reached a score > 60% in agreement with NMCP procedures and had acceptable responses to cross-checked slides.

Conclusions: The study was conducted as part of the activities relating to "Ensuring early diagnosis and prompt malaria treatment" component of the national malaria control strategy with NMCP support. More laboratories must implement clear and standardised malaria microscopy procedures, and need to include more rigorous quality control.

Introduction: Human habitats remain the main point of human-vector interaction leading to malaria transmission despite the sustained use of insecticide-treated nets and indoor residual spraying. Simple structural modifications involving screening of doors, windows and eaves have great potential for reducing indoor entry of mosquitoes. Moreover, insecticide treatment of the screen material may provide additional benefit in mosquito population reduction.

Materials and methods: Four huts, each constructed inside a semi-field structure, were used in the study. Two had untreated eave and door screens and screened air cavities in place of windows (experiment 1) or were similar but with the eave screens treated with Actellic® 300CS insecticide (experiment 2). The other two huts remained unscreened throughout the study. Two hundred, 3-day old adults of F1 generation Anopheles funestus collected by aspiration or F0 reared from An. arabiensis larvae or An. arabiensis (Dongola strain) were released in each semi-field structure at dusk and recaptured the following morning. A single volunteer slept in each hut under an untreated bednet each night of the study. Recaptured mosquitoes were counted and recorded by location, either indoor or outdoor of each hut in the different semi-field structures.

Results: Based on modelled estimates, significantly fewer, 10% An. arabiensis from Ahero, 11% An. arabiensis Dongola strain and 10% An. funestus from Siaya were observed inside modified huts compared to unmodified ones. Treating of eave screen material with Actellic® 300CS significantly reduced indoor numbers of An. arabiensis from Ahero, to nearly 0%, and An. arabiensis Dongola strain, to 3%, compared to huts with untreated eave screens, while eliminating An. funestus indoors. These modifications cost US$180 /structure and have been observed to last more than 15 years in a different location.

Conclusions: Eave, door and window screening are effective ways of reducing mosquito entry into houses. Additionally, treatment of eave screen material with an effective insecticide further reduces the Anopheles population in and around the screened huts under semi-field conditions and could greatly complement existing vector control efforts.

During the first World War (1914-1918), the British Army found itself confronting enemy armies in several countries in which malaria potentially hampered its ability to engage with the enemy. This article contrasts how it dealt with malaria on two of these fronts, the Macedonia front and the Palestine front. One front resulted in a failure of the Army to protect itself against the disease, with the other front resulting in successful protection of its troops, enabling those troops to create a decisive victory. The paper briefly explains the major differences between the two fronts, including the different attempts to deal with the disease, and draws lessons for contemporary malaria elimination efforts.

Background: Malaria is a major global public health issue that disproportionately affects pregnant women in sub-Saharan Africa. The World Health Organization recommends intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) for its control. Despite its proven efficacy, drug uptake remains low. Sulphadoxine-pyrimethamine (SP) safety concerns have been cited as one of several reasons for this low uptake.

Methods: We conducted a scoping review using the Arksey and O'Malley framework and the health belief model to investigate perceptions of SP use among pregnant women in sub-Saharan Africa. We looked for peer-reviewed publications in five international databases.

Results: The review included 19 articles out of a total of 246. It showed that pregnant women in sub-Saharan Africa have a good understanding of malaria and its consequences, but this does not necessarily translate into increased IPTp-SP uptake. It is worrisome to know that some pregnant women (from 2 studies) did not believe that SP use is beneficial, and several participants (from 4 studies) were unsure or did not see the drug as an effective intervention. Many pregnant women believe SP harms them, their partners, or their unborn children.

Conclusions: Healthcare professionals should continue prescribing and encouraging pregnant women to use SP for malaria prevention until a better substitute becomes available.

A century ago, Dr. I. Kligler, a Jewish Zionist in Palestine, initiated the first start anywhere in the world of a successful national malaria elimination campaign. It is little realised today that Palestine back then was drenched in malaria, rendering it uninhabitable in many areas, leaving it a country almost empty. Kligler recognised in his quest for malaria elimination firstly the need to demonstrate that malaria elimination was in fact possible. Secondly, he noted that the old colonial attitudes which then prevailed around the world towards subject populations also existed in Palestine. He realised that to be effective in educating anyone to assist with malaria elimination in such a colonial environment, that person would need to be educated, and such education had to be conducted with 'dignity and respect'. Such an attitude is something that was (and still is in many places) sadly missing within former colonies. Kligler knew the Zionist dream of a Jewish homeland in Palestine would in all probability be an impossibility unless malaria could be defeated there. He accordingly set out to initially demonstrate on a very small scale what could be achieved by way of malaria control. With dignity and respect, he engaged with all the inhabitants, both Arabs and Jews, sometimes even individually if necessary, to educate about the disease and to explain why his anti-malarial works were necessary, thereby enlisting the inhabitants effective assistance in these works. The result was enthusiastic co-operation by the inhabitants for over twenty years which was eventually rewarded with malaria elimination. Unfortunately, the example shown by Kligler is little known to the rest of the world today, and unless communities suffering from the disease learn from such examples, the task of malaria elimination elsewhere around the world will continue to be fraught with great difficulty, and more than likely to result in failure.

Background: Malaria in pregnancy is a significant public health concern in Nigeria. It threatens pregnant women and their unborn babies and undermines the achievement of Sustainable Development Goal 3. The World Health Organization has recommended intermittent preventive treatment with sulfadoxine-pyrimethamine [IPTp-SP] for its control, but there are challenges to its access and uptake.

Methods: Using the Arksey and O'Malley framework and the cascade of care model, we conducted a scoping review to investigate barriers and facilitators of IPTp-SP access and uptake, including their influence on pregnant women's health-seeking behaviour for the control of malaria in pregnancy in Nigeria. We searched seven scientific databases for papers published from 2005 to date.

Results: We included a total of 31 out of 2149 articles in the review. Poor provider knowledge of the IPTp-SP protocol and lack of essential commodities for sulphadoxine-pyrimethamine administration in clinics are significant barriers to IPTp-SP use. Staff shortages and poor remuneration of health care professionals are obstacles to IPTp-SP utilisation.

Conclusions: To improve IPTp-SP access and uptake, the government should ensure a continuous supply to clinics and support the employment of additional health care professionals who should be well paid and trained on using the IPTp-SP protocol.