Pub Date : 2025-11-01DOI: 10.1016/j.medcle.2025.107148
Montserrat Bosch , Elena Ballarín , Immaculada Danés
{"title":"Reply to: “Effectiveness of alirocumab and evolocumab (PCSK9i) for the treatment of hypercholesterolemia”","authors":"Montserrat Bosch , Elena Ballarín , Immaculada Danés","doi":"10.1016/j.medcle.2025.107148","DOIUrl":"10.1016/j.medcle.2025.107148","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 5","pages":"Article 107148"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145435569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.medcle.2025.107174
Montserrat Martínez Muñoz , Maria Ángeles Barba Flores , María José Abadias Medrano , Albert Salazar Soler , on behalf of the ACI-VH (Integrated Knowledge Areas - Vall d'Hebron) group
{"title":"Hospital transformation: From departmental specialties to integrated knowledge areas. An analysis of health outcomes and the experience of patients and professionals","authors":"Montserrat Martínez Muñoz , Maria Ángeles Barba Flores , María José Abadias Medrano , Albert Salazar Soler , on behalf of the ACI-VH (Integrated Knowledge Areas - Vall d'Hebron) group","doi":"10.1016/j.medcle.2025.107174","DOIUrl":"10.1016/j.medcle.2025.107174","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 5","pages":"Article 107174"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145435558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.medcle.2025.107191
José M. Porcel , Laura Porcel , Ricardo Campo-Linares
Point-of-care ultrasound (POCUS) is a rapid bedside imaging modality available to clinicians for the diagnosis of pleuropulmonary infections. Compared with chest radiography, POCUS is more sensitive in identifying pneumonia and its complications (parapneumonic pleural effusions, necrosis, and abscesses). The most common sonographic features of pneumonia are consolidation (with irregular margins and dynamic air bronchograms), B-lines, and pleural effusion. POCUS also has prognostic applications, for example, to determine the severity of COVID-19 pneumonia or to predict residual pleural thickening in a tuberculous effusion. Finally, the presence of a complex septated ultrasound pattern in the context of pleural infection is indicative of the need for drainage, which is performed using a thoracostomy tube and instillation of intrapleural enzyme therapy.
{"title":"Point-of-care ultrasound in pulmonary and pleural infections","authors":"José M. Porcel , Laura Porcel , Ricardo Campo-Linares","doi":"10.1016/j.medcle.2025.107191","DOIUrl":"10.1016/j.medcle.2025.107191","url":null,"abstract":"<div><div>Point-of-care ultrasound (POCUS) is a rapid bedside imaging modality available to clinicians for the diagnosis of pleuropulmonary infections. Compared with chest radiography, POCUS is more sensitive in identifying pneumonia and its complications (parapneumonic pleural effusions, necrosis, and abscesses). The most common sonographic features of pneumonia are consolidation (with irregular margins and dynamic air bronchograms), B-lines, and pleural effusion. POCUS also has prognostic applications, for example, to determine the severity of COVID-19 pneumonia or to predict residual pleural thickening in a tuberculous effusion. Finally, the presence of a complex septated ultrasound pattern in the context of pleural infection is indicative of the need for drainage, which is performed using a thoracostomy tube and instillation of intrapleural enzyme therapy.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 5","pages":"Article 107191"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145435247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.medcle.2025.107120
Carolina Tornero , Gabriel Á. Martos-Moreno , Núria Guañabens , Helena Flórez , Anna Ribera , Pilar Aguado
Background
The Global HPP Registry, an observational, prospective, multinational registry of patients with hypophosphatasia (HPP) (NCT02306720; EUPAS13514), was initiated in 2015. The aim of this study is to assess the symptomatology and impact of the disease in patients included in the national registry.
Methods
Baseline characteristics of patients included in the Registry by national centres were analysed (5/11/2015–4/03/2024).
Results
Of the 83 patients, 16 (19.3%) were under 18 years of age and 67 (80.7%) were adults. Median time to diagnosis was 4.8 (minimum: 0; maximum: 49.9) years. In paediatric patients, median age at symptom onset was 4 (minimum: 1.2; maximum: 11.8) years and the most prevalent symptoms were dental (37.5%), neurological (25%), and skeletal (18.8%). 23.7% of adults started with HPP-related symptoms before the age of 18 years and the most frequent symptoms were pain (64.2%), dental (50.7%), and skeletal (32.8%). Heterozygous ALPL variants were found in 96.3% of patients and the most frequent were c.343_348dup, c.334 G > C, and c.407 G > A. In adult patients, patient-reported outcomes (median [Q1; Q3]) on the quality of life questionnaire (SF-36v2) (scales 0–100) were 44.8 (34.5;50.2) for the physical component and 50.4 (38.9;56.5) for the mental component.
Conclusions
There is a significant delay in the diagnosis of HPP. The most frequent manifestations were dental in paediatric patients and pain in adults, with a relevant impact on quality of life.
全球HPP注册（NCT02306720; EUPAS13514）于2015年启动，是一项观察性、前瞻性、跨国的低磷代谢（HPP）患者注册。本研究的目的是评估纳入国家登记的患者的症状和疾病的影响。方法分析国家中心登记患者的基线特征（5/11/2015-4/03/2024）。结果83例患者中，18岁以下16例（19.3%），成人67例（80.7%）。中位诊断时间为4.8年（最小0年，最大49.9年）。在儿科患者中，症状发作的中位年龄为4岁（最小1.2岁，最大11.8岁），最常见的症状是牙齿（37.5%）、神经系统（25%）和骨骼（18.8%）。23.7%的成年人在18岁之前开始出现hp相关症状，最常见的症状是疼痛（64.2%）、牙齿（50.7%）和骨骼（32.8%）。在96.3%的患者中发现杂合ALPL变异，最常见的是C .343_348dup、C .334 G >； C和C .407 G >； A。在成人患者中，患者报告的生活质量问卷（SF-36v2）（量表0-100）的结果（中位数[Q1； Q3]）在身体部分为44.8(34.5;50.2)，在精神部分为50.4（38.9;56.5）。结论HPP的诊断存在明显的延迟。最常见的表现是儿科患者的牙齿和成人的疼痛，并对生活质量产生相关影响。
{"title":"Clinical characterization and impact of hypophosphatasia in Spain: An observational analysis of the Spanish cohort included in the Global HPP Registry","authors":"Carolina Tornero , Gabriel Á. Martos-Moreno , Núria Guañabens , Helena Flórez , Anna Ribera , Pilar Aguado","doi":"10.1016/j.medcle.2025.107120","DOIUrl":"10.1016/j.medcle.2025.107120","url":null,"abstract":"<div><h3>Background</h3><div>The Global HPP Registry, an observational, prospective, multinational registry of patients with hypophosphatasia (HPP) (<span><span>NCT02306720</span><svg><path></path></svg></span>; EUPAS13514), was initiated in 2015. The aim of this study is to assess the symptomatology and impact of the disease in patients included in the national registry.</div></div><div><h3>Methods</h3><div>Baseline characteristics of patients included in the Registry by national centres were analysed (5/11/2015–4/03/2024).</div></div><div><h3>Results</h3><div>Of the 83 patients, 16 (19.3%) were under 18 years of age and 67 (80.7%) were adults. Median time to diagnosis was 4.8 (minimum: 0; maximum: 49.9) years. In paediatric patients, median age at symptom onset was 4 (minimum: 1.2; maximum: 11.8) years and the most prevalent symptoms were dental (37.5%), neurological (25%), and skeletal (18.8%). 23.7% of adults started with HPP-related symptoms before the age of 18 years and the most frequent symptoms were pain (64.2%), dental (50.7%), and skeletal (32.8%). Heterozygous <em>ALPL</em> variants were found in 96.3% of patients and the most frequent were c.343_348dup, c.334 G > C, and c.407 G > A. In adult patients, patient-reported outcomes (median [Q1; Q3]) on the quality of life questionnaire (SF-36v2) (scales 0–100) were 44.8 (34.5;50.2) for the physical component and 50.4 (38.9;56.5) for the mental component.</div></div><div><h3>Conclusions</h3><div>There is a significant delay in the diagnosis of HPP. The most frequent manifestations were dental in paediatric patients and pain in adults, with a relevant impact on quality of life.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 5","pages":"Article 107120"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145435547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.medcle.2025.107157
Ana Zugasti Murillo , Javier Salvador Rodríguez
{"title":"The role of artificial intelligence in reducing obesity stigma in healthcare","authors":"Ana Zugasti Murillo , Javier Salvador Rodríguez","doi":"10.1016/j.medcle.2025.107157","DOIUrl":"10.1016/j.medcle.2025.107157","url":null,"abstract":"","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 5","pages":"Article 107157"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145435557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.medcle.2025.107145
Lucía Cayuela , Anna Michela Gaeta , Aurelio Cayuela
Background
This study analysed long-term trends in interstitial lung diseases (ILDs) incidence in Spain from 1992 to 2021, focusing on age, sex and temporal patterns.
Methods
We conducted an ecological trend study using data from the Global Burden of Disease (GBD) Study 2021. Age-standardized incidence rates (ASIRs) were calculated, and joinpoint regression was applied to evaluate temporal trends. An age-period-cohort (A-P-C) analysis was performed to assess the influence of age, calendar periods, and birth cohorts on incidence patterns.
Results
From 1992 to 2021, 141,141 incident cases of ILDs were estimated in Spain, with a slight male predominance (53.2%). ASIRs increased over the study period, with an average annual percentage change (AAPC) of 1.3% for men and 1.7% for women. Incidence rates rose with age, peaking in the 70–79 age group for both sexes. A-P-C analysis identified cohort effects, with later-born cohorts showing higher risks of ILDs. Period effects indicated a steady increase in incidence. Men consistently exhibited higher incidence rates than women, although the gap narrowed slightly over time.
Conclusions
The increasing incidence of ILDs in Spain underscores a growing public health challenge. Early diagnosis, targeted interventions, and ongoing research are vital to mitigate this rising burden.
{"title":"Long-term trends in interstitial lung diseases incidence in Spain","authors":"Lucía Cayuela , Anna Michela Gaeta , Aurelio Cayuela","doi":"10.1016/j.medcle.2025.107145","DOIUrl":"10.1016/j.medcle.2025.107145","url":null,"abstract":"<div><h3>Background</h3><div>This study analysed long-term trends in interstitial lung diseases (ILDs) incidence in Spain from 1992 to 2021, focusing on age, sex and temporal patterns.</div></div><div><h3>Methods</h3><div>We conducted an ecological trend study using data from the Global Burden of Disease (GBD) Study 2021. Age-standardized incidence rates (ASIRs) were calculated, and joinpoint regression was applied to evaluate temporal trends. An age-period-cohort (A-P-C) analysis was performed to assess the influence of age, calendar periods, and birth cohorts on incidence patterns.</div></div><div><h3>Results</h3><div>From 1992 to 2021, 141,141 incident cases of ILDs were estimated in Spain, with a slight male predominance (53.2%). ASIRs increased over the study period, with an average annual percentage change (AAPC) of 1.3% for men and 1.7% for women. Incidence rates rose with age, peaking in the 70–79 age group for both sexes. A-P-C analysis identified cohort effects, with later-born cohorts showing higher risks of ILDs. Period effects indicated a steady increase in incidence. Men consistently exhibited higher incidence rates than women, although the gap narrowed slightly over time.</div></div><div><h3>Conclusions</h3><div>The increasing incidence of ILDs in Spain underscores a growing public health challenge. Early diagnosis, targeted interventions, and ongoing research are vital to mitigate this rising burden.</div></div>","PeriodicalId":74154,"journal":{"name":"Medicina clinica (English ed.)","volume":"165 5","pages":"Article 107145"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145435548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号