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Medicina clinica (English ed.)最新文献

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Meningitis after prostatic abscess due to hypervirulent Klebsiella pneumoniae 高化脓性肺炎克雷伯菌引起的前列腺脓肿后脑膜炎
Medicina clinica (English ed.)
Pub Date : 2024-08-31 DOI: 10.1016/j.medcle.2024.03.011
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引用次数: 0
Bisalbuminemia 双白蛋白血症
Medicina clinica (English ed.)
Pub Date : 2024-08-30 DOI: 10.1016/j.medcle.2023.12.027
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引用次数: 0
Forensic medicine units in hospitals, a necessary care system 医院法医室，必要的护理系统
Medicina clinica (English ed.)
Pub Date : 2024-08-30 DOI: 10.1016/j.medcle.2024.03.009
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引用次数: 0
Pulmonary and mediastinal nocardiosis due to lymph node involvement 淋巴结受累导致的肺部和纵隔线虫病
Medicina clinica (English ed.)
Pub Date : 2024-08-30 DOI: 10.1016/j.medcle.2024.07.005
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引用次数: 0
Clinico-pathological evaluation of tumor budding in the oncological progression of colorectal cancer 结直肠癌肿瘤进展过程中肿瘤出芽的临床病理学评估
Medicina clinica (English ed.)
Pub Date : 2024-08-30 DOI: 10.1016/j.medcle.2024.07.004

Introduction

Tumor Budding (TB), defined as the presence of individual neoplastic cells or isolated groups of up to 4 cells at the front of tumor invasion, has become an adverse prognostic marker in colorectal cancer (CRC) in recent decades. The prognostic impact of TB in CRC remains not clearly defined and histological methods for its evaluation vary depending on the center. The objective of this study is to investigate the association between TB and CRC, in terms of oncological evolution and pathological stage.

Methods

A retrospective observational study was conducted, including patients undergoing curative oncological surgery for CRC between January 2017 and December 2022. The effects of TB on disease-free survival (DFS) and overall survival (OS) were evaluated according to the Kaplan-Meier curves.

Results

In 78 cases TB was described in the pathology report. TB was present in 56 patients (71.8%), divided into the following categories: low grade in 22 (39.3%), intermediate grade in 17 (30.4%) and high grade in 17 (30.4%). The proportion of patients who presented lymph node metastases, lympho-vascular and perineural invasion was significantly higher in patients with TB (26.8% vs 0%, P = .008; 41.1% vs 4.5%, P = .002; 16.1% vs 0% P = .054; respectively). DFS was 86.3% in low-grade TB, 75.3% in intermediate-grade TB, and 70.3% in high-grade TB. Cases with intermediate and high grade were associated with a shorter OS compared to the low grade group (93.7% and 75.4% vs 100% P = .012, respectively).

Conclusion

These results suggest that TB expression may be a useful risk factor as a prognostic factor for the detection of lymph node metastasis, local recurrence, and distant metastasis in CRC.

导言肿瘤萌发（TB）是指肿瘤侵袭前沿出现单个肿瘤细胞或最多由 4 个细胞组成的孤立细胞群，近几十年来已成为结直肠癌（CRC）的一个不良预后标志。TB 对 CRC 预后的影响仍未明确界定，而且不同中心评估 TB 的组织学方法也不尽相同。本研究旨在从肿瘤演变和病理分期的角度探讨结核与 CRC 之间的关联。研究方法开展了一项回顾性观察研究，研究对象包括 2017 年 1 月至 2022 年 12 月间接受治愈性肿瘤手术治疗的 CRC 患者。根据 Kaplan-Meier 曲线评估了 TB 对无病生存期（DFS）和总生存期（OS）的影响。56例患者（71.8%）存在肺结核，分为以下几类：低分级22例（39.3%）、中分级17例（30.4%）和高级别17例（30.4%）。肺结核患者出现淋巴结转移、淋巴管和神经周围侵犯的比例明显更高（分别为26.8% vs 0%，P = .008；41.1% vs 4.5%，P = .002；16.1% vs 0% P = .054）。低级别肺结核的 DFS 为 86.3%，中级肺结核为 75.3%，高级别肺结核为 70.3%。这些结果表明，TB 表达可能是检测 CRC 淋巴结转移、局部复发和远处转移的一个有用的预后风险因素。
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引用次数: 0
Vasospasm due to ingestion of a combination of psychoactive substances: A case study 摄入多种精神活性物质导致血管痉挛：病例研究
Medicina clinica (English ed.)
Pub Date : 2024-08-30 DOI: 10.1016/j.medcle.2024.07.002
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引用次数: 0
Plasmacytoma of the maxillary sinus in a patient with refractory multiple myeloma 一名难治性多发性骨髓瘤患者的上颌窦浆细胞瘤
Medicina clinica (English ed.)
Pub Date : 2024-08-30 DOI: 10.1016/j.medcle.2023.12.028
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引用次数: 0
Endobronchial leiomyoma in a patient of 19 years 一名 19 岁患者的支气管内膜良性肌瘤
Medicina clinica (English ed.)
Pub Date : 2024-08-30 DOI: 10.1016/j.medcle.2024.02.013
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引用次数: 0
Medical death certificate, need for the electronic medical certificate and its benefits for public health 死亡医学证明书、电子医学证明书的必要性及其对公共卫生的益处
Medicina clinica (English ed.)
Pub Date : 2024-08-30 DOI: 10.1016/j.medcle.2024.04.009
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引用次数: 0
Xanthogranulomatous pyelonephritis: “Bear's paw sign” 黄疽性肾盂肾炎："熊掌征
Medicina clinica (English ed.)
Pub Date : 2024-08-30 DOI: 10.1016/j.medcle.2023.11.044
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引用次数: 0
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