Pub Date : 2023-07-01DOI: 10.3928/25731777-20230710-09
D. Beeler, K. Mileham, Beth York, M. Szafranski, D. Walsh
{"title":"Supportive Oncology in Lung Cancer: Program Development for Patients and Care Partners","authors":"D. Beeler, K. Mileham, Beth York, M. Szafranski, D. Walsh","doi":"10.3928/25731777-20230710-09","DOIUrl":"https://doi.org/10.3928/25731777-20230710-09","url":null,"abstract":"","PeriodicalId":74342,"journal":{"name":"Oncology issues","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47621851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.3928/25731777-20230710-08
K. Rogen, Brenda Ramczyk, Tessa Bachinski, Deborah Wham, Amy M. Schoenebeck, M. Mullane
provider or the physician who referred them to genetic counseling. Primary care providers have demonstrated a knowledge gap about the management of BRCA1 and BRCA2 and report feeling uncom-fortable with cancer risk management due to the rapidly changing landscape of genetics. 4,18 Patients also report that they receive differing
{"title":"A Comprehensive Cancer Risk Management Clinic for Families With Hereditary Cancer Syndromes: Outcomes After 6 Years","authors":"K. Rogen, Brenda Ramczyk, Tessa Bachinski, Deborah Wham, Amy M. Schoenebeck, M. Mullane","doi":"10.3928/25731777-20230710-08","DOIUrl":"https://doi.org/10.3928/25731777-20230710-08","url":null,"abstract":"provider or the physician who referred them to genetic counseling. Primary care providers have demonstrated a knowledge gap about the management of BRCA1 and BRCA2 and report feeling uncom-fortable with cancer risk management due to the rapidly changing landscape of genetics. 4,18 Patients also report that they receive differing","PeriodicalId":74342,"journal":{"name":"Oncology issues","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47552909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.3928/25731777-20230710-04
Monique J. Marino
{"title":"Trending Now in Cancer Care","authors":"Monique J. Marino","doi":"10.3928/25731777-20230710-04","DOIUrl":"https://doi.org/10.3928/25731777-20230710-04","url":null,"abstract":"","PeriodicalId":74342,"journal":{"name":"Oncology issues","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45023977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16eCollection Date: 2024-01-01DOI: 10.1016/j.pld.2023.06.005
Tongzhou Tao, Richard I Milne, Jialiang Li, Heng Yang, Shiyang Wang, Sihan Chen, Kangshan Mao
Endangered species generally have small populations with low genetic diversity and a high genetic load. Thuja sutchuenensis is an endangered conifer endemic to southwestern China. It was once considered extinct in the wild, but in 1999 was rediscovered. However, little is known about its genetic load. We collected 67 individuals from five wild, isolated T. sutchuenensis populations, and used 636,151 SNPs to analyze the level of genetic diversity and genetic load in T. sutchuenensis to delineate the conservation units of T. sutchuenensis, based on whole transcriptome sequencing data, as well as target capture sequencing data. We found that populations of T. sutchuenensis could be divided into three groups. These groups had low levels genetic diversity and were moderately genetically differentiated. Our findings also indicate that T. sutchuenensis suffered two severe bottlenecks around the Last Glaciation Period and Last Glacial Maximum. Among Thuja species, T. sutchuenensis presented the lowest genetic load and hence might have purged deleterious mutations efficiently through purifying selection. However, distribution of fitness effects analysis indicated a high extinction risk for T. sutchuenensis. Multiple lines of evidence identified three management units for T. sutchuenensis. Although T. sutchuenensis possesses a low genetic load, low genetic diversity, suboptimal fitness, and anthropogenic pressures all present an extinction risk for this rare conifer. This might also hold true for many endangered plant species in the mountains all over the world.
{"title":"Conservation genomic investigation of an endangered conifer, <i>Thuja sutchuenensis</i>, reveals low genetic diversity but also low genetic load.","authors":"Tongzhou Tao, Richard I Milne, Jialiang Li, Heng Yang, Shiyang Wang, Sihan Chen, Kangshan Mao","doi":"10.1016/j.pld.2023.06.005","DOIUrl":"10.1016/j.pld.2023.06.005","url":null,"abstract":"<p><p>Endangered species generally have small populations with low genetic diversity and a high genetic load. <i>Thuja sutchuenensis</i> is an endangered conifer endemic to southwestern China. It was once considered extinct in the wild, but in 1999 was rediscovered. However, little is known about its genetic load. We collected 67 individuals from five wild, isolated <i>T. sutchuenensis</i> populations, and used 636,151 SNPs to analyze the level of genetic diversity and genetic load in <i>T. sutchuenensis</i> to delineate the conservation units of <i>T. sutchuenensis</i>, based on whole transcriptome sequencing data, as well as target capture sequencing data. We found that populations of <i>T. sutchuenensis</i> could be divided into three groups. These groups had low levels genetic diversity and were moderately genetically differentiated<i>.</i> Our findings also indicate that <i>T. sutchuenensis</i> suffered two severe bottlenecks around the Last Glaciation Period and Last Glacial Maximum. Among <i>Thuja</i> species, <i>T. sutchuenensis</i> presented the lowest genetic load and hence might have purged deleterious mutations efficiently through purifying selection. However, distribution of fitness effects analysis indicated a high extinction risk for <i>T. sutchuenensis</i>. Multiple lines of evidence identified three management units for <i>T. sutchuenensis</i>. Although <i>T. sutchuenensis</i> possesses a low genetic load, low genetic diversity, suboptimal fitness, and anthropogenic pressures all present an extinction risk for this rare conifer. This might also hold true for many endangered plant species in the mountains all over the world.</p>","PeriodicalId":74342,"journal":{"name":"Oncology issues","volume":"19 1","pages":"78-90"},"PeriodicalIF":4.8,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10851309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81723860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.3928/25731777-20230515-01
Mark Liu
{"title":"#AMCCBS, the 2023 ACCC Innovator Award Winners, and More","authors":"Mark Liu","doi":"10.3928/25731777-20230515-01","DOIUrl":"https://doi.org/10.3928/25731777-20230515-01","url":null,"abstract":"","PeriodicalId":74342,"journal":{"name":"Oncology issues","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48289833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.3928/25731777-20230515-15
Teri Bedard
{"title":"Returning to “Normal” The End of the COVID-19 Public Health Emergency","authors":"Teri Bedard","doi":"10.3928/25731777-20230515-15","DOIUrl":"https://doi.org/10.3928/25731777-20230515-15","url":null,"abstract":"","PeriodicalId":74342,"journal":{"name":"Oncology issues","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47811104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.3928/25731777-20230515-07
{"title":"ACCC's Call to Action:\u0000 Delivery of Psychosocial Care in Oncology Summit","authors":"","doi":"10.3928/25731777-20230515-07","DOIUrl":"https://doi.org/10.3928/25731777-20230515-07","url":null,"abstract":"","PeriodicalId":74342,"journal":{"name":"Oncology issues","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43413105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.3928/25731777-20230515-08
P recision medicine is all about the details. It is stepping away from a one-size-fits-all approach for cancer diagnostics and when implemented correctly, ensures each patient has access to the most appropriate biomarker testing and associated treatment options. Therefore, it is only natural that with the transition to more complex testing, cancer programs can benefit from customizing their staff as well, by designating a precision medicine expert to navigate the labyrinth of biomarker testing processes and results.
{"title":"An Innovative Approach to Navigating Patients Through Cancer Diagnostics: Precision Medicine Stewards: Applying Precision Principles to Biomarker Testing Processes to Improve Patient Access","authors":"","doi":"10.3928/25731777-20230515-08","DOIUrl":"https://doi.org/10.3928/25731777-20230515-08","url":null,"abstract":"P recision medicine is all about the details. It is stepping away from a one-size-fits-all approach for cancer diagnostics and when implemented correctly, ensures each patient has access to the most appropriate biomarker testing and associated treatment options. Therefore, it is only natural that with the transition to more complex testing, cancer programs can benefit from customizing their staff as well, by designating a precision medicine expert to navigate the labyrinth of biomarker testing processes and results.","PeriodicalId":74342,"journal":{"name":"Oncology issues","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42444105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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