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Principles and practice of clinical research (2015)最新文献

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Effectiveness of an mHealth App as an add-on for Smoking Cessation in One year: A multicenter and randomized Trial (The MASCOT study) 一款移动健康应用在一年内作为戒烟辅助工具的有效性:一项多中心随机试验(MASCOT研究)
Principles and practice of clinical research (2015)
Pub Date : 2022-12-20 DOI: 10.21801/ppcrj.2022.83.6
Tatiana Gomez Gomez
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引用次数: 0
Neuromuscular Electrical Stimulation (NMES) as an Add-on Therapy for the Improvement of Dyspnea in Patients with Post-Covid Syndrome: a Protocol for a Phase II Randomized, Non-Pharmacological Intervention-Controlled, Double-Blind Study. 神经肌肉电刺激(NMES)作为改善新冠肺炎后综合征患者呼吸困难的附加疗法:一项随机、非药物干预对照、双盲研究方案
Principles and practice of clinical research (2015)
Pub Date : 2022-12-20 DOI: 10.21801/ppcrj.2022.83.1
Anusree Anil Kumar
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引用次数: 0
Efficacy of Cannabidiol Versus Ibuprofen in the Relief of Menstrual Pain in Females Living with Primary Dysmenorrhea A phase II, Non-Inferiority trial 大麻二酚与布洛芬缓解女性原发性痛经疼痛的疗效:II期非劣效性试验
Principles and practice of clinical research (2015)
Pub Date : 2022-12-20 DOI: 10.21801/ppcrj.2022.83.7
Haneesha Mohan
Introduction: Pain is the cardinal symptom in women living with primary dysmenorrhea (PDM), resulting in a relentless negative effect on their quality of life. Women with PDM have higher levels of prostaglandin in their endometrial fluid, which correlates with the degree of pain. The standard of care treatment for pain associated with PDM starts with nonsteroidal anti-inflammatory drugs (NSAIDs) that block prostaglandin-triggering enzymes. Although NSAIDs are a feasible option, they are also associated with a significant risk of side effects. Around 20 to 25% of patients will experience pain refractory to NSAIDs and seek alternative therapies. Cannabidiol (CBD) is a well-tolerated potential therapy for several chronic diseases, including pain, and acts by blocking prostaglandin-triggering enzymes, similar to NSAIDs. The safety of CBD is well established, with the advantage of acting via central and peripheral mechanisms. To date, no previous trials assessing CBD alone for dysmenorrhea have been conducted. Objective: To evaluate the effect of CBD alone in reducing acute menstrual pain compared to ibuprofen, as assessed by the total pain relief (TOTPAR) scale. Design: Randomized (with random block sizes), triple-blinded, multicenter, parallel-group, non-inferiority clinical trial. Participants: PDM patients aged 18 to 40 years, with regular menstrual cycles (ranging from 21 to 35 days) and a visual analog scale (VAS) score of ≥ 5. Academic Editor: Felipe Fregni Peer-reviewers: Natalia Suarez; Giovani Farina; Magali Andrea Pestana; Luis Morales Ojeda. Copyright: © 2022 by the authors. Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
简介:疼痛是原发性痛经(PDM)女性的主要症状，对她们的生活质量产生了无情的负面影响。患有PDM的女性子宫内膜液中前列腺素水平较高，这与疼痛程度有关。PDM相关疼痛的标准治疗开始于非甾体抗炎药(NSAIDs)，阻断前列腺素触发酶。尽管非甾体抗炎药是一种可行的选择，但它们也有显著的副作用风险。大约20%到25%的患者会对非甾体抗炎药产生难治性疼痛，并寻求替代疗法。大麻二酚(CBD)是一种耐受性良好的潜在治疗多种慢性疾病，包括疼痛，并通过阻断前列腺素触发酶起作用，类似于非甾体抗炎药。CBD的安全性是公认的，具有通过中枢和外周机制起作用的优势。迄今为止，还没有单独评估CBD治疗痛经的试验。目的:通过总疼痛缓解(TOTPAR)量表评估CBD与布洛芬在减轻急性经期疼痛方面的效果。设计:随机(随机分组大小)、三盲、多中心、平行组、非劣效性临床试验。参与者:年龄18 - 40岁，月经周期正常(21 - 35天)，视觉模拟评分(VAS)评分≥5的PDM患者。学术编辑:Felipe Fregni同行评审:Natalia Suarez;Giovani淀粉;Magali Andrea Pestana;路易斯·莫拉莱斯·奥赫达。版权所有:©2022作者所有。知识共享署名(CC BY)许可(https://creativecommons.org/licenses/by/4.0/)。
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引用次数: 0
Clinical and hemodynamic phenotype of BMPR2 variation carriers with pulmonary arterial hypertension: A systematic review and a call to action 肺动脉高压BMPR2变异携带者的临床和血流动力学表型:系统回顾和行动呼吁
Principles and practice of clinical research (2015)
Pub Date : 2022-12-20 DOI: 10.21801/ppcrj.2022.83.9
David Rodríguez, Miguel A. Floran-Bautista, B. Illigens, Tiago Lemos Cerqueira, A. Ramírez-Rivera, C. Jerjes-Sánchez
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引用次数: 0
Efficacy and safety of over-the-scope clips® com-pared to through-the-scope clips for initial bleeding control in non-variceal upper gastrointestinal bleeding: a multicenter randomized clinical trial 非静脉曲张性上消化道出血患者经内镜夹与经内镜夹治疗初期出血的疗效和安全性：一项多中心随机临床试验
Principles and practice of clinical research (2015)
Pub Date : 2022-12-20 DOI: 10.21801/ppcrj.2022.83.3
F. Lopes
:
：
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引用次数: 0
Protective Effect of Surgical Masks versus N95 Respirator in Prevention of SARS-CoV-2 Contami-nation in Healthcare Professionals: Systematic Re-view Protocol 医用口罩与N95口罩对医护人员预防SARS-CoV-2污染的防护效果:系统评价方案
Principles and practice of clinical research (2015)
Pub Date : 2022-12-20 DOI: 10.21801/ppcrj.2022.83.4
R. L. Gonçalves
: Introduction
：简介
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引用次数: 0
The KDEP Trial: Protocol for a phase II, multicenter, open label, randomized controlled trial to evaluate the efficacy of ketogenic diet for symptomatic improvement of moderate to severe Major Depressive Disorder KDEP试验：一项II期、多中心、开放标签、随机对照试验的方案，旨在评估生酮饮食对中重度重度抑郁症症状改善的疗效
Principles and practice of clinical research (2015)
Pub Date : 2022-12-20 DOI: 10.21801/ppcrj.2022.83.10
Gargi Kakani
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引用次数: 0
Editorial: Bench to Bedside - the translation of intracortical inhibition marker to clinical practice. 编辑:从实验室到床边——皮质内抑制标志物到临床实践的转化。
Principles and practice of clinical research (2015)
Pub Date : 2022-12-02 DOI: 10.21801/ppcrj.2022.83.11
Danielle Carolina Pimenta, Daniel Lima, Eric Slawka, Kevin Pacheco-Barrios, Felipe Fregni
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引用次数: 0
Telehealth usability evaluation by healthcare professionals in post-pandemic treatment of non-communicable diseases (hypertension and diabetes): Systematic Review Protocol 卫生保健专业人员在大流行后非传染性疾病(高血压和糖尿病)治疗中的远程保健可用性评价:系统审查议定书
Principles and practice of clinical research (2015)
Pub Date : 2022-11-28 DOI: 10.21801/ppcrj.2022.82.6
R. L. Gonçalves, A. Pagano, Z. Reis, Seth Kwaku Afagbedzi, Michael Head, K. Brackstone, M. Marcolino, T. Lopes, S. A. Cordeiro, J. M. Nunes, James Batchelor, A. L. P. Ribeiro
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引用次数: 0
Neurofeedback for Attention Deficit Disorder in preschoolers (NeFAP): A randomized, sham-controlled, efficacy study protocol of a novel non-pharmacological therapy 学龄前儿童注意缺陷障碍的神经反馈（NeFAP）：一种新的非药物治疗的随机、假对照、疗效研究方案
Principles and practice of clinical research (2015)
Pub Date : 2022-11-28 DOI: 10.21801/ppcrj.2022.82.7
A. Pugliesi, Niraj A. Mehta, Daniel Guimarães Silva, Jennifer P. Khouri López, Cornelis Anibal Luna Fuerte, Nicolas Nuñez-Ordonez, Suzy Krimon, Omar Kotb, Sahilly Adelina Rodríguez-Martínez, Janaina Lima, Douaa Omer Mohamed, Cristiane Paulain David, Nathalia Satoo Demian F., Joyce Macedo da Silva, A. Yock-Corrales
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引用次数: 0
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