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Psoriasis (Auckland, N.Z.)最新文献

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Psoriasis patients' experiences concerning medical adherence to treatment with topical corticosteroids. 银屑病患者对局部皮质类固醇治疗的依从性的经验。
Q1 DERMATOLOGY Pub Date : 2016-08-23 eCollection Date: 2016-01-01 DOI: 10.2147/PTT.S109557
Mathias Tiedemann Svendsen, Klaus Ejner Andersen, Flemming Andersen, Jakob Hansen, Anton Pottegård, Helle Johannessen

Nonadherence to topical treatment of psoriasis is a common cause of treatment failure. This focus group study was conducted to obtain the patients' own experiences and explanations regarding medical adherence. The participants consisted of eight primary adherent patients with moderate psoriasis treated with corticosteroid or corticosteroid-calcipotriol combinations, purposefully sampled by age and sex at a dermatology outpatient clinic. Secondary medical adherence was supported by accessibility of the prescribing physician, the prescriber taking time to listen, having a more manageable disease, using a nonstaining product, and establishing routines around treatment at home. Secondary medical adherence was affected negatively by changes in daily routines, if the treatment influenced the patient's sexual life, having too little time in the consultation room, lack of confidence in the prescriber, diverging information from health care personnel, experiencing side effects, having fear of side effects, impractical formulations of topical products, and impatience regarding time before an effect of the treatment was observed. From this study, the recommendations for the prescribing doctor to improve medical adherence are, the doctor needs to take time to listen to the patient, prescribe a topical product that is easy to apply and less greasy, inform the patients about benefits from treatments, and explain the rationale behind the treatment plan.

不坚持局部治疗牛皮癣是治疗失败的常见原因。本焦点小组研究是为了获得患者自身的经验和对医疗依从性的解释。参与者包括8名接受皮质类固醇或皮质类固醇-钙化三醇联合治疗的中度牛皮癣患者,有目的地按年龄和性别在皮肤科门诊进行抽样。二级医疗依从性得到了以下方面的支持:开处方的医生的可及性、开处方的医生花时间倾听、疾病更易于控制、使用不染色的产品,以及在家中建立治疗常规。如果治疗影响了患者的性生活,在诊室呆的时间太少,对处方医生缺乏信心,与卫生保健人员的信息不一致,经历副作用,害怕副作用,局部产品的配方不切实际,以及在观察到治疗效果之前对时间缺乏耐心,则日常生活的变化会对二级医疗依从性产生负面影响。从这项研究中,对开处方的医生提高医疗依从性的建议是,医生需要花时间倾听病人的意见,开一种易于使用且不油腻的局部产品,告知病人治疗的好处,并解释治疗计划背后的理由。
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引用次数: 13
Combining biologic and phototherapy treatments for psoriasis: safety, efficacy, and patient acceptability. 银屑病生物与光疗联合治疗:安全性、有效性和患者可接受性。
Q1 DERMATOLOGY Pub Date : 2016-07-28 eCollection Date: 2016-01-01 DOI: 10.2147/PTT.S98952
Benjamin Farahnik, Viraat Patel, Kourosh Beroukhim, Tian Hao Zhu, Michael Abrouk, Mio Nakamura, Rasnik Singh, Kristina Lee, Tina Bhutani, John Koo

Background: The efficacy and safety of biologic and phototherapy in treating moderate-to-severe psoriasis is well known. However, some patients may not respond well to biologic agents or phototherapy on their own and may require combination therapy. Skillfully combining a biologic agent and phototherapy may provide an additive improvement without much increase in risks.

Objective: To summarize the current state of evidence for the efficacy and safety of combining biologics with phototherapy in the treatment of moderate-to-severe plaque psoriasis.

Methods: We conducted an extensive search on Pubmed database for English language literature that evaluated the use of a combination of biologic and phototherapy for the treatment of moderate-to-severe psoriasis through January 2016. The search included the following key-words: psoriasis, etanercept, adalimumab, infliximab, ustekinumab, biologics, phototherapy, and combination therapy.

Results: The primary literature included randomized controlled trials, a head-to-head study, open-label controlled and uncontrolled trials, case series, and case reports. Etanercept was used in over half of the reported cases, but other biologic agents used included ustekinumab, adalimumab, and infliximab. The vast majority of phototherapy was narrowband ultraviolet B (NBUVB) radiation. Most cases reported enhanced improvement with combination therapy. Serious adverse events throughout the study duration were reported in <3% of the patients. Long-term adverse events cannot be excluded.

Conclusion: Combination of biologic and phototherapy appears to be a viable clinical strategy in the treatment of moderate-to-severe psoriasis not responsive to monotherapy, despite limitations in the data available. NBUVB in combination with biologics appears to be especially effective. However, the long-term impact of these combinations is yet to be determined.

背景:生物和光疗治疗中重度牛皮癣的有效性和安全性是众所周知的。然而,一些患者可能对生物制剂或光疗本身反应不佳,可能需要联合治疗。巧妙地结合生物制剂和光疗法可以提供一种附加的改善,而不增加太多的风险。目的:总结生物制剂联合光疗治疗中重度斑块型银屑病的疗效和安全性的证据现状。方法:我们在Pubmed数据库中进行了广泛的英语文献检索,评估了截至2016年1月生物和光疗联合治疗中重度牛皮癣的使用情况。搜索的关键词包括:银屑病、依那西普、阿达木单抗、英夫利昔单抗、乌斯特金单抗、生物制剂、光疗和联合治疗。结果:主要文献包括随机对照试验、头对头研究、开放标签对照和非对照试验、病例系列和病例报告。超过一半的报告病例使用依那西普,但使用的其他生物制剂包括乌斯特金单抗、阿达木单抗和英夫利昔单抗。绝大多数光疗是窄带紫外线B (NBUVB)辐射。大多数病例报告了联合治疗的改善。结论中报道了整个研究期间的严重不良事件:尽管现有数据有限,但生物和光疗法联合治疗对单一疗法无反应的中重度牛皮癣似乎是一种可行的临床策略。NBUVB与生物制剂联合使用似乎特别有效。然而,这些组合的长期影响还有待确定。
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引用次数: 9
Psoriasis and inflammatory bowel disease: links and risks. 牛皮癣和炎症性肠病:联系和风险。
Q1 DERMATOLOGY Pub Date : 2016-07-20 eCollection Date: 2016-01-01 DOI: 10.2147/PTT.S85194
Christoforos Vlachos, Georgios Gaitanis, Konstantinos H Katsanos, Dimitrios K Christodoulou, Epameinondas Tsianos, Ioannis D Bassukas

Psoriasis and the spectrum of inflammatory bowel diseases (IBD) are chronic, inflammatory, organotropic conditions. The epidemiologic coexistence of these diseases is corroborated by findings at the level of disease, biogeography, and intrafamilial and intrapatient coincidence. The identification of shared susceptibility loci and DNA polymorphisms has confirmed this correlation at a genetic level. The pathogenesis of both diseases implicates the innate and adaptive segments of the immune system. Increased permeability of the epidermal barrier in skin and intestine underlies the augmented interaction of allergens and pathogens with inflammatory receptors of immune cells. The immune response between psoriasis and IBD is similar and comprises phagocytic, dendritic, and natural killer cell, along with a milieu of cytokines and antimicrobial peptides that stimulate T-cells. The interplay between dendritic cells and Th17 cells appears to be the core dysregulated immune pathway in all these conditions. The distinct similarities in the pathogenesis are also reflected in the wide overlapping of their therapeutic approaches. Small-molecule pharmacologic immunomodulators have been applied, and more recently, biologic treatments that target proinflammatory interleukins have been introduced or are currently being evaluated. However, the fact that some treatments are quite selective for either skin or gut conditions also highlights their crucial pathophysiologic differences. In the present review, a comprehensive comparison of risk factors, pathogenesis links, and therapeutic strategies for psoriasis and IBD is presented. Specific emphasis is placed on the role of the immune cell species and inflammatory mediators participating in the pathogenesis of these diseases.

牛皮癣和炎症性肠病谱(IBD)是慢性、炎症性、嗜器官疾病。这些疾病的流行病学共存被疾病水平、生物地理、家族内和患者内巧合的发现所证实。共同易感位点和DNA多态性的鉴定在遗传水平上证实了这种相关性。这两种疾病的发病机制都与免疫系统的先天和适应性部分有关。皮肤和肠道表皮屏障通透性的增加是过敏原和病原体与免疫细胞炎症受体相互作用增强的基础。牛皮癣和IBD之间的免疫反应是相似的,包括吞噬细胞、树突状细胞和自然杀伤细胞,以及刺激t细胞的细胞因子和抗菌肽环境。树突状细胞和Th17细胞之间的相互作用似乎是所有这些疾病中核心的失调免疫途径。在发病机制上的明显相似性也反映在它们的治疗方法的广泛重叠上。小分子药理学免疫调节剂已经被应用,最近,针对促炎白细胞介素的生物治疗已经被引入或正在评估中。然而,一些治疗方法对皮肤或肠道疾病都很有选择性,这一事实也凸显了它们关键的病理生理差异。本文就牛皮癣和IBD的危险因素、发病机制和治疗策略进行综述。特别强调免疫细胞种类和炎症介质参与这些疾病的发病机制的作用。
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引用次数: 50
Psoriasis and smoking: links and risks. 牛皮癣和吸烟:联系和风险。
Q1 DERMATOLOGY Pub Date : 2016-05-27 eCollection Date: 2016-01-01 DOI: 10.2147/PTT.S85189
Luigi Naldi

Smoking is a complex environmental exposure influenced by genetic, environmental, and social factors. Nicotine is the principal alkaloid in tobacco that mediates the addicting effects of tobacco products. Tobacco is a mixture of more than 7,000 chemicals, and smoking is recognized as a risk factor for many diseases in humans, including cardiovascular and pulmonary disease and several cancers, and is the single most preventable cause of mortality worldwide. A number of inflammatory immune-related conditions have been associated with smoking, including psoriasis. Smoking affects the onset of psoriasis. In a pooled analysis of 25 case-control studies, the odds ratio of psoriasis among smokers was 1.78 (95% confidence interval [CI]: 1.53-2.06). A dose-effect relationship is also documented. In a pooled analysis of three cohort studies, the risk of incident psoriasis was 1.81 (95% CI: 1.38-2.36) in those who smoked 1-14 cigarettes per day, and 2.29 (95% CI: 1.74-3.01) in those who smoked ≥25 cigarettes per day. Smoking also impacts on the clinical severity of psoriasis, its response to treatment, and explains some of the associated comorbidities, eg, cardiovascular disease, inflammatory bowel disease, and several cancers (especially those of the respiratory tract). Data on the role of smoking in psoriatic arthritis are less consistent compared with those concerning psoriasis. Several pathophysiological mechanisms may explain the association of psoriasis with smoking, including oxidative stress, interaction with signaling pathways active in psoriasis, and vascular influences. In conclusion, psoriasis is just one of the many diseases associated with smoking, but it is visible and disabling. Dermatologists could play a major role in reducing the health burden of smoking by influencing the patients to change their behavior.

吸烟是一种受遗传、环境和社会因素影响的复杂环境暴露。尼古丁是烟草中主要的生物碱,介导烟草制品的成瘾性。烟草是7 000多种化学物质的混合物,吸烟被认为是人类许多疾病的风险因素,包括心血管疾病和肺病以及几种癌症,并且是全世界最可预防的单一死亡原因。许多炎症性免疫相关疾病都与吸烟有关,包括牛皮癣。吸烟会影响牛皮癣的发病。在25项病例对照研究的汇总分析中,吸烟者患牛皮癣的优势比为1.78(95%可信区间[CI]: 1.53-2.06)。还记录了剂量效应关系。在三项队列研究的汇总分析中,每天吸烟1-14支的人发生牛皮癣的风险为1.81 (95% CI: 1.38-2.36),每天吸烟≥25支的人发生牛皮癣的风险为2.29 (95% CI: 1.74-3.01)。吸烟还影响牛皮癣的临床严重程度及其对治疗的反应,并解释了一些相关的合并症,例如心血管疾病、炎症性肠病和几种癌症(特别是呼吸道癌症)。与银屑病相关的数据相比,吸烟在银屑病关节炎中的作用的数据不太一致。几种病理生理机制可以解释银屑病与吸烟的关联,包括氧化应激、银屑病中活跃的信号通路的相互作用以及血管的影响。总之,牛皮癣只是与吸烟有关的许多疾病之一,但它是可见的,并且使人致残。皮肤科医生可以通过影响患者改变他们的行为,在减轻吸烟带来的健康负担方面发挥重要作用。
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引用次数: 61
Improving access to home phototherapy for patients with psoriasis: current challenges and future prospects. 改善牛皮癣患者家庭光疗的可及性:当前挑战和未来前景
Q1 DERMATOLOGY Pub Date : 2016-05-18 eCollection Date: 2016-01-01 DOI: 10.2147/PTT.S81958
Sylvie M Franken, Carlijn L Vierstra, Thomas Rustemeyer

Introduction: Although the treatment burden for phototherapy in the outpatient setting is considerable, prescription of home-based phototherapy has not been instigated. Home-based phototherapy seems more patient friendly in terms of avoiding the thrice-weekly hospital visits. So why are most treatments still given in a hospital setting? Is home-based treatment less effective? Are there financial barriers? Is the treatment not available? To answer these questions, a literature search was done.

Methods: A literature search of PubMed, Embase, and Cochrane Library databases was performed, using the search terms "psoriasis" and "phototherapy". Selection was based on two rounds; the first round involved screening the title and abstract of all records and second involved evaluating the full text of the remaining articles for eligibility according to inclusion and exclusion criteria.

Results: In total, 23 publications were included with consensus of both researchers. Overall, the patients reported being very satisfied with home-based phototherapy. Results regarding effectivity in terms of improvement from disease severity and in quality of life were variable but generally positive. Reasons for reluctance varied from medicolegal and social aspects to lack of reimbursement and unfamiliarity on the side of the prescriber.

Conclusion: In the treatment for psoriasis, home-based phototherapy is as effective and safe as phototherapy in an outpatient setting. Patients were more satisfied with home-based phototherapy. Factors that negatively influence the prescription of or choice for home-based phototherapy can be summarized in terms of lack of control, lack of knowledge, and lack of a good reimbursement system.

导读:虽然光疗在门诊的治疗负担相当大,但家庭光疗的处方并没有被提倡。以家庭为基础的光疗似乎对病人更友好,因为它避免了每周三次的医院就诊。那么,为什么大多数治疗仍然在医院进行呢?家庭治疗是否效果较差?是否存在财务障碍?是否没有治疗方法?为了回答这些问题,我们进行了文献检索。方法:检索PubMed、Embase和Cochrane图书馆数据库的文献,检索词为“牛皮癣”和“光疗”。评选基于两轮;第一轮涉及筛选所有记录的标题和摘要,第二轮涉及根据纳入和排除标准评估剩余文章的全文是否合格。结果:共纳入23篇文献,并获得两位研究者的一致意见。总体而言,患者报告对家庭光疗非常满意。从疾病严重程度的改善和生活质量方面来看,有效性的结果各不相同,但总体上是积极的。不情愿的原因多种多样,从医学和社会方面到缺乏报销和处方方不熟悉。结论:在银屑病的治疗中,家庭光疗与门诊光疗同样有效和安全。患者对以家庭为基础的光疗更满意。影响家庭光疗处方或选择的负面因素可以总结为缺乏控制、缺乏知识和缺乏良好的报销制度。
{"title":"Improving access to home phototherapy for patients with psoriasis: current challenges and future prospects.","authors":"Sylvie M Franken,&nbsp;Carlijn L Vierstra,&nbsp;Thomas Rustemeyer","doi":"10.2147/PTT.S81958","DOIUrl":"https://doi.org/10.2147/PTT.S81958","url":null,"abstract":"<p><strong>Introduction: </strong>Although the treatment burden for phototherapy in the outpatient setting is considerable, prescription of home-based phototherapy has not been instigated. Home-based phototherapy seems more patient friendly in terms of avoiding the thrice-weekly hospital visits. So why are most treatments still given in a hospital setting? Is home-based treatment less effective? Are there financial barriers? Is the treatment not available? To answer these questions, a literature search was done.</p><p><strong>Methods: </strong>A literature search of PubMed, Embase, and Cochrane Library databases was performed, using the search terms \"psoriasis\" and \"phototherapy\". Selection was based on two rounds; the first round involved screening the title and abstract of all records and second involved evaluating the full text of the remaining articles for eligibility according to inclusion and exclusion criteria.</p><p><strong>Results: </strong>In total, 23 publications were included with consensus of both researchers. Overall, the patients reported being very satisfied with home-based phototherapy. Results regarding effectivity in terms of improvement from disease severity and in quality of life were variable but generally positive. Reasons for reluctance varied from medicolegal and social aspects to lack of reimbursement and unfamiliarity on the side of the prescriber.</p><p><strong>Conclusion: </strong>In the treatment for psoriasis, home-based phototherapy is as effective and safe as phototherapy in an outpatient setting. Patients were more satisfied with home-based phototherapy. Factors that negatively influence the prescription of or choice for home-based phototherapy can be summarized in terms of lack of control, lack of knowledge, and lack of a good reimbursement system.</p>","PeriodicalId":74589,"journal":{"name":"Psoriasis (Auckland, N.Z.)","volume":"6 ","pages":"55-64"},"PeriodicalIF":0.0,"publicationDate":"2016-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/PTT.S81958","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35783439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Assessment and monitoring of biologic drug adverse events in patients with psoriasis. 银屑病患者生物药物不良事件的评估与监测。
Q1 DERMATOLOGY Pub Date : 2016-04-01 eCollection Date: 2016-01-01 DOI: 10.2147/PTT.S68869
Tessa Hanley, Marc Handford, Dawn Lavery, Zenas Zn Yiu

Background: Current treatment guidelines for biologic therapies in psoriasis differ in their recommendation for the monitoring of adverse events.

Objective: The aim of this paper was to draw together evidence from the currently available guidelines as a summary of how biologics licensed for the treatment of psoriasis should be monitored for adverse events.

Methods: The MEDLINE database was searched to identity the current literature on the safety and screening guidance associated with infliximab, etanercept, adalimumab, ustekinumab, and secukinumab.

Limitations: This study was limited by the lack of data evaluating monitoring in patients with psoriasis undergoing treatment with a biologic therapy.

Results: This review of the current literature highlights that there are areas of routine screening, which are recommended in current practice, which require further evidence to investigate its true utility.

Conclusion: Most screening and monitoring tests performed routinely in clinical practice are supported by minimal clinical evidence, highlighting the need for more studies to evaluate the role and value of the different modalities of screening and monitoring for adverse events in those with psoriasis receiving treatment with biologic therapies.

背景:目前银屑病生物治疗指南对不良事件监测的建议存在差异。目的:本文的目的是从目前可用的指南中收集证据,总结如何监测用于治疗牛皮癣的生物制剂的不良事件。方法:检索MEDLINE数据库,以确定目前有关英夫利昔单抗、依那西普、阿达木单抗、乌斯特金单抗和secukinumab的安全性和筛选指南的文献。局限性:由于缺乏对银屑病患者进行生物治疗的监测评估数据,本研究受到限制。结果:对现有文献的回顾强调了常规筛查的一些领域,这些领域在目前的实践中是推荐的,但需要进一步的证据来调查其真正的效用。结论:在临床实践中,大多数常规筛查和监测试验都缺乏临床证据的支持,因此需要更多的研究来评估在接受生物治疗的银屑病患者中,不同方式的筛查和监测不良事件的作用和价值。
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引用次数: 6
Management of scalp psoriasis: current perspectives. 头皮牛皮癣的管理:目前的观点。
Q1 DERMATOLOGY Pub Date : 2016-03-29 eCollection Date: 2016-01-01 DOI: 10.2147/PTT.S85330
Kim Blakely, Melinda Gooderham

Psoriasis is a chronic inflammatory condition. The age of onset, chronicity, physical, and psychosocial consequences of the disease cause psoriasis to have a significant impact on patient quality of life. Scalp psoriasis is no different, and effective treatment results in an improvement in quality of life. Successful management of scalp psoriasis includes topical therapies that are acceptable to the patient for mild-to-moderate disease, and systemic therapies for recalcitrant or moderate-to-severe disease. The most effective topical therapies are corticosteroid products, or combination products with calcipotriol and corticosteroid. Newer vehicle options provide more attractive and pleasing products for patients and may improve adherence. The current perspectives for management of scalp psoriasis are discussed including available data for systemic therapy of severe disease.

牛皮癣是一种慢性炎症。牛皮癣的发病年龄、慢性、身体和社会心理后果对患者的生活质量产生重大影响。头皮牛皮癣没有什么不同,有效的治疗可以改善生活质量。头皮牛皮癣的成功治疗包括轻度至中度疾病患者可接受的局部治疗和顽固性或中度至重度疾病的全身治疗。最有效的局部治疗是皮质类固醇产品,或与钙化三醇和皮质类固醇的联合产品。较新的车辆选择为患者提供更有吸引力和令人愉悦的产品,并可能提高依从性。目前的观点,管理头皮牛皮癣进行了讨论,包括现有的数据系统治疗严重的疾病。
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引用次数: 21
Current knowledge on psoriasis and autoimmune diseases. 关于牛皮癣和自身免疫性疾病的最新知识。
Q1 DERMATOLOGY Pub Date : 2016-02-22 eCollection Date: 2016-01-01 DOI: 10.2147/PTT.S64950
Nilmarie Ayala-Fontánez, David C Soler, Thomas S McCormick

Psoriasis is a prevalent, chronic inflammatory disease of the skin, mediated by crosstalk between epidermal keratinocytes, dermal vascular cells, and immunocytes such as antigen presenting cells (APCs) and T cells. Exclusive cellular "responsibility" for the induction and maintenance of psoriatic plaques has not been clearly defined. Increased proliferation of keratinocytes and endothelial cells in conjunction with APC/T cell/monocyte/macrophage inflammation leads to the distinct epidermal and vascular hyperplasia that is characteristic of lesional psoriatic skin. Despite the identification of numerous susceptibility loci, no single genetic determinant has been identified as responsible for the induction of psoriasis. Thus, numerous other triggers of disease, such as environmental, microbial and complex cellular interactions must also be considered as participants in the development of this multifactorial disease. Recent advances in therapeutics, especially systemic so-called "biologics" have provided new hope for identifying the critical cellular targets that drive psoriasis pathogenesis. Recent recognition of the numerous co-morbidities and other autoimmune disorders associated with psoriasis, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus suggest common signaling elements and cellular mediators may direct disease pathogenesis. In this review, we discuss common cellular pathways and participants that mediate psoriasis and other autoimmune disorders that share these cellular signaling pathways.

银屑病是一种常见的皮肤慢性炎症性疾病,由表皮角质形成细胞、真皮血管细胞和免疫细胞(如抗原提呈细胞(APCs)和T细胞)之间的串扰介导。诱导和维持银屑病斑块的唯一细胞“责任”尚未明确定义。角化细胞和内皮细胞增殖增加,并伴有APC/T细胞/单核细胞/巨噬细胞炎症,导致明显的表皮和血管增生,这是病变性银屑病皮肤的特征。尽管确定了许多易感位点,但没有单一的遗传决定因素被确定为诱导牛皮癣的原因。因此,许多其他疾病的触发因素,如环境、微生物和复杂的细胞相互作用,也必须被认为是这种多因素疾病发展的参与者。治疗学的最新进展,特别是系统性所谓的“生物制剂”,为确定驱动牛皮癣发病机制的关键细胞靶点提供了新的希望。最近对银屑病的许多合并症和其他自身免疫性疾病的认识,包括炎症性肠病、多发性硬化症、类风湿性关节炎和系统性红斑狼疮,表明共同的信号元件和细胞介质可能指导疾病的发病机制。在这篇综述中,我们讨论了介导牛皮癣和其他共享这些细胞信号通路的自身免疫性疾病的常见细胞通路和参与者。
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引用次数: 143
Integrating lifestyle-focused approaches into psoriasis care: improving patient outcomes? 将以生活方式为重点的方法纳入牛皮癣护理:改善患者预后?
Q1 DERMATOLOGY Pub Date : 2016-01-19 eCollection Date: 2016-01-01 DOI: 10.2147/PTT.S81957
Angelo Landriscina, Adam J Friedman

Psoriasis is one of the most well described cutaneous disorders, with a large body of literature devoted to describing its pathogenesis and treatment. In recent years, attention has turned toward the mechanisms by which lifestyle can impact psoriatic disease, and how lifestyle interventions may help to alleviate cutaneous, rheumatological, and comorbid disease in the setting of psoriasis. The following review explores our current understanding of the interaction between lifestyle factors and psoriasis and describes outcomes of interventions meant to target these factors.

牛皮癣是一种描述最充分的皮肤疾病,有大量的文献致力于描述其发病机制和治疗。近年来,人们的注意力转向了生活方式影响银屑病的机制,以及生活方式干预如何有助于缓解银屑病的皮肤、风湿病和合并症。以下综述探讨了我们目前对生活方式因素与牛皮癣之间相互作用的理解,并描述了针对这些因素的干预措施的结果。
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引用次数: 5
Erythrodermic psoriasis: pathophysiology and current treatment perspectives. 红皮病型银屑病:病理生理学与当前治疗前景。
Q1 DERMATOLOGY Pub Date : 2016-01-01 Epub Date: 2016-07-20 DOI: 10.2147/PTT.S101232
Rasnik K Singh, Kristina M Lee, Derya Ucmak, Merrick Brodsky, Zaza Atanelov, Benjamin Farahnik, Michael Abrouk, Mio Nakamura, Tian Hao Zhu, Wilson Liao

Erythrodermic psoriasis (EP) is a rare and severe variant of psoriasis vulgaris, with an estimated prevalence of 1%-2.25% among psoriatic patients. The condition presents with distinct histopathologic and clinical findings, which include a generalized inflammatory erythema involving at least 75% of the body surface area. The pathogenesis of EP is not well understood; however, several studies suggest that the disease is associated with a predominantly T helper 2 (Th2) phenotype. Given the morbidity and potential mortality associated with the condition, there is a need for a better understanding of its pathophysiology. The management of EP begins with a comprehensive assessment of the patient's presentation and often requires multidisciplinary supportive measures. In 2010, the medical board of the US National Psoriasis Foundation published consensus guidelines advocating the use of cyclosporine or infliximab as first-line therapy in unstable cases, with acitretin and methotrexate reserved for more stable cases. Since the time of that publication, additional information regarding the efficacy of newer agents has emerged. We review the latest data with regard to the treatment of EP, which includes biologic therapies such as ustekinumab and ixekizumab.

红皮病型银屑病(EP)是寻常型银屑病的一种罕见的严重变异型,估计在银屑病患者中的发病率为 1%-2.25%。该病具有独特的组织病理学和临床表现,包括全身炎症性红斑,涉及至少 75% 的体表面积。EP 的发病机制尚不十分清楚,但一些研究表明,该病主要与 T 辅助细胞 2(Th2)表型有关。鉴于该病的发病率和潜在死亡率,有必要更好地了解其病理生理学。EP 的治疗始于对患者表现的全面评估,通常需要采取多学科支持措施。2010 年,美国国家银屑病基金会医学委员会发布了共识指南,主张将环孢素或英夫利昔单抗作为不稳定型病例的一线治疗药物,而阿曲汀和甲氨蝶呤则用于较稳定型病例。自该指南发布以来,有关新型药物疗效的更多信息不断涌现。我们回顾了有关 EP 治疗的最新数据,其中包括乌司他单抗(ustekinumab)和伊克珠单抗(ixekizumab)等生物疗法。
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引用次数: 0
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Psoriasis (Auckland, N.Z.)
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