Pub Date : 2023-08-16DOI: 10.1089/psymed.2023.0013
Jacob S. Aday, B. Barnett, Dan Grossman, K. Murnane, C. Nichols, P. Hendricks
{"title":"Psychedelic Commercialization: A Wide-Spanning Overview of the Emerging Psychedelic Industry","authors":"Jacob S. Aday, B. Barnett, Dan Grossman, K. Murnane, C. Nichols, P. Hendricks","doi":"10.1089/psymed.2023.0013","DOIUrl":"https://doi.org/10.1089/psymed.2023.0013","url":null,"abstract":"","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73883125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-07DOI: 10.1089/psymed.2023.0030
Zachary Herrmann, Adam W. Levin, S. Cole, Sarah Slabaugh, B. Barnett, Andrew D. Penn, R. Jain, Charles Raison, Bhavya Rajanna, Saundra Jain
{"title":"Psychedelic Use Among Psychiatric Medication Prescribers: Effects on Well-Being, Depression, Anxiety, and Associations with Patterns of Use, Reported Harms, and Transformative Mental States","authors":"Zachary Herrmann, Adam W. Levin, S. Cole, Sarah Slabaugh, B. Barnett, Andrew D. Penn, R. Jain, Charles Raison, Bhavya Rajanna, Saundra Jain","doi":"10.1089/psymed.2023.0030","DOIUrl":"https://doi.org/10.1089/psymed.2023.0030","url":null,"abstract":"","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"131 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84772464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.1089/psymed.2023.0011
Kelley C. O'Donnell, Daniel E. Roberts, Terence H. W. Ching, Gianni Glick, N. Goldway, N. Gukasyan, Jamila Hokansen, B. Kelmendi, Stephen Ross, Mary E. Yaden, C. Pittenger
{"title":"Letter to the Editor: What Is in a Name? The Many Meanings of “Psychedelic”","authors":"Kelley C. O'Donnell, Daniel E. Roberts, Terence H. W. Ching, Gianni Glick, N. Goldway, N. Gukasyan, Jamila Hokansen, B. Kelmendi, Stephen Ross, Mary E. Yaden, C. Pittenger","doi":"10.1089/psymed.2023.0011","DOIUrl":"https://doi.org/10.1089/psymed.2023.0011","url":null,"abstract":"","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78113683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-10DOI: 10.1089/psymed.2022.0018
N. Carlisle, Haley Maria Dourron, S. MacCarthy, A. J. Zarrabi, P. Hendricks
{"title":"Exploring the Unique Therapeutic Potential of Psychedelics to Reduce Chronic Shame Among Sexual and Gender Minority Adults","authors":"N. Carlisle, Haley Maria Dourron, S. MacCarthy, A. J. Zarrabi, P. Hendricks","doi":"10.1089/psymed.2022.0018","DOIUrl":"https://doi.org/10.1089/psymed.2022.0018","url":null,"abstract":"","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75186190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-26DOI: 10.1089/psymed.2023.0023
Harpreet Kaur, Sedat Karabulut, J. Gauld, Stephen A. Fagot, Kalee N. Holloway, Hannah E. Shaw, W. Fantegrossi
{"title":"Balancing Therapeutic Efficacy and Safety of MDMA and Novel MDXX Analogues as Novel Treatments for Autism Spectrum Disorder","authors":"Harpreet Kaur, Sedat Karabulut, J. Gauld, Stephen A. Fagot, Kalee N. Holloway, Hannah E. Shaw, W. Fantegrossi","doi":"10.1089/psymed.2023.0023","DOIUrl":"https://doi.org/10.1089/psymed.2023.0023","url":null,"abstract":"","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87538842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.1089/psymed.2022.0017
Mollie M Pleet, Joshua White, Joseph A Zamaria, Rachel Yehuda
Introduction: A resurgence of interest in the use of psychedelics for mental health and wellness has stimulated greater experimentation with psychedelics in society. Although clinical psychedelic trials protect research participants by offering a safe setting, thorough preparation, and containment during and after ingestion of psychedelic medicines, many try these substances without the benefit of these safeguards.
Materials and methods: We analyzed data gathered from 884 callers to a psychedelic helpline to determine whether a helpline model could reduce the risks associated with nonclinical psychedelics use.
Results: In total, 65.9% of callers indicated that the helpline de-escalated them from psychological distress. If not for their conversation with the helpline, 29.3% of callers indicated they may have been harmed; 12.5% indicated that they may have called 911; and 10.8% indicated they may have gone to the emergency room.
Conclusion: The data suggest that access to a psychedelic helpline surrounding psychedelic experiences may avert harmful outcomes and offset the burden on emergency and medical services.
{"title":"Reducing the Harms of Nonclinical Psychedelics Use Through a Peer-Support Telephone Helpline.","authors":"Mollie M Pleet, Joshua White, Joseph A Zamaria, Rachel Yehuda","doi":"10.1089/psymed.2022.0017","DOIUrl":"https://doi.org/10.1089/psymed.2022.0017","url":null,"abstract":"<p><strong>Introduction: </strong>A resurgence of interest in the use of psychedelics for mental health and wellness has stimulated greater experimentation with psychedelics in society. Although clinical psychedelic trials protect research participants by offering a safe setting, thorough preparation, and containment during and after ingestion of psychedelic medicines, many try these substances without the benefit of these safeguards.</p><p><strong>Materials and methods: </strong>We analyzed data gathered from 884 callers to a psychedelic helpline to determine whether a helpline model could reduce the risks associated with nonclinical psychedelics use.</p><p><strong>Results: </strong>In total, 65.9% of callers indicated that the helpline de-escalated them from psychological distress. If not for their conversation with the helpline, 29.3% of callers indicated they may have been harmed; 12.5% indicated that they may have called 911; and 10.8% indicated they may have gone to the emergency room.</p><p><strong>Conclusion: </strong>The data suggest that access to a psychedelic helpline surrounding psychedelic experiences may avert harmful outcomes and offset the burden on emergency and medical services.</p>","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"1 2","pages":"69-73"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9715691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.1089/psymed.2023.0010
Praachi Tiwari, Andrea P. Berghella, Ceyda Sayalı, Manoj K. Doss, F. Barrett, D. Yaden
{"title":"Learned Helplessness As a Potential Transdiagnostic Therapeutic Mechanism of Classic Psychedelics","authors":"Praachi Tiwari, Andrea P. Berghella, Ceyda Sayalı, Manoj K. Doss, F. Barrett, D. Yaden","doi":"10.1089/psymed.2023.0010","DOIUrl":"https://doi.org/10.1089/psymed.2023.0010","url":null,"abstract":"","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86602317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01Epub Date: 2023-06-14DOI: 10.1089/psymed.2023.0009
Jasper A Heinsbroek, Giuseppe Giannotti, Joel Bonilla, David E Olson, Jamie Peters
Background: The potential use of psychedelic drugs as therapeutics for neuropsychiatric disorders has been limited by their hallucinogenic properties. To overcome this limitation, we developed and characterized tabernanthalog (TBG), a novel analogue of the indole alkaloids ibogaine and 5-methoxy-N,N-dimethyltryptamine with reduced cardiac arrhythmogenic risk and a lack of classical psychedelic drugs-induced sensory alterations. We previously demonstrated that TBG has therapeutic efficacy in a preclinical model of opioid use disorder (OUD) in rats and in a binge model of alcohol drinking in mice. Alcohol is commonly co-used in ∼35-50% of individuals with OUD, and yet, preclinical models that recapitulate this comorbidity are lacking.
Methodology: Here we employed a polydrug model of heroin and alcohol couse to screen the therapeutic efficacy of TBG on metrics of both opioid and alcohol seeking. We first exposed rats to alcohol (or control sucrose-fade solution) in the home-cage (HC), using a two-bottle binge protocol, over a period of 1 month. Rats were then split into two groups that underwent self-administration training for either intravenous heroin or oral alcohol, so that we could assess the impact of HC alcohol exposure on the self-administration of each substance separately. Thereafter, rats began self-administering both heroin and alcohol in the same sessions. Finally, we tested the effects of TBG on break points for heroin and alcohol in a progressive ratio test, where the number of lever presses required to obtain a single reward increased exponentially.
Results and conclusion: TBG effectively reduced motivation for heroin and alcohol in this test, indicating its efficacy is preserved in animals with a history of heroin and alcohol polydrug use.
{"title":"Tabernanthalog Reduces Motivation for Heroin and Alcohol in a Polydrug Use Model.","authors":"Jasper A Heinsbroek, Giuseppe Giannotti, Joel Bonilla, David E Olson, Jamie Peters","doi":"10.1089/psymed.2023.0009","DOIUrl":"10.1089/psymed.2023.0009","url":null,"abstract":"<p><strong>Background: </strong>The potential use of psychedelic drugs as therapeutics for neuropsychiatric disorders has been limited by their hallucinogenic properties. To overcome this limitation, we developed and characterized tabernanthalog (TBG), a novel analogue of the indole alkaloids ibogaine and 5-methoxy-<i>N,N</i>-dimethyltryptamine with reduced cardiac arrhythmogenic risk and a lack of classical psychedelic drugs-induced sensory alterations. We previously demonstrated that TBG has therapeutic efficacy in a preclinical model of opioid use disorder (OUD) in rats and in a binge model of alcohol drinking in mice. Alcohol is commonly co-used in ∼35-50% of individuals with OUD, and yet, preclinical models that recapitulate this comorbidity are lacking.</p><p><strong>Methodology: </strong>Here we employed a polydrug model of heroin and alcohol couse to screen the therapeutic efficacy of TBG on metrics of both opioid and alcohol seeking. We first exposed rats to alcohol (or control sucrose-fade solution) in the home-cage (HC), using a two-bottle binge protocol, over a period of 1 month. Rats were then split into two groups that underwent self-administration training for either intravenous heroin or oral alcohol, so that we could assess the impact of HC alcohol exposure on the self-administration of each substance separately. Thereafter, rats began self-administering both heroin and alcohol in the same sessions. Finally, we tested the effects of TBG on break points for heroin and alcohol in a progressive ratio test, where the number of lever presses required to obtain a single reward increased exponentially.</p><p><strong>Results and conclusion: </strong>TBG effectively reduced motivation for heroin and alcohol in this test, indicating its efficacy is preserved in animals with a history of heroin and alcohol polydrug use.</p>","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"1 2","pages":"111-119"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10291736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-18DOI: 10.1089/psymed.2023.0002
Stephanie Lake, P. Lucas
{"title":"The Canadian Psychedelic Survey: Characteristics, Patterns of Use, and Access in a Large Sample of People Who Use Psychedelic Drugs","authors":"Stephanie Lake, P. Lucas","doi":"10.1089/psymed.2023.0002","DOIUrl":"https://doi.org/10.1089/psymed.2023.0002","url":null,"abstract":"","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83207959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-14DOI: 10.1089/psymed.2022.0011
Noah D. Gold, Samantha K. Podrebarac, Lindsay A. White, Christina Marini, Naomi M. Simon, Mary S. Mittelman, Stephen Ross, M. Bogenschutz, Petros D Petridis
{"title":"Examining the Rationale for Studying Psychedelic-Assisted Psychotherapy for the Treatment of Caregiver Distress","authors":"Noah D. Gold, Samantha K. Podrebarac, Lindsay A. White, Christina Marini, Naomi M. Simon, Mary S. Mittelman, Stephen Ross, M. Bogenschutz, Petros D Petridis","doi":"10.1089/psymed.2022.0011","DOIUrl":"https://doi.org/10.1089/psymed.2022.0011","url":null,"abstract":"","PeriodicalId":74590,"journal":{"name":"Psychedelic medicine (New Rochelle, N.Y.)","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77852956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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