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Retraction notice to “Pseudocyesis in a deployed military member” [Psychiatry Research Case Reports Volume 2, Issue 2, December 2023, 100183] 关于“一名派驻军人的伪作”的撤回通知[精神病学研究病例报告第2卷第2期,2023年12月,100183]
Pub Date : 2025-12-01 DOI: 10.1016/j.psycr.2025.100275
Ezie Nguyen , Allison Watkins , Lauren Wells
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引用次数: 0
Retraction notice to “Exploring the Risk of Magnesium Use for Antipsychotic Induced Constipation: A Case study for consideration” [Psychiatry Research Case Reports Volume 2, Issue 1, June 2023, 100132] “探索镁用于抗精神病药物引起的便秘的风险:一个案例研究”的撤回通知[精神病学研究病例报告第2卷,第1期,2023年6月,100132]
Pub Date : 2025-12-01 DOI: 10.1016/j.psycr.2025.100277
TammieLee Demler , TammieLee Demler , Samara White
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引用次数: 0
Retraction notice to “Diagnosis of unsuspected catatonia with an inadvertent lorazepam challenge test” [Volume 1, Issue 2, December 2022, 100073] 撤回“用无意的劳拉西泮激发试验诊断未怀疑的紧张症”的通知[第1卷,第2期,2022年12月,100073]
Pub Date : 2025-12-01 DOI: 10.1016/j.psycr.2025.100272
Ila Gautham , Annise Wilson
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引用次数: 0
Removal notice to “Announcing Suicide on the Internet: A Case Report” [Psychiatry Research Case Reports Volume 1, Issue 1, June 2022, 100010] 关于“在网络上宣布自杀:一个案例报告”的删除通知[精神病学研究案例报告第一卷第一期,2022年6月,100010]
Pub Date : 2025-12-01 DOI: 10.1016/j.psycr.2025.100278
John F. Gunn III , David Lester
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引用次数: 0
Retraction notice to “A vulnerable young adult using cannabis for therapeutic purposes despite emerging psychosis” [Psychiatry Research Case Reports 1 (2022) 100037] 对“一名易受伤害的年轻人在出现精神病的情况下使用大麻进行治疗”的撤回通知[精神病学研究病例报告1 (2022)100037]
Pub Date : 2025-12-01 DOI: 10.1016/j.psycr.2025.100264
Jill M Williams , Mary Barna Bridgeman , Lisa Laitman
This article has been retracted: please see Elsevier policy on article withdrawal (https://www.elsevier.com/about/policies-and-standards/article-withdrawal).
A post-publication investigation conducted by Elsevier's Research Integrity & Publishing Ethics team on behalf of the journal determined that the patient or nominated representative of the patient did not provide informed consent for this publication in line with the journal's policy. The editor has decided to retract the article.
本文已被撤回:请参阅Elsevier关于文章撤回的政策(https://www.elsevier.com/about/policies-and-standards/article-withdrawal).A), Elsevier的研究诚信和出版伦理团队代表期刊进行了发表后调查,确定患者或患者指定的代表未根据期刊政策为本文发表提供知情同意。编辑已决定撤回这篇文章。
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引用次数: 0
Clozapine treatment in chronic lymphocytic leukaemia and pancytopenia 氯氮平治疗慢性淋巴细胞白血病和全血细胞减少症
Pub Date : 2025-11-13 DOI: 10.1016/j.psycr.2025.100299
Daniel Morgan , Gurvir Singh Rai , Danilo Arnone
There is a paucity of literature regarding clozapine initiation in patients with haematologic malignancies. We present the case of a patient with chronic lymphocytic leukaemia (CLL) and schizoaffective disorder whose clozapine was discontinued and restarted. A woman in her 60s presented to the emergency department with hypotension and symptomatic pancytopenia. Clozapine was discontinued due to the risk of neutropenia during her admission to the haematology service. Bone marrow aspiration revealed that the pancytopenia was due to CLL clonal invasion, and the decision was made to restart clozapine. The subsequent development of hospital-acquired pneumonia led to clozapine discontinuation. An evaluation of the harms and benefits of clozapine re-initiation is discussed considering the possible additive effects of clozapine and CLL on degrading immune function, the risk of opportunistic infections, and the cytotoxic effects of CLL treatment. In medicated patients with stable psychopathology the introduction of clozapine after completion of CCL treatment can help minimise the risk of physical complications. Earlier introduction of clozapine may be justified in symptomatic patients with close monitoring. Informed decisions should be guided by patients’ preferences after judicious evaluation of risks and benefits. Haematology-psychiatry collaboration is essential to best manage cases with complex, comorbid psychiatric and haematological conditions.
关于血液恶性肿瘤患者开始使用氯氮平的文献很少。我们提出的情况下,患者慢性淋巴细胞白血病(CLL)和分裂情感性障碍的氯氮平被停止和重新启动。一名60多岁的妇女因低血压和症状性全血细胞减少症就诊于急诊科。在她进入血液科服务期间,由于中性粒细胞减少的风险,氯氮平被停用。骨髓穿刺显示全血细胞减少是CLL克隆侵袭所致,决定重新使用氯氮平。随后发生的医院获得性肺炎导致氯氮平停药。考虑到氯氮平和CLL在降低免疫功能、机会性感染的风险以及CLL治疗的细胞毒性作用方面可能的叠加效应,对氯氮平重新开始治疗的利弊进行了评估。在精神病理稳定的服药患者中,在完成CCL治疗后引入氯氮平可以帮助减少身体并发症的风险。密切监测有症状的患者早期应用氯氮平可能是合理的。在对风险和收益进行审慎评估后,应根据患者的偏好做出明智的决定。血液学-精神病学合作对于最好地管理复杂的精神和血液学合并症病例至关重要。
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引用次数: 0
Treatment-resistant psychosis in familial cerebral cavernous malformation: A case series 家族性脑海绵状血管瘤的治疗抵抗性精神病:一个病例系列
Pub Date : 2025-10-23 DOI: 10.1016/j.psycr.2025.100298
Tianyi Hui , Thanita Pilunthanakul , Li Keat Oon , Charmaine Tang

Background

Familial Cerebral Cavernous Malformations (FCCMs) are associated with symptomatic clinical findings, including neurological deficits and seizures, a positive family history, and supportive gene mutations. Current evidence on neuropsychiatric manifestations is limited to case reports, primarily describing mood and anxiety symptoms. The use of Electroconvulsive Therapy (ECT) has been limited, largely due to concerns about precipitating cavernoma bleeding. Notably, there are no documented cases of psychotic manifestations in cavernomas that are not actively haemorrhagic.

Methods and Results

We report on two siblings with FCCMs, diagnosed based on brain imaging and family history, who presented with rare neuropsychiatric symptoms of psychosis.

Case 1

A 15-year-old female presented with auditory hallucinations, delusions of erotomania and passivity, affective symptoms including overfamiliarity and disinhibition, and significant aggression toward herself and others. She demonstrated resistance to multiple trials of antipsychotics and lithium. Treatment with clozapine and ECT was required, alongside propranolol to manage blood pressure and mitigate the risk of cavernoma bleeding during ECT.

Case 2

A 21-year-old male presented with auditory hallucinations, delusions of guilt, and aggression. He also exhibited treatment resistance and required clozapine for symptom management.

Conclusions

Patients with FCCMs may exhibit genetic and clinical overlaps, posing significant medical challenges when managing psychotic symptoms. Their psychosis may demonstrate resistance to conventional treatments. ECT appears to be a novel, potentially safe, and effective therapeutic option when precautions are taken to minimize the risk of cavernoma bleeding.
家族性脑海绵状血管瘤(FCCMs)与症状性临床表现相关,包括神经功能障碍和癫痫发作、阳性家族史和支持性基因突变。目前关于神经精神表现的证据仅限于病例报告,主要描述情绪和焦虑症状。电痉挛疗法(ECT)的使用受到限制,主要是由于担心会导致海绵状瘤出血。值得注意的是,海绵状瘤中没有记录的非活动性出血的精神病性表现。方法和结果我们报告了两名兄弟姐妹患有FCCMs,根据脑成像和家族史诊断,他们表现出罕见的精神病神经精神症状。病例1A 15岁女性,表现为幻听、色欲妄想和被动妄想,情感性症状包括过度熟悉和去抑制,对自己和他人有明显的攻击行为。她对抗精神病药物和锂的多次试验都有抗药性。需要氯氮平和电痉挛治疗,同时使用心得安来控制血压并减轻电痉挛期间海绵状瘤出血的风险。病例2A, 21岁男性,表现为幻听,内疚妄想和攻击性。他也表现出治疗抵抗,需要氯氮平治疗症状。结论FCCMs患者可能表现出遗传和临床重叠,这给治疗精神病症状带来了重大的医学挑战。他们的精神病可能表现出对常规治疗的抗药性。当采取预防措施将海绵状瘤出血的风险降至最低时,ECT似乎是一种新颖、潜在安全且有效的治疗选择。
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引用次数: 0
Pure, anxious-depressive, and panic anxiety attacks: A Freud-inspired case series 纯粹,焦虑抑郁和恐慌性焦虑发作:弗洛伊德启发的案例系列
Pub Date : 2025-10-23 DOI: 10.1016/j.psycr.2025.100297
Hisanobu Kaiya , Takeshi Otowa
Freud described three types of anxiety attacks: pure anxiety attacks (PAA), characterized by sudden affective surges without ideation or somatic symptoms; anxious-depressive attacks (ADA), involving ruminative and depressive thoughts; and panic attacks (PA), dominated by autonomic arousal. Although PA has been extensively documented, PAA and ADA have received limited clinical attention.
In this retrospective case series, we reviewed outpatient clinic charts and descriptively classified recorded anxiety episodes by their predominant features, which enabled us to identify attacks lacking prominent physical symptoms. Two Japanese outpatients illustrate how these subtypes can manifest and shift within the same individual. Case A showed a temporal progression from PA to PAA and then ADA, each phase marked by distinct features. Case B initially presented ADA, followed by episodes of PA and PAA, sometimes alternating rapidly within a single episode.
These observations suggest a shared psychodynamic origin expressed through somatic, cognitive, or affective channels depending on individual and situational factors. Distinguishing PAA and ADA from PA is clinically significant, as these subtypes lack the somatic arousal that typically guides diagnosis and may show different responses to psychological versus pharmacological strategies. Our findings highlight less recognized non-somatic variants that might otherwise be overlooked in clinical practice and point toward more tailored therapeutic approaches.
弗洛伊德描述了三种类型的焦虑发作:纯粹的焦虑发作(PAA),其特征是突然的情感激增,没有思想或躯体症状;焦虑抑郁发作(ADA),包括沉思和抑郁的想法;以及由自主神经觉醒主导的恐慌发作(PA)。尽管PA已被广泛记载,但PAA和ADA的临床关注有限。在这个回顾性病例系列中,我们回顾了门诊图表,并根据主要特征对记录的焦虑发作进行了描述性分类,这使我们能够识别没有明显身体症状的发作。两个日本门诊病人说明了这些亚型是如何在同一个人身上表现和转移的。病例A表现为从PA到PAA再到ADA的时间进展,每个阶段都有明显的特征。病例B最初表现为ADA,随后是PA和PAA发作,有时在一次发作内迅速交替。这些观察结果表明,根据个体和情境因素,通过躯体、认知或情感渠道表达了共同的心理动力学起源。区分PAA和ADA与PA具有重要的临床意义,因为这些亚型缺乏通常指导诊断的躯体唤醒,并且可能对心理和药物策略表现出不同的反应。我们的研究结果强调了在临床实践中可能被忽视的非体细胞变异,并指出了更有针对性的治疗方法。
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引用次数: 0
Delayed onset tacrolimus-induced neuropsychiatric symptoms in a pancreas-after-kidney transplant recipient 肾后胰腺移植受者迟发性他克莫司诱导的神经精神症状
Pub Date : 2025-10-20 DOI: 10.1016/j.psycr.2025.100295
Sara Briker , Aria Vitale , Sara Wierbowski , Jonathan Galla , Kelly Hamilton , Steven Potter , Jennifer F. Schreiber
The introduction of tacrolimus as an anti-rejection medication has markedly improved the outcomes of patients receiving organ transplants. While the use of tacrolimus has been instrumental in preventing organ rejection, especially in the case of pancreas and multi-organ transplants, the neuropsychiatric side effects are less commonly reported. Here, we present the complicated psychiatric and behavioral presentation of a 38-year-old woman with a psychiatric history of treatment-resistant depression, anxiety, and an unspecified eating disorder, who had been maintained uneventfully on tacrolimus after receiving a living-donor kidney transplant two years earlier. The patient then underwent an isolated pancreas transplant. Psychiatry was consulted six days after transplant for hyperactivity, disruptive behaviors, physical agitation, impaired cognition, disorientation, disorganized speech, and occasional hallucinations; these symptoms were refractory to multiple trials of psychiatric medications. After extensive medical and neurological work-up, and several instances of critically elevated tacrolimus levels, the patient was transitioned to cyclosporine, with gradual improvement, and eventual return to cognitive baseline. In exploring the possible causes of this complicated psychiatric presentation, we highlight the correlation between tacrolimus use and psychiatric symptoms, even when levels are in the therapeutic range, and emphasize the need to consider switching to an alternate agent. To our knowledge, this is the first case of tacrolimus-induced psychotic symptoms in the setting of a second organ transplant, years after initiation of tacrolimus for an initial transplant. Considering this, clinicians should remain vigilant in monitoring patients with chronic tacrolimus use, while awaiting more research into the neurotoxic implications of its long-term use.
他克莫司作为一种抗排斥药物的引入显著改善了接受器官移植的患者的预后。虽然他克莫司的使用有助于防止器官排斥,特别是在胰腺和多器官移植的情况下,神经精神方面的副作用较少报道。在这里,我们报告了一位38岁的女性复杂的精神病学和行为表现,她有治疗难治性抑郁、焦虑和不明原因的饮食失调的精神病史,两年前接受活体肾移植后,她一直在他克莫司的治疗下保持平稳。患者随后接受了孤立的胰腺移植手术。移植后6天就诊精神科,诊断为多动、破坏性行为、身体躁动、认知受损、定向障碍、言语混乱和偶尔出现幻觉;这些症状对精神科药物的多次试验都是难以治愈的。经过广泛的医学和神经学检查,以及几例他克莫司水平严重升高后,患者改用环孢素,逐渐改善,最终恢复到认知基线。在探讨这种复杂的精神病学表现的可能原因时,我们强调他克莫司的使用与精神病学症状之间的相关性,即使其水平在治疗范围内,并强调需要考虑改用替代药物。据我们所知,这是第一例在他克莫司首次移植数年后,在第二次器官移植的情况下,他克莫司引起的精神病症状。考虑到这一点,临床医生应该保持警惕,监测长期使用他克莫司的患者,同时等待更多关于其长期使用的神经毒性影响的研究。
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引用次数: 0
Delusions of hermaphroditism and pregnancy in bipolar mania 双相狂躁症的雌雄同体妄想与妊娠
Pub Date : 2025-10-09 DOI: 10.1016/j.psycr.2025.100294
Felipe Londoño Gómez, Paola Hernández Rúa, Kelly Duica, Camilo Andrés Agudelo V
Delusional misidentification syndromes are a group of rare psychiatric phenomena involving disturbances in the recognition of oneself or others. Among them, delusional hermaphroditism and delusional pregnancy are exceptionally uncommon. We present the case of a 58-year-old male with bipolar disorder in a manic episode, who has a persistent belief of possessing both male and female genitalia and experiencing multiple pregnancies and miscarriages. The patient's delusional symptoms proved refractory to antipsychotic treatment, necessitating electroconvulsive therapy (ECT), which led to complete symptom resolution. This case underscores the clinical relevance of rare delusional presentations in bipolar mania and highlights the therapeutic role of ECT in treatment-resistant cases.
妄想误认综合征是一组罕见的精神病学现象,涉及对自己或他人的认知障碍。其中,妄想性雌雄同体和妄想性怀孕是极为罕见的。我们提出的情况下,58岁的男性躁郁症躁狂症发作,谁有一个持久的信念,拥有男性和女性的生殖器,并经历多次怀孕和流产。患者的妄想症状对抗精神病药物治疗难治性,需要电休克治疗(ECT),导致症状完全缓解。本病例强调了双相躁狂症罕见妄想表现的临床相关性,并强调了ECT在治疗难治性病例中的治疗作用。
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引用次数: 0
期刊
Psychiatry research case reports
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