Skin health and disease最新文献

Cylindromas are rare, benign adnexal neoplasms primarily found on the scalp and face, with a higher incidence in women and typically manifesting in the second or third decade of life. These tumours can present as single or multiple nodules, with the latter form often linked to CYLD gene mutations, particularly in the context of CYLD cutaneous syndrome. Here, we report a case of a 61-year-old male presenting with multiple cylindromas of the scalp, prompting genetic testing that revealed a novel pathogenic variant in the CYLD gene.

Sunscreens are topical formulations incorporating filters that protect our skin against ultraviolet radiation (UVR) emitted by the sun. Sunscreen use has been increasingly encouraged to protect against sunburn, skin cancer and photoaging that can occur because of prolonged and cumulative sun exposure. However, sunscreens and their constituent UVR filters have been purported to be problematic themselves. In this narrative review, we will describe the history of sunscreens, types of UVR filters and how sunscreens are classified and rated. We will also explore some of the controversies regarding sunscreens, including concerns about their safety and environmental impact. Awareness of these potential consequences is paramount to the process of informed decision-making.

Acute cutaneous presentations in immunocompromised patients demand careful and thorough evaluation. Here, we present the case of a 26-year-old female with acute myeloid leukaemia undergoing salvage chemotherapy, who developed an acutely expanding subcutaneous mass starting on the frontotemporal scalp to the angle of the jaw. Histopathologic evaluation was consistent with sclerosing fat necrosis with overlying psoriasiform spongiotic dermatitis. Tissue cultures revealed multi-drug resistant Pseudomonas aeruginosa. Given these findings, the patient was diagnosed with infectious panniculitis. This case underscores the necessity of comprehensive diagnostic approaches and multidisciplinary collaboration in managing unusual cutaneous presentations in immunocompromised individuals.

Botryomycosis of the tongue is a rare chronic bacterial infection that presents as nodular masses, mimicking other infectious or neoplastic conditions such as mycetoma. A case of an 80-year-old male was presented with painless swelling on the right lateral side of his tongue to the outpatient clinic. Biopsy and microbiological investigations revealed an unexpected Staphylococcus aureus-related botryomycosis. This case highlights the diagnostic challenge for unusual clinical presentations of bacterial infections. Healthcare providers in countries endemic with diseases that manifest similarly should investigate thoroughly to ensure a positive clinical outcome through early diagnosis and effective case management.

A 32-year-old male presented with diffuse plaques accompanied by multiple large, painful swellings predominantly distributed over the trunk, face and both upper and lower extremities for 11 years. There was no family history of similar complaints. The histopathological examination (HPE), supplemented with special stains confirmed the diagnosis of cutaneous leiomyoma (CL). The immunohistochemical analysis showed a strong expression of smooth muscle actin. The final diagnosis of sporadic diffuse multiple cutaneous leiomyomatosis was made. This presentation of CL is uncommon and resembled plexiform neurofibroma. The clinical diagnosis of this presentation was challenging. Therefore, HPE combined with special stains aided in confirming this surgically challenging rare tumour. In resource-poor settings regular screening is required for early detection of renal cancer and other associated complications.