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Acta medica Austriaca. Supplement最新文献

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[Circulating immune complexes in patients with malignant diseases]. [恶性疾病患者的循环免疫复合物]。
Pub Date : 1979-01-01
J S Smolen, E J Menzel, P Aiginger, O Scherak, W Knapp, J Kühböck

Circulating immune complexes were determined by a solid phase C1q assay in patients with divers malignancies. In Hodgkin's disease (n = 20), immune complexes were detected only in two patients during chemotherapy. Both patients succumbed shortly thereafter. In patients with testicular malignancies (n = 18), immune complexes were detected especially in patients without evidence of metastatic disease. Sequential investigations did not reveal prognostic insights. Summing up these data and the data obtained in additional patients with malignancies, it is interesting to note, that patients with carcinomas have a significant higher incidence of circulating immune complexes with malignancies of the lymphatic system. Our data, however, do not exclude presence of other than C1q binding immune complexes.

采用固相C1q法测定多种恶性肿瘤患者的循环免疫复合物。在霍奇金病(n = 20)中,只有2例患者在化疗期间检测到免疫复合物。此后不久,两名患者均死亡。在睾丸恶性肿瘤患者(n = 18)中,检测到免疫复合物,特别是在没有转移性疾病证据的患者中。连续的调查没有揭示预后的见解。总结这些数据和其他恶性肿瘤患者的数据,有趣的是,癌症患者淋巴系统恶性肿瘤循环免疫复合物的发生率明显更高。然而,我们的数据并不排除C1q结合免疫复合物以外的存在。
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引用次数: 0
[A new insulin radioimmunotest and its use in the determination of anti-insulin antibodies]. 一种新的胰岛素放射免疫试验及其在测定抗胰岛素抗体中的应用
Pub Date : 1979-01-01
E J Menzel, J S Smolen, M Kojer

Acetylation of insulin with 3H-acetic anhydride resulted in the predominant 3H-labeling at the aminoterminal position of the B-chain (B1). The labeled insulin was unchanged in its immunologic reactivity as compared to native insulin. It was used in a second antibody radioimmunoassay for the detection of antiinsulin-antibodies in insulin-dependent patients with Diabetes mellitus.

胰岛素与3h -乙酸酐的乙酰化导致b链氨基末端的3h标记占主导地位(B1)。与天然胰岛素相比,标记胰岛素的免疫反应性没有变化。它被用于第二抗体放射免疫测定,用于检测胰岛素依赖的糖尿病患者的抗胰岛素抗体。
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引用次数: 0
[Radiologic diagnosis of the hemodynamic situation in the pulmonary circulation in chronic obstructive ventilatory disorders]. 慢性阻塞性通气障碍肺循环血流动力学的影像学诊断
Pub Date : 1979-01-01
W Hofner

Hemodynamic consequences, especially in view of a developing pulmonary hypertension are essential factors regarding the course and prognosis of an obstructive airflow disturbance. The characteristic roentgen symptoms of pulmonary vascular changes in a group of patients are collected and statistically evaluated to find those symptoms correlating best with the results of cardiac catheterisation. The importance of using not a single symptom but characteristic groups of symptoms for the radiological diagnosis of pulmonary hypertension is stressed. Radiological signs of increased pulmonary pressure do not directly correlate to the degree of measurements, false positive radiological reports need not be expected. Positive radiological symptoms indicate irreversible anatomical changes in pulmonary circulation. For the individual patient the pulmonary arterial pressure by cardiac catheterisation alone is not sufficient for the diagnosis and prognosis of this case as in obstructive air-way disturbance two definitely different types of diseases, namely type A (emphysema) and type B (bronchitis) with divergent hemodynamic consequences must be distinguished. For this differentiation the radiological evaluation of the anatomical situation is essential.

血流动力学后果,特别是发展中的肺动脉高压是影响阻塞性气流障碍病程和预后的重要因素。收集一组患者肺血管改变的特征性伦线症状并进行统计评估,以找到与心导管插入术结果最相关的症状。强调在肺动脉高压的影像学诊断中,不应使用单一症状,而应使用特征性的症状群。肺压增高的放射学征象与测量的程度没有直接关系,因此不需要期望出现假阳性的放射学报告。放射学阳性症状提示肺循环不可逆的解剖改变。对于单个患者,仅通过心导管检查肺动脉压不足以诊断和预后,因为在阻塞性气道障碍中,必须区分两种截然不同的疾病,即A型(肺气肿)和B型(支气管炎),它们具有不同的血流动力学后果。对于这种区分,解剖情况的放射学评估是必不可少的。
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引用次数: 0
[Physiopathology of prostaglandin I2 synthesis in the human gastrointestinal mucosa]. [人胃肠道粘膜前列腺素I2合成的生理病理]。
Pub Date : 1979-01-01
H Sinzinger, K Silberbauer, H Seyfried

1. PGI2 is synthetized in human gastrointestinal mucosa. 2. PGI2 seems to be responsible for pathophysiological conditions. 3. Disorders caused by an enhanced or diminished PGI2-synthesis could be treated in the future by inhibition of prostacyclin synthetase or exogenous synthetic PGI2 respectively. 4. In order to remove the problems with the unstable PGI2, synthetic analogs could be used for the treatment.

1. PGI2是在人胃肠道粘膜中合成的。2. PGI2似乎与病理生理状况有关。3.由PGI2合成增强或减少引起的疾病可以通过抑制前列环素合成酶或外源性合成PGI2来治疗。4. 为了消除PGI2不稳定的问题,可以使用合成类似物进行处理。
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引用次数: 0
[Serum ferritin in patients with malignant melanoma]. [恶性黑色素瘤患者血清铁蛋白]。
Pub Date : 1979-01-01
W Linkesch, T Luger, E M Kokoschka

In 55 patients with malignant melanoma, in addition to hematologic parameters and blood chemistry, serumferritin was measured by a two-site IRMA-technique using a heterologous antibody system (Behringwerke). Tumor localisation was exactly classified due to a staging system (stage I--III). Elevation of serumferritin values in stage III was highly significant (p less than 0.0005) compared to stage I and II, as well as to normal controls (n = 60). There was no significant correlation between serumferritin and sedimentation rate, erythrocytes or serum iron. Only in stage III we found a significant negative correlation (p less than 0.05) between serumferritin and hemoglobin. Compared to normal controls, patients with stage III showed a significant decrease in serum-iron (p less than 0.01). A significant increase was found concerning serum-copper levels in all patients with melanoma. Though radioimmunometric methods now are not sensitive enough for the determination of tumor-specific isoferritins, serumferritin might be useful in detecting patients with malignant melanoma (stage III).

在55例恶性黑色素瘤患者中,除了血液学参数和血液化学外,还使用异源抗体系统(Behringwerke)通过双位点irma技术测量血清铁蛋白。由于分期系统(I- III期),肿瘤定位被准确分类。与I期和II期以及正常对照(n = 60)相比,III期血清铁蛋白升高非常显著(p < 0.0005)。血清铁蛋白与沉降率、红细胞或血清铁无显著相关性。只有在III期,我们发现血清铁蛋白与血红蛋白之间存在显著的负相关(p < 0.05)。与正常对照相比,III期患者血清铁含量显著降低(p < 0.01)。所有黑色素瘤患者血清铜水平均显著升高。虽然放射免疫测定法目前还不够灵敏,无法测定肿瘤特异性异铁蛋白,但血清铁蛋白可能有助于检测恶性黑色素瘤(III期)患者。
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引用次数: 0
[Anemias significant in occupational medicine]. [职业医学中重要的贫血]。
Pub Date : 1979-01-01
E Neumann, O Jahn

The role of anaemia in occupational medicine is reviewed briefly. Although anaemia is an infrequent symptom, it may be important by its severeness. Irreversible bone marrow failure following exposition to benzene, is discussed more in detail and finally the importance of evaluating professional exposition to potentially myelo-toxic compounds in every patient, is emphasized.

简要回顾了贫血在职业医学中的作用。虽然贫血是一种罕见的症状,但它的严重性可能是重要的。不可逆的骨髓衰竭暴露于苯后,更详细地讨论,最后评估的重要性专业暴露于潜在的髓毒性化合物的每一个病人,强调。
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引用次数: 0
[Prognostic factors in the drug therapy of metastasizing breast cancer]. 转移性乳腺癌药物治疗的预后因素。
Pub Date : 1979-01-01
R Mörz, M Schemper, P Bettelheim, S Breyer, M Francesconi, W Graninger, R Jakesz, R Kolb, M Micksche, H Rainer, G Reiner, K Moser

175 patients with metastatic breast cancer, treated with chemotherapy, were analyzed retrospectively to identify the characteristics of prognostic importance in predicting response to chemotherapy and survival from onset of the chemotherapy. The most significant factors were the sites of metastatic disease and an estimate of the total extent of disease.

对175例接受化疗的转移性乳腺癌患者进行回顾性分析,以确定预测化疗反应和化疗开始后生存的预后重要性特征。最重要的因素是转移性疾病的部位和对疾病总体程度的估计。
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引用次数: 0
[Heme synthesis and iron status in pregnancy]. [妊娠期血红素合成与铁状态]。
Pub Date : 1979-01-01
W Linkesch, R Pavelka, E Kofler, M Müller

In 130 pregnant women (41 without complications, 40 with prematurity, 49 with EPH-Gestosis) Serumferritin, ferrochelatase (FCH), delta-aminolaevulinic-aciddehydratase (D-ALA-D), porphobilinogendeaminase (PBG-D) as well as hematologic routine parameters were measured. Regarding serumferritin, both uncomplicated and cases with pathologic conditions revealed a significant decrease in group II (28th week of pregnancy) as compared to group I (12th to 28th week of pregnancy). Women with EPH-Gestosis showed the lowest values. Activities of hemesynthesizing enzymes did not show any significant differences, neither between the two groups nor between uncomplicated and pathologic cases. Compared to healthy, non pregnant women; in pregnant women we found a significant increase in D-ALA-D and PBG-D, but a significant decrease in FCH. Enzyme pattern in pregnancy reveals an increased synthesis of porphobilinogen and an increased conversion of porphobilinogen to porphyrin. The low activity of FCH we measured in our study could be a reason for the elevation of free protoporphyrin in the erythrocytes.

对130例孕妇(无并发症41例,早产40例,妊高征妊娠期49例)测定血清铁蛋白、铁螯合酶(FCH)、氨基乙酰丙酸脱水酶(D-ALA-D)、卟啉胆碱原脱氨酶(PBG-D)及血液学常规指标。在血清铁蛋白方面,II组(妊娠28周)与I组(妊娠12 - 28周)相比,无并发症和有病理条件的病例均显着降低。ef - gestosis患者的血压最低。血合成酶活性在两组之间、非复杂病例和病理病例之间均无显著差异。与健康、未怀孕的妇女相比;在孕妇中,我们发现D-ALA-D和PBG-D显著增加,但FCH显著降低。酶模式在怀孕期间显示增加合成的卟啉胆色素原和增加转化为卟啉。我们在研究中测量到的FCH活性低可能是红细胞中游离原卟啉升高的原因。
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引用次数: 0
[Diagnosis of adriamycin myocardiopathy using echocardiography]. 超声心动图诊断阿霉素心肌病
Pub Date : 1979-01-01
H Harpf, M Lehnert, G Tschech

27 patients with a mean cumulative dose of 450 +/- 150 mg adriamycin for the treatment of solid malignoma and clinical symptoms of left heart failure are examined by echocardiography. 14 patients had an abnormal ejection fraction, 21 patients an abnormal mean circumferential fiber shortening and 4 patients presented with pericardial effusion. The results demonstrate that echocardiography is a safe, noninvasive and reliable method for diagnosing a reduced left ventricular function in patients treated with adriamycin.

用超声心动图检查了27例阿霉素治疗实体恶性肿瘤和左心衰临床症状的患者,平均累积剂量为450 +/- 150 mg。射血分数异常14例,平均周纤维缩短异常21例,心包积液4例。结果表明超声心动图是一种安全、无创、可靠的诊断阿霉素治疗患者左心室功能减退的方法。
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引用次数: 0
[Results of radiotherapy of gastrointestinal malignancies]. [胃肠道恶性肿瘤放疗结果]。
Pub Date : 1979-01-01
E Kahr, A Hackl

Irradiation offers only a palliative treatment for malignant tumours of the gastrointestinal tract. Cancer of the rectum and rectosigmoid represents an exception; above all, preoperative irradiation improves a five year survival rate up to 15%. There is a better prognosis for non-Hodgkin's and Hodgkin's lymphomas of the entire gastrointestinal tract.

放射治疗对胃肠道恶性肿瘤只能起到治标不治本的作用。直肠和直肠乙状结肠癌是个例外;最重要的是,术前放疗可使5年生存率提高15%。整个胃肠道的非霍奇金淋巴瘤和霍奇金淋巴瘤预后较好。
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Acta medica Austriaca. Supplement
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