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Acta paediatrica Scandinavica. Supplement最新文献

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6th International Symposium on Growth and Growth Disorders. Proceedings of a meeting. Brussels, Belgium, 28-29 October 1988. 第六届生长和生长障碍国际研讨会。会议记录。1988年10月28日至29日，比利时布鲁塞尔。
Acta paediatrica Scandinavica. Supplement
Pub Date : 1989-01-01
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引用次数: 0
Outcome after cessation of therapy in childhood leukemia. A population-based Nordic study of 986 patients. 儿童白血病停止治疗后的预后。一项以人群为基础的北欧986例患者研究。
Acta paediatrica Scandinavica. Supplement
Pub Date : 1989-01-01
R Nygaard, P J Moe
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引用次数: 0
New imaging techniques in endocrinology: magnetic resonance of the pituitary gland and sella turcica. 内分泌成像新技术:垂体和蝶鞍磁共振成像。
Acta paediatrica Scandinavica. Supplement
Pub Date : 1989-01-01 DOI: 10.1111/j.1651-2227.1989.tb11235.x
G Scotti, F Triulzi, G Chiumello, B Dinatale
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引用次数: 29
Cystic fibrosis--from lung damage to symptoms. 囊性纤维化从肺损伤到症状
Acta paediatrica Scandinavica. Supplement
Pub Date : 1989-01-01 DOI: 10.1111/apa.1989.78.s363.52
D M Geddes, R Shiner

Respiratory symptoms in cystic fibrosis are both local and systemic. The local symptoms include cough, sputum, wheezing, haemoptysis and breathlessness, while systemic symptoms of malaise and fever occur with pulmonary infection. There are also interactions between respiratory and gastrointestinal systems in producing symptoms of malaise and weakness and these also contribute to the secondary psychological and social problems that a number of patients with cystic fibrosis experience. These local respiratory symptoms can be attributed in part to lung damage, but are also a manifestation of the CF defect itself. Similarly, lung damage, allergy, haemodynamic and nutritional changes all contribute to the symptom of breathlessness. Further improvement in symptoms in the future will come not only from limiting the lung damage but also from therapy aimed at reversing the CF defect itself.

囊性纤维化患者的呼吸道症状既有局部症状，也有全身性症状。局部症状包括咳嗽、咳痰、喘息、咯血和呼吸困难，而全身不适和发烧症状伴肺部感染。呼吸系统和胃肠系统之间也有相互作用，产生不适和虚弱的症状，这些也导致了许多囊性纤维化患者经历的继发性心理和社会问题。这些局部呼吸道症状可部分归因于肺损伤，但也是CF缺陷本身的表现。同样，肺损伤、过敏、血流动力学和营养变化都会导致呼吸困难的症状。未来症状的进一步改善不仅来自肺损伤的限制，还来自旨在逆转CF缺陷本身的治疗。
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引用次数: 3
Iron nutrition in childhood. Papers presented at the Milupa Workshop. Athens 10-11 March 1989. Proceedings. 儿童铁营养。在Milupa研讨会上发表的论文。1989年3月10日至11日雅典。程序。
Acta paediatrica Scandinavica. Supplement
Pub Date : 1989-01-01
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引用次数: 0
Diagnostic value of growth hormone-releasing hormone tests in short children. 生长激素释放激素试验对矮个子儿童的诊断价值。
Acta paediatrica Scandinavica. Supplement
Pub Date : 1989-01-01 DOI: 10.1111/j.1651-2227.1989.tb17176.x
O Butenandt
Butenandt O. (Department of Paediatric Endocrinology, Children's Hospital, University of Munich, Munich, West Germany). Diagnostic value of growth hormone‐releasing hormone tests in short children. Acta Paediatr Scand [Suppl] 349 93, 1989.
生长激素释放激素(GHRH)测试应用于230多名儿童。61例生长激素(GH)缺乏症患者中有25例对GHRH有反应，GH增加大于10 ng/ml。在大多数特发性生长激素缺乏症患者中，使用每日注射GHRH的启动程序可以改善对GHRH的分泌反应。几乎所有家族性身材矮小的儿童都表现出生长激素水平的迅速增加，平均峰值水平为34.9 ng/ml(范围0.5- 144ng /ml)。第二次测试是在五名家族性身材矮小的儿童中进行的，因为他们对第一次测试没有反应。先天性生长发育迟缓儿童的生长激素反应与家族性身材矮小患者的生长激素反应没有差别。10名患有乌尔里希-特纳综合征的女孩的GH平均升高22 ng/ml(范围10.1-34.0 ng/ml)。糖皮质激素治疗，以及内源性皮质醇的高分泌，抑制垂体对GHRH的反应。在8名肥胖儿童的类固醇抑制试验中，单剂量地塞米松也观察到抑制。脑垂体反应性低也见于地中海贫血和输血诱导的血色素沉着症患者。这是结论，它是不可能检测GH缺乏与单一的GHRH试验。全面的内分泌学评估是证实诊断的必要条件。
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引用次数: 14
Hepatobiliary pathology in patients with cystic fibrosis. 囊性纤维化患者的肝胆病理。
Acta paediatrica Scandinavica. Supplement
Pub Date : 1989-01-01 DOI: 10.1111/apa.1989.78.s363.45
M Sinaasappel

Overt liver disease in cystic fibrosis is a rare condition. Only 1-5% of all patients show a severe disturbance of the liver cell function or portal hypertension. In contrast, liver architecture is much more often disturbed at post mortem examination. The experience is that liver pathology increases with age which will result in rising numbers of patients in the future parallel to the increasing life expectancy of the patients. Bile plugs are commonly found in the portal tract and probably represent the essential abnormality of the liver in CF. Recently new methods have been developed for the investigation of the bile synthesis which will be helpful in the understanding of the CF defect in the liver.

囊性纤维化的明显肝脏疾病是一种罕见的疾病。只有1-5%的患者表现为严重的肝细胞功能障碍或门静脉高压症。相比之下，肝脏结构在尸检时更常受到干扰。经验是，肝脏病理随着年龄的增长而增加，这将导致未来患者数量的增加，同时患者的预期寿命也在增加。胆管塞常见于门静脉，可能是CF中肝脏的本质异常。近年来，人们发展了新的方法来研究胆汁合成，这将有助于了解肝内CF缺陷。
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引用次数: 28
Perspectives of neonatology. In honour of Bent Friis-Hansen. 新生儿学观点。为了纪念本特·弗里斯-汉森。
Acta paediatrica Scandinavica. Supplement
Pub Date : 1989-01-01
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引用次数: 0
The infancy-childhood-puberty model of growth: clinical aspects. 婴儿期-儿童期-青春期生长模式:临床方面。
Acta paediatrica Scandinavica. Supplement
Pub Date : 1989-01-01 DOI: 10.1111/j.1651-2227.1989.tb11238.x
W Y Tse, P C Hindmarsh, C G Brook

The infancy-childhood-puberty (ICP) growth model describes human growth from the latter half of the intrauterine life to maturity as three additive and partly superimposed components--infancy, childhood and puberty. Each component can be analysed mathematically and appears to be controlled by distinct biological mechanisms. The infancy component is largely nutrition dependent, the childhood component is mostly dependent on growth hormone (GH) and the pubertal component depends on the synergism between sex steroids and GH. The ICP model offers a method for detecting abnormalities in the three components, so that early intervention can be targeted and therapy monitored.

婴儿期-儿童期-青春期(ICP)生长模型描述了人类从子宫内生命的后半段到成熟的三个附加和部分重叠的组成部分——婴儿期、儿童期和青春期。每个组成部分都可以用数学方法进行分析，并且似乎是由不同的生物机制控制的。婴儿期成分主要依赖于营养，儿童期成分主要依赖于生长激素(GH)，青春期成分依赖于性类固醇和GH之间的协同作用。ICP模型提供了一种检测这三种成分异常的方法，从而可以有针对性地进行早期干预并监测治疗情况。
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引用次数: 43
Standardization of growth. 标准化的增长。
Acta paediatrica Scandinavica. Supplement
Pub Date : 1989-01-01 DOI: 10.1111/j.1651-2227.1989.tb17170.x
M A Preece
In considering the development of growth standards, four general questions need to be addressed. First, it is necessary to know why the standards are being prepared and in particular what questions will be asked of them. Second, the need for regular revision of these standards must be considered, together with the choice of interval between such revisions. Third, the relative value of national (as opposed to international or reference) standards must be established, and fourth, the requirements for the development of such standards should be taken into account.
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引用次数: 16
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