Pub Date : 1984-01-01DOI: 10.1016/s1054-3589(08)60265-3
A K Tyagi, D A Cooney
{"title":"Biochemical pharmacology, metabolism, and mechanism of action of L-alanosine, a novel, natural antitumor agent.","authors":"A K Tyagi, D A Cooney","doi":"10.1016/s1054-3589(08)60265-3","DOIUrl":"https://doi.org/10.1016/s1054-3589(08)60265-3","url":null,"abstract":"","PeriodicalId":75449,"journal":{"name":"Advances in pharmacology and chemotherapy","volume":"20 ","pages":"69-121"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1054-3589(08)60265-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17458216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1984-01-01DOI: 10.1016/s1054-3589(08)60264-1
A F Hadfield, A C Sartorelli
{"title":"The pharmacology of prodrugs of 5-fluorouracil and 1-beta-D-arabinofuranosylcytosine.","authors":"A F Hadfield, A C Sartorelli","doi":"10.1016/s1054-3589(08)60264-1","DOIUrl":"https://doi.org/10.1016/s1054-3589(08)60264-1","url":null,"abstract":"","PeriodicalId":75449,"journal":{"name":"Advances in pharmacology and chemotherapy","volume":"20 ","pages":"21-67"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1054-3589(08)60264-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17153035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1984-01-01DOI: 10.1016/s1054-3589(08)60266-5
M Nasr, K D Paull, V L Narayanan
Several types of Michael acceptors, including alpha,beta-unsaturated ketones, lactones, and lactams, have been extensively studied as potential anticancer agents. A concerted effort was made to explore the relationship between the structures of these compounds and their antitumor activity against P388 and L1210 leukemias. This article describes the computer-assisted structure-activity evaluation of more than 14,000 compounds, representing different classes of Michael acceptors, in the NCI file. In this study, advantage has been taken of the computer's ability to search substructures according to precise definitions and to manipulate these substructures utilizing Boolean logic. Olefinic conjugated Michael-type acceptors, e.g., styrenes with different activating groups, cinnamic acid derivatives, and alpha,beta-unsaturated nitro, cyano, sulfone, sulfoxide, and acetylenic compounds, have shown appreciable activity against P388 lymphocytic leukemia. The analysis of lactones and lactams includes substructures representing a wide variety of exocyclic and endocyclic alpha,beta-unsaturated compounds. The analysis describes the effect of certain groups, such as an --OH, --OR, alpha,beta-unsaturated ester, or epoxide, adjacent to the alpha,beta-unsaturated center, on the antitumor activity of these compounds. A combination of one or more of these activating groups with an alpha-methylene-gamma-lactone moiety significantly enhanced the activity against P388. In general, many of the classes of compounds studied have shown poor activity against the more stringent L1210 lymphoid leukemia.
{"title":"Computer-assisted structure-activity correlations.","authors":"M Nasr, K D Paull, V L Narayanan","doi":"10.1016/s1054-3589(08)60266-5","DOIUrl":"https://doi.org/10.1016/s1054-3589(08)60266-5","url":null,"abstract":"<p><p>Several types of Michael acceptors, including alpha,beta-unsaturated ketones, lactones, and lactams, have been extensively studied as potential anticancer agents. A concerted effort was made to explore the relationship between the structures of these compounds and their antitumor activity against P388 and L1210 leukemias. This article describes the computer-assisted structure-activity evaluation of more than 14,000 compounds, representing different classes of Michael acceptors, in the NCI file. In this study, advantage has been taken of the computer's ability to search substructures according to precise definitions and to manipulate these substructures utilizing Boolean logic. Olefinic conjugated Michael-type acceptors, e.g., styrenes with different activating groups, cinnamic acid derivatives, and alpha,beta-unsaturated nitro, cyano, sulfone, sulfoxide, and acetylenic compounds, have shown appreciable activity against P388 lymphocytic leukemia. The analysis of lactones and lactams includes substructures representing a wide variety of exocyclic and endocyclic alpha,beta-unsaturated compounds. The analysis describes the effect of certain groups, such as an --OH, --OR, alpha,beta-unsaturated ester, or epoxide, adjacent to the alpha,beta-unsaturated center, on the antitumor activity of these compounds. A combination of one or more of these activating groups with an alpha-methylene-gamma-lactone moiety significantly enhanced the activity against P388. In general, many of the classes of compounds studied have shown poor activity against the more stringent L1210 lymphoid leukemia.</p>","PeriodicalId":75449,"journal":{"name":"Advances in pharmacology and chemotherapy","volume":"20 ","pages":"123-90"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1054-3589(08)60266-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17458214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1984-01-01DOI: 10.1016/s1054-3589(08)60263-x
J M Venditti, R A Wesley, J Plowman
{"title":"Current NCI preclinical antitumor screening in vivo: results of tumor panel screening, 1976-1982, and future directions.","authors":"J M Venditti, R A Wesley, J Plowman","doi":"10.1016/s1054-3589(08)60263-x","DOIUrl":"https://doi.org/10.1016/s1054-3589(08)60263-x","url":null,"abstract":"","PeriodicalId":75449,"journal":{"name":"Advances in pharmacology and chemotherapy","volume":"20 ","pages":"1-20"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1054-3589(08)60263-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17458213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1984-01-01DOI: 10.1016/s1054-3589(08)60268-9
E Groll
{"title":"Praziquantel.","authors":"E Groll","doi":"10.1016/s1054-3589(08)60268-9","DOIUrl":"https://doi.org/10.1016/s1054-3589(08)60268-9","url":null,"abstract":"","PeriodicalId":75449,"journal":{"name":"Advances in pharmacology and chemotherapy","volume":"20 ","pages":"219-38"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1054-3589(08)60268-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17458215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1984-01-01DOI: 10.1016/s1054-3589(08)60267-7
A Jori
{"title":"The sugar alcohols: a profile.","authors":"A Jori","doi":"10.1016/s1054-3589(08)60267-7","DOIUrl":"https://doi.org/10.1016/s1054-3589(08)60267-7","url":null,"abstract":"","PeriodicalId":75449,"journal":{"name":"Advances in pharmacology and chemotherapy","volume":"20 ","pages":"191-218"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1054-3589(08)60267-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17500878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1982-01-01DOI: 10.1016/s1054-3589(08)60020-4
A Mantovani
{"title":"The interaction of cancer chemotherapy agents with mononuclear phagocytes.","authors":"A Mantovani","doi":"10.1016/s1054-3589(08)60020-4","DOIUrl":"https://doi.org/10.1016/s1054-3589(08)60020-4","url":null,"abstract":"","PeriodicalId":75449,"journal":{"name":"Advances in pharmacology and chemotherapy","volume":"19 ","pages":"35-66"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1054-3589(08)60020-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17814432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1982-01-01DOI: 10.1016/s1054-3589(08)60023-x
V L Narayanan, W W Lee
{"title":"Development of radiosensitizers: a medicinal chemistry perspective.","authors":"V L Narayanan, W W Lee","doi":"10.1016/s1054-3589(08)60023-x","DOIUrl":"https://doi.org/10.1016/s1054-3589(08)60023-x","url":null,"abstract":"","PeriodicalId":75449,"journal":{"name":"Advances in pharmacology and chemotherapy","volume":"19 ","pages":"155-205"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1054-3589(08)60023-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17814430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1982-01-01DOI: 10.1016/s1054-3589(08)60024-1
U Bode, A Oliff
{"title":"The effects of antineoplastic therapy on growth and development in children.","authors":"U Bode, A Oliff","doi":"10.1016/s1054-3589(08)60024-1","DOIUrl":"https://doi.org/10.1016/s1054-3589(08)60024-1","url":null,"abstract":"","PeriodicalId":75449,"journal":{"name":"Advances in pharmacology and chemotherapy","volume":"19 ","pages":"207-47"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1054-3589(08)60024-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17814431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1982-01-01DOI: 10.1016/s1054-3589(08)60019-8
R J Weinkam, H S Lin
{"title":"Chloroethylnitrosourea cancer chemotherapeutic agents.","authors":"R J Weinkam, H S Lin","doi":"10.1016/s1054-3589(08)60019-8","DOIUrl":"https://doi.org/10.1016/s1054-3589(08)60019-8","url":null,"abstract":"","PeriodicalId":75449,"journal":{"name":"Advances in pharmacology and chemotherapy","volume":"19 ","pages":"1-33"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s1054-3589(08)60019-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17814428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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