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Bone and joint infections caused by mucormycetes: A challenging osteoarticular mycosis of the twenty-first century. 由粘孢子菌引起的骨与关节感染:二十一世纪具有挑战性的骨关节真菌病。
IF 1 Pub Date : 2017-10-01 DOI: 10.1093/mmy/myw136
Saad J Taj-Aldeen, Maria N Gamaletsou, Blandine Rammaert, Nikolaos V Sipsas, Valerie Zeller, Emmanuel Roilides, Dimitrios P Kontoyiannis, Michael Henry, Vidmantas Petraitis, Brad Moriyama, David W Denning, Olivier Lortholary, Thomas J Walsh

Osteomyelitis and arthritis caused by mucormycetes are rare diseases that rank among the most challenging complications in orthopedic and trauma surgery. The aim of this work is to review the epidemiological, clinical, diagnostic, and therapeutic aspects of the osteoarticular mucormycosis with particular emphasis on high-risk patients. A systematic review of osteoarticular mucormycosis was performed using PUBMED and EMBASE databases from 1978 to 2014. Among 34 patients with median age 41 (0.5-73 years), 24 (71%) were males. While 12 (35%) were immunocompromised patients, 14 (41%) had prior surgery, and seven (21%) suffered trauma. Other underlying conditions included diabetes mellitus, hematological malignancies, transplantation, and corticosteroid therapy. The median diagnostic delay from onset of symptoms and signs was 60 (10-180) days. The principal mechanism of the infection was direct inoculation (n = 19; 56%), and in immunocompromised patients was usually hematogenous disseminated. The long bones were infected by trauma or surgery, while a wide variety of bones were involved by hematogenous dissemination. Combined surgery and amphotericin B treatment were implemented in 28 (82%) and eight (23%) had an unfavorable outcome. Osteoarticular mucormycosis occurs most frequently after trauma or surgical procedures. These infections are progressively destructive and more virulent in individuals with impaired immune systems. Early diagnosis, timely administration of amphotericin B, control of underlying conditions, and surgical debridement of infected tissue are critical for successful management of osteoarticular mucormycosis.

由粘孢子虫引起的骨髓炎和关节炎是一种罕见疾病,是骨科和创伤外科最具挑战性的并发症之一。本研究旨在回顾骨关节粘液瘤病的流行病学、临床、诊断和治疗方面的内容,重点关注高危患者。研究人员使用 PUBMED 和 EMBASE 数据库对 1978 年至 2014 年期间的骨关节粘液瘤病进行了系统回顾。在 34 名中位数年龄为 41(0.5-73 岁)的患者中,24 名(71%)为男性。12人(35%)为免疫力低下患者,14人(41%)曾接受过手术,7人(21%)受过外伤。其他潜在疾病包括糖尿病、血液恶性肿瘤、移植和皮质类固醇治疗。从出现症状和体征到确诊的中位延迟时间为 60 (10-180) 天。感染的主要机制是直接接种(19 人;56%),在免疫力低下的患者中通常是血源性播散。长骨因外伤或手术感染,而各种骨骼则因血行播散而受累。28例(82%)患者接受了手术和两性霉素B联合治疗,8例(23%)患者的治疗效果不佳。骨关节粘液瘤病最常发生在创伤或外科手术后。在免疫系统受损的人群中,这些感染会逐渐恶化,毒性更强。早期诊断、及时使用两性霉素 B、控制基础疾病和手术清创受感染组织是成功治疗骨关节粘液瘤病的关键。
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引用次数: 0
Morton's metatarsalgia in rheumatoid arthritis. 类风湿性关节炎的莫顿跖痛。
Pub Date : 1979-07-01 DOI: 10.1097/00003086-197907000-00013
V. Ritama, K. Vainio
Findings in a follow-up study of 66 operations Morton's metatarsalgia performed on 52 patients suffering from rheumatoid arthritis during the years 1954-1977 were in many respects different from those described as "classic" Morton's neuroma. The incidence was one to 520 in rheumatoid patients. The ratio of females to males was 9.4 to one. Histology revealed inflammatory or degenerative changes of the walls of synovial cavities often in connection with typical rheumatoid nudules. The changes of the nerves were non-specific alterations caused by chronic compression. Surgical removal of the tumor-like formations gave uniformly good results. Early metatarsophalangeal synovectomy for rheumatoid arthritis decreased in need of operations for Morton's metatarsalgia from 4.5 to 0.6 operations per year and can be recommended as a prophylactic procedure.
对1954-1977年间52例类风湿关节炎患者进行的66例莫顿跖骨痛手术的随访研究发现,在许多方面与“典型”莫顿神经瘤不同。类风湿患者的发病率为1比520。男女比例为9.4比1。组织学显示滑膜腔壁的炎症或退行性改变通常与典型的类风湿结节有关。神经的改变是由慢性压迫引起的非特异性改变。手术切除肿瘤样组织的结果一致良好。类风湿关节炎的早期跖趾滑膜切除术减少了Morton跖骨痛的手术需求,从每年4.5次减少到0.6次,可以作为一种预防性手术。
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引用次数: 23
The effect of systematic treatment of toxaemia of pregnancy upon fetal prognosis. 妊娠毒血症系统治疗对胎儿预后的影响。
Pub Date : 1976-06-01 DOI: 10.1097/00006254-197606000-00014
L. Rauramo, A. Kivikoski, T. Salmi
Systematic therapy for pre-eclampsia including diuretics was investigated in 604 patients in whom therapy was begun immediately the first symptoms appeared and continued until delivery. The control group consisted of 368 patients with toxemia from the two previous years who received no systematic therapy but who also underwent delivery at either the Turku City Maternity Hospital or the Women's Clinic of Turku University Central Hospital. Cases of pre-eclampsia gravis were significantly reduced (2.3 as compared with 7.3%). A significant difference was seen in the percentage of premature deliveries. In the experimental group this was 4.3% and in the control group 11.2%, (p less than 0.001). There was also a significant difference in the perinatal mortality, the values being 2.3 and 4.6%, respectively (p less than 0.05). The overal premature birth rate during these two periods remained unchanged, at 5.5 and 5.7%. The difference between the overall perinatal mortality rates was also slight (1.8 and 2.2%).
对604例患者进行了包括利尿剂在内的先兆子痫的系统治疗,这些患者在首次症状出现后立即开始治疗并持续到分娩。对照组包括368名前两年的毒血症患者,他们没有接受系统治疗,但也在图尔库市妇产医院或图尔库大学中心医院的妇女诊所分娩。先兆子痫的发生率显著降低(2.3%比7.3%)。早产的比例有显著差异。实验组为4.3%,对照组为11.2% (p < 0.001)。两组围产期死亡率差异有统计学意义,分别为2.3%和4.6% (p < 0.05)。这两个期间的整体早产率维持不变,分别为5.5%和5.7%。总体围产期死亡率之间的差异也很小(1.8%和2.2%)。
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引用次数: 3
Clonidine in the treatment of menopausal symptoms. 可乐定在治疗更年期症状中的作用。
Pub Date : 1976-05-01 DOI: 10.1097/00006254-197605000-00019
O. Ylikorkala
Twenty-five women suffering from climacteric complaints after surgical castration were treated with clonidine in a placebo controlled trial. Clonidine in the dose of 75 to 150 mug daily diminished the attack rates of flushing and sweating significantly. It can be recommended as a safe therapy for climacteric patients, at least those with contra-indications to oestrogen therapy.
在一项安慰剂对照试验中,25名手术阉割后出现更年期症状的女性接受了可乐定治疗。每天服用75 ~ 150杯可乐定可显著降低潮红和出汗的发生率。它可以作为一种安全的治疗方法推荐给更年期患者,至少是那些有雌激素治疗禁忌症的患者。
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引用次数: 11
The prognosis in pregnancy after threatened abortion. 先兆流产后妊娠的预后。
Pub Date : 1975-08-01 DOI: 10.1097/00006254-197508000-00005
P. Jouppila, M. Koivisto
A study of the outcome of pregnancy in 143 cases of threatened abortion is presented. Fetal life was confirmed by ultrasonic technique during the 1st half of pregnancy. 7% of the pregnancies terminated in abortion and the remainder ended in delivery. The frequency of preeclampsia (21%) and placenta praevia (3%) was significantly higher than in the control group, as was the case with the number of manual removals (6) of the placenta (p less than .001). Breech extractions were required in 5 cases. 13.2% of the deliveries occurred before Week 37 of pregnancy, and 8.1% of the infants weighed less than 2500 gm. The perinatal mortality rate (3.7%) and the frequency of infant malformation (5.2%) were not statistically significant compared with the control group. However, the frequency of respiratory difficulties (14.7%) and hyperbilirubinemia (8.1%) was significantly higher (p less than .001). It was concluded that a pregnancy continuing after threatened abortion does not noticeably increase the risk of severe infant malformations or perinatal death, though mothers with threatened abortion constitute a high-risk group that requires careful follow-up.
对143例先兆流产的妊娠结局进行了研究。在妊娠前半期采用超声技术确认胎儿寿命。7%的怀孕以流产告终,其余的以分娩告终。先兆子痫(21%)和前置胎盘(3%)的发生率显著高于对照组,人工胎盘移除次数(6次)也显著高于对照组(p < 0.001)。5例需要拔除髋部。13.2%的分娩发生在妊娠第37周之前,8.1%的婴儿体重小于2500克。围产儿死亡率(3.7%)和婴儿畸形发生率(5.2%)与对照组比较,差异无统计学意义。然而,呼吸困难(14.7%)和高胆红素血症(8.1%)的发生率显著高于对照组(p < 0.001)。结论是,先兆流产后继续怀孕不会明显增加婴儿严重畸形或围产期死亡的风险,尽管先兆流产的母亲是需要仔细跟踪的高危群体。
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引用次数: 8
The absorption of conjugated oestrogen and sodium oestrone sulphate from the vagina. 从阴道吸收共轭雌激素和硫酸雌酮钠。
Pub Date : 1975-05-01 DOI: 10.1097/00006254-197505000-00019
O. Widholm, E. Vartiainen
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引用次数: 26
Effects of high-dose medroxyprogesterone given for endometrial carcinoma on serum proteins. 大剂量甲孕酮对子宫内膜癌患者血清蛋白的影响。
Pub Date : 1975-04-01 DOI: 10.1097/00006254-197504000-00026
P. Ylöstalo, A. Vehaskari, A. Kauppila
29 women with endometrial cancer were treated with 50-mg medroxyprogesterone twice daily for 1 year and studied to determine what effect this dose of progesterone had on serum proteins. Total serum proteins were significantly (p less than .01) elevated at 3 months until 6 months after treatment. There was a transient decline in albumin at 1 month (p less than .01) which reelevated after 3 months. Alpha-1-globulin and alpha-2-globulin increased at the beginning of therapy (p less than .001 at 1 month) and returned to pretreatment levels at the end of therapy. Gamma globulin levels were significantly less after 1 year of therapy. Alpha-1-acid-glycoprotein was significantly elevated at 1 month and returned to normal after therapy ended. These protein levels are compared with those in pregnancy and during oral contraceptive therapy. It is concluded that these changes are smaller and even the reverse of those seen in pregnancy and oral contraceptive therapy; the changes are attributed to the effect of sex hormones on hepatic metabolic activities.
29名患有子宫内膜癌的妇女接受50毫克甲孕酮治疗,每天两次,持续1年,研究该剂量的孕酮对血清蛋白的影响。治疗后3 ~ 6个月血清总蛋白显著升高(p < 0.01)。白蛋白在1个月时短暂下降(p < 0.01), 3个月后再次升高。α -1球蛋白和α -2球蛋白在治疗开始时升高(1个月时p < 0.001),并在治疗结束时恢复到治疗前水平。治疗1年后,丙种球蛋白水平显著降低。1个月时α -1-酸性糖蛋白显著升高,治疗结束后恢复正常。将这些蛋白质水平与怀孕期间和口服避孕药治疗期间的蛋白质水平进行比较。结论是,这些变化较小,甚至与怀孕和口服避孕药治疗时的变化相反;这些变化归因于性激素对肝脏代谢活动的影响。
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引用次数: 2
A case of malignant arrhenoblastoma. 恶性肾母细胞瘤1例。
O Widholm, M Ikonen

The patient was a 72-year-old married woman from whom a recurrent arrhenoblastoma had been removed three time in the course of six years. She was clearly virilized and her voice had become deep. Endocrine studies before removal of the recurrences showed pronounced elevation of the serum testosterone values. The 17-KS values did not as clearly parallel growth of the tumour. Histochemical examination showed moderate 3beta-steroid dehydrogenase activity in limited areas. The histological features were those of so-called intermediate type of arrhenoblastoma with a very scanty tubular component. Histologically the tumour was malignant, but with a relatively low degree of malignancy. Regardless of the treatment there was twice a recurrence of the tumour. The increase of the serum testosterone values during the follow-up period reflected recurrence on of the tumour.

患者是一名72岁的已婚妇女,在6年的时间里,她曾三次切除了复发性肾母细胞瘤。她显然受到了侮辱,声音也变得低沉了。切除复发前的内分泌检查显示血清睾酮值明显升高。17-KS值不清楚肿瘤的平行生长。组织化学检查显示在有限区域有适度的3 - β -类固醇脱氢酶活性。组织学特征为所谓的中间型成瘤,很少有管状成分。组织学上肿瘤为恶性,但恶性程度相对较低。不管治疗如何,肿瘤复发了两次。随访期间血清睾酮值升高反映肿瘤复发。
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引用次数: 0
Haemophilus influenzae as a cause of salpingitis. 流感嗜血杆菌引起输卵管炎。
E Herva, R Pokela, O Ylikorkala

A case is reported of acute unilateral salpingitis, the cause of which was Haemophilus influenzae cultured from a pus sample taken from the infected Fallopian tube during laparotomy. The significance of the findings is discussed with reference to the literature.

病例报告急性单侧输卵管炎,其原因是流感嗜血杆菌培养从感染输卵管脓液样本在剖腹手术期间。本文结合文献讨论了研究结果的意义。
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引用次数: 0
Gastric retention following antrectomy and gastroduodenal anastomosis combined with truncal vagotomy. 胃前切除术及胃十二指肠吻合联合迷走神经截切术后胃潴留。
T Monclair

A clinical series of 208 patients who had elective operations for gastroduodenal ulcer in Surgical Department II, Oslo City Hospital, has been reviewed. The study concentrates on postoperative gastric retention, comparing the frequency of this complication following antrectomy and gastroduodenal anastomosis with and without vagotomy. The patients in the nonvagotomy group had no retention problem. In the vagotomy group, 19 patients (35%) of 54 operated had troublesome postoperative retention. 7 patients (13%) had to have a further operation for this complication, all within 1 year. We no longer use the combined operation as a routine procedure for duodenal ulcer.

本文回顾了奥斯陆市立医院外科二科208例择期胃十二指肠溃疡手术患者的临床资料。本研究集中于术后胃潴留,比较前切除术和胃十二指肠吻合伴迷走神经切开术和不伴迷走神经切开术后胃潴留并发症的发生率。非迷走神经切开术组患者无潴留问题。迷走神经切开术组54例患者中有19例(35%)出现术后潴留问题。7例(13%)患者因该并发症再次手术,均在1年内。我们不再把联合手术作为治疗十二指肠溃疡的常规手术。
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引用次数: 0
期刊
Annales chirurgiae et gynaecologiae Fenniae
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