Introduction Sarcoidosis is a granulomatous disease that affects a variety of populations. It was first described in 1869 by Jonathan Hutchinson, a British dermatologist who defined a 58-year-old coal wharf worker with purple, symmetrical skin plaques on legs and hands that were not painful. In 1897, a Norwegian dermatologist, Caesar Boeck, presented a patient with “multiple benign sarcoid of the skin” which histologically showed well-defined foci of epithelioid cells with giant cells. Although, nearly 150 years later, the etiology of sarcoidosis remains unknown and the course of the disease is unpredictable. The immune-pathogenesis involves a complex interaction between host, genetic factors and environmental or infectious triggers which produces granuloma formation. The disease can affect any organs but mostly involves the lungs and lymph nodes. The disease has a wide range of clinical manifestations, varies from asymptomatic patients with radiographic abnormalities to progressive disease causing morbidity and mortality. Treatment depends on the severity of the disease and organ involvement. This review summarizes the pathogenesis, clinical manifestation, pathological and radiological features, and management focusing on pulmonary sarcoidosis.
{"title":"[Pulmonary sarcoidosis].","authors":"A. Blasi, P. Giacomelli, R. Montella","doi":"10.32388/u2nu3h","DOIUrl":"https://doi.org/10.32388/u2nu3h","url":null,"abstract":"Introduction Sarcoidosis is a granulomatous disease that affects a variety of populations. It was first described in 1869 by Jonathan Hutchinson, a British dermatologist who defined a 58-year-old coal wharf worker with purple, symmetrical skin plaques on legs and hands that were not painful. In 1897, a Norwegian dermatologist, Caesar Boeck, presented a patient with “multiple benign sarcoid of the skin” which histologically showed well-defined foci of epithelioid cells with giant cells. Although, nearly 150 years later, the etiology of sarcoidosis remains unknown and the course of the disease is unpredictable. The immune-pathogenesis involves a complex interaction between host, genetic factors and environmental or infectious triggers which produces granuloma formation. The disease can affect any organs but mostly involves the lungs and lymph nodes. The disease has a wide range of clinical manifestations, varies from asymptomatic patients with radiographic abnormalities to progressive disease causing morbidity and mortality. Treatment depends on the severity of the disease and organ involvement. This review summarizes the pathogenesis, clinical manifestation, pathological and radiological features, and management focusing on pulmonary sarcoidosis.","PeriodicalId":75550,"journal":{"name":"Archivio Monaldi per la tisiologia e le malattie dell'apparato respiratorio","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46370870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Clinical follow-up of mechanical prostheses].","authors":"A Renzulli, B Giannolo, E Micheletti","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75550,"journal":{"name":"Archivio Monaldi per la tisiologia e le malattie dell'apparato respiratorio","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14564226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Biological prostheses: what they are, how they are and how the behave].","authors":"F Lupis, E Micheletti, B Giannolo, G Palma","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75550,"journal":{"name":"Archivio Monaldi per la tisiologia e le malattie dell'apparato respiratorio","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14564220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Which prosthesis to select in aortic position?].","authors":"A Renzulli, G Palma","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75550,"journal":{"name":"Archivio Monaldi per la tisiologia e le malattie dell'apparato respiratorio","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14564224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Valve replacement in pediatric cardiosurgery].","authors":"P Arciprete, G Caianiello, O Fittipaldi, G Palma","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75550,"journal":{"name":"Archivio Monaldi per la tisiologia e le malattie dell'apparato respiratorio","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14564229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Echocardiographic assessment in the selection of mitral prostheses].","authors":"A Renzulli, S Callipari, F Cacciapuoti","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75550,"journal":{"name":"Archivio Monaldi per la tisiologia e le malattie dell'apparato respiratorio","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14455557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Which prosthesis to select in mitral and tricuspid positions].","authors":"E Micheletti, G Cafarella, O Casale","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75550,"journal":{"name":"Archivio Monaldi per la tisiologia e le malattie dell'apparato respiratorio","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14564221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Echocardiographic examination in the follow-up of patients with heart valve prostheses].","authors":"G Dialetto, E Appratto, F E Covino, S Mancusi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75550,"journal":{"name":"Archivio Monaldi per la tisiologia e le malattie dell'apparato respiratorio","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14564227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Clinical follow-up of biological prostheses].","authors":"B Giannolo, G Cafarella, E Micheletti, D Lama","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75550,"journal":{"name":"Archivio Monaldi per la tisiologia e le malattie dell'apparato respiratorio","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14564222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Mechanical cardiac prostheses: what they are, how they are and how they behave].","authors":"E Micheletti, G Cafarella, F Longobardi, G Palma","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75550,"journal":{"name":"Archivio Monaldi per la tisiologia e le malattie dell'apparato respiratorio","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14455559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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