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Australian and New Zealand journal of medicine最新文献

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Recent Advances in the Treatment of Colorectal Cancer 结直肠癌治疗的最新进展
Australian and New Zealand journal of medicine
Pub Date : 2019-01-01 DOI: 10.1007/978-981-13-3050-6
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引用次数: 3
Gemcitabine and the blood brain barrier. 吉西他滨和血脑屏障。
Australian and New Zealand journal of medicine
Pub Date : 1999-12-01 DOI: 10.1111/j.1445-5994.1999.tb00795.x
J R Davis, C Fernandes, J R Zalcberg
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引用次数: 11
Surgical palliation of carcinoid syndrome. 类癌综合征的手术缓解。
Australian and New Zealand journal of medicine
Pub Date : 1999-12-01 DOI: 10.1111/j.1445-5994.1999.tb00801.x
F Wu, J McCall, I Holdaway
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引用次数: 0
Methods and messages in geriatric science - Reply to Loh and Flicker 老年科学的方法和信息——回复Loh和Flicker
Australian and New Zealand journal of medicine
Pub Date : 1999-12-01 DOI: 10.1111/J.1445-5994.1999.TB00786.X
I. Scott
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引用次数: 0
Evaluation of antibodies to beta2-glycoprotein 1 in the causation of coronary atherosclerosis as part of the antiphospholipid syndrome. 作为抗磷脂综合征一部分的β -糖蛋白1抗体在冠状动脉粥样硬化病因中的评价
Australian and New Zealand journal of medicine
Pub Date : 1999-12-01 DOI: 10.1111/j.1445-5994.1999.tb00781.x
V Limaye, J Beltrame, R Cook, D Gillis, K Pile

Background: Anticardiolipin antibodies (aCL) are associated with accelerated coronary atherosclerosis. Beta2-glycoprotein 1 is a cofactor necessary for the binding of aCL.

Aim: The aim of this study was to determine whether antibodies to beta2-glycoprotein 1 (anti-beta2GP1) predispose to coronary artery disease (CAD), and whether the measurement of anti-beta2GP1 will be more useful than aCL alone in the evaluation of coronary risk.

Methods: Persons who had undergone coronary angiography were invited to participate, and risk factors for coronary atherosclerosis recorded. IgG aCL and anti-beta2GP1 were measured and fasting triglyceride (TG) and total cholesterol (TC) levels were determined. Angiographic score (AS) was defined as the number of diseased vessels (0, 1, 2, 3), (>50% stenosis). Ethics Committee approval was obtained. Statistical comparison used the Student's t test and Chi-squared test.

Results: Ninety-seven subjects (63 male) with age range 38-81 years (mean 66.0) participated. There were 31 subjects with AS=0, 27 with AS=1, 22 with AS=2, and 17 with AS=3. The three subjects with positive aCL all had CAD, as did three of the four subjects with positive anti-beta2GP1. Among patients with CAD, there was an equal incidence (4.5%, three/66) of aCL and anti-beta2GP1, and an incidence of either aCL or anti-beta2GP1 of 7.6% (five/66). Compared to the group with AS=0, those with AS=1, 2 or 3 comprised a higher mean age (p=0.001) however, there was no significant difference in the prevalence of other coronary risk factors between the two groups. There was no difference in the proportions of patients with either aCL or anti-beta2GP1 in the group with AS=1, 2, or 3, compared to the group with AS=0 (5/66 c.f. 1/31, chi2=0.146, p>0.5).

Conclusions: Our study has not supported an association between anti-beta2GP1 and CAD. The measurement of anti-beta2GP1 (or aCL) in the investigation of premature CAD is not justified on the basis of our results.

背景:抗心磷脂抗体(aCL)与冠状动脉粥样硬化加速有关。β -糖蛋白1是aCL结合所必需的辅助因子。目的:本研究的目的是确定β -糖蛋白1抗体(抗β - 2gp1)是否易患冠状动脉疾病(CAD)，以及在评估冠状动脉风险方面，检测抗β - 2gp1是否比单独检测aCL更有用。方法:邀请接受冠状动脉造影的患者参与，记录冠状动脉粥样硬化的危险因素。测定血清IgG aCL和抗β 2gp1水平，测定空腹甘油三酯(TG)和总胆固醇(TC)水平。血管造影评分(AS)定义为病变血管数(0、1、2、3)，(>50%狭窄)。获得伦理委员会批准。统计比较采用学生t检验和卡方检验。结果:受试者97名，男性63名，年龄38 ~ 81岁，平均66.0岁。AS=0 31例，AS=1 27例，AS=2 22例，AS=3 17例。三名aCL阳性的受试者均患有CAD，四名抗- β 2gp1阳性的受试者中有三人患有CAD。在CAD患者中，aCL和anti-beta2GP1的发生率相等(4.5%，3 /66)，aCL或anti-beta2GP1的发生率为7.6%(5 /66)。与AS=0组相比，AS=1、2或3组的平均年龄更高(p=0.001)，但两组之间其他冠状动脉危险因素的患病率无显著差异。与AS=0组相比，AS=1、2、3组aCL或抗β 2gp1患者比例无差异(5/66 c.f 1/31, chi2=0.146, p>0.5)。结论:我们的研究不支持抗β 2gp1与CAD之间的关联。根据我们的研究结果，抗β 2gp1(或aCL)的测量在早期CAD的调查中是不合理的。
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引用次数: 24
New treatments for multiple sclerosis. 多发性硬化症的新疗法。
Australian and New Zealand journal of medicine
Pub Date : 1999-12-01 DOI: 10.1111/j.1445-5994.1999.tb00783.x
T J Kilpatrick, M Soilu-Hänninen
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引用次数: 4
Systematic reviews and geriatric interventions--the need for scientific methodology. 系统评价和老年干预——对科学方法的需求。
Australian and New Zealand journal of medicine
Pub Date : 1999-12-01 DOI: 10.1111/j.1445-5994.1999.tb00785.x
P K Loh, L Flicker
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引用次数: 0
Blood screening--the next generation in testing. 血液筛查，下一代检测。
Australian and New Zealand journal of medicine
Pub Date : 1999-12-01 DOI: 10.1111/j.1445-5994.1999.tb00776.x
R J Chappel, E M Dax
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引用次数: 2
Asp or spa (snakebite or drowning)? Asp还是spa(被蛇咬还是溺水)?
Australian and New Zealand journal of medicine
Pub Date : 1999-12-01 DOI: 10.1111/j.1445-5994.1999.tb00790.x
A A Fisher, D Richardson, D G Le Couteur
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引用次数: 1
Oestrogen and vascular disease. 雌激素与血管疾病。
Australian and New Zealand journal of medicine
Pub Date : 1999-12-01 DOI: 10.1111/j.1445-5994.1999.tb00791.x
W K Lim, G Caplan
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引用次数: 0
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