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Membrane phospholipid asymmetry and the adherence of loaded red blood cells. 膜磷脂不对称和负载红细胞的粘附。
Bibliotheca haematologica
Pub Date : 1985-01-01 DOI: 10.1159/000410238
R A Schlegel, L McEvoy, P Williamson

The phospholipids of the red cell membrane are asymmetrically distributed across the bilayer. Loss of this asymmetry by certain normal and pathological red cells is correlated with their increased adherence both in vitro and in vivo. Red cells loaded under conditions which result in loss of asymmetry adhere to cultured endothelial cells and are phagocytized in vitro by macrophages more readily than red cells loaded under conditions in which asymmetry is maintained. These results suggest that preserving phospholipid asymmetry during loading may prevent undesired in vivo interactions by reinfused red cell carriers.

红细胞膜的磷脂不对称地分布在双分子层上。某些正常和病理红细胞失去这种不对称性与它们在体外和体内的粘附性增加有关。在不对称性丧失的条件下负载的红细胞粘附在培养的内皮细胞上，并且在体外被巨噬细胞吞噬比在不对称性保持的条件下负载的红细胞更容易。这些结果表明，在装载过程中保持磷脂的不对称性可能会防止再输注红细胞载体在体内的不良相互作用。
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引用次数: 10
Entrapment of L-asparaginase in red blood cells. A strategy to improve treatment of acute lymphoblastic leukemia. l -天冬酰胺酶在红细胞中的滞留。改善急性淋巴细胞白血病治疗的策略。
Bibliotheca haematologica
Pub Date : 1985-01-01
S J Updike

Autologous red blood cells were loaded with L-asparaginase and injected intravenously into monkeys. A single dose of 1850 IU/Kg suppressed plasma asparagine for 19 days compared to 10 days for the same dose injected free in solution. Rabbit antisera to asparaginase was used to passively immunize guinea-pigs. These animals were then challenged with RBC-entrapped asparaginase versus asparaginase free in solution. RBC entrapment allowed a ten fold greater dose of asparaginase before anaphylaxis became a problem. RBC entrapment prolongs the duration of action of asparaginase and offers protection against anaphylaxis. Clinical trial in patients with acute lymphoblastic leukemia is recommended.

将携带l -天冬酰胺酶的自体红细胞静脉注射到猴子体内。单剂量1850 IU/Kg对血浆天冬酰胺的抑制作用为19天，而相同剂量的溶液游离注射对天冬酰胺的抑制作用为10天。采用兔抗天冬酰胺酶血清对豚鼠进行被动免疫。然后用红细胞包裹的天冬酰胺酶和不含天冬酰胺酶的溶液对这些动物进行攻击。在过敏反应成为问题之前，红细胞包裹允许十倍大剂量的天冬酰胺酶。红细胞包裹延长了天冬酰胺酶的作用时间，并提供了对过敏反应的保护。建议对急性淋巴细胞白血病患者进行临床试验。
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引用次数: 0
Multiparameter studies on 650 bone marrow biopsy cores. Diagnostic value of combined utilisation of imprints, cryostat and plastic sections in medical practice. 650个骨髓活检芯的多参数研究。印迹、低温和整形切片联合应用在医学实践中的诊断价值。
Bibliotheca haematologica
Pub Date : 1984-07-01 DOI: 10.1159/000409639
R. Bartl, B. Frisch, B. Buchenrieder, W. Sommerfeld, H. Muthmann, K. Jäger, G. Hoffmann-Fezer, R. Burkhardt
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引用次数: 14
Current methodology in experimental hematology. 实验血液学的现行方法学。
Bibliotheca haematologica
Pub Date : 1984-01-01
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引用次数: 0
Erythropoietic cells. 红血球生成的细胞。
Bibliotheca haematologica
Pub Date : 1984-01-01 DOI: 10.1159/000408404
C J Eaves, G Krystal, A C Eaves
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引用次数: 0
Special techniques for the separation of hemopoietic cells. Elutriation. 造血细胞分离的特殊技术。淘洗。
Bibliotheca haematologica
Pub Date : 1984-01-01
J F Jemionek, R L Monroy
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引用次数: 0
Cell proliferation kinetics analyzed with BrdU and near-UV light treatment. 用BrdU和近紫外光处理分析细胞增殖动力学。
Bibliotheca haematologica
Pub Date : 1984-01-01 DOI: 10.1159/000408411
M P Hagan
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引用次数: 6
Bone marrow biopsies updated. New prospects for clinical diagnosis. Satellite symposium of the 7th congress of the International Society of Haematology, European and African Division, Barcelona, September 4-9, 1983. 骨髓活组织检查更新。临床诊断的新前景。国际血液学学会欧洲和非洲分会第七届大会卫星专题讨论会，巴塞罗那，1983年9月4-9日。
Bibliotheca haematologica
Pub Date : 1984-01-01
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引用次数: 0
Clinical significance of patterns of bone marrow involvement in chronic lymphocytic leukemia and small lymphocytic (well-differentiated) non-Hodgkin's lymphoma. 慢性淋巴细胞白血病和小淋巴细胞(高分化)非霍奇金淋巴瘤骨髓受累模式的临床意义。
Bibliotheca haematologica
Pub Date : 1984-01-01 DOI: 10.1159/000409646
G A Pangalis, P A Roussou, C Kittas, P Fessas
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引用次数: 2
Studies on cellular interactions between stromal and haemopoietic stem cells in normal and leukaemic bone marrows. 正常和白血病骨髓间质干细胞和造血干细胞之间细胞相互作用的研究。
Bibliotheca haematologica
Pub Date : 1984-01-01 DOI: 10.1159/000409641
A Islam, D Catovsky, J M Goldman, D A Galton
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引用次数: 7
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