{"title":"Abstracts of the joint meeting of the Cell Kinetics Society and the International Cell Cycle Society. 28-31 March 1990, St Louis, Missouri, U.S.A.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75682,"journal":{"name":"Cell and tissue kinetics","volume":"23 4","pages":"341-74"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13539155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Abstracts of the 16th meeting of the European Study Group for Cell Proliferation. 3-6 May 1989, Milan.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75682,"journal":{"name":"Cell and tissue kinetics","volume":"22 2","pages":"123-201"},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13928507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Proceedings of the Cell Kinetics Society, thirteenth annual meeting. 29 March-1 April 1989, White Plains, New York, U.S.A.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75682,"journal":{"name":"Cell and tissue kinetics","volume":"22 1","pages":"63-92"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13930568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It has previously been shown that in toad epidermis the cell birth rate (Kb) exceeds the rate of cell loss through moulting (Kd) and that the 'surplus' of cells seems to be removed in a controlled manner. Assuming that the epidermis is non-expanding, a Kb/Kd ratio greater than 1 indicates that cell deletion additional to desquamation takes place. In normal toads this ratio is 2-3. Following implantation of hydrocortisone pellets into intact toads (release rate, 18 micrograms/g toad/d), the Kb/Kd ratio, over a period of 14 d of hormone treatment, had increased to about 7, due mainly to an increased Kb and to a lesser extent to a decreased Kd. No change in the epidermal cell pool size had taken place. It was previously shown that, following removal of the pars distalis of the pituitary gland, the Kb/Kd ratio decreased with time, due to a decreasing Kb and an increasing Kd, eventually leading to a decreased epidermal cell pool size. In this paper it is shown that, in pars distalisectomized toads with hydrocortisone pellets implanted, the Kb/Kd ratio is restored to control levels by a restoration of the Kb as well as the Kd. The results differ from those of previous studies in which ACTH or adrenocorticosteroids were administered discontinuously (by injection). Thus, by experimental manipulation, different Kb/Kd ratios can be obtained: low (less than 1, pars distalis ablation), medium (2-3, normal toads) and high (7, hydrocortisone implantation). The potentiality of this unique situation in analysing the important question of how the 'surplus' cells are deleted is discussed.
{"title":"Epidermal tissue homeostasis. III. Effect of hydrocortisone on cell pool size, cell birth rate and cell loss in normal toads and in toads deprived of the pars distalis of the pituitary gland.","authors":"P E Budtz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It has previously been shown that in toad epidermis the cell birth rate (Kb) exceeds the rate of cell loss through moulting (Kd) and that the 'surplus' of cells seems to be removed in a controlled manner. Assuming that the epidermis is non-expanding, a Kb/Kd ratio greater than 1 indicates that cell deletion additional to desquamation takes place. In normal toads this ratio is 2-3. Following implantation of hydrocortisone pellets into intact toads (release rate, 18 micrograms/g toad/d), the Kb/Kd ratio, over a period of 14 d of hormone treatment, had increased to about 7, due mainly to an increased Kb and to a lesser extent to a decreased Kd. No change in the epidermal cell pool size had taken place. It was previously shown that, following removal of the pars distalis of the pituitary gland, the Kb/Kd ratio decreased with time, due to a decreasing Kb and an increasing Kd, eventually leading to a decreased epidermal cell pool size. In this paper it is shown that, in pars distalisectomized toads with hydrocortisone pellets implanted, the Kb/Kd ratio is restored to control levels by a restoration of the Kb as well as the Kd. The results differ from those of previous studies in which ACTH or adrenocorticosteroids were administered discontinuously (by injection). Thus, by experimental manipulation, different Kb/Kd ratios can be obtained: low (less than 1, pars distalis ablation), medium (2-3, normal toads) and high (7, hydrocortisone implantation). The potentiality of this unique situation in analysing the important question of how the 'surplus' cells are deleted is discussed.</p>","PeriodicalId":75682,"journal":{"name":"Cell and tissue kinetics","volume":"21 4","pages":"259-70"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14278354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The twelfth biennial conference of the International Cell Cycle Society. St. Petersburg, Florida, 20-23 April 1988. Abstracts.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75682,"journal":{"name":"Cell and tissue kinetics","volume":"21 3","pages":"205-12"},"PeriodicalIF":0.0,"publicationDate":"1988-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14352155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1988-01-01DOI: 10.1111/j.1365-2184.1988.tb00859.x
{"title":"The twelfth biennial conference of the International Cell Cycle Society. St. Petersburg, Florida, 20-23 April 1988. Abstracts.","authors":"","doi":"10.1111/j.1365-2184.1988.tb00859.x","DOIUrl":"https://doi.org/10.1111/j.1365-2184.1988.tb00859.x","url":null,"abstract":"","PeriodicalId":75682,"journal":{"name":"Cell and tissue kinetics","volume":"21 3 1","pages":"205-12"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2184.1988.tb00859.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62980186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1987-09-01DOI: 10.1111/j.1365-2184.1987.tb01357.x
V A Kozlov, I A Orlovskaya, I G Tsyrlova
A study was made of the effect of humoral factors, isolated from bone marrow cell (BMC) supernatant fluid and capable of modifying CFU-S proliferation, on the generation of IgM plaque-forming cells (PFC) against sheep red blood cells (SRBC) in mice after adoptive transfer. Adoptive transfer of BMC, preincubated with the humoral factor RBME-III, which stimulates CFU-S proliferation, was shown to suppress the splenic PFC generation in recipients; treatment of BMC with a further factor NBME-IV, which inhibits CFU-S proliferation, was followed by augmentation of PFC generation. Similar effects were obtained while studying the IgM PFC generation in the bone marrow of mice after secondary immunization when relevant factors were injected, in vivo, 24 hr following primary immunization. The results of adoptive transfer experiments indicate that populations of T- and B-cells are not the targets for the action of CFU-S proliferation regulatory factors. These factors are shown to modulate the erythroid differentiation of CFU-S. The possibility of quantitative modification of immune response parameters with the help of bone marrow factors that influence the proliferation and differentiation of CFU-S is discussed.
{"title":"The effect of haemopoietic stem cell proliferation on the humoral immune response in mice.","authors":"V A Kozlov, I A Orlovskaya, I G Tsyrlova","doi":"10.1111/j.1365-2184.1987.tb01357.x","DOIUrl":"https://doi.org/10.1111/j.1365-2184.1987.tb01357.x","url":null,"abstract":"<p><p>A study was made of the effect of humoral factors, isolated from bone marrow cell (BMC) supernatant fluid and capable of modifying CFU-S proliferation, on the generation of IgM plaque-forming cells (PFC) against sheep red blood cells (SRBC) in mice after adoptive transfer. Adoptive transfer of BMC, preincubated with the humoral factor RBME-III, which stimulates CFU-S proliferation, was shown to suppress the splenic PFC generation in recipients; treatment of BMC with a further factor NBME-IV, which inhibits CFU-S proliferation, was followed by augmentation of PFC generation. Similar effects were obtained while studying the IgM PFC generation in the bone marrow of mice after secondary immunization when relevant factors were injected, in vivo, 24 hr following primary immunization. The results of adoptive transfer experiments indicate that populations of T- and B-cells are not the targets for the action of CFU-S proliferation regulatory factors. These factors are shown to modulate the erythroid differentiation of CFU-S. The possibility of quantitative modification of immune response parameters with the help of bone marrow factors that influence the proliferation and differentiation of CFU-S is discussed.</p>","PeriodicalId":75682,"journal":{"name":"Cell and tissue kinetics","volume":"20 5","pages":"485-91"},"PeriodicalIF":0.0,"publicationDate":"1987-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2184.1987.tb01357.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14625566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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