Dakar medical最新文献

Introduction: The "Diffuse Infiltrative Lymphocytosis Syndrome" [DILS] is a seldom complication and even very particular case of HIV-1 infection, characterized by a merely syndrome and a systemic symptomatology superimposable to the figure met during the Gougerot-Sjögren Syndrome. GSS is nevertheless underlied by a lymphocyte infiltrate composed mainly of TCD8+ lymphocytes, while in the Gougerot-Sjögren syndrome (GSS), the lymphocyte infiltrate is essentially composed of TCD4+ lymphocytes. Despite the antiquity and significance of the HIV/AIDS pandemic, the DILS is not according to our knowledge individualized in the African literature.

Observation: We are reporting a case revealed by a polyarthritis associated among others with a merely syndrome and a HIV-1 infection in a 32 years old Senegalese patient. Her CD4 rate was 327/mm3 and her viral load 17052. The biopsy of the accessory salivary glands showed a 4 grade lymphocite sialoadenitis according to Chisholm classification. The investigation of rheumatoid factors et anti-nuclear antibodies was negative. Under prednisone, hydroxychloroquine, methotrexate and tritherapy treatment, the evolution was favourable with a current return of 2 years. The rarity of DILS has pushed us to study its epidemiological, clinical, paraclinical, physiopathological and therapeutical aspects.

Introduction: the dental age which can be deduced from the stages of dental maturation is accepted as being a reliable indicator in the estimate of civil age of children whose date of birth is unknown. It is also a good indicator of the biological maturity of growing children and the relevance of its use in paediatric dentistry and orthodontics was proven. Various methods of determination of maturation or dental development from radiographies were described. The mostly used method is that of Demirjian. Studies have shown that genetic factors could influence the maturation of certain organs. Thus, the generalisation of Demirjian standards to others population can be questioned. The aim of the present study was to test the applicability of Demirjian's standards for the determination of the civil age from dental maturation stages.

Material and methods: The dental maturation stages of a randomised sample of 200 Senegalese children aged from 6 to 14 years (101 boys and 99 girls) was evaluated by Demirjian's method. Data collected were converted into Dental Age from the conversion charts proposed by Demirjian. The dental age obtained was compared with the civil age of the subjects.

Results: The results of this study indicate that the civil age of the patients was overestimated when evaluated from Demirjian's standards (0.89 years for girls and 0.48 years for boys). A linear regression equation was then proposed for the correct estimate of the civil age from the dental maturation stages.

Introduction: Renal involvement determines the prognosis of systemic lupus erythematosus. The aims of this study were to precise clinical, laboratory, therapeutic and evolutive aspects of lupus nephritis in Senegal in order to improve its management.

Patients and methods: According to ACR criteria we included all patients presenting a systemic lupus erythematosus followed in internal medicine and in the dermatology services of university teaching hospital Aristide le Dantec of Dakar from January 1993 to December 2002. All the patients who didn't have a lupus nephritis defined by the existence of more than 0.5 g/24 h of proteinuria and or hematuria were excluded.

Results: The prevalence of lupus nephritis was 56.75% among 74 patients with systemic lupus erythematosus. Mean age was 29.6 years and sex ratio 0.13 (male to female). There was a nephritic syndrome in 45.23% of the cases and renal insufficiency in 37.71%. Renal biopsy performed in 52.38% of cases showed predominantly WHO classes IV and V. The key treatment was corticotherapy while immunosuppressive were used in 35.71%. The short term evolution was favourable but in the medium term, many patients were lost or followed up irregularly.

Conclusion: To improve the management and the prognosis of lupus nephritis in Senegal it is necessary to make patients with a systemic lupus erythematosus sensitive to it and to make systematically urine tests aiming the screening for an early diagnosis of lupus nephritis. In addition we should have aggressive policies in order to lower the costs of immunosuppressive therapy and haemodialysis.

Introduction: To date no study in our country was specifically dedicated on toxic nodular goiter. They were just mentioned in generally studies about hyperthyroidism.

Method: The authors report a retrospective series of 62 cases of toxic nodular goitre collected between 1979 and 1999 at the internal medical clinic of Dakar teaching hospital. The diagnostic of toxic nodule was retained on following criteria: to existence of one or several thyroid nodule with signs or thyrotoxicosis, the existence of a hyperfixating nodule at 131 iodine scintigraphy. Increasing of T3 and/or T4 thyroide hormone. The aims of the study was to analyse the epidemiological, clinical, and therapeutics aspects.

Results: We are collected 49 cases of solitary nodule (79.03%) and 13 cases of multi nodular goitre (20.97%). In the cases of solitary nodule, mean age was 40 years, sex ratio of 0.04 (47 female, 2 men). The nodule was clinically diagnosed in 47 cases (95.9%) and extinctive in 73.5%. 34.3% of patients have cardiothyreosis. In the cases of multi nodular goitre mean age was 45 years, all cases were female, goitre was clinically identified in 95.3% (12 patients) and 46.5% had cardiothyreosis. 62% of patients were lost to follow up during medical treatment. Only 2 patients on the 37 who were addressed for surgery come back after thyroidectomy.

Conclusion: This study confirm the predominance of toxic nodular goitre in young female, its severity related to cardiothyreosis and underlines the difficulties limited to the therapeutical care.

Introduction: To evaluate the quality of malaria prevention during prenatal consultations, this study was carried out in Niakhar, one sub-prefecture of the Fatick region.

Method: It was a matter of a descriptive transverse study, based on the listens and the observation of 60 prenatal consultations carried out within three health posts. The studied variables were related to the criteria of a good quality of prophylaxis at three levels: questioning, examination, and attitude after consultation.

Results: Questioning was centred by frequency order on: the pregnancy antecedents (65%), the chloroquine direction for use (34.3%), the fever notion (6%), and the chloroquine secondary effects (3%). During the physical examination, all the providers looked for clinical signs of weakens, blood pressure, and presence of oedemas of the legs; but the temperature was taken only in 8.6% of the cases. At the end of the consultation, the chemoprophylaxis prescription and the next consultation appointment were systematic; the duration of the treatment recalled in 57% and malaria seriousness during the pregnancy in 3% of the cases; no one of the providers didn't evoked neither the methods of the treatment nor the attitude to hold in case of fever.

Conclusion: The prevention of the malaria in pregnancy through the CPN necessitates a fitting formation supported by regular supervision of the health posts.

Introduction: Methotrexate used as antimetabolite since 40 years in cancerology, is curretly pointed out at weak dose in the treatment of rheumatoid arthitis. However, the intervening of undesirable effects is currently the principal factor limiting its use. The main of our study was evaluate the nature and the frequency of undesirable effects during treatement of rhumatoid arthritis by methotrexate in a prospective study in the department of internal medecine of A.L.D hospital.

Material and methods: Fifty patients were included in the study, they were 43 female and 7 male (sex ratio of 0.161).The mean age were 40.8 years, ranging from 18 to 68. The mean last of MTX treatment was 16.58 months, ranging from 1 to 64.

Results: Twenty seven patients (54%) had at least one undesirable effect. Undesirable effect appeared early in 74.1%. they were 61.5% when MTX was associated with others drugs versus 27.3% when MTX was used alone. Undesirable effects mostly were digestives (38%), general (30%), mucouscutaneous (8%) and hepatics (2%).for patients undesirable effects had involved. They were responsable of definitive stopping treatment in two cases of pulmonary tuberculosis.

Introduction: The solitary rectal ulcer syndrome is a rare disease. In Africa only few studies have been held on this subject. The aim of this study was to determine the epidemiological, clinical and endoscopic aspects of this syndrome in the digestive endoscopy unit of hospital Aristide Le Dantec in Dakar.

Patients and method: It was a retrospective study based on all the cases of solitary rectal ulcer regarding to the conclusion of endoscopic examination from January 1994 to June 2002. All the patients without histological confirmation were excluded.

Results: We had recruited 11 cases among 4250 endoscopic exam (0.26 %). The mean age was 40 years (extreme 23 to 63 years). Female to male ratio was 1.75 with 4 males and 7 females patients. The main indications of endoscopic examination were frequently associated and were dominated by intermittent bleeding (8 cases) chronic constipation (6 cases) and false chronic diarrhea with muco hemorrhagic discharge (4 cases). The mean duration of the symptoms was 5 years. Ulcers were ovoid or circular. Their mean diameter was 8 mm and they were located 8 cm above the anal margin. The lesion was unique in 55 % of the cases and concerned the anterior wall of the rectum in 74% of the cases. There was an internal rectal prolapse in 54% of the cases.

Conclusion: The solitary rectal ulcer syndrome is not frequent in the endoscopy unit of hospital Aristide Le Dantec in Dakar. It affects mostly young adult female. The symptoms are chronic and non specific. In tropical areas the disease is frequently misdiagnosed as colic amoebiasis.

Introduction: the toxoplasmosis can occur complications during pregnancy as serious repercussions on the foetus with the risks linked to this pathology such as abortion. However these complications can be avoided during the pregnancy by an early diagnosis. The objective of this study is to determine the prevalence of toxoplasmosis during pregnancy.

Materials and methods: we undertook this study on 109 pregnant women addressed to the laboratory of parasitology and mycology of the CHU Dantec for toxoplasmosis serological test on 2002. We used a immunoenzymatic technical in solid phase whose principle rests on the change of coloration in the presence of antibody of IgM or IgG; coloration whose intensity is function of the title of antibody. For that, two serological tests (S1 and S2), starting from two venous blood at 3 weeks of interval, are carried out among these pregnant women. This second serology will make it possible to confirm or cancel an evolutionary toxoplasmosis based on the variation of the title in antibody between the first (S1) and the second serology (S2). A control is carried out among these women among whom the diagnosis of the evolutionary toxoplasmosis was established.

Results: they show that with the first (S1), from the 109 patients, 3% were positive with the antibodies IgM type, 22% positive with IgG, and 11% positive with IgG and IgM. 36% of the women present a positive diagnostic at the first serology (S1). The second serology (S2) shows that among the 36% of the women diagnosed positive with the first serology, 11% made an evolutionary toxoplasmosis.

Conclusion: This study shows a rather significant of serological toxoplasmosis discovered fortuitously among pregnant women at the time of their assessment of pregnancy.

Introduction: The follow-up of performances and the prevention about possible incidents at the athletes make necessary the medical supervision in physical training. The aims of this study are to estimate the effect of a precompetition training program in athletes' body composition, and cardiovascular modifications (in clinical examination and electrocardiogram)

Materials and methods: Ten athletes (3 men and 7 women; mean age of 23.6 +/- 3.16 years) of Dakar international Athletics' Center are subjected to a training on a period of 2 months in aerobic dominant followed by a period of 3 months in anaerobic dominant. At the beginning and the end of training program, an electrocardiogram is recorded after blood pressure (BP) measure in lying and standing posture and heart rate (HR) take. The weight, height and cutaneous folds are measured to calculate the body fat percentage, fat body mass, fat-free mass and body mass index. Every athlete has performed the Ruffier test Comparisons are realized by the paired t-test, statistically significant for a p value < 0,05 RESULTS: Significant declines after training interest HR (79.2 +/- 14.7 vs 63.2 +/- 10.25 beat min(-1); p< 0.001), systolic BP in standing posture (11.8 +/- 0.44 vs 10.6 +/- 0.96 mmHg; p= 0.02), and Ruffier index (4.4 +/- 3.28 vs 2.23 +/- 1.62; p= 0.048) whereas the fat-free mass increased (53.14 +/- 8.41 vs 54.16 +/- 9.67 kg; p= 0.046). At the electrocardiogram, the number of athletes having sinusal bradycardia is crossed from 1 to 4; there is no modification as for the two cases of uncomplete right bundle-branch block and the pre-existent left ventricular hypertrophy. Negative T waves in V1 and V2 leads are present in one athlete before training and in two others after.

Conclusion: The impact of the specific training on body is real, interesting more the cardiovascular system.

Introduction: In Senegal, the rate of penetrating wound of the abdomen seems to be in great progression. The purpose of this study was to make a descriptive analysis of the epidemiological data on the patient suffering from a penetrating wound of the abdomen.

Material and method: It is about a retrospective study performed on a 5 years period from January 1997 to January 2002. This study covered 90 cases of penetrating wounds of the abdomen listed at the emergency department of Dakar teaching hospital. The rate, age, sex, responsible agent, circumstances of the wound, place of the injury, evacuation mode, time of admission and check-up injury were studied.

Results: The average absolute rate of the penetrating wounds of the abdomen was 18 cases per year. The average age was about 27 +/- 10 years with 88 men for 2 women. The responsible agent was a knife (87%), a firearm (6%), a broken glass (4%), a bullock horn (2%) and a piece of iron (1%). Circumstances of the injury was aggression (91%), accident (6%), self-mutilation (2%), suicide attempt (1%). Evacuation was done by firemen (60%), by the ambulances of the medical structures (22%), and by private individuals (18%). The average time of admission was 5 hours. Nearly 61% of the wounds were located in the umbilical, epigastric, left hypochondre and left side areas. Wound was single in 93,4% of cases and linear in 71,8% of cases. We noted an exit of epiploon (38 cases), peritoneal signs (13 cases) and a small bowel evisceration (9 cases). The treatment was a systematic laparotomy (68%) and a simple closure of the wound with a good follow-up for any further aggravation (32%).

Conclusion: The patient admitted at the surgical emergency unit of Dakar teaching hospital for penetrating wound of the abdomen is generally a young man, victim of aggression by knife, evacuated by firemen within 5 hours, which present a single and linearwound in perish-umbilical area with exit of epiploon and/or small bowel evisceration, which would undertaken a surgical operation in 68% of cases.