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Horizons in biochemistry and biophysics最新文献

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Liposomes as a drug delivery system in cancer chemotherapy. 脂质体作为肿瘤化疗中的药物传递系统。
A Gabizon
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引用次数: 0
The use of liposomes as drug carriers in the immunotherapy of cancer. 脂质体作为药物载体在癌症免疫治疗中的应用。
I J Fidler
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引用次数: 0
Human genes and diseases. 人类基因和疾病。
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引用次数: 0
The molecular genetics of hyperlipidemia. 高脂血症的分子遗传学。
C C Shoulders, F E Baralle
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引用次数: 0
Monoclonal antibodies to the insulin receptor as probes of insulin receptor structure and function. 胰岛素受体单克隆抗体作为胰岛素受体结构和功能的探针。
I D Goldfine, R A Roth
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引用次数: 0
Cellular oncogenes and the pathogenesis of human cancer. 细胞癌基因与人类癌症的发病机制。
R Dalla-Favera, E Cesarman
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引用次数: 0
Towards a complete linkage map of the human X chromosome. 迈向人类X染色体的完整连锁图谱。
K E Davies, R Williamson

In the seven years since the first human gene was cloned, several hundred coding sequences and many more random single copy DNA sequences have been isolated. Many of these show restriction fragment length polymorphisms (RFLPs) and can be used as genetic markers in inheritance studies. RFLPs enable the construction of complete linkage maps of individual human chromosomes which can then be used as a mapping resource for other genes and disease loci. The isolation of chromosome specific sequences has been greatly facilitated by the purification of human chromosomes by flow cytometry. Sub-localisation of the polymorphic DNA probes along the chromosome can be achieved using in situ hybridisation or rodent/human hybrid cell lines. There are now more than one hundred DNA probes assigned to the human X chromosome and a preliminary genetic map suggests that the chromosome is at least 200 cm long. Some of these DNA sequences have been shown to be linked to disease loci such as Duchenne and Becker muscular dystrophy, X-linked mental retardation and retinitis pigmentosa.

自第一个人类基因被克隆以来的七年里,数百个编码序列和更多的随机单拷贝DNA序列被分离出来。其中许多显示限制性片段长度多态性(RFLPs),可作为遗传研究中的遗传标记。RFLPs能够构建单个人类染色体的完整连锁图谱,然后将其用作其他基因和疾病位点的图谱资源。用流式细胞术纯化人类染色体,极大地促进了染色体特异性序列的分离。多态DNA探针沿染色体的亚定位可以使用原位杂交或啮齿动物/人类杂交细胞系来实现。现在有超过100个DNA探针被分配到人类X染色体上,初步的遗传图谱表明染色体至少有200厘米长。其中一些DNA序列已被证明与疾病基因位点有关,如杜氏和贝克尔肌营养不良症、x连锁智力迟钝和视网膜色素变性。
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引用次数: 0
Beta-globin gene disorders in Italy and the Mediterranean area. 意大利和地中海地区的-珠蛋白基因紊乱。
S Ottolenghi, C Carestia
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引用次数: 0
From hemophilia B to hemophilia A via the fragile X locus: genes and recombination in the distal region of the human X chromosome long arm. 从血友病B到血友病A通过脆弱的X位点:基因和重组在人类X染色体长臂远端区域。
I Oberlé, J L Mandel
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引用次数: 0
Molecular genetics of human B cell neoplasia. 人B细胞瘤的分子遗传学。
C M Croce
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引用次数: 0
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Horizons in biochemistry and biophysics
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