A yellowish aromatic hydrocarbon consisting of five fused rings formed by the incomplete burning of organic matter. Dibenz[a,j]acridine is primarily found in gasoline exhaust, petroleum refinery incinerator emissions, coal combustion emissions, cigarette smoke and coal tar pitch. T his substance is used only for research purposes. Dibenz[a,j]acridine is reasonably anticipated to be a human carcinogen. (NCI05) Qeios · Definition, February 7, 2020
{"title":"Dibenz[a,j]acridine.","authors":"","doi":"10.32388/geuhq7","DOIUrl":"https://doi.org/10.32388/geuhq7","url":null,"abstract":"A yellowish aromatic hydrocarbon consisting of five fused rings formed by the incomplete burning of organic matter. Dibenz[a,j]acridine is primarily found in gasoline exhaust, petroleum refinery incinerator emissions, coal combustion emissions, cigarette smoke and coal tar pitch. T his substance is used only for research purposes. Dibenz[a,j]acridine is reasonably anticipated to be a human carcinogen. (NCI05) Qeios · Definition, February 7, 2020","PeriodicalId":75918,"journal":{"name":"IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans","volume":"32 1","pages":"283-8"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42270511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Norgestrel.","authors":"","doi":"10.32388/not5vx","DOIUrl":"https://doi.org/10.32388/not5vx","url":null,"abstract":"","PeriodicalId":75918,"journal":{"name":"IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans","volume":"21 1","pages":"479-90"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49518121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"7H-Dibenzo[c,g]carbazole","authors":"","doi":"10.32388/p6ckqi","DOIUrl":"https://doi.org/10.32388/p6ckqi","url":null,"abstract":"","PeriodicalId":75918,"journal":{"name":"IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69638968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-07DOI: 10.1016/b0-12-369400-0/00212-x
H. Mehendale, Zhengwei Cai
{"title":"Chlordecone.","authors":"H. Mehendale, Zhengwei Cai","doi":"10.1016/b0-12-369400-0/00212-x","DOIUrl":"https://doi.org/10.1016/b0-12-369400-0/00212-x","url":null,"abstract":"","PeriodicalId":75918,"journal":{"name":"IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans","volume":"20 1","pages":"67-81"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46016429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A colorless, odorless crystalline, aromatic amine with a bitter taste. Amitrole is a widely used herbicide for nonfood croplands to control annual and perennial grass type weeds, pondweeds and broad leaf. This substance has a very low acute toxicity in humans and is characterized by skin rash, diarrhea, nausea, vomiting and nose bleeds. Amitrole is reasonably anticipated to be a human carcinogen.
{"title":"Amitrole.","authors":"","doi":"10.32388/uv40yx","DOIUrl":"https://doi.org/10.32388/uv40yx","url":null,"abstract":"A colorless, odorless crystalline, aromatic amine with a bitter taste. Amitrole is a widely used herbicide for nonfood croplands to control annual and perennial grass type weeds, pondweeds and broad leaf. This substance has a very low acute toxicity in humans and is characterized by skin rash, diarrhea, nausea, vomiting and nose bleeds. Amitrole is reasonably anticipated to be a human carcinogen.","PeriodicalId":75918,"journal":{"name":"IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans","volume":"41 1","pages":"293-317"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47010181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This monograph on mestranol includes chemical and physical data (synonyms and trade names), structural and molecular formulae and molecular weight of the substance, chemical and physical properties of mestranol, and the production, use, occurrence, and analysis of mestranol. Production of mestranol, which is not known to occur naturally, is synthesis via the reaction of 3-methoxy-1,3,5-oestratrien-17-one with potassium acetylide. All known methods for analyzing mestranol for purity and chemical clarity are summarized tabularly. Biological data relevant to the evaluation of carcinogenic risk to humans of mestranol, which is used mainly in contraceptive preparations, are also presented in brief. Studies of various experimental species and routes of administration led to the conclusion that there is sufficient for the carcinogenicity of mestranol in experimental animals. Data on humans are not available, but it is reasonable to assume mestranol holds potential risk for humans. When mestranol was tested in mice and rats (studies on dogs and monkeys are still in progress) orally in combination with a progestin, it produced pituitary tumors and vaginal and cervical squamous cell carcinomas. Increased incidence of mammary tumors was also noted in both males and females of different species. When used alone, mestranol, by the oral route, increased incidences of pituitary tumors in both sexes, mammary tumors in castrated males, and mammary tumors in females of another mouse species. Mestranol is embryolethal for pre- and postimplantation embryos in some species.
{"title":"Mestranol.","authors":"","doi":"10.32388/ip33yq","DOIUrl":"https://doi.org/10.32388/ip33yq","url":null,"abstract":"\u0000 This monograph on mestranol includes chemical and physical data (synonyms and trade names), structural and molecular formulae and molecular weight of the substance, chemical and physical properties of mestranol, and the production, use, occurrence, and analysis of mestranol. Production of mestranol, which is not known to occur naturally, is synthesis via the reaction of 3-methoxy-1,3,5-oestratrien-17-one with potassium acetylide. All known methods for analyzing mestranol for purity and chemical clarity are summarized tabularly. Biological data relevant to the evaluation of carcinogenic risk to humans of mestranol, which is used mainly in contraceptive preparations, are also presented in brief. Studies of various experimental species and routes of administration led to the conclusion that there is sufficient for the carcinogenicity of mestranol in experimental animals. Data on humans are not available, but it is reasonable to assume mestranol holds potential risk for humans. When mestranol was tested in mice and rats (studies on dogs and monkeys are still in progress) orally in combination with a progestin, it produced pituitary tumors and vaginal and cervical squamous cell carcinomas. Increased incidence of mammary tumors was also noted in both males and females of different species. When used alone, mestranol, by the oral route, increased incidences of pituitary tumors in both sexes, mammary tumors in castrated males, and mammary tumors in females of another mouse species. Mestranol is embryolethal for pre- and postimplantation embryos in some species.\u0000","PeriodicalId":75918,"journal":{"name":"IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans","volume":"21 1","pages":"257-78"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45276662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Attapulgite.","authors":"X. P. Brannmjk","doi":"10.32388/df1p70","DOIUrl":"https://doi.org/10.32388/df1p70","url":null,"abstract":"","PeriodicalId":75918,"journal":{"name":"IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans","volume":"42 1","pages":"159-73"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42461350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A colorless, aromatic hydrocarbon consisting of five fused rings and formed by the incomplete burning of organic matter. Benzo(b)fluoranthene is primarily found in gasoline exhaust, tobacco and cigarette smoke, coal tar, soot, amino acids and fatty acid pyrolysis products. T his substance is used only for research purposes. Benzo(b)fluoranthene is reasonably anticipated to be a human carcinogen. (NCI05) Qeios · Definition, February 7, 2020
{"title":"Benzo[b]fluoranthene.","authors":"","doi":"10.32388/n3rsj9","DOIUrl":"https://doi.org/10.32388/n3rsj9","url":null,"abstract":"A colorless, aromatic hydrocarbon consisting of five fused rings and formed by the incomplete burning of organic matter. Benzo(b)fluoranthene is primarily found in gasoline exhaust, tobacco and cigarette smoke, coal tar, soot, amino acids and fatty acid pyrolysis products. T his substance is used only for research purposes. Benzo(b)fluoranthene is reasonably anticipated to be a human carcinogen. (NCI05) Qeios · Definition, February 7, 2020","PeriodicalId":75918,"journal":{"name":"IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans","volume":"32 1","pages":"147-53"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47785980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
hydrocarbon of six rings incomplete organic primarily in tar. reasonably to human carcinogen.
六环碳氢化合物主要存在于焦油中。对人类致癌物合理。
{"title":"Dibenzo[a,i]pyrene.","authors":"","doi":"10.32388/vbqo0v","DOIUrl":"https://doi.org/10.32388/vbqo0v","url":null,"abstract":"hydrocarbon of six rings incomplete organic primarily in tar. reasonably to human carcinogen.","PeriodicalId":75918,"journal":{"name":"IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans","volume":"32 1","pages":"337-42"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48562341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-07DOI: 10.15227/orgsyn.008.0102
{"title":"Styrene oxide.","authors":"","doi":"10.15227/orgsyn.008.0102","DOIUrl":"https://doi.org/10.15227/orgsyn.008.0102","url":null,"abstract":"","PeriodicalId":75918,"journal":{"name":"IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans","volume":"19 1","pages":"275-83"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49504815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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