From this review it is evident that our understanding of the control of testicular function has advanced greatly over the past decade. Many of the advances have depended on techniques to isolate and study the function of Sertoli cells and Leydig cells. Although this knowledge has been essential, it is important to proceed cautiously in the extrapolation of this information to the in vivo situation. The likely interdependence of the two compartments of the testis in normal function highlights the need to consider the testis as a whole, and future studies must give cognizance to this concept. Furthermore, the importance of blood and lymphatic flow and the evidence of hormonal influences on the vasculature of the testis add yet another dimension to the in vivo function of this organ.
{"title":"The regulation of testicular function.","authors":"Y Hodgson, D M Robertson, D M de Kretser","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>From this review it is evident that our understanding of the control of testicular function has advanced greatly over the past decade. Many of the advances have depended on techniques to isolate and study the function of Sertoli cells and Leydig cells. Although this knowledge has been essential, it is important to proceed cautiously in the extrapolation of this information to the in vivo situation. The likely interdependence of the two compartments of the testis in normal function highlights the need to consider the testis as a whole, and future studies must give cognizance to this concept. Furthermore, the importance of blood and lymphatic flow and the evidence of hormonal influences on the vasculature of the testis add yet another dimension to the in vivo function of this organ.</p>","PeriodicalId":75948,"journal":{"name":"International review of physiology","volume":"27 ","pages":"275-327"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17365635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gonadal steroid influences on brain development and sexual differentiation.","authors":"B S McEwen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75948,"journal":{"name":"International review of physiology","volume":"27 ","pages":"99-145"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17365636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Brunner's glands.","authors":"I M Lang, M F Tansy","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75948,"journal":{"name":"International review of physiology","volume":"28 ","pages":"85-102"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17408721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Receptors and biological responses to ovarian steroid hormones in the fetal and perinatal periods.","authors":"J R Pasqualini, C Sumida, A Gulino","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75948,"journal":{"name":"International review of physiology","volume":"27 ","pages":"225-73"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17403391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Integrated circulatory response to volume expansion.","authors":"S P Sit, S F Vatner","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75948,"journal":{"name":"International review of physiology","volume":" ","pages":"323-54"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40718004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mechanism of contraction in cardiac muscle.","authors":"S Winegrad","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75948,"journal":{"name":"International review of physiology","volume":"26 ","pages":"87-117"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17348521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regulation of renal hemodynamics.","authors":"J E Hall","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75948,"journal":{"name":"International review of physiology","volume":"26 ","pages":"243-321"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17972739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vasopressin and cardiovascular regulation.","authors":"A W Cowley","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75948,"journal":{"name":"International review of physiology","volume":" ","pages":"189-242"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40718003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Resetting of the baroreceptors.","authors":"E M Krieger, H C Salgado, L C Michelini","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75948,"journal":{"name":"International review of physiology","volume":" ","pages":"119-46"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40718001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
With a model in which arterial pressure is a function of cardiac output and total peripheral resistance as the composite resistance of parallel regional peripheral resistances in mind, the measured values of these and other cardiovascular parameters in the SHR and other hypertensive animals are reviewed. In most studies, the hypertensive state is ascribable to an increased total peripheral resistance with almost normal cardiac output. Regional peripheral resistances are elevated diffusely in most hypertensive animals, but the extent is topographically different, as numerically demonstrated by the help of the indices proposed by the reviewer. Besides the elevation of flow resistance, decreases in compliance and volume in different parts of the cardiovascular system seem to be noteworthy hemodynamic findings. Several theories for development and maintenance of hypertension are also reviewed, and hypothetical modes of action of two representative antihypertensives, diuretics and beta-adrenoceptor blockers, are also briefly described.
{"title":"Hemodynamics of hypertensive animals.","authors":"J Iriuchijima","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>With a model in which arterial pressure is a function of cardiac output and total peripheral resistance as the composite resistance of parallel regional peripheral resistances in mind, the measured values of these and other cardiovascular parameters in the SHR and other hypertensive animals are reviewed. In most studies, the hypertensive state is ascribable to an increased total peripheral resistance with almost normal cardiac output. Regional peripheral resistances are elevated diffusely in most hypertensive animals, but the extent is topographically different, as numerically demonstrated by the help of the indices proposed by the reviewer. Besides the elevation of flow resistance, decreases in compliance and volume in different parts of the cardiovascular system seem to be noteworthy hemodynamic findings. Several theories for development and maintenance of hypertension are also reviewed, and hypothetical modes of action of two representative antihypertensives, diuretics and beta-adrenoceptor blockers, are also briefly described.</p>","PeriodicalId":75948,"journal":{"name":"International review of physiology","volume":" ","pages":"51-86"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40718005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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