Unacylated ghrelin (UAG), the unacylated form of ghrelin, accounts for 80-90% of circulation. Accumulated studies have pointed out that UAG may be used to treat metabolic disorders. This study aimed to investigate the effect of intestinal perfusion of UAG on metabolic associated fatty liver disease (MAFLD) induced by a high-fat diet and its possible mechanism. Neuronal retrograde tracking combined with immunofluorescence, central administration of GLP-1R antagonist, and hepatic vagotomy were performed to reveal its possible mechanism involving a central glucagon-like peptide-1 pathway. The results showed that intestinal perfusion of UAG significantly reduced serum lipids, aminotransferases, and food intake in MAFLD rats. Steatosis and lipid accumulation in the liver were significantly alleviated and lipid metabolism-related enzymes in the liver were regulated. UAG upregulated the expression of GLP-1 receptor (GLP-1R) in the paraventricular nucleus (PVN) and GLP-1 in the nucleus tractus solitarii (NTS), as well as activated GLP-1 neurons in the NTS. Furthermore, GLP-1 fibers projected from NTS to PVN were activated by intestinal perfusion of UAG. However, hepatic vagotomy and GLP-1R antagonist delivered into PVN before intestinal perfusion of UAG partially attenuated its alleviation on MAFLD. In conclusion, intestinal perfusion of UAG showed a therapeutic effect on MAFLD, which might be related to its activating on GLP-1 neuronal pathway from NTS to PVN. The present results provide a new strategy for the treatment of MAFLD.
{"title":"Intestinal Perfusion of Unacylated Ghrelin Alleviated Metabolic Associated Fatty Liver Disease in Rat via a Central Glucagon-Like Peptide-1 Pathway","authors":"Pengfei Lv, Hongzeng Li, Xiangbo Li, Xueyuying Wang, Jiantong Yu, Yanling Gong","doi":"10.1152/ajpgi.00217.2023","DOIUrl":"https://doi.org/10.1152/ajpgi.00217.2023","url":null,"abstract":"Unacylated ghrelin (UAG), the unacylated form of ghrelin, accounts for 80-90% of circulation. Accumulated studies have pointed out that UAG may be used to treat metabolic disorders. This study aimed to investigate the effect of intestinal perfusion of UAG on metabolic associated fatty liver disease (MAFLD) induced by a high-fat diet and its possible mechanism. Neuronal retrograde tracking combined with immunofluorescence, central administration of GLP-1R antagonist, and hepatic vagotomy were performed to reveal its possible mechanism involving a central glucagon-like peptide-1 pathway. The results showed that intestinal perfusion of UAG significantly reduced serum lipids, aminotransferases, and food intake in MAFLD rats. Steatosis and lipid accumulation in the liver were significantly alleviated and lipid metabolism-related enzymes in the liver were regulated. UAG upregulated the expression of GLP-1 receptor (GLP-1R) in the paraventricular nucleus (PVN) and GLP-1 in the nucleus tractus solitarii (NTS), as well as activated GLP-1 neurons in the NTS. Furthermore, GLP-1 fibers projected from NTS to PVN were activated by intestinal perfusion of UAG. However, hepatic vagotomy and GLP-1R antagonist delivered into PVN before intestinal perfusion of UAG partially attenuated its alleviation on MAFLD. In conclusion, intestinal perfusion of UAG showed a therapeutic effect on MAFLD, which might be related to its activating on GLP-1 neuronal pathway from NTS to PVN. The present results provide a new strategy for the treatment of MAFLD.","PeriodicalId":7598,"journal":{"name":"American Journal of Physiology - Gastrointestinal and Liver Physiology","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-19DOI: 10.1152/ajpgi.00304.2023
Eva Maria Schleicher, Simon Johannes Gairing, Darko Castven, Charlotte Sophie Hock, Henrike Dobbermann, Sophia Heinrich, Myriam Meineck, Leonard Kaps, Peter Robert Galle, Julia Weinmann-Menke, Marc Nguyen-Tat, Jens Uwe Marquardt, Christian Labenz
American Journal of Physiology-Gastrointestinal and Liver Physiology, Ahead of Print.
美国生理学杂志-胃肠道和肝脏生理学》（American Journal of Physiology-Gastrointestinal and Liver Physiology），提前出版。
{"title":"Lower uromodulin serum levels are associated with poorer prognosis in patients with cirrhosis and hepatorenal syndrome type 2","authors":"Eva Maria Schleicher, Simon Johannes Gairing, Darko Castven, Charlotte Sophie Hock, Henrike Dobbermann, Sophia Heinrich, Myriam Meineck, Leonard Kaps, Peter Robert Galle, Julia Weinmann-Menke, Marc Nguyen-Tat, Jens Uwe Marquardt, Christian Labenz","doi":"10.1152/ajpgi.00304.2023","DOIUrl":"https://doi.org/10.1152/ajpgi.00304.2023","url":null,"abstract":"American Journal of Physiology-Gastrointestinal and Liver Physiology, Ahead of Print. <br/>","PeriodicalId":7598,"journal":{"name":"American Journal of Physiology - Gastrointestinal and Liver Physiology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140168075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-05DOI: 10.1152/ajpgi.00281.2023
Yongke Lu, Joseph George
American Journal of Physiology-Gastrointestinal and Liver Physiology, Ahead of Print.
美国生理学杂志-胃肠道和肝脏生理学》（American Journal of Physiology-Gastrointestinal and Liver Physiology），提前出版。
{"title":"Interaction between fatty acid oxidation and ethanol metabolism in liver","authors":"Yongke Lu, Joseph George","doi":"10.1152/ajpgi.00281.2023","DOIUrl":"https://doi.org/10.1152/ajpgi.00281.2023","url":null,"abstract":"American Journal of Physiology-Gastrointestinal and Liver Physiology, Ahead of Print. <br/>","PeriodicalId":7598,"journal":{"name":"American Journal of Physiology - Gastrointestinal and Liver Physiology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140036741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
American Journal of Physiology-Gastrointestinal and Liver Physiology, Ahead of Print.
美国生理学杂志-胃肠道和肝脏生理学》（American Journal of Physiology-Gastrointestinal and Liver Physiology），提前出版。
{"title":"Alterations in descending brain-spinal pathways regulating colorectal motility in a rat model of Parkinson's disease","authors":"Tomoya Sawamura, Natsufu Yuki, Kanae Aoki, Kazuhiro Horii, Yuuki Horii, Kiyotada Naitou, Shumpei Tsukamoto, Takahiko Shiina, Yasutake Shimizu","doi":"10.1152/ajpgi.00181.2023","DOIUrl":"https://doi.org/10.1152/ajpgi.00181.2023","url":null,"abstract":"American Journal of Physiology-Gastrointestinal and Liver Physiology, Ahead of Print. <br/>","PeriodicalId":7598,"journal":{"name":"American Journal of Physiology - Gastrointestinal and Liver Physiology","volume":"233 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138742277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-19DOI: 10.1152/ajpgi.00203.2023
Eglantina Idrizaj, Silvia Nistri, Patrizia Nardini, Maria Caterina Baccari
American Journal of Physiology-Gastrointestinal and Liver Physiology, Ahead of Print.
美国生理学杂志-胃肠道和肝脏生理学》（American Journal of Physiology-Gastrointestinal and Liver Physiology），提前出版。
{"title":"Adiponectin affects ileal contractility of mouse preparations","authors":"Eglantina Idrizaj, Silvia Nistri, Patrizia Nardini, Maria Caterina Baccari","doi":"10.1152/ajpgi.00203.2023","DOIUrl":"https://doi.org/10.1152/ajpgi.00203.2023","url":null,"abstract":"American Journal of Physiology-Gastrointestinal and Liver Physiology, Ahead of Print. <br/>","PeriodicalId":7598,"journal":{"name":"American Journal of Physiology - Gastrointestinal and Liver Physiology","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138742278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-12DOI: 10.1152/ajpgi.00230.2023
James W. King, Aidan S. W. Bennett, Hannah M. Wood, Corey C. Baker, Hanin Alsaadi, Max Topley, Stephen A. Vanner, David E. Reed, Alan E. Lomax
American Journal of Physiology-Gastrointestinal and Liver Physiology, Ahead of Print.
美国生理学杂志-胃肠道和肝脏生理学》（American Journal of Physiology-Gastrointestinal and Liver Physiology），提前出版。
{"title":"Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon","authors":"James W. King, Aidan S. W. Bennett, Hannah M. Wood, Corey C. Baker, Hanin Alsaadi, Max Topley, Stephen A. Vanner, David E. Reed, Alan E. Lomax","doi":"10.1152/ajpgi.00230.2023","DOIUrl":"https://doi.org/10.1152/ajpgi.00230.2023","url":null,"abstract":"American Journal of Physiology-Gastrointestinal and Liver Physiology, Ahead of Print. <br/>","PeriodicalId":7598,"journal":{"name":"American Journal of Physiology - Gastrointestinal and Liver Physiology","volume":"123 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138572800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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