Medical journal of Osaka University最新文献

We now keep HFRSV free WF-Osaka rats and ACI rats together in the separate three animal rooms (animal room 1, 2 and 3) and the incidence of colon carcinoma is still high on the WF-Osaka rats in animal room 1 with the high humidity. Two female ACI rats developed colon carcinomas in the ascending colon. The gross and the histological appearance of the colon carcinoma were completely the same as those of WF-Osaka rats. ACI and WF-Osaka rat strain together have been kept bred in neighborhood of each other in different racks in the identical animal room 1. To obtain HFRSV free ACI rat strain, Antecedents born by cesarean section of ACI female pregnant rat were foster-bred by WF-Osaka female nursing rat incidentally, and at the fourth mating generation after the start of foster-breeding, they developed colon carcinomas at the age of four months. Before five out of eight F1 hybrids by WF-Osaka cancer carrying female rat x male ACI rat had developed the same colon carcinoma, but none of F1 hybrids by the contrary mating had developed colon carcinomas in this same animal room 1. Animal room 1 and 2 where there was a high incidence of colon carcinomas, had happened to be kept moistened. However, after disinfection of these animal rooms, the animal room 2 and 3 occurred to be kept dried, and rats of WF-Osaka strain ceased to develop colon carcinomas in the animal room 2. Thereafter, animal room 2 and 3 were adjusted to be kept moistened again. Subsequently WF-Osaka rats in the animal room 2 began to have colon carcinomas in the ascending colon as before, but none of rats developed colon carcinomas in the animal room 3. Based on these findings, we consider that milk factor at the time of foster-breeding played an important role first and high moistened condition of the animal room resulted in promoting effect on colon carcinogenesis on ACI rats and WF-Osaka rats as well.

The pathological findings of temporal bone in two cases of thanatophoric dysplasia were reported. Thanatophoric dysplasia is classified into type 1 and type 2, each of which has been reported to show specific clinical and radiographic-findings. The present study revealed that each type also showed specific characteristic in the structure of the temporal bones. The developmental mechanisms of hearing impairment in this disease were also discussed on the basis of the pertinent literature.

Intraperitoneal injection of the serum of colon cancer carrying WF rats induced, within two months, colon carcinomas in the ascending colon of LE and Wistar/Shi rats when they were given it during their suckling. We had also induced colon carcinomas in the ascending colon of ACI rats by the same methods. Therefore, it is supported that this serum derived from colon cancer carrying WF rats must have some transmissible agent in itself. In addition, we ultracentrifuged the serum of cancer carrying WF rats and we found, in the sediment, numerous round or oval virus like corpuscles by electron microscopy studies. Negatively stained corpuscles by phosphotungstic acid staining clearly revealed fine spike appearance on their surface. We believe that these virus like corpuscles are the etiological agent for the transmissible colon carcinoma of WF rat strain.

It is known that the recurrence rate is high when an acoustic neurinoma is incompletely excised, but the details of the process of recurrence are still unclear. We reviewed the recurrence of acoustic neurinomas, as evaluated by computed tomography (CT) or magnetic resonance imaging (MRI), in 51 consecutive patients over the past 10 years who underwent tumor resection and had postoperative follow-up by CT or MRI. The factors promoting recurrence related to incomplete excision of tumor were analyzed. Total resection of the tumor was performed in 22 patients (43%), nearly total resection in 17 patients (33%) and subtotal resection in 12 patients (24%). The recurrence rates were 29% (5 of 17 patients) and 25% (2 of 8 patients) for nearly total and subtotal resection, respectively, whereas no recurrence occurred following total resection. Of the patients having nearly total resection, all recurrences arose from residual tumor in the internal auditory meatus (5 of 12 patients). In contrast, there were no recurrences from residual tumor at the site of the brain stem (none of 4 patients). Acoustic neurinomas should be totally removed through neurosurgical and neuro-otological approaches whenever possible. If a small fragment of tumor is left in the internal auditory meatus due to fear of damaging the facial or cochlear nerves, it should be strictly followed up by CT or MRI.

A 20-years-old woman with fever and an abnormal shadow on a chest roentgenogram was admitted to our hospital. High grade fever continued even after gradual disappearance of the ill-defined shadow on the right upper lobe (S3) with minor fissure deviation upward, while neck pain and bruit gradually developed. She was diagnosed as aortitis syndrome from a digital subtraction angiography. The initial appearance of an ill-defined shadow on a chest roentgenogram, considered as pulmonary infarction, is rare in the aortitis syndrome and this kind of onset is interesting in relation to the pathogenesis and diagnosis of this syndrome.

Skeletal fixation characteristics of the stainless steel implants coated by 60 microns thick porous alumina layer using a flame spray method were evaluated in vivo for the duration of up to 12 weeks. Surface roughness of the implants appeared to be the determining factor for the fixation characteristics, irrespective of the implant materials.

A case of pancreatic pseudocyst complicating with pregnancy and delivery was reported. This primipara patient with pancreatic pseudocyst was able to achieve a full-term, transvaginal delivery of a mature baby. The usefulness of ultrasonic monitoring of the pseudocyst during labor was clinically demonstrated. When intra-abdominal pressure increased, pancreatic pseudocyst was deformed.

We investigated the effects of different injection intervals, (24 hr, 48 hr, and 72 hr) on the development of kindled seizures induced by repetitive pentylenetetrazol (PTZ) injections (30 mg/kg) in rats. Regardless of injection interval, kindled seizures were obtained 1 week after the completion of consecutive PTZ injections. This PTZ kindled seizure model appears to mimick generalized seizure and be useful in the investigation of seizure phenomenon. With 48 and 72 hr injection interval, the seizure responses gradually increased with consecutive injections. The convulsive severity of 24 hr interval group showed a transient increased and then stabilized at a low score (2/6). This difference between these injection interval might reflect the appearance of some short of inhibition during the more closely spaced (24 hr) repeated injections.

One hundred and ten diabetic patients who were apparently non-insulin dependent at 1984 were followed up for 5 years from 1984 to 1989. Islet cell antibodies (ICA) of the patients were tested in 1987. Eleven patients were positive for ICA and 99 were negative. There was no significant difference in age, sex, duration of diabetes, and HbA1c levels between ICA-positive and negative groups. Six of 11 (54.5%) patients in ICA-positive group developed insulin-requiring state in the period from 1984 to 1989, while only 5 of 99 (5.1%) patients in ICA negative group became insulin-requiring. Glucagon tolerance test (1 mg i.v.) was performed on 8 patients who developed insulin-requiring state; among them 4 patients were ICA-positive and other 4 patients were ICA negative. The serum C-peptide response to intravenous glucagon injection was markedly decreased in 3 of the 4 ICA-positive patients, and only mildly decreased in all the 4 ICA-negative patients. The markedly decreased C-peptide response indicates that these ICA-positive subjects had developed insulin-dependency. We conclude that the presence of ICA in apparently non-insulin dependent diabetics indicates a high risk for developing insulin-dependency.

Duodenitis was investigated by endoscopy in 93 cases from among 1242 subjects. Endoscopic duodenitis was classified into three types endoscopically--reddening type, erosive type and nodular type. There was a relatively high correlation between the endoscopic and the histological diagnosis of duodenitis. Severely inflamed cases were found histologically more frequently in erosive- or nodular-type duodenitis than in reddening-type duodenitis. During the follow-up period, changes in endoscopic findings were observed more frequently, from the erosive type to the reddening type, and from the reddening type to normal. There were no cases which subsequently developed duodenal ulcers. We found a significantly high incidence of "endoscopic duodenitis" in uremic patients who had been given regular dialysis, and not in hepatic cirrhosis patients.