A 10-year-old Lhasa Apso with a history of vomiting and hemorrhagic diarrhea of several hours' duration died despite emergency treatment. Necropsy revealed alimentary necrosis, and liver samples contained thallium at 7.6 ppm, indicative of thallium intoxication. The source of the thallium was not determined but was thought to be a rodenticide from a building being renovated. Recommended treatment includes use of diphenylthiocarbazone at 50-70 mg/kg every 8 hours PO, followed by ferric cyanoferrate at 100-200 mg/kg every 8 hours PO.
Hematologic alterations unrelated to neoplastic bone marrow involvement include polycythemia, anemia, leukocytosis, leukopenia, thrombocytosis, thrombocytopenia and coagulopathies. Serum globulin levels may be increased or decreased, depending on the type of neoplasm. Plasma fibrinogen and fibrin degradation product concentrations are usually elevated in cancer patients, whereas cancer patients with DIC have low plasma fibrinogen concentrations. Hypercalcemia can be a sequel of osseous metastases. Neoplasia may cause the nephrotic syndrome in some patients. Effusions should be examined microscopically for signs of malignancy. Elevated serum enzyme levels are not specific in neoplastic disease.
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