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Monographs on endocrinology最新文献

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High performance liquid chromatography in the analysis of prostaglandins, thromboxanes and leukotrienes. 高效液相色谱法分析前列腺素、血栓烷和白三烯。
Pub Date : 1988-01-01 DOI: 10.1007/978-3-642-83467-7_5
I A Tavares
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引用次数: 0
High-performance liquid chromatography of the neuropeptides: the endogenous opioid peptides. 神经肽的高效液相色谱分析:内源性阿片肽。
Pub Date : 1988-01-01 DOI: 10.1007/978-3-642-83467-7_3
A T McKnight, A D Corbett, S J Paterson, L E Robson, H W Kosterlitz
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引用次数: 0
Introduction to the theory and practice of high-performance liquid chromatography. 介绍高效液相色谱的理论与实践。
Pub Date : 1988-01-01 DOI: 10.1007/978-3-642-83467-7_1
R Newton

For those readers interested in researching the theory of HPLC and the associated instrumentation a brief bibliography is listed below in addition to the references cited. The reader is also referred to the many good quality International Journals which are dedicated to the techniques of HPLC.

对于那些有兴趣研究HPLC理论和相关仪器的读者,除了引用的参考文献外,下面还列出了简要的参考书目。读者还可以参考许多致力于HPLC技术的高质量国际期刊。
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引用次数: 2
High-performance liquid chromatography in endocrinology. 高效液相色谱在内分泌学中的应用。
Pub Date : 1988-01-01
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引用次数: 0
Regulation of aldosterone biosynthesis. Physiological and clinical aspects. 醛固酮生物合成的调控。生理和临床方面。
Pub Date : 1987-01-01
J Müller
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引用次数: 0
Steroid-Protein Interactions II 类固醇-蛋白质相互作用2
Pub Date : 1986-01-01 DOI: 10.1007/978-3-642-82486-9
U. Westphal
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引用次数: 91
Steroid-protein interactions II. 类固醇-蛋白相互作用2。
Pub Date : 1986-01-01
U Westphal
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引用次数: 0
Hormones and lung maturation. 激素和肺成熟。
Pub Date : 1986-01-01
P L Ballard
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引用次数: 0
Congenital adrenal hyperplasia. 先天性肾上腺增生。
Pub Date : 1984-01-01
M I New, L S Levine

The enzyme defects of steroidogenesis appear to be monogenic disorders. The clinical heterogeneity of these disorders suggests allelic variations at the loci for these disorders, as has been reported for other gentic inborn errors. When the genes for these enzymes are cloned and sequenced, the final proof of allelism will be obtained. Prenatal diagnosis of one of the enzyme defects is possible by biochemical and HLA studies of the amniotic fluid. In the others, DNA restriction fragment polymorphism may provide a tool in the future for prenatal diagnosis. Since all these disorders are compatible with normal intelligence and a productive life, the more frequent ones at least are worthy of screening for early diagnosis and treatment.

甾体生成酶缺陷表现为单基因性疾病。这些疾病的临床异质性表明这些疾病的等位基因变异,正如其他遗传先天性错误所报道的那样。当这些酶的基因被克隆和测序时,等位基因的最终证据将被获得。产前诊断的酶缺陷之一是可能的生化和HLA研究的羊水。另一方面,DNA限制性片段多态性可能为产前诊断提供一种工具。由于所有这些障碍都与正常的智力和富有成效的生活相兼容,至少更频繁的障碍值得进行筛查,以便早期诊断和治疗。
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引用次数: 0
Changes in the pituitary-testicular axis with age. 垂体-睾丸轴随年龄的变化。
Pub Date : 1983-01-01 DOI: 10.1007/978-3-642-81912-4_4
H W Baker, B Hudson

A large number of endocrinological studies of testicular function in men of different ages suggest that primary testicular failure becomes common and more severe with aging. There is an increasing frequency of impotence, reduced secondary sex hair and testicular atrophy. Serum LH and FSH levels rise, androgen production rates and levels fall and oestrogen levels rise. The clearance of oestradiol falls but the production rate is maintained, in part, through increased peripheral conversion of testosterone to oestradiol. The levels of SHBG rise and free testosterone levels are reduced. Leydig cell responsiveness to hCG is probably reduced but gonadotrope responsiveness to GnRH reasonably maintained in the elderly. There are histological changes in the seminiferous epithelium of old men but these are non-specific. Senescent testicular failure is mainly a primary gonadal disorder but its cause and significance are only poorly understood.

大量不同年龄段男性睾丸功能的内分泌学研究表明,原发性睾丸功能衰竭随着年龄的增长而变得常见和严重。阳痿、第二性发减少和睾丸萎缩的频率增加。血清LH和FSH水平上升,雄激素产生率和水平下降,雌激素水平上升。雌二醇的清除率下降,但产出率维持,部分是通过增加外周睾酮向雌二醇的转化。SHBG水平升高,游离睾酮水平降低。间质细胞对hCG的反应性可能降低,但促性腺激素对GnRH的反应性在老年人中合理维持。老年男性精原上皮有组织学变化,但这些变化是非特异性的。衰老性睾丸功能衰竭主要是一种原发性性腺疾病,但其病因和意义尚不清楚。
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引用次数: 32
期刊
Monographs on endocrinology
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