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Pharmakopsychiatrie, Neuro-Psychopharmakologie最新文献

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Present state of the quantitative analysis of the EMG related to drug effectiveness. 肌电图与药物有效性的定量分析现状。
Pharmakopsychiatrie, Neuro-Psychopharmakologie
Pub Date : 1979-01-01 DOI: 10.1055/s-0028-1094602
A Arrigo, A Moglia, G Sandrini, A Pernice
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引用次数: 0
Amplitude histography of the EEG in psychopharmacological research. 脑电图振幅直方图在精神药理学研究中的应用。
Pharmakopsychiatrie, Neuro-Psychopharmakologie
Pub Date : 1979-01-01 DOI: 10.1055/s-0028-1094599
H Rieger, J Krieglstein, H Schütz
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引用次数: 5
EEG and clinical profile of a synthetic analogue of methionine-enkephalin - FK 33-824. 蛋氨酸-脑啡肽- FK 33-824合成类似物的脑电图和临床特征。
Pharmakopsychiatrie, Neuro-Psychopharmakologie
Pub Date : 1979-01-01 DOI: 10.1055/s-0028-1094598
E Krebs, J Roubicek
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引用次数: 29
A comparative study of the effects of imipramine in normal subjects: power spectrum vs amplitude variance. 丙咪嗪对正常人影响的比较研究:功率谱与振幅方差。
Pharmakopsychiatrie, Neuro-Psychopharmakologie
Pub Date : 1979-01-01 DOI: 10.1055/s-0028-1094595
L Goldstein
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引用次数: 0
Multichannel EEG preprocessing: analogue matrix operations in the study of local effects. 多通道脑电图预处理:模拟矩阵运算中局部效应的研究。
Pharmakopsychiatrie, Neuro-Psychopharmakologie
Pub Date : 1979-01-01 DOI: 10.1055/s-0028-1094601
B Hjorth
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引用次数: 19
Progresses of statistical spectral analysis in pharmaco-electroencephalography. 药物脑电图统计谱分析研究进展。
Pharmakopsychiatrie, Neuro-Psychopharmakologie
Pub Date : 1979-01-01 DOI: 10.1055/s-0028-1094600
P Etevenon, B Pidoux
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引用次数: 1
Computer-aided classification and assessment of patients in multicenter trials. 多中心试验中患者的计算机辅助分类和评估。
Pharmakopsychiatrie, Neuro-Psychopharmakologie
Pub Date : 1978-11-01 DOI: 10.1055/s-0028-1094587
G B Cassano, L Conti, P Castrogiovanni, J Levine

The automated diagnostic procedure appears to be particularly suitable for clinical psychopharmacological trials since it provides a diagnostic definition and a psychopathological profile of patients assessed by various investigators of different centers where a different kind of psychopathology as well as different cultural, clinical and psychopharmacological backgrounds may be present. Furthermore, this procedure offers the possibility of reexamining and analyzing the characteristics of the experimental sample as related to the responses to the drugs. It also provides a new approach for solving some of the problems which play an important role in determining divergent results in clinical psychopharmacology such as that of patients selection and diagnostic definition. In the present study the automated diagnostic procedure derived by the scores of each item of I.M.P.S. and by factor scores are evaluated comparatively. The data reported show that the automated diagnosis should be based on the scores of single aspects of the symptomatology rather than on the basis of the factor scores.

自动诊断程序似乎特别适合临床精神药理学试验，因为它提供了由不同中心的不同研究者评估的诊断定义和患者的精神病理学概况，不同的精神病理学以及不同的文化、临床和精神药理学背景可能存在。此外，该程序提供了重新检查和分析与药物反应相关的实验样品特征的可能性。这也为解决临床精神药理学中一些影响结果分歧的重要问题，如患者选择和诊断定义，提供了一种新的途径。在本研究中，比较评价了由I.M.P.S.各项目得分和因子得分得出的自动诊断程序。报告的数据表明，自动诊断应该基于症状的单个方面的得分，而不是基于因素得分。
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引用次数: 0
A multidimensional test approach for the description of the CNS activity of drugs in human pharmacology. 人类药理学中药物中枢神经系统活性描述的多维测试方法。
Pharmakopsychiatrie, Neuro-Psychopharmakologie
Pub Date : 1978-11-01 DOI: 10.1055/s-0028-1094585
W M Herrmann, R J McDonald

In a double-blind cross-over trial ten healthy male volunteers were administered placebo as well as one representative of each of the four hypothetical psychotropic drug classes, antipsychotics, antidepressants, anxiolytics, and psychostimulants. The drugs were: 75 mg of chlorpromazine, 75 mg of amitriptyline, 10 mg of diazepam and 18 mg of dextroamphetamine sulfate. The effects of the compounds were assessed by pharmaco EEG, an adjective checklist, and a battery of psychological performance tests. The results demonstrate that the test model differentiates well between sedative and stimulatory drug effects. In addition, this multidimensional test approach discriminates adequately the effects of the various sedative drugs. The advantages and limitations of multidimensional test approaches for the description of psychotropic drugs along with the importance of employing such an approach for the development of psychotropic drugs are discussed.

在一项双盲交叉试验中，10名健康男性志愿者分别服用安慰剂和四种假设的精神药物，抗精神病药、抗抑郁药、抗焦虑药和精神兴奋剂。这些药物分别是:氯丙嗪75毫克、阿米替林75毫克、地西泮10毫克和硫酸右苯丙胺18毫克。通过药物脑电图、形容词检查表和一系列心理表现测试来评估化合物的作用。结果表明，实验模型可以很好地区分镇静和刺激药物的作用。此外，这种多维测试方法可以充分区分各种镇静药物的作用。讨论了精神药物描述的多维测试方法的优点和局限性，以及采用这种方法开发精神药物的重要性。
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引用次数: 16
[Dopamine-receptor stimulators and neuroleptic-induced dyskinesia (author's transl)]. [多巴胺受体刺激剂和抗精神病药引起的运动障碍(作者译)]。
Pharmakopsychiatrie, Neuro-Psychopharmakologie
Pub Date : 1978-11-01 DOI: 10.1055/s-0028-1094589
E Ringwald

We have examined bromocriptine, levodopa and trihexyphenydil ins ingle-blind design in 16 chronic productive schizophrenics having the same degree of tardive dyskinesias. Treatment time for each patient was 60 days: Bromocriptine was given in mean daily doses of 32 mg, levodopa 3,2 g and trihexyphenydil 27 mg. Bromocriptine and trihexyphenydil allowed the continued use of neuroleptics, without necessitating an increase in dosage. On the other hand, with levodopa 25% of the patients deteriorated, and this could not be prevented by increasing the dose of neuroleptics. Bromocriptine and trihexyphenydil permitted treatment of tardive dyskinesias, whereby bromocriptione was clinically (and statistically) superior to trihexyphenydil. Trihexyphenydil had only a slight effect on tremor, whilst treatment with levodopa was ineffective.

我们采用单盲设计对16例具有相同程度迟发性运动障碍的慢性生产性精神分裂症患者进行了溴隐亭、左旋多巴和三苯二酚的研究。每例患者的治疗时间为60天:溴隐亭平均每日剂量32 mg，左旋多巴3.2 g，三己苯二醇27 mg。溴隐亭和三己苯地尔允许继续使用抗精神病药，而不需要增加剂量。另一方面，左旋多巴组有25%的患者病情恶化，这不能通过增加抗精神病药的剂量来预防。溴隐亭和三己苯二醇允许治疗迟发性运动障碍，因此溴隐亭在临床上(和统计上)优于三己苯二醇。三己苯地尔对震颤只有轻微的作用，而左旋多巴治疗无效。
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引用次数: 10
Prejudices in pharmacology and pharmacotherapy: reserpine as a model for experimental research in depression. 药理学和药物治疗的偏见:利血平作为抑郁症实验研究的模型。
Pharmakopsychiatrie, Neuro-Psychopharmakologie
Pub Date : 1978-11-01 DOI: 10.1055/s-0028-1094588
H J Bein
The choice of reserpine as practically the sole model substance used in research in depression over two decades was not dictated by rational considerations alone: hypothetical notions, prospects of the rapid realization of experimental research aims and the fascination of the exotic origin of this "natural" drug made a significant contribution.
选择利血平作为二十年来抑郁症研究中实际使用的唯一模型物质并不仅仅是出于理性考虑:假设的概念、快速实现实验研究目标的前景以及这种“天然”药物的异国起源的魅力都做出了重大贡献。
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引用次数: 3
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