{"title":"[Current developments in the diagnosis and treatment of periarteritis nodosa].","authors":"M Georgescu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76447,"journal":{"name":"Revista de medicina interna, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicina interna","volume":"42 2","pages":"133-44"},"PeriodicalIF":0.0,"publicationDate":"1990-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13139406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G Gluhovschi, N Barbu, A Schiller, P Arcan, I Drăgan, L Buzilă, I Sporea, M Teretean, N Csaky
{"title":"[Bacterial immunofluorescence in the intestinal juice in relation to other cellular and humoral immunity factors in the intestinal juice and blood serum of patients with chronic nonspecific enteropathy].","authors":"G Gluhovschi, N Barbu, A Schiller, P Arcan, I Drăgan, L Buzilă, I Sporea, M Teretean, N Csaky","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76447,"journal":{"name":"Revista de medicina interna, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicina interna","volume":"42 2","pages":"175-84"},"PeriodicalIF":0.0,"publicationDate":"1990-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13141289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The paper reports on a new way of cardiological, radionuclidic investigation of the patients, a technique used for the first time in Romania. The technique and investigation method are presented in detail, with emphasis on some more important stages. As resulting from the description of the methodology, the performances of the left ventricle consist of three types of radioactivity/time curves at: first passage, beat by beat, and their summation. Of the advantages offered by the nuclear stethoscope, mention should be made that, besides the evaluation of systolic and diastolic parameters, it monitors the left ventricle functions in the rhythm disturbances, beat by beat, and being mobile, it permits the investigation at the patient's bed. Finally, the paper presents several cases investigated by the authors, and their special clinical applicability.
{"title":"[Nuclear stethoscopy. The clinical technic, methods and applications].","authors":"T Pop, T Nanea, D Dumitrache, M Onu, P Popescu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The paper reports on a new way of cardiological, radionuclidic investigation of the patients, a technique used for the first time in Romania. The technique and investigation method are presented in detail, with emphasis on some more important stages. As resulting from the description of the methodology, the performances of the left ventricle consist of three types of radioactivity/time curves at: first passage, beat by beat, and their summation. Of the advantages offered by the nuclear stethoscope, mention should be made that, besides the evaluation of systolic and diastolic parameters, it monitors the left ventricle functions in the rhythm disturbances, beat by beat, and being mobile, it permits the investigation at the patient's bed. Finally, the paper presents several cases investigated by the authors, and their special clinical applicability.</p>","PeriodicalId":76447,"journal":{"name":"Revista de medicina interna, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicina interna","volume":"42 2","pages":"119-32"},"PeriodicalIF":0.0,"publicationDate":"1990-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13139405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The niphedipine pharmacokinetics was investigated in the patients with hepatic cirrhosis, in comparison with a group of healthy subjects, after administering unique doses of 10 mg per os. The niphedipine concentrations in serum were determined by a gas chromatography method. The niphedipine pharmacokinetics may be described in correspondence with the open pharmacokinetic model. The values of pharmacokinetic parameters of niphedipine in the patients with hepatic cirrhosis are significantly modified in comparison with those noticed in the healthy subjects. An increase in the level of the maximum concentrations (158 ng/ml versus 68 ng/ml), of the biological half time (11.9 hours versus 2.5 hours) and of the area under the curve of the drug concentrations in time (450 ng.ml-1.hour versus 205 ng.ml-1.hour) were found. The relative bioavailability [correction of biodisponibility] of niphedipine was double in the patients with hepatic cirrhosis versus the healthy subjects. The modified pharmacokinetics of niphedipine in the patients with hepatic cirrhosis and the great individual variations found, require a decrease of the dose in this category of patients and a surveillance of the clinical effect.
{"title":"[Nifedipine pharmacokinetics in liver cirrhosis patients after the administration of a single oral dose].","authors":"S E Leucuţa, M Grigorescu, D Dumitraşcu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The niphedipine pharmacokinetics was investigated in the patients with hepatic cirrhosis, in comparison with a group of healthy subjects, after administering unique doses of 10 mg per os. The niphedipine concentrations in serum were determined by a gas chromatography method. The niphedipine pharmacokinetics may be described in correspondence with the open pharmacokinetic model. The values of pharmacokinetic parameters of niphedipine in the patients with hepatic cirrhosis are significantly modified in comparison with those noticed in the healthy subjects. An increase in the level of the maximum concentrations (158 ng/ml versus 68 ng/ml), of the biological half time (11.9 hours versus 2.5 hours) and of the area under the curve of the drug concentrations in time (450 ng.ml-1.hour versus 205 ng.ml-1.hour) were found. The relative bioavailability [correction of biodisponibility] of niphedipine was double in the patients with hepatic cirrhosis versus the healthy subjects. The modified pharmacokinetics of niphedipine in the patients with hepatic cirrhosis and the great individual variations found, require a decrease of the dose in this category of patients and a surveillance of the clinical effect.</p>","PeriodicalId":76447,"journal":{"name":"Revista de medicina interna, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicina interna","volume":"42 2","pages":"185-90"},"PeriodicalIF":0.0,"publicationDate":"1990-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13141291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The adverse digestive effects of nonsteroidal anti-inflammatory agents. Current physiopathological and clinical aspects. I. The adverse effects on the digestive track].","authors":"A Duţu, I Parasca","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76447,"journal":{"name":"Revista de medicina interna, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicina interna","volume":"42 2","pages":"97-109"},"PeriodicalIF":0.0,"publicationDate":"1990-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13141290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The authors studied 160 cases of biliary stasis: 120 having intrahepatic cause (101 hepatic cirrhoses and 19 primitive biliary cirrhoses) and 40 extrahepatic cause (17 choledochal lithiases and 23 cancers of the pancreas head) and check up the diagnosis value of two investigation algorithms: echography, the first investigation, followed by hepatic biopsy puncture, if the intrahepatic biliary ducts are not dilated, or transhepatic cutaneous cholangiography if the intrahepatic biliary ducts are dilated in comparison with intravenous cholangiography in the first investigation. Echography has an increased diagnosis yield (96% sensitivity, 99% specificity), is cheap, noninvasive and is the first imaging exploration used in biliary stasis syndrome.
{"title":"[The cholestasis syndrome. A critical evaluation of an exploratory strategy].","authors":"L Buligescu, M Voiculescu, G Jovin, S Georgescu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors studied 160 cases of biliary stasis: 120 having intrahepatic cause (101 hepatic cirrhoses and 19 primitive biliary cirrhoses) and 40 extrahepatic cause (17 choledochal lithiases and 23 cancers of the pancreas head) and check up the diagnosis value of two investigation algorithms: echography, the first investigation, followed by hepatic biopsy puncture, if the intrahepatic biliary ducts are not dilated, or transhepatic cutaneous cholangiography if the intrahepatic biliary ducts are dilated in comparison with intravenous cholangiography in the first investigation. Echography has an increased diagnosis yield (96% sensitivity, 99% specificity), is cheap, noninvasive and is the first imaging exploration used in biliary stasis syndrome.</p>","PeriodicalId":76447,"journal":{"name":"Revista de medicina interna, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicina interna","volume":"42 2","pages":"153-66"},"PeriodicalIF":0.0,"publicationDate":"1990-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13139410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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