Revue medicale de la Suisse romande最新文献

Articular chondrocalcinosis (ACC) is a metabolic arthropathy caused by calcium pyrophosphate crystal deposits. It is frequent in the second half of the life (6% of the population aged between 60 and 70 years, 30% of the elderly after 80 years). Both males and females, are involved in the same proportion. Clinical manifestations include pseudogout attacks, mainly of the knee and wrist joints, secondary osteoarthritis and destructive arthropathy (mainly of the knee and hip joints). There is no basis therapy. The pyrophosphate calcium deposits do not disappear during the evolution of the disease. Symptomatic therapy with NSAIDS, analgesic drugs or intra-articular corticosteroids may be very useful. Orthopaedic surgery is necessary in cases with severe destructive arthropathy.

The popliteal fossa is located at an important place of the osteo-articular system near the knee of course but also in strong relationship with the neighboured vascular, muscular and nervous structures. The symptomatology of the Baker's cyst is well known but its physiopathology is less obvious. It is important to remain aware of some unusual conditions that must prompt a differential diagnosis reaching from functional articular conditions over vascular and nervous problems to major tumoral problems. The patient's history and a rigorous clinical examination must remain the main stone of the medical evaluation; however, most situations require complementary diagnostic procedures among which the ultrasonography and/or the MRI represent nowadays the gold standards. It belongs to the physician's skill to use these tools in an efficient way according to the clinical condition. Actually, the Baker's cyst is in most cases secondary to a mechanical or inflammatory intraarticular knee problem; the treatment of this condition will cure the cyst that usually doesn't require any own treatment.

Until recently, treatment of osteoarthritis targeted the pain and the disability of the involved joints. It consisted in a mix of analgesics, anti-inflammatory drugs, steroid infiltrations and physical therapies. Usefulness of slow but long acting substances is increasing not only by their action on the symptoms but also because they positively influence the evolution of the disease. Some of them seem to induce a structural effect on the cartilage confirmed by a slow down of the joint space narrowing on successive radiographs of the knees. Presently, only basic matricial precursors such as chondroitin sulfate, glucosamine sulfate and hyaluronic acid are available in the clinic. They act by reducing cartilage destruction and enhancing chondrocyte anabolism. These preliminary results should be confirmed by further studies based on magnetic resonance imaging and surrogate markers of the cartilage matrix. Recent developments in the understanding of the physiopathology of osteoarthritis, including the key role of some cytokines, should allow new therapic ways, individually or in combination.

This article reviews, through illustrative cases, five rheumatic diseases associated with drug treatments: statins and myopathy, quinolones and tendinopathy, viscosupplementation and pseudoseptic arthritis, diuretics and gout, barbiturates and adhesive capsulitis. Due to the rarity of such cases, we lack validated therapeutic recommendations. Announcement to the adverse drug reaction reporting system is the best way to enhance our knowledge and to improve the public health.

A radiologist should be included in the multidisciplinary approach which will allow optimal diagnostic evaluation and treatment of sarcoma. The appropriate use of ultrasound, computed tomography and magnetic resonance imaging plays a significant role in the evaluation of these tumors and their recurrences. The potential role of dynamic magnetic resonance imaging has also been evaluated. A review of diagnostic imaging and their clinical utility is discussed.

Feet problems are a very often reason for searching medical advice: one out every people after 65 years of age have foot problems. Conservative medical treatment associated with insoles, braces and special shoes is a very important part of treatment. Patient with foot problem could have just a simple conflict due to too narrow shoes or be as severe as an destructive diabetic arthropathy. After reminding the great groups of pathologies, causes and effects, we describe successively effects, kinds indication and fabrication of foot orthosis and shoes. Prevention of complications is a very important tool in treating feet problems. Every patient with a foot orthosis should have a very good footwear. The interdisciplinary approach with orthesist is mandatory, as is the precise and meticulous follow-up of this patient.

When a soft tissue tumor is initially misdiagnosed as a simple trauma or a mass, treatment may be adversely affected by the delay in diagnosis or an inappropriate invasive procedure that results in extension of a probable malignant tumor. Patients with soft tissue tumors present a diagnostic challenge to the clinician. A systematic approach to the evaluation and biopsy is necessary in order to minimize diagnostic errors and biopsy complications. With a multidisciplinary approach and adequate surgical management, the prognosis with a five-year survival rate can be excellent.

We report the case of a 69-year-old woman, with a BMI of 42.9, suffering from bilateral struvite calculi and who raised end stage renal failure. Urease-synthesizing bacteria, leading to the hydrolysis of urea into ammonium and to an alkaline urine (pH > 7.2), are required for struvite stone formation in humans. Struvite component constitutes the majority of staghom calculi. Patients with struvite stones could lose renal function because of obstructive or pyelonephritic episodes and surgical interventions on the kidney. Therapeutic success needs a follow up by a specialized uro-nephrologist team as soon as possible.

Cystinuria is a common inherited amino-aciduria resulting in abnormal urinary excretion of cystine and the dibasic aminoacids, lysine, arginine and ornithine. Formation of cystine kidney stones, recurrent infections and subsequent renal failure are the main complications of the disease. Recently, the gene SLC3A1 and SLC7A9, encoding the two subunits rBAT et b0,+AT of the proximal renal transporter complex, have been identified. In this article, we report the medical history of a 30-year-old patient and discuss the recent molecular progress, the clinical evolution, and the medical treatment of the cystinuria.