Pub Date : 2026-02-01DOI: 10.1176/appi.ajp.20251225
Stephen R Marder,Susan M Essock
{"title":"Rethinking Antipsychotic Comparisons: The Role of Prior Exposure and Tolerability.","authors":"Stephen R Marder,Susan M Essock","doi":"10.1176/appi.ajp.20251225","DOIUrl":"https://doi.org/10.1176/appi.ajp.20251225","url":null,"abstract":"","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"62 1","pages":"90-92"},"PeriodicalIF":17.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1176/appi.ajp.20251138
Harriet de Wit
{"title":"Co-Use of Alcohol and Cannabis: How Are They Related?","authors":"Harriet de Wit","doi":"10.1176/appi.ajp.20251138","DOIUrl":"https://doi.org/10.1176/appi.ajp.20251138","url":null,"abstract":"","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"140 1","pages":"96-97"},"PeriodicalIF":17.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1176/appi.ajp.20251328
Tanner J Bommersbach,Mark Olfson,Taeho Greg Rhee
{"title":"Interpreting the Signal Beyond the Trend: Response to Hanyu.","authors":"Tanner J Bommersbach,Mark Olfson,Taeho Greg Rhee","doi":"10.1176/appi.ajp.20251328","DOIUrl":"https://doi.org/10.1176/appi.ajp.20251328","url":null,"abstract":"","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"8 1","pages":"145-146"},"PeriodicalIF":17.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1176/appi.ajp.20250750
Shota Hanyu
{"title":"Rising Suicidality Among U.S. Adolescents: Interpreting the Signal Beyond the Trend.","authors":"Shota Hanyu","doi":"10.1176/appi.ajp.20250750","DOIUrl":"https://doi.org/10.1176/appi.ajp.20250750","url":null,"abstract":"","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"43 1","pages":"144-145"},"PeriodicalIF":17.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1176/appi.ajp.20250721
Erin Richardson,Fouzia Sheikh,Kyce Darouiche,Julie Farrington,Charles B Nemeroff,D Jeffrey Newport
{"title":"Intravenous Brexanolone for the Treatment of Posttraumatic Stress Disorder: A Case Report.","authors":"Erin Richardson,Fouzia Sheikh,Kyce Darouiche,Julie Farrington,Charles B Nemeroff,D Jeffrey Newport","doi":"10.1176/appi.ajp.20250721","DOIUrl":"https://doi.org/10.1176/appi.ajp.20250721","url":null,"abstract":"","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"4 1","pages":"108-111"},"PeriodicalIF":17.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1176/appi.ajp.20251336
Ned H Kalin
{"title":"Neuroplasticity, Antipsychotic Efficacy, Schizophrenia Risk Reduction With Doxycycline Exposure, and Cannabis and Alcohol Use Interactions.","authors":"Ned H Kalin","doi":"10.1176/appi.ajp.20251336","DOIUrl":"https://doi.org/10.1176/appi.ajp.20251336","url":null,"abstract":"","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"14 1","pages":"87-89"},"PeriodicalIF":17.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1176/appi.ajp.20251253
T Scott Stroup
{"title":"Comparative Effectiveness Trials and the Quest for Personalized Treatments: The Case of Antipsychotics.","authors":"T Scott Stroup","doi":"10.1176/appi.ajp.20251253","DOIUrl":"https://doi.org/10.1176/appi.ajp.20251253","url":null,"abstract":"","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"84 1","pages":"93-95"},"PeriodicalIF":17.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1176/appi.ajp.20251212
Patricio O'Donnell,Amit Etkin,Husseini Manji
Neuroplasticity-the brain's capacity to modify synaptic strength and connectivity-likely underlies both the pathophysiology of psychiatric disorders and the mechanisms through which treatments exert therapeutic effects. Direct assessment of plasticity requires measuring changes in synaptic responses, which remains technically challenging in humans. The most proximal human indicators are behavioral changes reflecting learning and memory, or physiological responses to neurostimulation paradigms that engage cortical circuits. More commonly, plasticity is inferred indirectly through postmortem analyses of neuronal and glial structure or via neuroimaging measures such as functional and structural connectivity. Together, these approaches suggest that altered and potentially reversible plasticity is central to understanding and treating psychiatric illness, but the field needs to be cautious about what is, what could be, and what is not plasticity.
{"title":"Brain Neuroplasticity Mechanisms in Psychiatric Illnesses and in the Development of Novel Treatments.","authors":"Patricio O'Donnell,Amit Etkin,Husseini Manji","doi":"10.1176/appi.ajp.20251212","DOIUrl":"https://doi.org/10.1176/appi.ajp.20251212","url":null,"abstract":"Neuroplasticity-the brain's capacity to modify synaptic strength and connectivity-likely underlies both the pathophysiology of psychiatric disorders and the mechanisms through which treatments exert therapeutic effects. Direct assessment of plasticity requires measuring changes in synaptic responses, which remains technically challenging in humans. The most proximal human indicators are behavioral changes reflecting learning and memory, or physiological responses to neurostimulation paradigms that engage cortical circuits. More commonly, plasticity is inferred indirectly through postmortem analyses of neuronal and glial structure or via neuroimaging measures such as functional and structural connectivity. Together, these approaches suggest that altered and potentially reversible plasticity is central to understanding and treating psychiatric illness, but the field needs to be cautious about what is, what could be, and what is not plasticity.","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"5 1","pages":"98-107"},"PeriodicalIF":17.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-28DOI: 10.1176/appi.ajp.20250878
María A Oquendo,Anissa Abi-Dargham,Jonathan E Alpert,Tami D Benton,Diana E Clarke,Wilson M Compton,Karen Drexler,Kenneth P Fung,Martien J H Kas,Dolores Malaspina,Victoria M O'Keefe,Dost Öngür,Milton L Wainberg,Kimberly A Yonkers,Lamyaa Yousif,Nitin Gogtay
{"title":"Initial Strategy for the Future of DSM.","authors":"María A Oquendo,Anissa Abi-Dargham,Jonathan E Alpert,Tami D Benton,Diana E Clarke,Wilson M Compton,Karen Drexler,Kenneth P Fung,Martien J H Kas,Dolores Malaspina,Victoria M O'Keefe,Dost Öngür,Milton L Wainberg,Kimberly A Yonkers,Lamyaa Yousif,Nitin Gogtay","doi":"10.1176/appi.ajp.20250878","DOIUrl":"https://doi.org/10.1176/appi.ajp.20250878","url":null,"abstract":"","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"26 1","pages":"appiajp20250878"},"PeriodicalIF":17.7,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146056566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-28DOI: 10.1176/appi.ajp.20250877
Bruce Cuthbert,Olusola Ajilore,Jonathan E Alpert,Diana E Clarke,Wilson M Compton,Karen Drexler,Kenneth P Fung,Nitin Gogtay,Martien J H Kas,Anand Kumar,Dolores Malaspina,Victoria M O'Keefe,Dost Öngür,Carol Tamminga,Milton L Wainberg,Kimberly A Yonkers,Lamyaa Yousif,Anissa Abi-Dargham,María A Oquendo
{"title":"The Future of DSM: Role of Candidate Biomarkers and Biological Factors.","authors":"Bruce Cuthbert,Olusola Ajilore,Jonathan E Alpert,Diana E Clarke,Wilson M Compton,Karen Drexler,Kenneth P Fung,Nitin Gogtay,Martien J H Kas,Anand Kumar,Dolores Malaspina,Victoria M O'Keefe,Dost Öngür,Carol Tamminga,Milton L Wainberg,Kimberly A Yonkers,Lamyaa Yousif,Anissa Abi-Dargham,María A Oquendo","doi":"10.1176/appi.ajp.20250877","DOIUrl":"https://doi.org/10.1176/appi.ajp.20250877","url":null,"abstract":"","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"4 1","pages":"appiajp20250877"},"PeriodicalIF":17.7,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146056565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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