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Assessment of pinacidil in patients with primary Raynaud's phenomenon. pinacidil在原发性雷诺现象患者中的应用评估。
VASA. Supplementum
Pub Date : 1992-01-01
E C Dompeling, A J Smit

In fourteen patients with primary Raynaud's phenomenon we performed a double-blind, controlled study, comparing single doses of 12.5 and 25 mg of the potassium channel opener pinacidil with placebo and the active control nifedipine in randomised order. The main response criterium was the area under the curve (AUC) of the photoelectric plethysmography (PEP) during cooling and rewarming, performed 2-3 hours after administration of the study medication. Single doses of 12.5 and 25 mg pinacidil were shown not to be superior to placebo in respect of the AUC of PEP. Nifedipine, on the contrary, was significantly better than placebo. We conclude that no efficacy can be expected from the potassium channel opener pinacidil in the treatment of primary Raynaud's phenomenon. The efficacy of nifedipine cannot be explained from central rheological effects, as total blood viscosity was the same after pinacidil, nifedipine and placebo.

在14例原发性雷诺现象患者中，我们进行了一项双盲对照研究，将单剂量12.5和25mg钾通道打开剂pinacidil与安慰剂和主动对照硝苯地平按随机顺序进行比较。主要反应标准为给药后2 ~ 3小时冷却和复温时光电体积脉搏波曲线下面积(AUC)。单剂量12.5和25mg pinacidil在PEP的AUC方面并不优于安慰剂。相反，硝苯地平明显优于安慰剂。我们的结论是，钾通道打开剂pinacidil在原发性雷诺现象的治疗中没有疗效。硝苯地平的疗效不能从中枢流变学效应来解释，因为品酸、硝苯地平和安慰剂后的总血液粘度相同。
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引用次数: 0
Laser Doppler blood flowmetry. Perinatal applications. 激光多普勒血流仪。围产期的应用程序。
VASA. Supplementum
Pub Date : 1992-01-01
J G Aarnoudse
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引用次数: 0
[Dose-dependent inhibition of plaque growth in the carotid artery by acetylsalicylic acid]. [剂量依赖性乙酰水杨酸抑制颈动脉斑块生长]。
VASA. Supplementum
Pub Date : 1992-01-01
C Ranke, A Creutzig, H Hecker, K Alexander
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引用次数: 0
Rheological properties of blood in Raynaud's phenomenon. 雷诺现象中血液的流变特性。
VASA. Supplementum
Pub Date : 1992-01-01
G Wichers, A J Smit, J van der Meer, A A Wouda, M R Halie

Rheological tests were performed in four rigorously defined groups of patients with Raynaud's phenomenon: primary family-related (n = 21), primary family-unrelated (n = 30), 'possible scleroderma' (n = 26), and scleroderma (n = 19). Whole blood and plasma viscosity, and hematocrit were significantly higher in the 'possible scleroderma' group. We conclude that the contribution of central rheological abnormalities in the pathogenesis of Raynaud's phenomenon is limited.

流变学试验在四组严格定义的雷诺氏现象患者中进行:原发性家族相关(n = 21)、原发性家族无关(n = 30)、“可能的硬皮病”(n = 26)和硬皮病(n = 19)。“可能患有硬皮病”组的全血和血浆粘度以及红细胞压积明显更高。我们得出结论，中枢流变异常在雷诺现象发病机制中的作用是有限的。
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引用次数: 0
[Measuring model for intraoperative determination of vascular resistance in crural vascular surgery]. [术中测定小腿血管手术血管阻力的测量模型]。
VASA. Supplementum
Pub Date : 1992-01-01
J Frank, U Scholz, V Henneken, C Bischoff-Everding, K de Jonge, E Hennig, W Hepp

The measurement of the vascular outflow resistance during reconstructive vascular operations was applied since 1989 on 45 subjects with reliable results. This measurement is an aid for decision of additional treatment increasing the outflow, like a jump- or sequential bypass or a pharmacological therapy. The principle of measurement is based on the injection of a known volume of saline in the vessel and the integration of the intravascular pressure during this injection. In the prototype used, the pressure integration was performed by means of a modified analog/digital conversion method, hereby the results could be achieved directly as numerical values. Further an automatic, microcomputer based implementation of the outflow resistance measurement, showed remarkable improvements of accuracy in laboratory tests.

自1989年以来，对45例患者进行了血管重建手术中血管流出阻力的测量，结果可靠。这一测量有助于决定是否采取增加流出量的额外治疗，如跳跃或序贯搭桥或药物治疗。测量原理是基于在血管中注射已知体积的生理盐水和注射过程中血管内压力的整合。在所使用的样机中，压力积分是通过改进的模数转换方法进行的，因此结果可以直接作为数值来实现。此外，在实验室测试中，基于微机的外流阻力自动测量显示出显著的准确性提高。
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引用次数: 0
[Antiphospholipid syndrome]. (Antiphospholipid综合症)。
VASA. Supplementum
Pub Date : 1992-01-01
A Obernosterer, E Pilger, P Auer-Grumbach, R Tischler, A Doder, M Lafer, M Decrinis
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引用次数: 0
[Long-term follow-up of patients with peripheral arterial occlusive disease after balloon dilatation in the femoropopliteal area]. 股腘区球囊扩张后外周动脉闭塞病患者的长期随访。
VASA. Supplementum
Pub Date : 1992-01-01
M Lafer, M Decrinis, E Pilger, G Stark, A Obernosterer, R Tischler, A Doder, E G Klein, H Hausegger
{"title":"[Long-term follow-up of patients with peripheral arterial occlusive disease after balloon dilatation in the femoropopliteal area].","authors":"M Lafer,&nbsp;M Decrinis,&nbsp;E Pilger,&nbsp;G Stark,&nbsp;A Obernosterer,&nbsp;R Tischler,&nbsp;A Doder,&nbsp;E G Klein,&nbsp;H Hausegger","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76788,"journal":{"name":"VASA. Supplementum","volume":"37 ","pages":"52-3"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12649961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Heparin and plasminogen increase the thrombolytic potential in recanalization of peripheral arterial occlusions by local streptokinase]. [肝素和纤溶酶原增加局部链激酶对周围动脉闭塞再通的溶栓电位]。
VASA. Supplementum
Pub Date : 1992-01-01
P Poredos, V Videcnik
{"title":"[Heparin and plasminogen increase the thrombolytic potential in recanalization of peripheral arterial occlusions by local streptokinase].","authors":"P Poredos,&nbsp;V Videcnik","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76788,"journal":{"name":"VASA. Supplementum","volume":"37 ","pages":"62-3"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12649965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Immunosuppression and cryopreservation of arterial allografts]. 异体动脉移植物的免疫抑制和低温保存。
VASA. Supplementum
Pub Date : 1992-01-01
T Schmitz-Rixen, C Berwanger, A Löhe-Quast, K Addicks, R D Hilgers, H Pichlmaier
{"title":"[Immunosuppression and cryopreservation of arterial allografts].","authors":"T Schmitz-Rixen,&nbsp;C Berwanger,&nbsp;A Löhe-Quast,&nbsp;K Addicks,&nbsp;R D Hilgers,&nbsp;H Pichlmaier","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76788,"journal":{"name":"VASA. Supplementum","volume":"35 ","pages":"169-72"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12650282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The value of laser angioplasty in occlusions of the upper leg]. [激光血管成形术在上肢闭塞中的应用价值]。
VASA. Supplementum
Pub Date : 1992-01-01
P E Huppert, H Seboldt, S H Duda, U Helber, C D Claussen, H E Hoffmeister
{"title":"[The value of laser angioplasty in occlusions of the upper leg].","authors":"P E Huppert,&nbsp;H Seboldt,&nbsp;S H Duda,&nbsp;U Helber,&nbsp;C D Claussen,&nbsp;H E Hoffmeister","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76788,"journal":{"name":"VASA. Supplementum","volume":"35 ","pages":"194-5"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12650294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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