首页 > 最新文献

Alcohol and alcoholism (Oxford, Oxfordshire). Supplement最新文献

英文 中文
Social inequalities in alcohol consumption and alcohol-related problems in the study countries of the EU concerted action 'Gender, Culture and Alcohol Problems: a Multi-national Study'. 欧盟研究国家在酒精消费方面的社会不平等和与酒精有关的问题"性别、文化和酒精问题:一项多国研究"协调行动。
Pub Date : 2006-10-01 DOI: 10.1093/alcalc/agl073
Kim Bloomfield, Ulrike Grittner, Stephanie Kramer, Gerhard Gmel

Aims: We investigated the presence of social inequalities of alcohol use and misuse using educational attainment as an indicator of socio-economic status in 15 countries: Sweden, Norway, Finland, Germany, The Netherlands, Switzerland, Hungary, the Czech Republic, Israel, Brazil, and Mexico.

Methods: Study surveys were independently conducted and the data centrally analysed. Most samples were national. Survey modes and sample sizes varied. The age range was restricted to between 25 and 59 years of age. Socio-economic status was measured by educational level. Multiple logistic regressions were employed to calculate age-adjusted odds ratios for men and women in each country by educational level for current drinking status, heavy drinking (>or=20 g ethanol per day for women, >or=30 g a day for men), heavy episodic (binge) drinking, and alcohol-related problems (using AUDIT).

Results: Men and women demonstrated similar patterns in inequalities with regard to current drinking status within a country. In Germany, The Netherlands, France, Switzerland, and Austria higher educated women were most likely to drink heavily, while among men the lower educated were more at risk in most countries. For heavy episodic drinking, almost no significant differences were evident among women, but for men a social gradient was observable with lower educated being more at risk in several countries. Among five countries with data from the AUDIT, men of lower education in Finland, Czech Republic, and Hungary had higher risks to report problems. Nordic countries shared a common pattern in social inequalities as did two Latin American countries, while a mixed picture was observed for middle European countries. Social inequalities in the two Latin American countries display a pattern emerging in other research on developing countries: namely that those in the higher educated groups are more likely to consume alcohol in a risky manner.

Conclusions: Patterns in the distribution of social inequalities are not universal. Social inequalities in alcohol use differ by gender according to alcohol measure used and differ also across groups of countries. These variations should be taken into account when formulating international and cross-cultural alcohol policies.

目的:我们在瑞典、挪威、芬兰、德国、荷兰、瑞士、匈牙利、捷克共和国、以色列、巴西和墨西哥等15个国家以受教育程度作为社会经济地位的指标,调查了酒精使用和滥用的社会不平等现象。方法:独立进行研究调查,集中分析资料。大多数样本都是全国性的。调查方式和样本量各不相同。年龄范围限制在25岁至59岁之间。社会经济地位以教育水平来衡量。采用多重逻辑回归计算每个国家男性和女性的年龄调整优势比,按当前饮酒状况、重度饮酒(女性每天>或=20克乙醇,男性每天>或=30克乙醇)、重度间歇性(狂欢)饮酒和酒精相关问题(使用AUDIT)的教育水平计算。结果:在一个国家内,男性和女性在当前饮酒状况方面表现出类似的不平等模式。在德国、荷兰、法国、瑞士和奥地利,受教育程度较高的女性最有可能酗酒,而在大多数国家,受教育程度较低的男性更容易酗酒。对于严重的间歇性饮酒,女性之间几乎没有明显的差异,但对于男性来说,可以观察到社会梯度,在几个国家,受教育程度较低的人更有风险。在有审计数据的五个国家中,芬兰、捷克共和国和匈牙利受教育程度较低的男性报告问题的风险更高。北欧国家和两个拉丁美洲国家在社会不平等方面有着共同的模式,而中欧国家的情况则是喜忧参半。这两个拉丁美洲国家的社会不平等现象显示了其他关于发展中国家的研究中出现的一种模式:即受过高等教育的群体更有可能以危险的方式饮酒。结论:社会不平等的分布模式并不普遍。酒精使用方面的社会不平等根据所使用的酒精衡量标准因性别而异,在不同的国家群体之间也存在差异。在制定国际和跨文化酒精政策时,应考虑到这些差异。
{"title":"Social inequalities in alcohol consumption and alcohol-related problems in the study countries of the EU concerted action 'Gender, Culture and Alcohol Problems: a Multi-national Study'.","authors":"Kim Bloomfield,&nbsp;Ulrike Grittner,&nbsp;Stephanie Kramer,&nbsp;Gerhard Gmel","doi":"10.1093/alcalc/agl073","DOIUrl":"https://doi.org/10.1093/alcalc/agl073","url":null,"abstract":"<p><strong>Aims: </strong>We investigated the presence of social inequalities of alcohol use and misuse using educational attainment as an indicator of socio-economic status in 15 countries: Sweden, Norway, Finland, Germany, The Netherlands, Switzerland, Hungary, the Czech Republic, Israel, Brazil, and Mexico.</p><p><strong>Methods: </strong>Study surveys were independently conducted and the data centrally analysed. Most samples were national. Survey modes and sample sizes varied. The age range was restricted to between 25 and 59 years of age. Socio-economic status was measured by educational level. Multiple logistic regressions were employed to calculate age-adjusted odds ratios for men and women in each country by educational level for current drinking status, heavy drinking (>or=20 g ethanol per day for women, >or=30 g a day for men), heavy episodic (binge) drinking, and alcohol-related problems (using AUDIT).</p><p><strong>Results: </strong>Men and women demonstrated similar patterns in inequalities with regard to current drinking status within a country. In Germany, The Netherlands, France, Switzerland, and Austria higher educated women were most likely to drink heavily, while among men the lower educated were more at risk in most countries. For heavy episodic drinking, almost no significant differences were evident among women, but for men a social gradient was observable with lower educated being more at risk in several countries. Among five countries with data from the AUDIT, men of lower education in Finland, Czech Republic, and Hungary had higher risks to report problems. Nordic countries shared a common pattern in social inequalities as did two Latin American countries, while a mixed picture was observed for middle European countries. Social inequalities in the two Latin American countries display a pattern emerging in other research on developing countries: namely that those in the higher educated groups are more likely to consume alcohol in a risky manner.</p><p><strong>Conclusions: </strong>Patterns in the distribution of social inequalities are not universal. Social inequalities in alcohol use differ by gender according to alcohol measure used and differ also across groups of countries. These variations should be taken into account when formulating international and cross-cultural alcohol policies.</p>","PeriodicalId":7689,"journal":{"name":"Alcohol and alcoholism (Oxford, Oxfordshire). Supplement","volume":"41 1","pages":"i26-36"},"PeriodicalIF":0.0,"publicationDate":"2006-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/alcalc/agl073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26299889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 302
Gender and cultural differences in the association between family roles, social stratification, and alcohol use: a European cross-cultural analysis. 家庭角色、社会分层和饮酒之间的性别和文化差异:一项欧洲跨文化分析。
Pub Date : 2006-10-01 DOI: 10.1093/alcalc/agl074
Sandra Kuntsche, Gerhard Gmel, Ronald A Knibbe, Hervé Kuendig, Kim Bloomfield, Stephanie Kramer, Ulrike Grittner

Aims: First, this paper investigates (i) gender differences in associations of social stratification, family roles, and heavy drinking, and (ii) country differences in these associations. Second, it seeks to explain country differences in the associations of social stratification and family roles with alcohol consumption by societal level variables.

Methods: Survey data of 25 to 49-years-old from eight European countries were used. Logistic regressions were used to analyse gender differences in the association between family roles (marriage, having children), social stratification (education, employment), and heavy drinking (>20 g/day for women; 30 g/day for men). Gender differences were tested by means of interactions between gender and social stratification/family roles. Structural measures of work desirability, social welfare, and gender equity were used to explain differences in associations across countries.

Results: The associations between social stratification, family roles, and heavy drinking varied across gender and countries. A country's social welfare system was associated with heavy drinking only among women. Women in countries with a strong social welfare system, such as Nordic countries, tended to drink more heavily if employed, having lower formal education, and a non-traditional family role. In countries with weak social welfare systems or work desirability, heavy drinking was associated with high education, while effects of family roles and employment were small.

Conclusions: It appeared that the social welfare system and gender equity of a country determines to a large extent how education, employment, and family roles are associated with heavy drinking.

目的:首先,本文调查了(i)社会分层、家庭角色和酗酒相关的性别差异,以及(ii)这些关联的国家差异。其次,它试图通过社会水平变量解释社会分层和家庭角色与酒精消费之间的联系的国家差异。方法:采用欧洲8个国家25 ~ 49岁人群的调查资料。采用Logistic回归分析家庭角色(婚姻、生育)、社会分层(教育、就业)和酗酒(女性>20 g/天;30克/天(男性)。通过性别与社会分层/家庭角色之间的相互作用来检验性别差异。工作吸引力、社会福利和性别平等等结构性指标被用来解释各国协会的差异。结果:社会阶层、家庭角色和酗酒之间的关系因性别和国家而异。一个国家的社会福利制度只与女性的酗酒有关。在拥有强大社会福利制度的国家,如北欧国家,如果有工作,受过较低的正规教育,以及非传统的家庭角色,妇女往往会喝得更多。在社会福利制度或工作意愿薄弱的国家,酗酒与高等教育有关,而家庭角色和就业的影响很小。结论:一个国家的社会福利制度和性别平等似乎在很大程度上决定了教育、就业和家庭角色与酗酒之间的关系。
{"title":"Gender and cultural differences in the association between family roles, social stratification, and alcohol use: a European cross-cultural analysis.","authors":"Sandra Kuntsche,&nbsp;Gerhard Gmel,&nbsp;Ronald A Knibbe,&nbsp;Hervé Kuendig,&nbsp;Kim Bloomfield,&nbsp;Stephanie Kramer,&nbsp;Ulrike Grittner","doi":"10.1093/alcalc/agl074","DOIUrl":"https://doi.org/10.1093/alcalc/agl074","url":null,"abstract":"<p><strong>Aims: </strong>First, this paper investigates (i) gender differences in associations of social stratification, family roles, and heavy drinking, and (ii) country differences in these associations. Second, it seeks to explain country differences in the associations of social stratification and family roles with alcohol consumption by societal level variables.</p><p><strong>Methods: </strong>Survey data of 25 to 49-years-old from eight European countries were used. Logistic regressions were used to analyse gender differences in the association between family roles (marriage, having children), social stratification (education, employment), and heavy drinking (>20 g/day for women; 30 g/day for men). Gender differences were tested by means of interactions between gender and social stratification/family roles. Structural measures of work desirability, social welfare, and gender equity were used to explain differences in associations across countries.</p><p><strong>Results: </strong>The associations between social stratification, family roles, and heavy drinking varied across gender and countries. A country's social welfare system was associated with heavy drinking only among women. Women in countries with a strong social welfare system, such as Nordic countries, tended to drink more heavily if employed, having lower formal education, and a non-traditional family role. In countries with weak social welfare systems or work desirability, heavy drinking was associated with high education, while effects of family roles and employment were small.</p><p><strong>Conclusions: </strong>It appeared that the social welfare system and gender equity of a country determines to a large extent how education, employment, and family roles are associated with heavy drinking.</p>","PeriodicalId":7689,"journal":{"name":"Alcohol and alcoholism (Oxford, Oxfordshire). Supplement","volume":"41 1","pages":"i37-46"},"PeriodicalIF":0.0,"publicationDate":"2006-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/alcalc/agl074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26299893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 86
ESBRA 2005. Abstracts of the 10th Congress of the European Society for Biomedical Research on Alcoholism, Canterbury, United Kingdom, 4-7 September 2005. ESBRA 2005。欧洲酒精中毒生物医学研究学会第十届大会摘要,2005年9月4日至7日,英国坎特伯雷。
{"title":"ESBRA 2005. Abstracts of the 10th Congress of the European Society for Biomedical Research on Alcoholism, Canterbury, United Kingdom, 4-7 September 2005.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7689,"journal":{"name":"Alcohol and alcoholism (Oxford, Oxfordshire). Supplement","volume":"40 1","pages":"i1-63"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25606189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Korsakoff's psychosis in Scotland: evidence for increased prevalence and regional variation. 苏格兰的科萨科夫精神病:患病率增加和地区差异的证据。
Pub Date : 2000-05-01 DOI: 10.1093/ALCALC/35.SUPPLEMENT_1.8
I. Smith, Ciara Flanigan
Surveys of new long-stay mental hospital patients in Scotland find that 9% have a diagnosis of alcohol-related brain damage, mainly Korsakoff's psychosis (KP), whereas the rate was 5% in the old long-stay patients. The national hospital database shows a rise in rates of KP in figures for discharge diagnosis and for diagnosis of hospital residents during the past three decades. There is an argument for more specialized provision given the significance of this group of patients.
对苏格兰精神病院新住院的长期病人的调查发现,9%的人被诊断为与酒精有关的脑损伤,主要是科萨科夫精神病(KP),而在老的长期住院病人中,这一比例为5%。国家医院数据库显示,在过去三十年中,出院诊断率和住院患者诊断率的KP率有所上升。考虑到这组患者的重要性,有一种观点认为应该提供更专业的服务。
{"title":"Korsakoff's psychosis in Scotland: evidence for increased prevalence and regional variation.","authors":"I. Smith, Ciara Flanigan","doi":"10.1093/ALCALC/35.SUPPLEMENT_1.8","DOIUrl":"https://doi.org/10.1093/ALCALC/35.SUPPLEMENT_1.8","url":null,"abstract":"Surveys of new long-stay mental hospital patients in Scotland find that 9% have a diagnosis of alcohol-related brain damage, mainly Korsakoff's psychosis (KP), whereas the rate was 5% in the old long-stay patients. The national hospital database shows a rise in rates of KP in figures for discharge diagnosis and for diagnosis of hospital residents during the past three decades. There is an argument for more specialized provision given the significance of this group of patients.","PeriodicalId":7689,"journal":{"name":"Alcohol and alcoholism (Oxford, Oxfordshire). Supplement","volume":"30 1","pages":"8-10"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85853180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Wernicke-Korsakoff syndrome in head injury: a missed insult. 韦尼克-科萨科夫综合征在头部损伤:一个错失的侮辱。
Pub Date : 2000-05-01 DOI: 10.1093/ALCALC/35.SUPPLEMENT_1.16
R. K. Ferguson, I. Soryal, B. Pentland
A survey of the use of thiamine in patients at risk from Wernicke-Korsakoff syndrome (WKS) in Scottish specialist neurosurgical units, and a 2-year retrospective study of 218 at-risk patients admitted to a regional neurosurgical unit with a head injury were undertaken. Although responses to the survey indicated otherwise, the study revealed that there was no consistent practice regarding thiamine administration. Overall, 20.6% of patients received thiamine, with an alcohol history being the only factor correlating with thiamine administration. Of known alcoholics and heavy drinkers, 56.1% and 26.2% respectively received thiamine as in-patients; 44.5% of patients received additional carbohydrate loads in the form of i.v. dextrose or parenteral nutrition, but only 28.9% of these received thiamine as well. Although the actual thiamine status of these patients was not known, given the difficulties of diagnosing WKS in the presence of a head injury, the conclusion is that written protocols are needed in units to ensure that head injury patients at risk of WKS receive appropriate thiamine treatment or prophylaxis.
对苏格兰专科神经外科单位中有患wernickke - korsakoff综合征(WKS)危险的患者使用硫胺素的情况进行了调查,并对218名区域神经外科单位中头部受伤的高危患者进行了为期2年的回顾性研究。尽管对调查的回应表明并非如此,但研究表明,在硫胺素的施用方面没有一致的做法。总体而言,20.6%的患者接受了硫胺素治疗,酒精史是唯一与硫胺素治疗相关的因素。在已知的酗酒者和重度饮酒者中,住院患者分别有56.1%和26.2%接受了硫胺素治疗;44.5%的患者以静脉注射葡萄糖或肠外营养的形式接受额外的碳水化合物负荷,但其中只有28.9%的患者同时接受硫胺素。虽然这些患者的实际硫胺素状况尚不清楚,但考虑到在出现头部损伤的情况下诊断WKS的困难,结论是单位需要书面协议,以确保有WKS风险的头部损伤患者接受适当的硫胺素治疗或预防。
{"title":"Wernicke-Korsakoff syndrome in head injury: a missed insult.","authors":"R. K. Ferguson, I. Soryal, B. Pentland","doi":"10.1093/ALCALC/35.SUPPLEMENT_1.16","DOIUrl":"https://doi.org/10.1093/ALCALC/35.SUPPLEMENT_1.16","url":null,"abstract":"A survey of the use of thiamine in patients at risk from Wernicke-Korsakoff syndrome (WKS) in Scottish specialist neurosurgical units, and a 2-year retrospective study of 218 at-risk patients admitted to a regional neurosurgical unit with a head injury were undertaken. Although responses to the survey indicated otherwise, the study revealed that there was no consistent practice regarding thiamine administration. Overall, 20.6% of patients received thiamine, with an alcohol history being the only factor correlating with thiamine administration. Of known alcoholics and heavy drinkers, 56.1% and 26.2% respectively received thiamine as in-patients; 44.5% of patients received additional carbohydrate loads in the form of i.v. dextrose or parenteral nutrition, but only 28.9% of these received thiamine as well. Although the actual thiamine status of these patients was not known, given the difficulties of diagnosing WKS in the presence of a head injury, the conclusion is that written protocols are needed in units to ensure that head injury patients at risk of WKS receive appropriate thiamine treatment or prophylaxis.","PeriodicalId":7689,"journal":{"name":"Alcohol and alcoholism (Oxford, Oxfordshire). Supplement","volume":"44 1","pages":"16-8"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80759815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Wernicke-Korsakoff syndrome and the use of brain imaging. Wernicke-Korsakoff综合征和脑成像的使用。
Pub Date : 2000-05-01 DOI: 10.1093/ALCALC/35.SUPPLEMENT_1.21
Pramod Jauhar, D. Montaldi
The proportion of patients with Korsakoff psychosis (KP) who have a history of Wernicke's encephalopathy is smaller in recent studies compared to previous studies. Neuropsychological tests, magnetic resonance imaging (MRI), and single photon emission computed tomography were conducted in eight patients with KP, only four of whom had had a documented Wernicke episode. All subjects showed amnesia without intellectual deterioration. MRI abnormalities were seen in each group to the same extent (atrophy of mammillary bodies, to a less extent thalamus and some generalized gyral atrophy). No MRI measure differentiated the groups. Cerebral blood flow showed reduction of flow to the anterior temporal regions bilaterally, extending to the parietal lobes, to the same degree in each group. Despite the small number of patients examined, the study supports the belief that patients with an insidious onset of KP have the same pathology as those with classical Wernicke-Korsakoff syndrome. This raises the question of whether episodes of alcohol withdrawal without adequate thiamine protection result in occasionally subclinical Wernicke's events, followed by a subsequently diagnosable KP.
在最近的研究中,有韦尼克脑病史的Korsakoff精神病(KP)患者的比例比以前的研究要小。对8例KP患者进行了神经心理测试、磁共振成像(MRI)和单光子发射计算机断层扫描,其中只有4例有记录的韦尼克发作。所有受试者均表现出健忘症,但没有智力退化。各组MRI异常程度相同(乳状体萎缩,丘脑及部分广泛性脑回萎缩程度较轻)。没有MRI测量区分各组。脑血流显示双侧颞叶前部血流减少,并延伸至顶叶,两组血流减少程度相同。尽管检查的患者数量很少,但该研究支持这样一种信念,即潜伏性KP患者与经典韦尼克-科萨科夫综合征患者具有相同的病理。这就提出了一个问题,即在没有充分硫胺素保护的情况下,酒精戒断是否会导致偶尔的亚临床韦尼克事件,随后会出现可诊断的KP。
{"title":"Wernicke-Korsakoff syndrome and the use of brain imaging.","authors":"Pramod Jauhar, D. Montaldi","doi":"10.1093/ALCALC/35.SUPPLEMENT_1.21","DOIUrl":"https://doi.org/10.1093/ALCALC/35.SUPPLEMENT_1.21","url":null,"abstract":"The proportion of patients with Korsakoff psychosis (KP) who have a history of Wernicke's encephalopathy is smaller in recent studies compared to previous studies. Neuropsychological tests, magnetic resonance imaging (MRI), and single photon emission computed tomography were conducted in eight patients with KP, only four of whom had had a documented Wernicke episode. All subjects showed amnesia without intellectual deterioration. MRI abnormalities were seen in each group to the same extent (atrophy of mammillary bodies, to a less extent thalamus and some generalized gyral atrophy). No MRI measure differentiated the groups. Cerebral blood flow showed reduction of flow to the anterior temporal regions bilaterally, extending to the parietal lobes, to the same degree in each group. Despite the small number of patients examined, the study supports the belief that patients with an insidious onset of KP have the same pathology as those with classical Wernicke-Korsakoff syndrome. This raises the question of whether episodes of alcohol withdrawal without adequate thiamine protection result in occasionally subclinical Wernicke's events, followed by a subsequently diagnosable KP.","PeriodicalId":7689,"journal":{"name":"Alcohol and alcoholism (Oxford, Oxfordshire). Supplement","volume":"1 1","pages":"21-3"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81077143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Prevention and treatment of Wernicke-Korsakoff syndrome. Wernicke-Korsakoff综合征的防治。
Pub Date : 2000-05-01 DOI: 10.1093/ALCALC/35.SUPPLEMENT_1.19
C. Cook
Wernicke's encephalopathy (WE) is both common and associated with high morbidity and mortality and yet there is evidence that appropriate and effective prophylaxis and treatment are often not given. Effective treatment and prophylaxis may only be achieved by use of parenteral vitamin supplements, since oral supplements are not absorbed in significant amounts. Although there are rare anaphylactoid reactions associated with the use of parenteral thiamine preparations, the risks and consequences of inadequate prophylaxis and treatment, in appropriately targeted groups of patients, are far greater. It is therefore proposed that all in-patient alcohol withdrawal should be covered by prophylactic use of parenteral thiamine, that there should be a low threshold for making a presumptive diagnosis of WE, and that there is a need for guidelines to assist physicians in appropriate management of this common clinical problem.
韦尼克脑病(WE)既常见又与高发病率和死亡率相关,但有证据表明,通常没有给予适当和有效的预防和治疗。有效的治疗和预防只能通过使用肠外维生素补充剂来实现,因为口服补充剂不能大量吸收。虽然与使用肠外硫胺素制剂相关的罕见类过敏反应,但在适当的目标患者群体中,预防和治疗不充分的风险和后果要大得多。因此,建议所有住院的戒酒患者都应预防性使用肠外硫胺素,对WE进行推定诊断应该有一个较低的阈值,并且需要有指导方针来帮助医生适当地管理这一常见的临床问题。
{"title":"Prevention and treatment of Wernicke-Korsakoff syndrome.","authors":"C. Cook","doi":"10.1093/ALCALC/35.SUPPLEMENT_1.19","DOIUrl":"https://doi.org/10.1093/ALCALC/35.SUPPLEMENT_1.19","url":null,"abstract":"Wernicke's encephalopathy (WE) is both common and associated with high morbidity and mortality and yet there is evidence that appropriate and effective prophylaxis and treatment are often not given. Effective treatment and prophylaxis may only be achieved by use of parenteral vitamin supplements, since oral supplements are not absorbed in significant amounts. Although there are rare anaphylactoid reactions associated with the use of parenteral thiamine preparations, the risks and consequences of inadequate prophylaxis and treatment, in appropriately targeted groups of patients, are far greater. It is therefore proposed that all in-patient alcohol withdrawal should be covered by prophylactic use of parenteral thiamine, that there should be a low threshold for making a presumptive diagnosis of WE, and that there is a need for guidelines to assist physicians in appropriate management of this common clinical problem.","PeriodicalId":7689,"journal":{"name":"Alcohol and alcoholism (Oxford, Oxfordshire). Supplement","volume":"52 1","pages":"19-20"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74000867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 47
Alcohol-related brain damage--the concerns of the Mental Welfare Commission. 与酒精有关的脑损伤——精神福利委员会的关注。
Pub Date : 2000-05-01 DOI: 10.1093/ALCALC/35.SUPPLEMENT_1.11
A. Jacques
Scottish mental health legislation permits 'guardianship' for certain mentally impaired individuals, which imposes a requirement on place of residence, access and attendance at specified services for treatment and rehabilitation. The use of guardianship for alcohol-related brain damage increased steeply in the years 1993-1998. Possible explanations include: (1) increased prevalence or diagnosis of these conditions; (2) reduction of hospital beds; (3) a trend towards diminishing family and social support; (4) increased social work involvement in caring for such individuals; (5) increased consideration of the use of guardianship; (6) new private residential services; (7) lack of interest in the condition by existing services. There have been legal and clinical concerns about such individuals under guardianship relating to quality of ongoing clinical assessment, need for specific treatment and for the management of associated psychiatric illness, issues over control of drinking and control of personal finances, uncertainty over the use of restraint, and need for programmes helping the individual's progress towards independent living.
苏格兰精神健康立法允许对某些精神残疾者进行"监护",这对居住地点、获得和参加特定的治疗和康复服务提出了要求。1993-1998年期间,对与酒精有关的脑损伤进行监护的情况急剧增加。可能的解释包括:(1)这些疾病的患病率或诊断增加;(2)减少医院床位;(3)家庭和社会支持的减少趋势;(4)增加社会工作参与照顾这类人士;(五)增加对监护使用的考虑;(六)新建私人住宅服务;(7)现有服务机构对该状况不感兴趣。对于这些受监护的人,存在着法律和临床方面的关切,涉及正在进行的临床评估的质量、具体治疗的需要和相关精神疾病的管理、控制饮酒和控制个人财务的问题、使用约束的不确定性,以及帮助个人走向独立生活的方案的需要。
{"title":"Alcohol-related brain damage--the concerns of the Mental Welfare Commission.","authors":"A. Jacques","doi":"10.1093/ALCALC/35.SUPPLEMENT_1.11","DOIUrl":"https://doi.org/10.1093/ALCALC/35.SUPPLEMENT_1.11","url":null,"abstract":"Scottish mental health legislation permits 'guardianship' for certain mentally impaired individuals, which imposes a requirement on place of residence, access and attendance at specified services for treatment and rehabilitation. The use of guardianship for alcohol-related brain damage increased steeply in the years 1993-1998. Possible explanations include: (1) increased prevalence or diagnosis of these conditions; (2) reduction of hospital beds; (3) a trend towards diminishing family and social support; (4) increased social work involvement in caring for such individuals; (5) increased consideration of the use of guardianship; (6) new private residential services; (7) lack of interest in the condition by existing services. There have been legal and clinical concerns about such individuals under guardianship relating to quality of ongoing clinical assessment, need for specific treatment and for the management of associated psychiatric illness, issues over control of drinking and control of personal finances, uncertainty over the use of restraint, and need for programmes helping the individual's progress towards independent living.","PeriodicalId":7689,"journal":{"name":"Alcohol and alcoholism (Oxford, Oxfordshire). Supplement","volume":"25 1","pages":"11-5"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82876810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Mechanisms of vitamin deficiency in chronic alcohol misusers and the development of the Wernicke-Korsakoff syndrome. 慢性酒精滥用者维生素缺乏的机制和Wernicke-Korsakoff综合征的发展。
Pub Date : 2000-05-01 DOI: 10.1093/ALCALC/35.SUPPLEMENT_1.2
A. Thomson
The classic signs of vitamin deficiency only occur in states of extreme depletion and are unreliable indicators for early treatment or prophylaxis of alcoholic patients at risk. Post-mortem findings demonstrate that thiamine (vitamin B1) deficiency sufficient to cause irreversible brain damage is not diagnosed ante mortem in 80-90% of these patients. The causes of vitamin deficiency are reviewed with special attention to the inhibition of oral thiamine hydrochloride absorption in man caused by malnutrition present in alcoholic patients or by the direct effects of ethanol on intestinal transport. As the condition of the patient misusing alcohol progresses, damage to brain, liver, gastrointestinal tract, and pancreas continue (with other factors discussed) to further compromise the patient. Decreased intake, malabsorption, reduced storage, and impaired utilization further reduce the chances of unaided recovery. Failure of large oral doses of thiamine hydrochloride to provide an effective treatment for Wernicke's encephalopathy emphasizes the need for adequate and rapid replacement of depleted brain thiamine levels by repeated parenteral therapy in adequate doses.
维生素缺乏症的典型症状只发生在极度缺乏维生素的状态,并不是早期治疗或高危酗酒患者预防的可靠指标。尸检结果表明,在这些患者中,80-90%的人在死前没有诊断出足以造成不可逆脑损伤的硫胺素(维生素B1)缺乏。对维生素缺乏的原因进行了综述,特别关注酒精患者营养不良或乙醇对肠道运输的直接影响引起的口服硫胺素盐酸盐吸收的抑制。随着患者滥用酒精病情的发展,对脑、肝、胃肠道和胰腺的损害继续(并讨论其他因素)进一步损害患者。摄入减少、吸收不良、储存减少和利用受损进一步降低了独立恢复的机会。大剂量的口服硫胺素盐酸盐不能有效治疗韦尼克脑病,这强调了需要通过适当剂量的反复肠外治疗来充分和快速地替代耗尽的脑硫胺素水平。
{"title":"Mechanisms of vitamin deficiency in chronic alcohol misusers and the development of the Wernicke-Korsakoff syndrome.","authors":"A. Thomson","doi":"10.1093/ALCALC/35.SUPPLEMENT_1.2","DOIUrl":"https://doi.org/10.1093/ALCALC/35.SUPPLEMENT_1.2","url":null,"abstract":"The classic signs of vitamin deficiency only occur in states of extreme depletion and are unreliable indicators for early treatment or prophylaxis of alcoholic patients at risk. Post-mortem findings demonstrate that thiamine (vitamin B1) deficiency sufficient to cause irreversible brain damage is not diagnosed ante mortem in 80-90% of these patients. The causes of vitamin deficiency are reviewed with special attention to the inhibition of oral thiamine hydrochloride absorption in man caused by malnutrition present in alcoholic patients or by the direct effects of ethanol on intestinal transport. As the condition of the patient misusing alcohol progresses, damage to brain, liver, gastrointestinal tract, and pancreas continue (with other factors discussed) to further compromise the patient. Decreased intake, malabsorption, reduced storage, and impaired utilization further reduce the chances of unaided recovery. Failure of large oral doses of thiamine hydrochloride to provide an effective treatment for Wernicke's encephalopathy emphasizes the need for adequate and rapid replacement of depleted brain thiamine levels by repeated parenteral therapy in adequate doses.","PeriodicalId":7689,"journal":{"name":"Alcohol and alcoholism (Oxford, Oxfordshire). Supplement","volume":"30 1","pages":"2-7"},"PeriodicalIF":0.0,"publicationDate":"2000-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88111890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 204
Consensus Conference on the Neuropharmacology of Alcohol Dependence and the Role of Pharmacotherapy in its Treatment. Amsterdam, The Netherlands, September 16-17, 1994. 酒精依赖的神经药理学和药物治疗在其治疗中的作用的共识会议。阿姆斯特丹,荷兰,1994年9月16-17日。
{"title":"Consensus Conference on the Neuropharmacology of Alcohol Dependence and the Role of Pharmacotherapy in its Treatment. Amsterdam, The Netherlands, September 16-17, 1994.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7689,"journal":{"name":"Alcohol and alcoholism (Oxford, Oxfordshire). Supplement","volume":"31 1","pages":"1-87"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20922579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1