首页 > 最新文献

Biotechnology (Reading, Mass.)最新文献

英文 中文
Polyethers. 聚醚。
Biotechnology (Reading, Mass.)
Pub Date : 1995-01-01 DOI: 10.1016/b978-0-7506-9095-9.50025-3
A W Birch, J A Robinson
{"title":"Polyethers.","authors":"A W Birch, J A Robinson","doi":"10.1016/b978-0-7506-9095-9.50025-3","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9095-9.50025-3","url":null,"abstract":"","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19662813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Chloramphenicol. 氯霉素。
Biotechnology (Reading, Mass.)
Pub Date : 1995-01-01 DOI: 10.1016/b978-0-7506-9095-9.50028-9
L C Vining, C Stuttard
{"title":"Chloramphenicol.","authors":"L C Vining, C Stuttard","doi":"10.1016/b978-0-7506-9095-9.50028-9","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9095-9.50028-9","url":null,"abstract":"","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/b978-0-7506-9095-9.50028-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19662815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Peptidolactones. 肽内酯。
Biotechnology (Reading, Mass.)
Pub Date : 1995-01-01 DOI: 10.1016/b978-0-7506-9095-9.50013-7
U Keller
{"title":"Peptidolactones.","authors":"U Keller","doi":"10.1016/b978-0-7506-9095-9.50013-7","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9095-9.50013-7","url":null,"abstract":"","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19662887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Glycopeptides. 糖肤。
Biotechnology (Reading, Mass.)
Pub Date : 1995-01-01 DOI: 10.1016/b978-0-7506-9095-9.50017-4
M J Zmijewski, J T Fayerman
{"title":"Glycopeptides.","authors":"M J Zmijewski, J T Fayerman","doi":"10.1016/b978-0-7506-9095-9.50017-4","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9095-9.50017-4","url":null,"abstract":"","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19662891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Lantibiotics. Lantibiotics。
Biotechnology (Reading, Mass.)
Pub Date : 1995-01-01 DOI: 10.1016/b978-0-7506-9095-9.50018-6
M J Gasson
{"title":"Lantibiotics.","authors":"M J Gasson","doi":"10.1016/b978-0-7506-9095-9.50018-6","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9095-9.50018-6","url":null,"abstract":"","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19662892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Mechanism-based screening for the discovery of novel antifungals. 基于机制的筛选发现新型抗真菌药物。
Biotechnology (Reading, Mass.)
Pub Date : 1994-01-01 DOI: 10.1016/b978-0-7506-9003-4.50012-5
D R Kirsch, B J DiDomenico
{"title":"Mechanism-based screening for the discovery of novel antifungals.","authors":"D R Kirsch, B J DiDomenico","doi":"10.1016/b978-0-7506-9003-4.50012-5","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9003-4.50012-5","url":null,"abstract":"","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/b978-0-7506-9003-4.50012-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18749597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Mechanism-based screens in the discovery of chemotherapeutic antibacterials. 基于机制的筛选在发现化疗抗菌素中的作用。
Biotechnology (Reading, Mass.)
Pub Date : 1994-01-01 DOI: 10.1016/b978-0-7506-9003-4.50014-9
S Kadam

Numerous assays have been developed over the last 40 years for the detection of novel antibacterial metabolites. I have discussed many of the successful strategies and suggested some potential targets. Although the trend toward mechanism-based assays is relatively recent, it is clear that they have had a profound impact on screening in drug discovery. Often a mechanism-based assay requires construction of specific strains and verification of the antibacterial role of the selected target. Since the conception and development of a mechanism-based screen depends upon knowledge of the specific target and perhaps a compound that affects that target, it is implicit that mode of action studies on compounds discovered through random screening may subsequently lead to new mechanistic assays. While serendipity continues to play a crucial role in any screen, target-directed assays appear to be a worthwhile approach in antibacterial screening.

在过去的40年里，已经开发了许多检测方法来检测新型抗菌代谢物。我已经讨论了许多成功的策略，并提出了一些潜在的目标。虽然以机制为基础的分析的趋势是相对较新的，但很明显，它们对药物发现的筛选产生了深远的影响。通常，基于机制的分析需要构建特定菌株并验证所选目标的抗菌作用。由于基于机制的筛选的概念和发展取决于对特定靶点的了解，可能还取决于影响该靶点的化合物，因此，通过随机筛选发现的化合物的作用模式研究可能随后导致新的机制分析。虽然意外发现在任何筛选中都继续发挥着至关重要的作用，但靶向检测似乎是抗菌筛选中有价值的方法。
{"title":"Mechanism-based screens in the discovery of chemotherapeutic antibacterials.","authors":"S Kadam","doi":"10.1016/b978-0-7506-9003-4.50014-9","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9003-4.50014-9","url":null,"abstract":"<p><p>Numerous assays have been developed over the last 40 years for the detection of novel antibacterial metabolites. I have discussed many of the successful strategies and suggested some potential targets. Although the trend toward mechanism-based assays is relatively recent, it is clear that they have had a profound impact on screening in drug discovery. Often a mechanism-based assay requires construction of specific strains and verification of the antibacterial role of the selected target. Since the conception and development of a mechanism-based screen depends upon knowledge of the specific target and perhaps a compound that affects that target, it is implicit that mode of action studies on compounds discovered through random screening may subsequently lead to new mechanistic assays. While serendipity continues to play a crucial role in any screen, target-directed assays appear to be a worthwhile approach in antibacterial screening.</p>","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/b978-0-7506-9003-4.50014-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18749599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Potential of fungi in the discovery of novel, low-molecular weight pharmaceuticals. 真菌在发现新型低分子量药物方面的潜力。
Biotechnology (Reading, Mass.)
Pub Date : 1994-01-01 DOI: 10.1016/b978-0-7506-9003-4.50009-5
M M Dreyfuss, I H Chapela
{"title":"Potential of fungi in the discovery of novel, low-molecular weight pharmaceuticals.","authors":"M M Dreyfuss,&nbsp;I H Chapela","doi":"10.1016/b978-0-7506-9003-4.50009-5","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9003-4.50009-5","url":null,"abstract":"","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/b978-0-7506-9003-4.50009-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18749608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 319
The discovery of drugs from higher plants. 从高等植物中发现药物。
Biotechnology (Reading, Mass.)
Pub Date : 1994-01-01 DOI: 10.1016/b978-0-7506-9003-4.50010-1
A D Kinghorn
{"title":"The discovery of drugs from higher plants.","authors":"A D Kinghorn","doi":"10.1016/b978-0-7506-9003-4.50010-1","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9003-4.50010-1","url":null,"abstract":"","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/b978-0-7506-9003-4.50010-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18749609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 42
Modern spectroscopic approaches to structure elucidation. 结构解析的现代光谱学方法。
Biotechnology (Reading, Mass.)
Pub Date : 1994-01-01 DOI: 10.1016/b978-0-7506-9003-4.50020-4
O D Hensens
{"title":"Modern spectroscopic approaches to structure elucidation.","authors":"O D Hensens","doi":"10.1016/b978-0-7506-9003-4.50020-4","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9003-4.50020-4","url":null,"abstract":"","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18749607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
类型
全部 化学•材料 生命科学 医学 物理 工程技术 环境•农林 材料科学 地球科学 法学 管理学 化学 环境科学与生态学 计算机科学 教育学 经济学 农林科学 人文科学 生物学 数学 物理与天体物理 心理学 综合性期刊 其他 工业工程 理学 历史学 农学 文学 信息工程
数据库
全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley
期刊
Biotechnology (Reading, Mass.)
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
﹀
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们：info@booksci.cn
Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1