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Epilepsy research. Supplement最新文献

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Active role of cortical inhibition in the development of generalized epilepsy with spike-and-wave discharges: evidence from electrophysiological, microiontophoretic and simulation studies. 皮层抑制在伴随峰波放电的全身性癫痫发展中的积极作用:来自电生理、微离子电泳和模拟研究的证据。
Epilepsy research. Supplement
Pub Date : 1992-01-01 DOI: 10.1016/b978-0-444-89710-7.50021-5
G Kostopoulos, G Antoniadis
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引用次数: 7
The role of NMDA receptors in in vitro epileptogenesis. NMDA受体在体外癫痫发生中的作用。
Epilepsy research. Supplement
Pub Date : 1992-01-01 DOI: 10.1016/b978-0-444-89710-7.50025-2
W A Wilson, S Stasheff, S Swartzwelder, S Clark, W W Anderson
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引用次数: 5
Granule cell inhibition and the activity of hilar neurons. 颗粒细胞的抑制作用与肺门神经元的活性。
Epilepsy research. Supplement
Pub Date : 1992-01-01
U Misgeld, M Bijak, H Brunner

Electrophysiological data from guinea pig hippocampal slices together with available morphological information about the dentate granule cell--hilar neuron circuitry strongly suggest that hilar neurons largely contribute to postsynaptic inhibition of granule cells. As in hippocampal pyramidal cells, inhibitory postsynaptic potentials in granule cells are either due to an increase in Cl-conductance or to an increase in K-conductance. It is therefore further suggested that hilar neurons inhibiting granule cells belong to at least two functionally distinct groups, those generating Cl-dependent and those generating K-dependent IPSPs. The presumed inhibitory action of hilar neurons is underlined by experiments applying pharmacological tools to suppress or enhance hilar neuron activity. Hyperpolarization of hilar neurons by the presumed GABAB-agonist (-)baclofen is associated with disinhibition of granule cells. If hilar neurons are activated by 4-amino-pyridine or picrotoxin to discharge in repetitive bursts, granule cells display repetitively occurring inhibitory postsynaptic potentials.

来自豚鼠海马切片的电生理数据以及有关齿状颗粒细胞-门门神经元回路的现有形态学信息强烈表明，门门神经元在很大程度上有助于颗粒细胞的突触后抑制。与海马锥体细胞一样，颗粒细胞的抑制性突触后电位要么是由于cl -电导增加，要么是由于k -电导增加。因此，进一步表明门脉神经元抑制颗粒细胞至少属于两个功能不同的组，即产生cl依赖性ipsp的组和产生k依赖性ipsp的组。通过应用药理学工具抑制或增强门门神经元活动的实验，强调了假定的门门神经元的抑制作用。假定gabab激动剂(-)巴氯芬的门部神经元的超极化与颗粒细胞的去抑制有关。如果肝门神经元被4-氨基吡啶或微毒素激活以重复爆发放电，颗粒细胞表现出重复发生的抑制性突触后电位。
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引用次数: 0
Synaptic plasticity and activity-induced gene expression: will molecular neurobiology provide all the answers? 突触可塑性和活动诱导的基因表达:分子神经生物学能提供所有答案吗?
Epilepsy research. Supplement
Pub Date : 1992-01-01
A J Tobin
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引用次数: 0
Benign Localized and Generalized Epilepsies of Early Childhood. Symposium proceedings. Bad Kreuznach, Germany, September 1990. 幼儿良性局部和全身性癫痫。研讨会论文集。1990年9月，德国Bad Kreuznach。
Epilepsy research. Supplement
Pub Date : 1992-01-01
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引用次数: 0
Changes in the levels of glutamate and related amino acids in the intact and decorticated rat neostriatum during various conditions associated with convulsions. 在与惊厥相关的各种情况下，完整和去皮大鼠新纹状体中谷氨酸和相关氨基酸水平的变化。
Epilepsy research. Supplement
Pub Date : 1992-01-01 DOI: 10.1016/b978-0-444-89710-7.50032-x
B A Engelsen, F Fonnum, K Furset
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引用次数: 1
Depth electrodes. 深度电极。
Epilepsy research. Supplement
Pub Date : 1992-01-01
S S Spencer
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引用次数: 0
Subdural electrodes in the presurgical evaluation for surgery of epilepsy. 硬膜下电极在癫痫手术术前评价中的应用。
Epilepsy research. Supplement
Pub Date : 1992-01-01
H Lüders, I Awad, R Burgess, E Wyllie, P Van Ness

This article gives first an overview of the advantages and disadvantages of electrodes of progressively greater invasiveness used in the evaluation of patients who are candidates for surgery of epilepsy. The following sections discuss the design of subdural electrodes, their clinical indications, and the relative advantages and disadvantages of subdural electrodes when compared with other invasive techniques.

本文首先概述了用于评估癫痫手术候选患者的逐渐增大的侵入性电极的优点和缺点。下面将讨论硬膜下电极的设计、临床适应症，以及与其他侵入性技术相比硬膜下电极的优缺点。
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引用次数: 0
Different approaches to resective epilepsy surgery: standard and tailored. 不同的方法切除癫痫手术:标准和量身定制。
Epilepsy research. Supplement
Pub Date : 1992-01-01
G A Ojemann

Intra-operative approaches to resective surgery for medically intractable epilepsy, especially cases involving temporal lobes, vary from anatomically standardized operations to those tailored to the location of epileptogenic zones and eloquent areas in individual subjects. The choice of approaches seems to depend on different views of the variability in epileptogenic zones and eloquent areas and on the reliability of identifying these areas intraoperatively, including the value of interictal epileptic activity. Evidence relating to these issues is reviewed. Although the choice of an intra-operative approach has a major effect on the risks and costs of the evaluation for epilepsy surgery, with higher risks and costs for approaches using standard operations or extra-operative recording, no controlled study has compared the approaches. Indeed, the reported outcome for optimal candidates for each approach is nearly identical, providing little justification for use of approaches with higher risks and costs in all patients.

对于医学上难治性癫痫，特别是涉及颞叶的病例，术中切除手术的方法各不相同，从解剖学上的标准化手术到针对个体受试者的癫痫发生区和功能区定位的手术。方法的选择似乎取决于对癫痫发生区和功能区可变性的不同看法，以及术中识别这些区域的可靠性，包括癫痫发作间期活动的价值。审查了与这些问题有关的证据。虽然术中入路的选择对癫痫手术评估的风险和成本有重要影响，但采用标准操作或术外记录的入路风险和成本更高，没有对照研究对这两种入路进行比较。事实上，每种方法的最佳候选者的报告结果几乎相同，几乎没有理由在所有患者中使用风险和成本较高的方法。
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引用次数: 0
Role of the neuropsychological evaluation and the intracarotid sodium amobarbital procedure in the surgical treatment for epilepsy. 神经心理学评价及颈动脉内阿莫巴比妥钠在癫痫手术治疗中的作用。
Epilepsy research. Supplement
Pub Date : 1992-01-01
R Rausch
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引用次数: 0
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