Pub Date : 1994-01-01DOI: 10.1201/9781003067245-14
C. Riccardi, E. Ayroldi, L. Cannarile, D. Delfino, F. D’Adamio, L. D’Adamio, G. Migliorati
{"title":"Studies on NK cell precursors in mice.","authors":"C. Riccardi, E. Ayroldi, L. Cannarile, D. Delfino, F. D’Adamio, L. D’Adamio, G. Migliorati","doi":"10.1201/9781003067245-14","DOIUrl":"https://doi.org/10.1201/9781003067245-14","url":null,"abstract":"","PeriodicalId":77171,"journal":{"name":"Immunology series","volume":"61 1","pages":"125-31"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65952679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tumor rejection antigens of the chemically induced BALB/c Meth A sarcoma.","authors":"A. Deleo","doi":"10.1201/9781003067245-4","DOIUrl":"https://doi.org/10.1201/9781003067245-4","url":null,"abstract":"","PeriodicalId":77171,"journal":{"name":"Immunology series","volume":"61 1","pages":"31-6"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65952797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Santoni, A. Gismondi, F. Mainiero, G. Palmieri, S. Morrone, M. Milella, M. Piccoli, L. Frati
{"title":"Regulation and function of fibronectin receptors expressed by natural killer cells.","authors":"A. Santoni, A. Gismondi, F. Mainiero, G. Palmieri, S. Morrone, M. Milella, M. Piccoli, L. Frati","doi":"10.1201/9781003067245-7","DOIUrl":"https://doi.org/10.1201/9781003067245-7","url":null,"abstract":"","PeriodicalId":77171,"journal":{"name":"Immunology series","volume":"61 1","pages":"55-62"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65952815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K L Komschlies, T T Back, T A Gregorio, M E Gruys, G Damia, R H Wiltrout, C R Faltynek
{"title":"Effects of rhIL-7 on leukocyte subsets in mice: implications for antitumor activity.","authors":"K L Komschlies, T T Back, T A Gregorio, M E Gruys, G Damia, R H Wiltrout, C R Faltynek","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77171,"journal":{"name":"Immunology series","volume":"61 ","pages":"95-104"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19004974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
As described above, monocytes/macrophages from such diverse areas as the CNS, lungs, peripheral blood, cord blood, and liver are susceptible to infection by HIV-1 and may serve as reservoirs for transmitting the virus throughout the body. In contrast to lymphocytes, the chronic and low-level mode of infection that HIV-1 takes on within monocytes/macrophages allows these cells to contribute to persistent viral infection. Infection of these cells by HIV-1 can alter a variety of their immunological functions such as cytokine production, chemotaxis, accessory cell function, and microbicidal activity. Furthermore, macrophages and macrophage-related microglial cells in the brain and CSF are thought to play a critical role in the pathogenesis of CNS disease. Infection with HIV-1 in monocytes/macrophages is regulated in an autocrine manner by a panel of cytokines and other soluble factors. Most HIV-1 isolates exhibit specific tropism for monocytes/macrophages, lymphocytes, or, in some cases, both cell types; this phenomenon of tropism may be linked to structural variabilities between different isolates. While in vitro studies clearly demonstrate that the replicating cycle of HIV-1 in monocytes/macrophages differs from its replicating cycle in lymphocytes, elucidation of the role of monocyte/macrophages in mediating the severe immunosuppression characteristic of AIDS is far more from complete, and further investigation into the role of monocytes/macrophages in the immunopathogenesis of HIV-1 infection is necessary to design therapeutic approaches to control viral infection and disease progression.
{"title":"The macrophage and HIV-1.","authors":"W Z Ho, R Cherukuri, S D Douglas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>As described above, monocytes/macrophages from such diverse areas as the CNS, lungs, peripheral blood, cord blood, and liver are susceptible to infection by HIV-1 and may serve as reservoirs for transmitting the virus throughout the body. In contrast to lymphocytes, the chronic and low-level mode of infection that HIV-1 takes on within monocytes/macrophages allows these cells to contribute to persistent viral infection. Infection of these cells by HIV-1 can alter a variety of their immunological functions such as cytokine production, chemotaxis, accessory cell function, and microbicidal activity. Furthermore, macrophages and macrophage-related microglial cells in the brain and CSF are thought to play a critical role in the pathogenesis of CNS disease. Infection with HIV-1 in monocytes/macrophages is regulated in an autocrine manner by a panel of cytokines and other soluble factors. Most HIV-1 isolates exhibit specific tropism for monocytes/macrophages, lymphocytes, or, in some cases, both cell types; this phenomenon of tropism may be linked to structural variabilities between different isolates. While in vitro studies clearly demonstrate that the replicating cycle of HIV-1 in monocytes/macrophages differs from its replicating cycle in lymphocytes, elucidation of the role of monocyte/macrophages in mediating the severe immunosuppression characteristic of AIDS is far more from complete, and further investigation into the role of monocytes/macrophages in the immunopathogenesis of HIV-1 infection is necessary to design therapeutic approaches to control viral infection and disease progression.</p>","PeriodicalId":77171,"journal":{"name":"Immunology series","volume":"60 ","pages":"569-87"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19240276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of interferons in the therapy of melanoma.","authors":"J M Kirkwood","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77171,"journal":{"name":"Immunology series","volume":"61 ","pages":"239-50"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18524430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R C Bast, F Xu, Y Yu, J Crews, Y Argon, L Maier, Y Lidor, A Berchuck, C M Boyer
{"title":"Additive and synergistic interactions of monoclonal antibodies and immunotoxins reactive with breast and ovarian cancer.","authors":"R C Bast, F Xu, Y Yu, J Crews, Y Argon, L Maier, Y Lidor, A Berchuck, C M Boyer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77171,"journal":{"name":"Immunology series","volume":"61 ","pages":"23-30"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18908718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Immunity and cancer therapy: present status and future projections.","authors":"E Mihich","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77171,"journal":{"name":"Immunology series","volume":"61 ","pages":"293-310"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19004965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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