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Medical and pediatric oncology. Supplement最新文献

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Genetics of retinoblastoma: implications for other human cancers. 视网膜母细胞瘤的遗传学:对其他人类癌症的启示。
Medical and pediatric oncology. Supplement
Pub Date : 1996-01-01
D W Yandell, C Poremba
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引用次数: 0
Methodologic issues in the study of second malignant neoplasms and pregnancy outcomes. 二次恶性肿瘤与妊娠结局研究的方法学问题。
Medical and pediatric oncology. Supplement
Pub Date : 1996-01-01
L L Robison

For future studies of late effects, it will be necessary for investigators to consider methodologic issues carefully as a means of insuring the quality of research in this increasingly important area. Recognizing the advantages and limitations in univariate and multivariate analyses will help in selecting the best analytic approach. There are many methods for denoting risk. Selection of the method will often be dependent on study design, but should also be the one believed most effective for communicating the study results. There is little question there is a need for well-designed studies for second malignancies, especially those designed to evaluate late-occurring second cancer (i.e., in the second, third, and fourth decade following treatment). With the aging of the childhood cancer survivor population, questions regarding pregnancy issues are increasing. These questions range from those relating to fertility to others associated with mutagenesis. When considering studies of these late effects, it is important to recognize the need for selecting the most appropriate study design and statistical methods.

对于未来的晚期效应研究，研究人员有必要仔细考虑方法问题，以确保这一日益重要领域的研究质量。认识到单变量和多变量分析的优点和局限性将有助于选择最佳的分析方法。有许多表示风险的方法。方法的选择通常取决于研究设计，但也应该是被认为最有效地传达研究结果的方法。毫无疑问，有必要对第二种恶性肿瘤进行精心设计的研究，特别是那些旨在评估晚期发生的第二种癌症(即治疗后的第二、第三和第四个十年)的研究。随着儿童癌症幸存者人口的老龄化，有关怀孕问题的问题越来越多。这些问题的范围从与生育有关的问题到与诱变有关的其他问题。在考虑这些后期效应的研究时，重要的是要认识到选择最合适的研究设计和统计方法的必要性。
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引用次数: 0
Regulation of cellular proliferation effects on alteration of normal signaling pathways. 细胞增殖调控对正常信号通路改变的影响。
Medical and pediatric oncology. Supplement
Pub Date : 1996-01-01
D Malkin
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引用次数: 0
Cancer following irradiation in childhood and adolescence. 儿童和青少年辐照后的癌症。
Medical and pediatric oncology. Supplement
Pub Date : 1996-01-01
J D Boice

The child appears more sensitive than the adult to the carcinogenic effects of radiation for certain sites such as the breast and thyroid. However, there are few studies of persons who were exposed as children and adolescents who have been followed for 40 or 50 years into the adult ages. Thus, it is extremely important that follow-up studies of children continue to evaluate the lifetime cancer risk that might be related to radiation exposures in childhood.

对于某些部位，如乳房和甲状腺，儿童似乎比成人对辐射的致癌作用更敏感。然而，很少有关于儿童和青少年时期受辐射的人的研究，这些人被跟踪了40或50年，直到成年。因此，对儿童的后续研究继续评估可能与儿童时期辐射暴露有关的终身癌症风险是极其重要的。
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引用次数: 0
Function of topoisomerase II and the consequences of inhibition. 拓扑异构酶II的功能和抑制的后果。
Medical and pediatric oncology. Supplement
Pub Date : 1996-01-01 DOI: 10.1002/(SICI)1096-911X(1996)27:1+<12::AID-MPO3>3.0.CO;2-Q
S. Davies
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引用次数: 0
p53 tumor suppressor gene: implications for iatrogenic cancer and cancer therapy. P53肿瘤抑制基因:医源性癌症和癌症治疗的意义。
Medical and pediatric oncology. Supplement
Pub Date : 1996-01-01 DOI: 10.1002/(SICI)1096-911X(1996)27:1+<2::AID-MPO2>3.0.CO;2-Z
V. D. Benedetti, W. Bennett, M. Greenblatt, C. Harris
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引用次数: 5
Colorectal cancer: molecular genetic studies and their future clinical applications. 结直肠癌:分子遗传学研究及其未来临床应用。
Medical and pediatric oncology. Supplement
Pub Date : 1996-01-01 DOI: 10.1002/(SICI)1096-911X(1996)27:1+<35::AID-MPO7>3.0.CO;2-O
E. Fearon
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引用次数: 10
Function of topoisomerase II and the consequences of inhibition. 拓扑异构酶II的功能和抑制的后果。
Medical and pediatric oncology. Supplement
Pub Date : 1996-01-01
S M Davies
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引用次数: 0
p53 tumor suppressor gene: implications for iatrogenic cancer and cancer therapy. P53肿瘤抑制基因:医源性癌症和癌症治疗的意义。
Medical and pediatric oncology. Supplement
Pub Date : 1996-01-01
V De Benedetti, W P Bennett, M S Greenblatt, C C Harris
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引用次数: 0
Colorectal cancer: molecular genetic studies and their future clinical applications. 结直肠癌:分子遗传学研究及其未来临床应用。
Medical and pediatric oncology. Supplement
Pub Date : 1996-01-01
E R Fearon
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引用次数: 0
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