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An epidemiological profile of dysarthria incidence and assistive technology use in the living population of people with MND in Scotland 苏格兰MND患者中构音障碍发生率和辅助技术使用的流行病学概况
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2019-10-09 DOI: 10.1080/21678421.2019.1672748
E. Elliott, J. Newton, Phillipa Rewaj, Jenna M. Gregory, Lynda Tomarelli, Shuna Colville, S. Chandran, S. Pal
Abstract Objectives: People with motor neurone disease (pwMND) experience communication impairments due to speech and motor dysfunction. Communication support in the form of Augmentative and Alternative Communication (AAC) in conjunction with Assistive Technology (AT) access methods are available, however, variation in provision care pathways exists across Scotland. We conducted a baseline study of communication support for pwMND in Scotland to inform and improve future service provision. Methods : A cross-sectional population-based study was undertaken. Anonymised demographic and clinical phenotypic data for all pwMND in Scotland were extracted from the Care Audit Research Evaluation of MND (CARE-MND) platform, the National MND Register for Scotland. Additional information for AT loans was provided by the third sector charitable organization MND Scotland (MNDS). Results : In total, 371 pwMND were included, 43% of all pwMND were recorded as having impaired speech (recent ALSFRS-R score assessment 3) and 69% had been referred to Speech and Language Therapist (SLT) services, although there was variation in referral time from diagnosis date. AAC equipment had been acquired by 17.3% of all pwMND; most commonly iPads and the LightwriterTM speech generating device. Conclusions : Our data highlight a high prevalence of speech impairment in pwMND irrespective of the subtype diagnosis. We therefore recommend standardized care pathways and earlier access to coordinated SLT and Occupational Therapist services to enable prospective and personalized decision making. Our findings further highlight the need for qualitative research to understand the preferences and impact of such interventions from the perspective of the user and their communication partners.
摘要目的:运动神经元疾病(pwMND)患者由于言语和运动功能障碍而出现沟通障碍。以辅助和替代通信(AAC)形式的通信支持与辅助技术(AT)获取方法相结合是可用的,但是,苏格兰各地的提供护理途径存在差异。我们为苏格兰的pwMND进行了一项通信支持的基线研究,以告知和改善未来的服务提供。方法:进行了一项以人群为基础的横断面研究。苏格兰所有pwMND的匿名人口统计学和临床表型数据来自MND的护理审计研究评估(Care -MND)平台,即苏格兰国家MND登记册。第三部门慈善组织MND Scotland (MNDS)提供了AT贷款的其他信息。结果:共有371名pwMND被纳入,43%的pwMND被记录为有语言障碍(最近的ALSFRS-R评分评估3),69%的pwMND被转诊到言语和语言治疗师(SLT)服务,尽管转诊时间从诊断日期起有所不同。AAC设备占所有pwMND的17.3%;最常见的是ipad和LightwriterTM语音生成设备。结论:我们的数据强调了与亚型诊断无关的pwMND中语言障碍的高患病率。因此,我们建议标准化的护理途径和尽早获得协调的SLT和职业治疗师服务,以实现前瞻性和个性化的决策。我们的研究结果进一步强调了定性研究的必要性,以便从用户及其沟通伙伴的角度了解此类干预措施的偏好和影响。
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引用次数: 5
The Edinburgh cognitive and behavioral amyotrophic lateral sclerosis screen (ECAS): sensitivity in differentiating between ALS and Alzheimer’s disease in a Greek population 爱丁堡认知和行为肌萎缩侧索硬化症筛查(ECAS):在希腊人群中区分ALS和阿尔茨海默病的敏感性
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2019-08-30 DOI: 10.1080/21678421.2019.1655059
Panagiotis Kourtesis, F. Christidi, E. Margioti, Christina Demenega, M. Rentzos, Ioannis Evdokimidis, Sharon Abrahams
Abstract Objectives: (1) Adapt the ECAS into Greek, validate it in ALS patients and compare with the ALS-CBS. (2) Determine the sensitivity and specificity of ECAS in the differentiation between AD and non-demented ALS patients as compared with the ACE-III and mini-ACE. Methods: ALS patients (n = 28) were recruited and AD patients (n = 26) were matched in age, sex, and education with ALS patients (n = 24). The normative data were derived from a random sample of controls (n = 52). Bayes correlation analysis was conducted to examine convergent validity. Bayes t-test was performed to assess between groups’ differences. Receiver operating characteristics (ROC) curve analyses and area under the curve (AUC) were implemented to appraise the sensitivity and specificity in the differentiation between the AD and non-demented ALS patients. Results: The ECAS and its sub-scores in addition to the behavior interview demonstrated robust correlations with the ALS-CBS. Impairment in language and verbal fluency were the most prominent deficits in the ALS patients. The most frequently reported change was apathy. The ROC analysis demonstrated that the ECAS-ALS nonspecific score (comprising memory and visuospatial domains) is the most sensitive and specific in differentiating the AD from ALS patients. The other measures expressed high sensitivity, yet a poor specificity. Conclusions: The ECAS is a multi-purpose screening tool. The ECAS-ALS specific appraises the whole spectrum of the highly prevalent cognitive impairments in ALS. The ECAS-ALS nonspecific (memory and visuospatial) is a sensitive score to detect AD related deficits and is able to differentiate the AD from the non-demented ALS patients better than the ACE-III and mini-ACE.
【摘要】目的:(1)对ECAS进行希腊文改编,在ALS患者中进行验证,并与ALS- cbs进行比较。(2)对比ACE-III和mini-ACE,确定ECAS在区分AD与非痴呆性ALS患者中的敏感性和特异性。方法:招募ALS患者(n = 28), AD患者(n = 26)与ALS患者(n = 24)进行年龄、性别、文化程度匹配。标准数据来源于随机抽样的对照(n = 52)。采用贝叶斯相关分析检验收敛效度。采用贝叶斯t检验评估组间差异。采用受试者工作特征(ROC)曲线分析和曲线下面积(AUC)来评估区分AD与非痴呆性ALS患者的敏感性和特异性。结果:除行为访谈外,ECAS及其分项得分与ALS-CBS表现出稳健的相关性。语言障碍和语言流畅性是ALS患者最突出的缺陷。最常见的变化是冷漠。ROC分析表明,ECAS-ALS非特异性评分(包括记忆和视觉空间域)是区分AD和ALS患者最敏感和特异性的评分。其他方法的灵敏度较高,但特异性较差。结论:ECAS是一种多用途的筛查工具。ECAS-ALS特异性评估ALS中高度普遍的认知障碍的全谱。ECAS-ALS非特异性(记忆和视觉空间)评分是检测AD相关缺陷的敏感评分,能够比ACE-III和mini-ACE更好地区分AD与非痴呆性ALS患者。
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引用次数: 3
Preventive effect of coffee and tea on amyotrophic lateral sclerosis 咖啡和茶对肌萎缩侧索硬化症的预防作用
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2019-08-28 DOI: 10.1080/21678421.2019.1655058
T. Kawada
Pupillo et al. conducted a case-control study to verify the association between food intake and amyotrophic lateral sclerosis (ALS) (1). I have some comments about their findings with special reference to coffee and tea consumption, which are protective factors for ALS. The authors reported that odds ratios (ORs) (95% confidence intervals [CIs]) of coffee and tea 0.29 (0.14–0.60). Beghi et al. also conducted a hospital-based case-control study to investigate the association between coffee intake and ALS (2). They set three controls, and ORs of current coffee drinkers for ALS significantly decreased. This finding supports preventive effect of coffee intake on ALS risk, although causal association should be verified by longitudinal and interventional studies. Relating to the causal association, Fondell et al. conducted a pooled analysis of prospective studies to examine the association between consumption of caffeine, coffee and tea and risk of ALS (3). ALS events were defined as incidence or death. Adjusted relative risk (95% CI) of highest quintile of caffeine intake against lowest quintile for ALS events was 0.96 (0.81–1.16), and there were no significant associations of caffeine or caffeinated beverages with ALS events. Events of incidence and death should be separated for the analysis as further study, because incident study would be more preferable for the prevention of ALS. About the mechanism of the association, Sc and Muralidhara summarized health benefits and risks of coffee and caffeine for ALS, which was mainly derived from animal and cell models (4). Not only caffeine, but also chlorogenic acid, caffeic acid, and hydroxy hydroquinone were considered as beneficial effects for ALS, although there were also undesirable effects of excessive coffee intakes. I recommend a prospective human study for ALS incidence with dose-response relationship to speculate the mechanism of the association.
Pupillo等人通过病例对照研究验证了食物摄入与肌萎缩性侧索硬化症(ALS)之间的关系(1)。我对他们的研究结果有一些评论,特别提到了咖啡和茶的摄入,这是ALS的保护因素。作者报告说,咖啡和茶的比值比(ORs)(95%可信区间[ci])为0.29(0.14-0.60)。Beghi等人还进行了一项以医院为基础的病例对照研究,以调查咖啡摄入量与ALS之间的关系(2)。他们设置了三个对照,目前喝咖啡的ALS患者的ORs显着降低。这一发现支持了咖啡摄入对ALS风险的预防作用,尽管因果关系需要通过纵向和干预性研究来验证。关于因果关系,Fondell等人对前瞻性研究进行了汇总分析,以研究咖啡因、咖啡和茶的摄入与ALS风险之间的关系(3)。ALS事件被定义为发病率或死亡。ALS事件中咖啡因摄入最高五分位数与最低五分位数的校正相对危险度(95% CI)为0.96(0.81-1.16),咖啡因或含咖啡因饮料与ALS事件没有显著关联。发病事件和死亡事件应分开分析作为进一步研究,因为事件研究更有利于预防ALS。Sc和Muralidhara总结了咖啡和咖啡因对ALS的健康益处和风险,主要来自动物和细胞模型(4)。除了咖啡因,绿原酸、咖啡酸和羟基对苯二酚也被认为对ALS有益,尽管过量摄入咖啡也有不良影响。我建议对ALS发病率与剂量-反应关系进行前瞻性人体研究,以推测其关联机制。
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引用次数: 0
Author response to a Letter to the Editor entitled: Preventive effect of coffee and tea on amyotrophic lateral sclerosis 作者对题为“咖啡和茶对肌萎缩性侧索硬化症的预防作用”的致编辑信的回复
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2019-08-27 DOI: 10.1080/21678421.2019.1655061
E. Pupillo, E. Beghi
We thank Dr Kawada for highlighting the results of our case-control studies (1,2) that suggest a preventive effect of coffee and tea on ALS risk. Our data find support from the consistency of the results from two independent studies and the purported mechanism of the association, derived from animal and cell models (3). In addition, the analogy of the results from studies in patients with Parkinson’s disease and, to some extent, with Alzheimer’s disease (4,5) enforces the positive effects of caffeine and other coffee derivatives against neurodegeneration. However, we also convene with Dr Kawada that the results of our studies were not confirmed by a large multi-cohort study that used mortality for ALS among exposed and unexposed individuals (6). As acknowledged by the authors, the use of ALS mortality as a proxy for the incidence of the disease could lead to an underestimation of the risk, the educational level of the cohort was high and not truly representative of the underlying populations, and measurement errors in estimating caffeine intake could not be excluded. As no definite conclusions can be drawn from the present findings on the protective role of coffee against ALS and other neurodegenerative diseases, we convene with Dr Kawada on the need to plan and undertake a prospective study comparing coffee users and non-users, measuring the quantity of caffeine intake, and assessing the incidence of ALS, Parkinson’s and Alzheimer’s disease during follow-up among exposed and unexposed individuals.
我们感谢Kawada博士强调了我们的病例对照研究的结果(1,2),这些研究表明咖啡和茶对ALS风险具有预防作用。我们的数据得到了两项独立研究结果的一致性以及从动物和细胞模型中得出的关联机制的支持(3)。此外,在帕金森病患者和阿尔茨海默病患者的研究结果的相似性(4,5)加强了咖啡因和其他咖啡衍生物对神经退行性疾病的积极作用。然而,我们也召集了Kawada博士,我们的研究结果并没有得到大型多队列研究的证实,该研究使用ALS暴露和未暴露个体的死亡率(6)。正如作者所承认的,使用ALS死亡率作为该疾病发病率的代表可能会导致风险低估,队列的教育水平很高,不能真正代表潜在人群。估计咖啡因摄入量的测量误差也不能排除。由于目前的研究结果无法得出关于咖啡对ALS和其他神经退行性疾病的保护作用的明确结论,我们与Kawada博士一起讨论了计划和开展一项前瞻性研究的必要性,该研究比较了咖啡使用者和非咖啡使用者,测量了咖啡因摄入量,并评估了接触者和未接触者在随访期间的ALS、帕金森病和阿尔茨海默病的发病率。
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引用次数: 0
Neurofilaments in pre-symptomatic ALS and the impact of genotype 症状前肌萎缩侧索硬化症的神经丝及基因型的影响
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2019-08-21 DOI: 10.1080/21678421.2019.1646769
M. Benatar, J. Wuu, V. Lombardi, A. Jeromin, R. Bowser, P. Andersen, A. Malaspina
Abstract Objective. To evaluate serum and cerebrospinal fluid (CSF) levels of phosphorylated neurofilament heavy (pNfH), and to compare these to levels of neurofilament light (NfL), as biomarkers of pre-symptomatic ALS. Design. The study population includes 34 controls, 79 individuals at-risk for ALS, 22 ALS patients, and 14 phenoconverters. At-risk individuals are enrolled through Pre-Symptomatic Familial ALS (Pre-fALS), a longitudinal natural history and biomarker study of individuals who are carriers of any ALS-associated gene mutation, but who demonstrate no clinical evidence of disease at the time of enrollment. pNfH and NfL in serum and CSF were quantified using established enzyme-linked immunosorbent assays. Results. There is a longitudinal increase in serum pNfH in advance of the emergence of clinically manifest ALS. A similar pattern is observed for NfL, but with the absolute levels also frequently exceeding a normative threshold. Although CSF data are more sparse, similar patterns are observed for both neurofilaments, with absolute levels exceeding a normative threshold prior to phenoconversion. In serum, these changes are observed in the 6–12 months prior to disease among SOD1 A4V mutation carriers, and as far back as 2 and 3.5 years, respectively, in individuals with a FUS c.521del6 mutation and a C9ORF72 hexanucleotide repeat expansion. Conclusions. Serum and CSF pNfH increase prior to phenoconversion. In CSF, the temporal course of these changes is similar to NfL. In serum, however, pNfH is less sensitive to pre-symptomatic disease than NfL. The duration of pre-symptomatic disease, as defined by changes in neurofilaments, may vary depending on underlying genotype.
摘要目的。评估血清和脑脊液(CSF)磷酸化神经丝重(pNfH)水平,并将其与神经丝轻(NfL)水平进行比较,作为症状前ALS的生物标志物。设计。研究人群包括34名对照组、79名ALS高危个体、22名ALS患者和14名表型转化者。有风险的个体通过症状前家族性ALS (Pre-fALS)纳入研究,这是一项纵向自然病史和生物标志物研究,研究对象是任何ALS相关基因突变携带者,但在入组时没有临床疾病证据。采用已建立的酶联免疫吸附法定量血清和脑脊液中的pNfH和NfL。结果。在临床表现的ALS出现之前,血清pNfH呈纵向上升趋势。在NfL中也观察到类似的模式,但其绝对水平也经常超过规范阈值。虽然脑脊液数据比较稀疏,但在两种神经丝中观察到相似的模式,绝对水平超过表型转化前的标准阈值。在血清中,SOD1 A4V突变携带者在发病前6-12个月观察到这些变化,在FUS c.521del6突变和C9ORF72六核苷酸重复扩增的个体中分别可追溯到2年和3.5年。结论。血清和脑脊液pNfH在表型转化前升高。在脑脊液中,这些变化的时间过程与NfL相似。然而,在血清中,pNfH对症状前疾病的敏感性低于NfL。症状前疾病的持续时间,由神经纤维的变化所定义,可能因潜在的基因型而异。
{"title":"Neurofilaments in pre-symptomatic ALS and the impact of genotype","authors":"M. Benatar, J. Wuu, V. Lombardi, A. Jeromin, R. Bowser, P. Andersen, A. Malaspina","doi":"10.1080/21678421.2019.1646769","DOIUrl":"https://doi.org/10.1080/21678421.2019.1646769","url":null,"abstract":"Abstract Objective. To evaluate serum and cerebrospinal fluid (CSF) levels of phosphorylated neurofilament heavy (pNfH), and to compare these to levels of neurofilament light (NfL), as biomarkers of pre-symptomatic ALS. Design. The study population includes 34 controls, 79 individuals at-risk for ALS, 22 ALS patients, and 14 phenoconverters. At-risk individuals are enrolled through Pre-Symptomatic Familial ALS (Pre-fALS), a longitudinal natural history and biomarker study of individuals who are carriers of any ALS-associated gene mutation, but who demonstrate no clinical evidence of disease at the time of enrollment. pNfH and NfL in serum and CSF were quantified using established enzyme-linked immunosorbent assays. Results. There is a longitudinal increase in serum pNfH in advance of the emergence of clinically manifest ALS. A similar pattern is observed for NfL, but with the absolute levels also frequently exceeding a normative threshold. Although CSF data are more sparse, similar patterns are observed for both neurofilaments, with absolute levels exceeding a normative threshold prior to phenoconversion. In serum, these changes are observed in the 6–12 months prior to disease among SOD1 A4V mutation carriers, and as far back as 2 and 3.5 years, respectively, in individuals with a FUS c.521del6 mutation and a C9ORF72 hexanucleotide repeat expansion. Conclusions. Serum and CSF pNfH increase prior to phenoconversion. In CSF, the temporal course of these changes is similar to NfL. In serum, however, pNfH is less sensitive to pre-symptomatic disease than NfL. The duration of pre-symptomatic disease, as defined by changes in neurofilaments, may vary depending on underlying genotype.","PeriodicalId":7740,"journal":{"name":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2019-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21678421.2019.1646769","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47764921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 66
Radicava (edaravone) for amyotrophic lateral sclerosis: US experience at 1 year after launch Radicava(依达拉奉)治疗肌萎缩侧索硬化症:美国上市后1年的经验
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2019-07-31 DOI: 10.1080/21678421.2019.1645858
C. Jackson, T. Heiman-Patterson, Pamela Kittrell, Tatyana Baranovsky, Glenn McAnanama, Laura Bower, W. Agnese, Mike Martin
Abstract Background: Radicava® (edaravone), approved for the treatment of amyotrophic lateral sclerosis (ALS) in 2017, may be administered intravenously at clinic sites, infusion centers or at home. Objective: To gain insights into the utilization of Radicava® at 1 year post-launch. Methods: Radicava® usage data were collected, and a survey was conducted among 75 physicians. Adverse events (AEs) were identified from a post-marketing safety database from 8 August 2017 through 3 August 2018 (cutoff date). Results: As of 6 August 2018, 3007 ALS patients were treated with Radicava®. Survey results indicated that 43% of patients received infusions at home, 32% in a clinician’s office, and 26% at a referred site. Infusions were administered mainly via implanted port. The most commonly reported AEs were drug ineffective, death (not specified), therapeutic response unexpected, asthenia, fatigue, gait disturbance, disease progression, muscular weakness, fall, and dyspnea. Conclusions: The first year of Radicava® availability to ALS patients in the US provided many key learnings that will help shape strategies for improved patient care.
摘要背景:Radicava®(依达拉奉)于2017年被批准用于治疗肌萎缩侧索硬化症(ALS),可在诊所、输液中心或家中静脉注射。目的:深入了解Radicava®在上市后1年的使用情况。方法:收集Radicava®的使用数据,并对75名医生进行调查。不良事件(AE)是从2017年8月8日至2018年8月3日(截止日期)的上市后安全性数据库中确定的。结果:截至2018年8月6日,3007名ALS患者接受了Radicava®治疗。调查结果显示,43%的患者在家接受输液,32%在临床医生办公室接受输液,26%在转诊点接受输液。输液主要通过植入口进行。最常见的不良事件包括药物无效、死亡(未具体说明)、意外治疗反应、乏力、疲劳、步态障碍、疾病进展、肌无力、跌倒和呼吸困难。结论:Radicava®在美国向ALS患者提供的第一年提供了许多关键知识,这些知识将有助于制定改善患者护理的策略。
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引用次数: 34
Nutritional prognostic factors for survival in amyotrophic lateral sclerosis patients undergone percutaneous endoscopic gastrostomy placement 肌萎缩侧索硬化症患者经皮内镜胃造口术后生存的营养预后因素
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2019-07-26 DOI: 10.1080/21678421.2019.1643374
M. Barone, M. T. Viggiani, Alessandro Introna, E. D’Errico, A. Scarafino, A. Iannone, A. Di Leo, I. Simone
Abstract Objective: There are conflicting data on nutritional factors influencing survival in amyotrophic lateral sclerosis (ALS) patients after percutaneous endoscopic gastrostomy (PEG) placement. We performed an observational cross-sectional study evaluating body mass index (BMI) categories and cholesterol levels as prognostic factors for survival after PEG. Moreover, we assessed body composition in a subgroup of patients to better explain the influence of BMI on survival. Methods: Neurological and nutritional parameters were evaluated at the time of PEG implantation in 47 consecutive patients. Moreover, body composition was evaluated in a subgroup of 22 patients by bioelectrical impedance analysis. Survival was calculated as the time from the PEG placement to death. Results: Underweight patients had a significantly increased risk of death as compared to normal-weight patients using Cox regression analysis [HR = 3.37 (1.29–8.81); p = 0.04]. Similarly, older age at the onset of symptoms significantly increased the risk of death [HR = 1.07 (1.02–1.12); p = 0.001]. Neither overweight/obesity nor hypercholesterolemia affected survival. All ALS patients showed an altered body composition compared to the general population. In addition, a BMI <18.5 kg/m2 identified patients with a significant reduction of body cell mass (BCM) and phase angle (PhA) compared to patients with normal BMI taken as the reference value. Conclusions: In the later stages of the disease, only a BMI < 18.5 kg/m2 and older age at symptom onset had a prognostic value on survival. Dyslipidemia did not affect survival. The low BCM and PhA characterizing underweight patients support the role of BMI as a predictor of survival.
摘要目的:关于影响肌萎缩侧索硬化症(ALS)患者经皮内镜胃造瘘术(PEG)后生存率的营养因素,存在相互矛盾的数据。我们进行了一项观察性横断面研究,评估了身体质量指数(BMI)类别和胆固醇水平作为PEG后生存的预后因素。此外,我们评估了一组患者的身体成分,以更好地解释BMI对生存率的影响。方法:对连续47例患者进行PEG植入时的神经和营养参数评估。此外,通过生物电阻抗分析对22名患者的亚组进行了身体成分评估。存活率计算为从放置PEG到死亡的时间。结果:使用Cox回归分析[HR,与正常体重患者相比,体重不足患者的死亡风险显著增加 = 3.37(1.29–8.81);p = 0.04]。同样,出现症状时年龄较大会显著增加死亡风险[HR = 1.07(1.02–1.12);p = 超重/肥胖和高胆固醇血症均不影响生存率。与普通人群相比,所有ALS患者的身体组成都发生了变化。此外,BMI<18.5 kg/m2确定的患者与以正常BMI作为参考值的患者相比,体细胞质量(BCM)和相位角(PhA)显著降低。结论:在疾病的后期,只有BMI < 18.5 kg/m2和症状出现时年龄较大对生存率具有预后价值。血脂异常不影响生存率。体重不足患者的低BCM和PhA特征支持BMI作为生存预测指标的作用。
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引用次数: 11
The “split-leg” syndrome in ALS: specific or variable? 肌萎缩性侧索硬化症的“裂腿”综合征:特异性还是变异性?
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2019-07-24 DOI: 10.1080/21678421.2019.1643376
M. de Carvalho, M. Swash
The “split hand” in amyotrophic lateral sclerosis (ALS), first described by Wilbourn (1), is characterized by predominant atrophy and weakness of the thenar muscles, with relative sparing of the hypothenar muscles. This clinical observation was confirmed by neurophysiological studies, evaluating compound muscle action potential (CMAP) amplitude and the number of motor units (MUs) (2–4). A split-hand index has been proposed (4), with a cutoff value for the differential diagnosis between ALS versus non-ALS. The physiological basis for the split-hand phenomenon is not clear, but both cortical and peripheral mechanisms may be important (5). More recently, a “split-leg phenomenon” has been described, with a greater reduction in the number of MUs and CMAP in plantar flexors compared with dorsiflexors (6). However, subsequent studies have described predominant dorsiflexor weakness, contrary to the original report (7). We here describe an ALS patient with “splitleg” features in one leg, but with an inverted splitleg phenomenon in his opposite leg, implying a measure of inconsistency of the predominant pattern of distal lower limb (LL) involvement. A 63-year-old man followed in our ALS clinic in Lisbon for progressive LL weakness and atrophy presented 6 years ago with right foot-drop. LL weakness progressed proximally, with fasciculation and cramps in the legs, without pain or sensory loss. He is now able to walk only with foot orthoses and a cane. He has no bulbar, respiratory, or upper limb (UL) symptoms. On recent examination, proximal (MRC 4) and distal (MRC 0-2) segments of the LLs were weak and atrophic. In the right leg plantar flexion was MRC 2, but foot dorsiflexion was absent. In the left leg foot dorsiflexion was MRC 2, but plantar flexion was absent. The knee jerks were brisk (þþþ). The right ankle jerk was just present, but the left ankle jerk and both plantar responses were absent. Nociceptive and large fiber-dependent sensibility in LLs was normal. In the ULs there was no weakness or atrophy, but fasciculations were present in proximal and distal muscles bilaterally, and the tendon reflexes were brisk (þþþ). A Hoffman sign was detected on the right side. The bulbar region was normal. Brain and spinal-cord MRI and CSF analysis were unremarkable. Laboratory investigation excluded autoimmune disorders, and respiratory tests have been repeatedly normal. Current electrophysiological investigation shows normal motor conduction velocities were normal in ULs (both ulnar nerves), and normal sensory potentials in UL and LLs (ulnar, sural, and peroneal nerves, bilaterally). LL motor conduction studies are summarized in Table 1. Needle electromyography (EMG) of the ULs confirmed the presence of fasciculation potentials in proximal (biceps) and distal (first dorsal interosseous) muscles, associated with chronic neurogenic changes in first dorsal interosseous muscles. In the LLs, frequent complex fasciculation potentials and very unstable MUs were detect
Wilbourn(1)首次描述了肌萎缩性侧索硬化症(ALS)的“裂手”,其特征是大鱼际肌肉主要萎缩和无力,而小鱼际肌肉相对较少。这一临床观察得到了神经生理学研究的证实,评估了复合肌肉动作电位(CMAP)振幅和运动单位数(MUs)(2-4)。有人提出了一个断手指数(4),该指数具有一个临界值,可用于ALS与非ALS的鉴别诊断。劈手现象的生理基础尚不清楚,但皮质和外周机制可能很重要(5)。最近,一种“劈腿现象”被描述,与背屈肌相比,足底屈肌的MUs和CMAP数量更少(6)。然而,随后的研究描述了主要的背屈肌无力,与最初的报道相反(7)。我们在这里描述了一位单侧腿有“劈腿”特征的ALS患者。但他的另一条腿有倒劈腿现象,这意味着下肢远端(LL)受累的主要模式不一致。一名63岁男性因6年前出现右脚下垂的进行性下肢无力和萎缩来到我们里斯本的ALS诊所。下肢近端无力进展,伴腿肌束和痉挛,无疼痛或感觉丧失。他现在只能靠脚矫形器和拐杖走路。他没有球、呼吸或上肢(UL)症状。在最近的检查中,LLs的近端(mrc4)和远端(mrc0 -2)节段虚弱和萎缩。右腿足底屈曲mrc2,但足背屈曲无。左腿足背屈曲mrc2,足底屈曲无。膝盖的抽搐很轻快(þþ)。右脚踝抽搐只是存在,但左脚踝抽搐和两个足底反应不存在。伤害性和大纤维依赖性敏感性在LLs中是正常的。在ULs中,没有虚弱或萎缩,但双侧近端和远端肌肉存在束状带,肌腱反射轻快(þ)。在右边发现了霍夫曼的标志。球区正常。脑、脊髓MRI及脑脊液分析无明显差异。实验室检查排除自身免疫性疾病,呼吸系统检查多次正常。目前的电生理调查显示,ULs(双侧尺神经)的运动传导速度正常,ULs和LLs(双侧尺神经、腓肠神经和腓神经)的感觉电位正常。表1总结了LL运动传导研究。ULs的针肌电图(EMG)证实在近端(二头肌)和远端(第一背骨间肌)肌肉中存在束状电位,与第一背骨间肌的慢性神经源性改变有关。在LLs中,双股内侧肌检测到频繁的复杂束状电位和非常不稳定的MUs,并伴有明显的神经源性改变。双侧胫前肌和腓肠肌内侧肌可见纤颤和锐波,但右侧胫前肌、趾短伸肌、左侧腓肠肌内侧肌和外展幻觉肌未见运动单位电位。然而,一些非常多相和不稳定的运动单位具有非常高的
{"title":"The “split-leg” syndrome in ALS: specific or variable?","authors":"M. de Carvalho, M. Swash","doi":"10.1080/21678421.2019.1643376","DOIUrl":"https://doi.org/10.1080/21678421.2019.1643376","url":null,"abstract":"The “split hand” in amyotrophic lateral sclerosis (ALS), first described by Wilbourn (1), is characterized by predominant atrophy and weakness of the thenar muscles, with relative sparing of the hypothenar muscles. This clinical observation was confirmed by neurophysiological studies, evaluating compound muscle action potential (CMAP) amplitude and the number of motor units (MUs) (2–4). A split-hand index has been proposed (4), with a cutoff value for the differential diagnosis between ALS versus non-ALS. The physiological basis for the split-hand phenomenon is not clear, but both cortical and peripheral mechanisms may be important (5). More recently, a “split-leg phenomenon” has been described, with a greater reduction in the number of MUs and CMAP in plantar flexors compared with dorsiflexors (6). However, subsequent studies have described predominant dorsiflexor weakness, contrary to the original report (7). We here describe an ALS patient with “splitleg” features in one leg, but with an inverted splitleg phenomenon in his opposite leg, implying a measure of inconsistency of the predominant pattern of distal lower limb (LL) involvement. A 63-year-old man followed in our ALS clinic in Lisbon for progressive LL weakness and atrophy presented 6 years ago with right foot-drop. LL weakness progressed proximally, with fasciculation and cramps in the legs, without pain or sensory loss. He is now able to walk only with foot orthoses and a cane. He has no bulbar, respiratory, or upper limb (UL) symptoms. On recent examination, proximal (MRC 4) and distal (MRC 0-2) segments of the LLs were weak and atrophic. In the right leg plantar flexion was MRC 2, but foot dorsiflexion was absent. In the left leg foot dorsiflexion was MRC 2, but plantar flexion was absent. The knee jerks were brisk (þþþ). The right ankle jerk was just present, but the left ankle jerk and both plantar responses were absent. Nociceptive and large fiber-dependent sensibility in LLs was normal. In the ULs there was no weakness or atrophy, but fasciculations were present in proximal and distal muscles bilaterally, and the tendon reflexes were brisk (þþþ). A Hoffman sign was detected on the right side. The bulbar region was normal. Brain and spinal-cord MRI and CSF analysis were unremarkable. Laboratory investigation excluded autoimmune disorders, and respiratory tests have been repeatedly normal. Current electrophysiological investigation shows normal motor conduction velocities were normal in ULs (both ulnar nerves), and normal sensory potentials in UL and LLs (ulnar, sural, and peroneal nerves, bilaterally). LL motor conduction studies are summarized in Table 1. Needle electromyography (EMG) of the ULs confirmed the presence of fasciculation potentials in proximal (biceps) and distal (first dorsal interosseous) muscles, associated with chronic neurogenic changes in first dorsal interosseous muscles. In the LLs, frequent complex fasciculation potentials and very unstable MUs were detect","PeriodicalId":7740,"journal":{"name":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2019-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21678421.2019.1643376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42087510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Longitudinal analysis of sniff nasal inspiratory pressure assessed using occluded and un-occluded measurement techniques in amyotrophic lateral sclerosis and primary lateral sclerosis 在肌萎缩性侧索硬化症和原发性侧索硬化症中,使用闭塞和未闭塞的测量技术评估鼻部吸气压力的纵向分析
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2019-07-17 DOI: 10.1080/21678421.2019.1639194
Deirdre Murray, J. Rooney, Anna Campion, Lauren Fenton, Michaela Hammond, M. Heverin, D. Meldrum, H. Moloney, R. Tattersall, O. Hardiman
Abstract Objective: Sniff nasal inspiratory pressure (SNIP) is a commonly used clinical measure of respiratory impairment in amyotrophic lateral sclerosis (ALS), which is used to guide the initiation of noninvasive ventilation (NIV). SNIP can be completed with either an occluded or an un-occluded contralateral nostril. The aim of this study was to compare occluded and un-occluded SNIP measurements and to examine the decline in occluded SNIP over time compared to the ALSFRS-R respiratory subscore. Methods: This was a prospective longitudinal study examining occluded and un-occluded SNIP scores in ALS and PLS patients recorded between 2001 and 2018. Bland and Altman graphs were plotted for occluded vs. un-occluded SNIP measurements taking account of the repeated measures nature of the data. Longitudinal models were constructed as linear mixed effects multi-level models with follow-up in ALS limited to 6 years. Results: SNIP measured with an occluded contralateral nostril was systematically higher than with an un-occluded nostril. SNIP measured using both methods declined non-linearly, particularly after 2–3 years. The best fit model for decline in occluded SNIP included a main effect and interaction between site of onset and time, with age and diagnostic delay as independent variables. This showed a linear decline in spinal onset with a floor effect in bulbar-onset ALS. Conclusion: SNIP measured with an occluded and un-occluded contralateral nostril is not interchangeable, which is relevant in interpreting thresholds for initiation of NIV. SNIP declines non-linearly, which is explained in spinal onset ALS by age and diagnostic delay, but an apparent floor effect remains in bulbar onset.
摘要目的:嗅鼻吸气压(SNIP)是肌萎缩侧索硬化症(ALS)呼吸障碍的一种常用临床测量方法,用于指导无创通气(NIV)的启动。SNIP可以通过对侧鼻孔闭塞或未闭塞来完成。本研究的目的是比较闭塞和未闭塞SNIP测量值,并检查与ALSFRS-R呼吸分量表相比,闭塞SNIP随时间的下降。方法:这是一项前瞻性纵向研究,检查2001年至2018年间记录的ALS和PLS患者的闭塞和未闭塞SNIP评分。考虑到数据的重复测量性质,绘制了闭塞和未闭塞SNIP测量的Bland和Altman图。纵向模型被构建为线性混合效应多层次模型,ALS的随访时间限制为6年。结果:对侧鼻孔闭塞测得的SNIP系统性高于未闭塞鼻孔。使用这两种方法测量的SNIP呈非线性下降,尤其是在2-3年后。闭塞SNIP下降的最佳拟合模型包括主要影响以及发病部位和时间之间的相互作用,年龄和诊断延迟是自变量。这表明脊髓性肌萎缩侧索硬化症的发病率呈线性下降,并伴有基底效应。结论:用封闭和未封闭的对侧鼻孔测量SNIP是不可互换的,这与解释NIV启动阈值有关。SNIP呈非线性下降,这在脊髓性发作的ALS中可以通过年龄和诊断延迟来解释,但在延髓性发作中仍然存在明显的基底效应。
{"title":"Longitudinal analysis of sniff nasal inspiratory pressure assessed using occluded and un-occluded measurement techniques in amyotrophic lateral sclerosis and primary lateral sclerosis","authors":"Deirdre Murray, J. Rooney, Anna Campion, Lauren Fenton, Michaela Hammond, M. Heverin, D. Meldrum, H. Moloney, R. Tattersall, O. Hardiman","doi":"10.1080/21678421.2019.1639194","DOIUrl":"https://doi.org/10.1080/21678421.2019.1639194","url":null,"abstract":"Abstract Objective: Sniff nasal inspiratory pressure (SNIP) is a commonly used clinical measure of respiratory impairment in amyotrophic lateral sclerosis (ALS), which is used to guide the initiation of noninvasive ventilation (NIV). SNIP can be completed with either an occluded or an un-occluded contralateral nostril. The aim of this study was to compare occluded and un-occluded SNIP measurements and to examine the decline in occluded SNIP over time compared to the ALSFRS-R respiratory subscore. Methods: This was a prospective longitudinal study examining occluded and un-occluded SNIP scores in ALS and PLS patients recorded between 2001 and 2018. Bland and Altman graphs were plotted for occluded vs. un-occluded SNIP measurements taking account of the repeated measures nature of the data. Longitudinal models were constructed as linear mixed effects multi-level models with follow-up in ALS limited to 6 years. Results: SNIP measured with an occluded contralateral nostril was systematically higher than with an un-occluded nostril. SNIP measured using both methods declined non-linearly, particularly after 2–3 years. The best fit model for decline in occluded SNIP included a main effect and interaction between site of onset and time, with age and diagnostic delay as independent variables. This showed a linear decline in spinal onset with a floor effect in bulbar-onset ALS. Conclusion: SNIP measured with an occluded and un-occluded contralateral nostril is not interchangeable, which is relevant in interpreting thresholds for initiation of NIV. SNIP declines non-linearly, which is explained in spinal onset ALS by age and diagnostic delay, but an apparent floor effect remains in bulbar onset.","PeriodicalId":7740,"journal":{"name":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2019-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21678421.2019.1639194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46622240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Poster Author Index 海报作者索引
IF 2.8 4区 医学 Q2 Medicine Pub Date : 2018-11-05 DOI: 10.1080/21678421.2018.1530871
{"title":"Poster Author Index","authors":"","doi":"10.1080/21678421.2018.1530871","DOIUrl":"https://doi.org/10.1080/21678421.2018.1530871","url":null,"abstract":"","PeriodicalId":7740,"journal":{"name":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21678421.2018.1530871","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47400474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
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