The state of self tolerance may well be an amalgam of many processes including (but not necessarily limited to) clonal deletion and specific suppressor cell networks. Cells with autoaggressive potential are clearly present in the blood of healthy individuals and have been implicated in diseases states. Given the critical importance of maintaining self tolerance, it is not at all surprising that several mechanisms appear to play a role in this process. Attempts to harness and manipulate these various mechanisms in order to prevent allograft rejection or to treat autoimmune diseases should prove to be exciting areas of investigation in the years ahead.
{"title":"Relevance of autocytotoxic and autoregulatory lymphocytes in the maintenance of self tolerance.","authors":"K Rosenkrantz, B Dupont, N Flomenberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The state of self tolerance may well be an amalgam of many processes including (but not necessarily limited to) clonal deletion and specific suppressor cell networks. Cells with autoaggressive potential are clearly present in the blood of healthy individuals and have been implicated in diseases states. Given the critical importance of maintaining self tolerance, it is not at all surprising that several mechanisms appear to play a role in this process. Attempts to harness and manipulate these various mechanisms in order to prevent allograft rejection or to treat autoimmune diseases should prove to be exciting areas of investigation in the years ahead.</p>","PeriodicalId":77513,"journal":{"name":"Concepts in immunopathology","volume":"4 ","pages":"24-41"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14022353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Immunotherapy of autoimmune disease with T cell subset specific antibodies.","authors":"S Sriram, G E Ranges","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77513,"journal":{"name":"Concepts in immunopathology","volume":"4 ","pages":"275-86"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14425909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of receptor-binding antibodies and anti-idiotypic antihormone antibodies in immune regulation.","authors":"S Marullo, A D Strosberg","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77513,"journal":{"name":"Concepts in immunopathology","volume":"3 ","pages":"176-92"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14168953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Idiotype network and its relevance to autoimmune diseases. Functional considerations.","authors":"M Zanetti","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77513,"journal":{"name":"Concepts in immunopathology","volume":"3 ","pages":"253-84"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14168954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of B cell lymphokines in immunoregulation.","authors":"P del Guercio, D H Katz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77513,"journal":{"name":"Concepts in immunopathology","volume":"3 ","pages":"109-57"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14090669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We have described a model system of immunoregulation in which gene products associated with both the H-2 and Igh complexes guide a series of cellular interactions. The Igh restriction represents the requirement for T cell recognition of Igh-linked NPb-related idiotypic determinants. The data provide additional evidence that the T and B cell Igh products are distinct. Immunoglobulin products are involved in the selection of T cell receptors; Igh genes are not expressed in T suppressor cell. The H-2 restrictions generally involve the I-J subregion. These restrictions are imposed by the presentation of antigen or suppressor factor on a specialized population of I-J bearing, antigen-presenting cells, thereby functioning in a manner analogous to that proposed for the induction of helper T cells. The NP suppressor cell pathway consists of multiple cellular elements, including at least 3 distinct T cell populations and 2 or more distinct antigen-presenting populations. Generally, specific soluble suppressor factors produced by each Ts cell subset are involved in the cellular communication process. The terminal phases of the suppressor cell cascade involve an antigen dependent non-specific bystander mechanism. Tables IX and X summarize our present view of the NP suppressor cell cascade. It is still not possible to include all the other experimental models involving suppressor cell interactions into the above scheme. However, the disparities between the various systems have in some cases narrowed and in other instances suggested that multiple mechanisms of immune regulation may occur concurrently.
{"title":"Regulation of hapten-specific T and B cell responses by suppressor cells.","authors":"P B Hausman, D H Sherr, M E Dorf","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have described a model system of immunoregulation in which gene products associated with both the H-2 and Igh complexes guide a series of cellular interactions. The Igh restriction represents the requirement for T cell recognition of Igh-linked NPb-related idiotypic determinants. The data provide additional evidence that the T and B cell Igh products are distinct. Immunoglobulin products are involved in the selection of T cell receptors; Igh genes are not expressed in T suppressor cell. The H-2 restrictions generally involve the I-J subregion. These restrictions are imposed by the presentation of antigen or suppressor factor on a specialized population of I-J bearing, antigen-presenting cells, thereby functioning in a manner analogous to that proposed for the induction of helper T cells. The NP suppressor cell pathway consists of multiple cellular elements, including at least 3 distinct T cell populations and 2 or more distinct antigen-presenting populations. Generally, specific soluble suppressor factors produced by each Ts cell subset are involved in the cellular communication process. The terminal phases of the suppressor cell cascade involve an antigen dependent non-specific bystander mechanism. Tables IX and X summarize our present view of the NP suppressor cell cascade. It is still not possible to include all the other experimental models involving suppressor cell interactions into the above scheme. However, the disparities between the various systems have in some cases narrowed and in other instances suggested that multiple mechanisms of immune regulation may occur concurrently.</p>","PeriodicalId":77513,"journal":{"name":"Concepts in immunopathology","volume":"3 ","pages":"38-60"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14090671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Immunoregulation and autoimmunity. Dedicated to the memory of Paul Ehrlich (1854-1915).","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77513,"journal":{"name":"Concepts in immunopathology","volume":"3 ","pages":"1-340"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14716240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Control of immune responsiveness by regulatory T lymphocytes.","authors":"P M Flood, B Chue, D R Green","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77513,"journal":{"name":"Concepts in immunopathology","volume":"3 ","pages":"17-37"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14022352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Auto-anti-idiotypic immunity and acetylcholine receptors.","authors":"A K Lefvert","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77513,"journal":{"name":"Concepts in immunopathology","volume":"3 ","pages":"285-310"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14425217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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