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Epidemiological review of laryngeal cancer: An Indian perspective. 喉癌流行病学回顾:印度视角。
IF 0.2 Pub Date : 2015-07-01 DOI: 10.4103/0971-5851.166721
Saurabh Bobdey, Aanchal Jain, Ganesh Balasubramanium

Background: Laryngeal cancer is one of the 10 leading causes of cancer in Indian men. The association of laryngeal cancer and tobacco smoking is well-established, but the peculiarities such as wide variation of disease distribution and survival, role of tobacco chewing, indoor air pollution, and dietary factors in laryngeal cancer causation needs to be understood. In this study, we review the descriptive and observational epidemiology of laryngeal cancer in India.

Materials and methods: MEDLINE and Web of science electronic database was searched from January 1995 to December 2013, using the using keywords "laryngeal cancer, laryngeal cancer outcome, epidemiology, etiological factor and their corresponding Mesh terms were used in combination like OR, AND." Two authors independently selected studies published in English and conducted in India. A total of 15 studies were found to be relevant and eligible for this review.

Results: In India, laryngeal cancer contributes to approximately 3-6% of all cancers in men. The age-adjusted incidence rate of cancer larynx in males varies widely among registries, highest is 8.18 per 100,000 in Kamprup Urban District and the lowest is 1.26 per 100,000 in Nagaland. The 5-year survival for laryngeal cancer in India is approximately 28%. Indian studies show tobacco, alcohol, long-term exposure to indoor air pollution, spicy food, and nonvegetarian diet as risk factors for laryngeal cancer.

Conclusion: There is wide regional variation in the incidence of laryngeal cancer in India. Survival rates of laryngeal carcinoma are much lower as compared to other Asian countries. Studies conducted in India to identify important risk factors of laryngeal cancer are very limited, especially on diet and indoor air pollution. Hence, more research is required for identifying the etiological factors and development of scientifically sound laryngeal cancer prevention programs.

背景:喉癌是印度男性十大癌症之一:喉癌是印度男性十大癌症病因之一。喉癌与吸烟的关系已得到证实,但疾病分布和存活率的巨大差异、咀嚼烟草、室内空气污染和饮食因素在喉癌病因中的作用等特殊性仍有待了解。在本研究中,我们回顾了印度喉癌的描述性和观察性流行病学:使用关键词 "喉癌、喉癌结果、流行病学、病因学因素 "及其相应的Mesh术语(如OR、AND)进行检索,检索期为1995年1月至2013年12月。两位作者独立选择了在印度进行的、以英语发表的研究。结果发现共有 15 项研究与本综述相关并符合条件:在印度,喉癌约占男性癌症总数的 3-6%。经年龄调整后的男性喉癌发病率在各登记处之间差异很大,最高的是坎普鲁普城区(Kamprup Urban District),为每10万人中8.18例,最低的是那加兰邦(Nagaland),为每10万人中1.26例。印度喉癌患者的 5 年生存率约为 28%。印度的研究表明,烟草、酒精、长期暴露于室内空气污染、辛辣食物和荤食是喉癌的风险因素:结论:印度喉癌发病率的地区差异很大。与其他亚洲国家相比,喉癌的存活率要低得多。印度为确定喉癌重要风险因素而开展的研究非常有限,尤其是关于饮食和室内空气污染的研究。因此,需要开展更多的研究来确定病因,并制定科学合理的喉癌预防计划。
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引用次数: 0
The Influence of Surface Preparation on the Surface Texture and Mechanical Properties of Castable Ceramics (OCC) 表面处理对可浇注陶瓷(OCC)表面织构和力学性能的影响
Pub Date : 2010-01-01 DOI: 10.2186/jjps.40.790
A. Furuya, K. Warita, Tadaharu, Kawawa, Yoshiko Ohnuki, M. Saito, T. Miyazaki
The purpose of this study was to investigate the surface texture and mechanical properties of Olympus Castable Ceramics (OCC) during crown fabrication. The results were as follows : 1. Surface roughness of the specimens decreased and bending strength increased after mechanical polishing using emery paper, a silicone wheel, and diamond paste. However, there were no significant differences among the three kinds of polished specimens. 2. Surface gloss of the specimens increased significantly after mechanical polishing using emery paper, a silicone wheel, and diamond paste in that order. 3. The stained specimens showed a little more surface roughness than that of the polished specimens. Bending strength of the stained specimens was significantly less than that of the polished specimens and was slightly less than that of the untreated specimens. Surface gloss of the stained specimens was slightly less than that of the specimens polished with diamond paste. 4. Different conditions of surface preparation influenced surface roughness, surface gloss, and bending strength of the OCC specimens significantly.
本研究的目的是研究奥林匹斯浇注陶瓷(OCC)在冠制作过程中的表面织构和力学性能。实验结果如下:1.实验结果表明:用金刚砂纸、硅胶轮和金刚石膏进行机械抛光后,试样的表面粗糙度降低,抗弯强度提高。然而,三种抛光试样之间没有显著差异。2. 用金刚砂纸、硅胶轮、金刚石膏进行机械抛光后,样品表面光泽度明显提高。3.染色后的样品表面粗糙度略高于抛光后的样品。染色后的试件抗弯强度明显小于抛光后的试件,且略小于未处理的试件。染色后的样品表面光泽度略低于用金刚石膏抛光的样品。4. 不同的表面处理条件对OCC试样的表面粗糙度、表面光泽度和抗弯强度有显著影响。
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引用次数: 0
In vitro Assessment of Ag-Sn-Zn Alloy in Organic Acid by Immersion Tests Ag-Sn-Zn合金在有机酸中的体外浸泡评价
Pub Date : 2010-01-01 DOI: 10.2186/jjps.45.315
M. Koike
抄 録 目的:Ag,Sn,Znを 主成分 とする歯科鋳造用銀合金はしばしばコアあるいは一部被覆冠に使用され, それらの約89%は 変色 している.し かし,現 在まで乳酸以外の有機酸に対する銀合金の腐食反応を観 察した報告は少ない.本 実験の目的は,唾 液やプラークに多 く含 まれる有機酸および人工唾液中におけ る銀合金の化学的安定性 を評価 し,腐 食試験などで用いられることが多い生理食塩水中で得られた結果 と比較検討することである. 方法:浸 漬試験法を用いて,成 分元素の溶出,重 量変化,表 面色の変化および腐食生成物の組成を分析 した. 結果:全 浸漬液で,銀 合金から解離 したZnとSnの 溶出および不溶性 の沈殿物 を認めた.Agの 溶出 はほとんど認められなかった.ま た,試 料の重量減少と変色を確認 した.さ らに,溶 出や重量の減少が 多い試料のなかに変色が少ない場合があることを観察した.銀 合金は生理食塩水に接触したときよりも 乳酸,ギ 酸および酢酸などの有機酸に接触 したときのほうが腐食 しやすいこと,有 機酸の種類によって 溶出イオンの動態が異なることがわかった. 結論:本 論文の結果は,銀 合金は口腔内環境のなかで腐食 しうることを示している。この腐食の程度は 変色だけでは評価すべきではない.
摘录目的:以Ag,Sn,Zn为主要成分的牙科铸造用银合金,常被用于芯或部分覆盖冠,其中约89%已变色,但迄今为止,很少有报告显示银合金对乳酸以外的有机酸有腐蚀反应。本实验的目的是评价唾液和菌斑中富含的有机酸以及人工唾液中所含的银合金的化学稳定性,以及在多用于腐食试验等的生理食盐水中得到的结果。和比较探讨。方法:采用浸泡测试法,分析了成分元素的溶出、重量变化、表面颜色的变化及腐蚀生成物的组成。结果:在全浸泡液中,发现了从银合金中解离的Zn和Sn的溶出及不溶性沉淀物,几乎不发现Ag的溶出,并确认了试料的重量减轻和变色。观察了出料和重量减少多的样品中有变色少的情况。银合金与生理盐水接触时相比,与乳酸、甲酸及乙酸等有机酸接触时更容易腐蚀,而且根据有机酸的种类不同,其溶出离子的动态也不同。结论:本文的结果表明,银合金在口腔内环境中有可能被腐蚀。这个腐蚀的程度不应该只以变色来评价。
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引用次数: 0
A Study on Adhesion of Dental Porcelain to Castable Glass Ceramics Part I Stress Analysis of Experimental Test Pieces 牙瓷与可浇注玻璃陶瓷黏附性能的研究——ⅰ。试验试件的应力分析
Pub Date : 2010-01-01 DOI: 10.2186/jjps.39.447
Hiroyuki, Minami, S. Yamabe, Atsuo, Nakashima, Kensuke, Nomura, Yoshito, Minesaki, Yasumi, Takenouchi, Tadashi, Onizuka, Jimi
Prior to the evaluation of the tensile adhesive strength of dental porcelain to castable glass ceramic, stress distribution was analyzed to determine the configuration of the tensile test pieces, by using the photoelastic stress analysis method. On the assumption that 3 type tensile test pieces of dental porcelain baked on castable glass ceramics, 3 photoelastic test models consisting of two layers were made of epoxy resin. A 2 kgf tensile load was added to each model, and the stress was maintained. The stress distribution of the median section was analyzed. The results were as follows: (1) The tensile stress was observed at the castable glass ceramic-porcelain interface of all test models. (2) Stress concentration effects were significant at the periphery of castable glass ceramic-porcelain interface in two of 3 test models. (3) Uniform tensile stress was observed at the castable glass ceramic-porcelain interface in only one of 3 test models.
在评价牙瓷与可浇注玻璃陶瓷的抗拉粘接强度之前,采用光弹性应力分析方法对应力分布进行分析,确定拉伸试件的配置。假设牙瓷在可浇注玻璃陶瓷上烘烤3个型拉伸试件,采用环氧树脂制作3个两层的光弹性试验模型。每个模型加2 kgf拉伸载荷,保持应力不变。分析了中间截面的应力分布。结果表明:(1)各试验模型在可浇注玻璃-陶瓷界面处均观察到了拉应力。(2)在3个试验模型中,有2个模型在可浇铸玻璃-陶瓷界面周边应力集中效应显著。(3)在3个试验模型中,只有一个模型在可浇注玻璃-陶瓷界面处观察到均匀的拉应力。
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引用次数: 0
Daily Change of Stress Induced Expression of c-fos mRNA in Rat Brain by Experimental Occlusal Interference Kobayashi Takuya and Mushimoto 实验性咬合干扰下应激诱导大鼠脑c-fos mRNA表达的日变化
Pub Date : 2010-01-01 DOI: 10.2186/jjps.48.203
Eiko
Purpose: This study observed the daily change of the stress response caused by experimental occlusal interference. Methods: 11-week-old male Wistar rats were used and divided into two groups: the control group and the occlusal interference group. Each group consisted of 36 rats. Six-session experiments were carried out over a period of 14 days. The concentration of corticosterone in blood was analyzed. Applying in situ hybridization, the stress-induced c-fos mRNA in the brain was observed. The regions of observation in the brain were amygdaloid, piriform cortex, hippocampus, cingulate cortex, paraventricular nucleus of hypothalamus, locus coeruleus, raphe magnus nucleus, and central gray. Results: Compared with the control group, c-fos mRNA expressions increased significantly in the occlusal interference group throughout the observation period. c-fos mRNA expressions were consistently manifested in the regions of the input system of the brain, and c-fos mRNA expressions in the regions of the output system of the brain adapted to the exprimental occlusal interference stress. The concentration of corticosterone in blood adapted to stress by experimental occlusal interference. Conclusions: The stress caused by experimental occlusal interference is a stress with physical and psychological factors, and the stress responss did not disappear when the experimental occlusal interference was worn.
目的:观察实验性咬合干扰引起的应激反应的日变化。方法:选用11周龄雄性Wistar大鼠,分为对照组和咬合干扰组。每组36只大鼠。在14天的时间内进行了6次试验。分析血中皮质酮浓度。应用原位杂交技术,观察应激诱导下脑内c-fos mRNA的表达。脑内观察区为杏仁核、梨状皮质、海马、扣带皮质、下丘脑室旁核、蓝斑核、中缝大核、中央灰质。结果:与对照组相比,咬合干扰组c-fos mRNA的表达在整个观察期内均显著升高。c-fos mRNA表达一致地表现在脑输入系统区域,c-fos mRNA表达一致地表现在适应实验咬合干扰应激的脑输出系统区域。实验性咬合干扰对血中皮质酮浓度的适应。结论:实验性咬合干扰引起的应激是一种具有生理和心理因素的应激,当佩戴实验性咬合干扰时,应激反应并未消失。
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引用次数: 2
短縮歯列(SDA)イ ンプラン ト療法の観点か らみたその臨床的問題点 小宮山彌太郎 SDA (Shortened Dental Arch): Its Clinical Problems for Implant Treatment 从缩短齿列(SDA)治疗方案和疗法的观点来看其临床问题小宫山弥太郎SDA (Shortened Dental Arch):Its Clinical Problems for Implant Treatment
Pub Date : 2010-01-01 DOI: 10.2186/jjps.47.745
Komiyama Yataro
It is well known that implant treatment based on the concept of osseointegration is an effective option in contemporary dentistry. The original protocol of the Branemark system recommends the shortened dental arch (SDA) in a totally edentulous jaw. Several Japanese patients were unsatisfied with the lack of second molars in terms of masticatory function and self-confidence. The author started the application combined with anterior and posterior fixtures even in the totally edentulous jaw in order to restore second molars in 1985. There were thought to be some disadvantages of such application in the beginning, but these were verified by the long-term clinical cases to be imaginary. Furthermore, restoration with second molars brings functional and mental satisfaction to patients. Installation into maxillary tuberosity, pterygoid process and/or palatine process has been done and shows excellent results. This paper discuss several options of design of the superstructure, in order to avoid SDA that is not acceptable for old-fashioned prosthodontists.
众所周知,基于骨整合概念的种植体治疗是当代牙科中一种有效的选择。Branemark系统的原始方案建议在完全无牙颌中缩短牙弓(SDA)。几名日本患者对缺第二磨牙的咀嚼功能和自信心不满意。作者于1985年开始在全无牙颌中应用前后固定装置联合修复第二磨牙。在一开始,人们认为这种应用有一些缺点,但这些缺点被长期的临床病例证实是虚构的。此外,第二磨牙的修复给患者带来了功能和精神上的满足。上颌粗隆,翼状突和/或腭突的安装已经完成,并显示出良好的效果。本文讨论了上部结构的几种设计方案,以避免老式义齿医生无法接受的SDA。
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引用次数: 0
Examination and Diagnosis for Masticatory and Swallowing Function 咀嚼和吞咽功能的检查和诊断
Pub Date : 2010-01-01 DOI: 10.2186/jjps.46.463
Sasaki Keiichi
Purpose: Swallowing is defined as taking a substance through the mouth and pharynx and passing it through the cricopharyngeal construction and esophagus and into the stomach. Mastication is the process by which food is held, chewed, and moved within the oral cavity, in preparation for swallowing. Examination and diagnosis of masticatory function and swallowing function is indispensable for evidence-based prosthodontic treatment. Previous articles concerning this issue were reviewed to consider the functional test of mastication and swallowing, suited in a society composed largely of elderly. Selection of study: Classic articles cited in textbooks, recent articles searched from Medline and Journal of Japan Prosthodontic Society were selected and reviewed in the separate categories with different objectives of assessments. Results: Masticatory function has been evaluated by questionnaires or personal interviews designed to subjectively assess an individual's chewing ability and by clinical functional tests to provide more objective information about masticatory efficiency. Such objective tests included fractional sieving tests and analyses of mandibular movement and of masticatory muscle activities during chewing. Most currently available methods are sensitive enough to assess target functions. However the function assessed by each method is a part of masticatory and swallowing function. Conclusions: Establishment of a examination and diagnostic system for masticatory and swallowing function requires an understanding of the objectives of individual measurements and construction of systematic examinations based on these available measurements.
目的:吞咽的定义是将一种物质通过口腔和咽部,通过环咽结构和食道进入胃。咀嚼是为了准备吞咽而在口腔内握住、咀嚼和移动食物的过程。咀嚼功能和吞咽功能的检查和诊断是循证修复治疗必不可少的。本文回顾了前人关于咀嚼和吞咽功能测试的研究,以适应以老年人为主的社会。研究选择:根据不同的评估目标,选择教科书中引用的经典文章、Medline和Journal of Japan Prosthodontic Society中检索的最新文章。结果:咀嚼功能已通过问卷调查或个人访谈进行评估,旨在主观评估个体的咀嚼能力,并通过临床功能测试提供有关咀嚼效率的更客观信息。这些客观测试包括分级筛分测试和咀嚼时下颌运动和咀嚼肌活动的分析。目前大多数可用的方法都足够敏感,可以评估目标函数。然而,每种方法评估的功能都是咀嚼和吞咽功能的一部分。结论:建立咀嚼和吞咽功能的检查诊断系统需要了解个体测量的目的,并在这些测量的基础上构建系统的检查。
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引用次数: 5
Bilinguals ' Responses to Oral Health Impact Profile ( OHIP ) Written in English and in Japanese 双语者对口腔健康影响概况(OHIP)的回应,以英文和日文书写
Pub Date : 2010-01-01 DOI: 10.2186/jjps.48.163
Nakai, Nobuyuki, Sadamori, Shinsuke, Kawamura, Makoto, Sasahara, Hisako
抄 録 目的:OralHealthImpactProfile(OHIP)は オース トラ リアで開発 された口腔QOLの 評価 法であ り,近 年では,ほ かの国々 で も徐 々に使用 され始めている.今 回われわれは,OHIPの 原版(英 語版) を日本語 に翻訳 し,日 本 での使用の妥当性 を確認 した。 方法:本 研究 は2力 国語 に通 じた もの(39名)を 対象 に,原 版 と邦 訳版 の回答 を比較 ・検 討 した. OHIPの 翻訳 の妥 当性 は項 目ごとの一致率 とλ係数(対 象性評価の指標)に よって分析 した. 結果:尺 度 ご との平均一致率 はそれぞれ,「 機能的な問題」75%,「 痛 み」76%,「 不快感」69%,「 身体 的 困 りご と」79%,「 心理 的 困 りご と〕77%,「 社 会的 困 りご と〕90%,「 ハ ンデ ィキャップ」85%で あった.全49項 目中41項 目は0.4以 上 の λ係数 を有 し,高 い一致性 が認 め られた.上 記7尺 度 の α 信頼性係数 は,原 版で は0.76~0.90,翻 訳版 では0.77~0.89に あ り,日 英両版 の尺度 の内的妥 当性が 変 わ らな い こ とが 示 唆 され た.日 英 両 版 にお け る7尺 度 のSpearmanの 順 位 相 関 係 数 は0.83~ 0.92(p<0.001)で,優 位 な相関性 を示 した. 結論:日 本語版OHIPは,こ のように高 い信頼性 と翻訳 の妥 当性 を有 す る ことか ら,日 英 の2言 語間 で使用可能 である ことが示唆 された.
翻译目的:OralHealthImpactProfile(OHIP)是由奥斯特里亚开发的口腔QOL评估法,近年来,在其他国家也逐渐使用开始被做了。此次我们将OHIP原版(英文版)翻译成日文,确认了在日文中使用的可行性。方法:本研究以精通2力国语的39名为对象,对原版和邦译版的答案进行了比较和检验。OHIP翻译的妥当性为每项一致率和λ系数(对象性评价的指标)来分析。结果:各尺度的平均一致率分别为:“功能问题”75%,“疼痛”76%,“不快感”69%,“身体上的困难”79%,“心理上的困难”77%,“社会上的困难”在全部49项中,有41项具有0.4以上的λ系数,具有高度的一致性。上述7尺度的α可靠性系数为原版本为0.76~0.90,翻译版本为0.77~0.89,表明日英两版尺度的内在妥当性没有变化。的Spearman的顺位相关性为0.83~ 0.92(p<0.001),显示出良好的相关性。结论:日语版OHIP具有如此高的可靠性和翻译妥当性。由此可以在日英两种语言之间使用。
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引用次数: 2
Effects of Eluates of Denture Adhesives on Human Gingival Fibroblasts 义齿胶粘剂洗脱液对人牙龈成纤维细胞的影响
Pub Date : 2010-01-01 DOI: 10.2186/jjps.45.403
Seicho, Makihira, Hiroki, Nikawa, Haruki, Nishimura, Masahiro, Hiroshi, Murata, Shinsuke, Sadamori, Kazuhiro, Ishida, Hirofumi, Yamashiro, Chen Jin, Egusa, Hitoshi, Fukushima
抄 録 目的:本 研究は,市 販義歯安定剤の細胞活性 への影響および炎症性サイ トカイ ンであるイ ンター ロイキ ン1β の発現誘導 に及 ぼす影響 を検討 した. 方法:細 胞活性へ の影響 はaqueous soluble tetrazolium/formazan assay(MTS法)を 用いて,ま たイ ンターロイキ ン1β の発現誘導 はEnzyme-linked immunosorbent assay(EUSA法)を 用いて評価 した. 結果:ク リームタイプを中心 とした義歯安定剤は,強 い細胞活性 の減少を示 した.特 に新 ポ リグ リップ 無添加が最 も低 い細 胞生存率 を示 した.一 方,ポ リデ ン トを除 くクッションタイプで は,細 胞活性 に対 す る影響 をほ とん ど認 めなかった.粉 末 タイプお よび シール タイプでは,こ れ らの中間の作 用 を示 し た.こ れ らの細胞 に対 す る作用 は,pHの 影響 ではな くむ しろ義歯安定剤の成分 に大 き く依存 している ことが示唆 された.ま た,細 胞活性 に影響 を与 えない6製 品でインターロイキン1β の発現 を検討 した 結果,す べての製 品で誘導 を示さなか った.し か しなが ら,歯 科で使用 される材料由来 の環境 ホルモンに よる人体への影響 が懸念 されているなか,今 後 さらに分子 レベルにまで踏み込んだ検討が必要 と思われる. 結論:義 歯安定剤 にはこれ まで報告 されてい る機能面 での為害性や細胞生物学的な為害性 も有 してい る 製品 もある ことか ら,そ の使用にあたって歯科医師の十分 な管理が必要 と考 えられる.
摘录目的:本研究探讨了市销假牙安定剂对细胞活性的影响以及诱导炎症性细胞因子-受体1β表达的影响。方法:对细胞活动性的影响采用aqueous soluble tetrazolium/formazan assay(MTS法),另外诱导蛋白质1β的表达是使用Enzyme-linked immunosorbent assay(EUSA法)进行评估的。结果:以克里姆型为中心的假牙安定剂显示出强细胞活性的减少。特别是无添加新聚合蛋白,显示出最低的细胞存活率。另一方面,消除聚氨酯的缓冲垫类型对细胞活性的影响基本未得到认可。在粉末型和贴纸型中,展示了它们的中间作用。它们对细胞的作用主要依赖于假牙安定剂的成分,而不是pH的影响。另外,在不影响细胞活动性的6种产品中研究了白细胞介素1β的表现,结果所有产品均显示有诱导作用。但在品甲、齿科使用由于担心来自所研究材料的环境激素会对人体产生影响,今后有必要进一步深入研究分子层面。结论:截止到目前,义齿安定剂中有报告指出,有些产品在功能方面具有危害性和细胞生物学方面具有危害性,因此在使用时需要牙科医生进行充分的管理。得到。
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引用次数: 3
A Study on the Utility of a Scale for Examination in Residual Ridge Shape Based on an Objective Assessment 基于客观评价的残脊形状检测尺度的实用性研究
Pub Date : 2009-01-01 DOI: 10.7881/DENTALMEDRES.29.1
Takahiro Higuchi, Hiroshi Ishihara, Yuji Sato, N. Kitagawa, Satoshi Hara, S. Ishibashi
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引用次数: 1
期刊
Nihon Hotetsu Shika Gakkai zasshi
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