A review of basal and squamous cell carcinoma of the skin is presented with emphasis on treatment modalities. A series of 312 cases of skin cancer is presented in which Mohs micrographic surgery was the treatment. This technique is indicated for tumors that are 1) recurrent; 2) on anatomic sites with a high risk for recurrence; 3) of large size; 4) of aggressive histologic type; 5) incompletely excised; or 6) present on important functional or asthetic areas.