Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc最新文献

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Difficulty in establishing diagnosis from lung biopsies and bronchial washing analysis in children with leukemia following bone marrow transplantation. 骨髓移植后白血病患儿肺活检及支气管冲洗分析诊断困难。

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc

Pub Date : 1987-01-01

T Miale, N Mody, B Dick, P Nanavati, L Mathew, R F Boedy, M Steinberg, D Davis, S Chaudhary, L G Thatcher

Three children developed severe respiratory distress at days +12, +11, and +11 following allogeneic bone marrow transplantation from donors. The first child was a 13-year-old Hispanic boy transplanted in relapse of Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL). At day -14, a bronchial washing done for a streaky pulmonary infiltrate was negative for acid-fast bacilli. Miliary tuberculosis was discovered at postmortem examination. A second child, transplanted in remission of null-cell ALL, developed severe hypoxia and hypercarbia on day +11 but recovered fully following prolonged mechanical ventilation. An open-lung biopsy showed a pattern of nonspecific, diffuse alveolar damage compatible with respiratory distress syndrome. The third child was transplanted in remission of B-cell ALL and developed fatal fungal and cytomegalovirus pneumonia on day +12. In these latter two cases, it is likely that open-lung biopsy would have missed the diagnosis because of the uneven pulmonary involvement and multiple etiologies observed. All three children received cyclosporine, granulocyte transfusions, and multiple antimicrobials, including amphotericin B. Hyperfractioned total-body irradiation with lung shielding was used in the latter two patients.

3名儿童在移植同种异体骨髓后第12、11和11天出现严重呼吸窘迫。第一个儿童是一名13岁的西班牙裔男孩，因费城染色体阳性急性淋巴细胞白血病(ALL)复发而接受移植。在第-14天，对条纹状肺浸润进行支气管冲洗，抗酸杆菌阴性。军人肺结核是在验尸时发现的。第二个孩子，移植缓解无细胞ALL，第11天出现严重缺氧和高碳化，但在延长机械通气后完全恢复。开肺活检显示非特异性弥漫性肺泡损伤与呼吸窘迫综合征相符。第三例患儿在b细胞ALL缓解后接受移植，并于第12天发生致命的真菌和巨细胞病毒肺炎。在后两例中，由于肺部受累不均匀且观察到多种病因，开肺活检可能会错过诊断。所有三名儿童均接受环孢素、粒细胞输注和多种抗菌素治疗，包括两性霉素b。后两名患者使用了肺屏蔽的高分次全身照射。

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引用次数: 0

Modulation of NK activity in regional lymph nodes by preoperative immunotherapy with OK-432 in patients with cancer of the oral cavity. 术前应用OK-432免疫治疗口腔癌患者局部淋巴结NK活性的调节

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc

Pub Date : 1987-01-01

K Vinzenz, M Matejka, G Watzek, H Porteder, N Neuhold, M Micksche

The influence of preoperative perilesional therapy with the potent bacterial biological response modifier (BRM) OK-432 on natural killer (NK) cell activity in peripheral blood and tumor draining lymph nodes (LNs) of patients with head and neck cancer (HNC) has been investigated. Pretreatment NK activity in peripheral blood (PB) was comparable within the group of HNC patients. However, after perilesional OK-432 therapy, a significant increase in cytotoxicity was observed by day 8. Furthermore, postoperative suppression of PB NK activity was less pronounced in patients with OK-432 therapy. In tumor draining LNs, NK activity was significantly higher in patients receiving OK-432 therapy than in those treated by surgery alone. No differences were detected concerning the in vitro stimulatory capacity of interferon (IFN) and/or Staphylococcus protein A (SPA) on LN NK activity in both the OK-432 treated and untreated group. Furthermore, by immunoperoxidase technique, LNs of OK-432 treated patients were found to express a higher number of cells reacting with the monoclonal antibody HNK-1 compared to LNs of the untreated group. Both these results suggest that perilesional OK-432 therapy leads to an increase in number and function of NK cells in regional LNs, together with an increase in NK activity in PB in some but not all patients.

研究了强效细菌生物反应调节剂(BRM) OK-432术前病灶周围治疗对头颈部癌(HNC)患者外周血和肿瘤引流淋巴结(LNs)自然杀伤细胞(NK)活性的影响。预处理后外周血NK活性(PB)在HNC患者组内具有可比性。然而，在瘤周OK-432治疗后，在第8天观察到细胞毒性显著增加。此外，在接受OK-432治疗的患者中，术后PB NK活性的抑制不太明显。在肿瘤引流LNs中，接受OK-432治疗的患者的NK活性明显高于单纯手术治疗的患者。在OK-432处理组和未处理组中，干扰素(IFN)和/或葡萄球菌蛋白A (SPA)对LN NK活性的体外刺激能力没有差异。此外，通过免疫过氧化物酶技术，发现与未治疗组相比，OK-432治疗组的LNs表达了更多与单克隆抗体HNK-1反应的细胞。这两个结果都表明，OK-432治疗导致局部LNs中NK细胞数量和功能的增加，以及部分(但不是所有)患者PB中NK细胞活性的增加。

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