P M Blumberg, A Y Jeng, B König, N A Sharkey, K L Leach, S Jaken
{"title":"Receptors and endogenous analogs for the phorbol ester tumor promoters.","authors":"P M Blumberg, A Y Jeng, B König, N A Sharkey, K L Leach, S Jaken","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15176465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cancer in ataxia-telangiectasia.","authors":"R B Painter","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15176467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A E Lagarde, D E Renwick, A J Franchi, J M Pouysségur
{"title":"Genetic dissection of growth factor-mediated controls of cell proliferation as an approach to analyze the process of tumor progression.","authors":"A E Lagarde, D E Renwick, A J Franchi, J M Pouysségur","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15017454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of pharmacokinetics and DNA dosimetry in relating in vitro to in vivo actions of N-nitroso compounds.","authors":"P N Magee","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15019452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Estimation of the potencies of chemicals that produce genetic damage.","authors":"A R Peterson, H Peterson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15022630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mechanisms of transformation and promotion of mouse epidermal cells.","authors":"S H Yuspa","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15165504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of retinoid stabilized carcinogen-initiated cells to the quantitation of transformation in the C3H/10T1/2 cell line.","authors":"J S Bertram","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15165506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Our inter- and intralaboratory results showed that the SHE transformation assay is not yet sufficiently developed for a large scale screening program. The major source of variability is largely due to the low number of transformed colonies induced by test chemicals in any one experiment. Although this limitation presumably can be overcome by scoring a larger number of colonies, we feel such an approach would defeat the practical purpose of a screening assay. Of the experimental variables examined, we believe that medium supplements other than fetal calf serum and alternative detection/selection methods for transformation are two areas that need further development in order to improve the reproducibility of the SHE assay system for testing diverse chemicals. Until then, this system under defined conditions should remain a useful tool for research purposes.
{"title":"Syrian hamster embryo cell transformation as a screening assay: sources of variability.","authors":"A S Tu, A Sivak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Our inter- and intralaboratory results showed that the SHE transformation assay is not yet sufficiently developed for a large scale screening program. The major source of variability is largely due to the low number of transformed colonies induced by test chemicals in any one experiment. Although this limitation presumably can be overcome by scoring a larger number of colonies, we feel such an approach would defeat the practical purpose of a screening assay. Of the experimental variables examined, we believe that medium supplements other than fetal calf serum and alternative detection/selection methods for transformation are two areas that need further development in order to improve the reproducibility of the SHE assay system for testing diverse chemicals. Until then, this system under defined conditions should remain a useful tool for research purposes.</p>","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15165512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It is from an analysis of these data that I proposed that losses of all or part of the long arm of chromosomes 5 and/or 7 may be indicators of exposure to mutagenic agents (8). Moreover, our analysis of the regions of chromosomes 5 and 7 that are consistently missing can define the critical region of each chromosome with some precision. Looked at from another perspective, the frequency of losses of chromosomes 5 and/or 7 may be an indicator of the proportion of ANLL in each particular population that is related to some mutagenic exposure. These aberrations are most frequent in cells of patients who were previously exposed to various cytotoxic regimens for treatment of a primary (usually malignant) disease; these patients are considered to have 2 degrees ANLL. Among patients with ANLL de novo, abnormalities of chromosomes 5 and 7 are much more frequent in older than younger patients. Finally, among adult patients with ANLL de novo, -5 and -7 are more common in those whose occupations could potentially expose them to mutagenic agents such as chemicals, pesticides, or petroleum products. With regard to chromosome 5, most of these deletions are interstitial and always include 5q23 through q31, which I have called the critical region. Although I am less certain with regard to chromosome 7, it appears that the critical region that is consistently deleted may be 7q32 or 7q34-35.
{"title":"Chromosome abnormalities in human leukemia as indicators of mutagenic exposure.","authors":"J D Rowley","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It is from an analysis of these data that I proposed that losses of all or part of the long arm of chromosomes 5 and/or 7 may be indicators of exposure to mutagenic agents (8). Moreover, our analysis of the regions of chromosomes 5 and 7 that are consistently missing can define the critical region of each chromosome with some precision. Looked at from another perspective, the frequency of losses of chromosomes 5 and/or 7 may be an indicator of the proportion of ANLL in each particular population that is related to some mutagenic exposure. These aberrations are most frequent in cells of patients who were previously exposed to various cytotoxic regimens for treatment of a primary (usually malignant) disease; these patients are considered to have 2 degrees ANLL. Among patients with ANLL de novo, abnormalities of chromosomes 5 and 7 are much more frequent in older than younger patients. Finally, among adult patients with ANLL de novo, -5 and -7 are more common in those whose occupations could potentially expose them to mutagenic agents such as chemicals, pesticides, or petroleum products. With regard to chromosome 5, most of these deletions are interstitial and always include 5q23 through q31, which I have called the critical region. Although I am less certain with regard to chromosome 7, it appears that the critical region that is consistently deleted may be 7q32 or 7q34-35.</p>","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15176359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analogous patterns of benzo[a]pyrene metabolism in human and rodent cells.","authors":"J K Selkirk","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15176459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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