Mechanical support of the heart is becoming an established method for emergency situations or bridge to transplant applications. Nevertheless the discussion concerning the importance of co- or counterpulsation isn't yet finished. Using a theoretical model of the cardiovascular system, the influence of a LVAD triggered to co- and counterpulsation will be discussed. The theoretically obtained results are compared to a series of six experiments in calves, where the influence of LVAD-pumping in co- and counterpulsation pumping mode was investigated. Additional benefits were seen compared to the copulsation pump method: there was more reduction of the cardiac stroke work, afterload and an increase of the diastolic pressure, which is important for the coronary blood flow. In order to verify the benefits of the additional reduction of pressure work a small series of animal experiments was performed.
{"title":"Counterpulsation in atrio-aortic bypass: theoretical and experimental aspects.","authors":"H B Lo, M Surmann, H Mückter, B J Messmer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mechanical support of the heart is becoming an established method for emergency situations or bridge to transplant applications. Nevertheless the discussion concerning the importance of co- or counterpulsation isn't yet finished. Using a theoretical model of the cardiovascular system, the influence of a LVAD triggered to co- and counterpulsation will be discussed. The theoretically obtained results are compared to a series of six experiments in calves, where the influence of LVAD-pumping in co- and counterpulsation pumping mode was investigated. Additional benefits were seen compared to the copulsation pump method: there was more reduction of the cardiac stroke work, afterload and an increase of the diastolic pressure, which is important for the coronary blood flow. In order to verify the benefits of the additional reduction of pressure work a small series of animal experiments was performed.</p>","PeriodicalId":77869,"journal":{"name":"Life support systems : the journal of the European Society for Artificial Organs","volume":"5 4","pages":"307-15"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14556372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F Lhote, L Guillevin, A Bussel, A Leon, C Lok, D Toledano, A Sobel, J Baudelot
Between 1981 and 1984, 72 patients (22-75 years) were included in a prospective study for treatment of Polyarteritis Nodosa (PN) which associated therapeutic plasma exchanges (TPE), corticosteroids (CS) 1 mg/kg/day, and a randomized trial of cyclophosphamide (CP) 2 mg/kg/day. We observed the incidence and analysed side effects (SE) occurring during TPE considering the technology of plasma removal. Full data were available for 63 patients. Seven hundred and eighteen TPE were performed. Centrifugation was used in 594 PE (82.7 per cent) with intermittent flow centrifugation (IFC) 320 times (44.5 per cent) and continuous flow centrifugation (CFC) 274 times (38.2 per cent). Filtration (F) was used in 124 sessions (17.3 per cent). Replacement fluid was 4 per cent albumin in 650 TPE and fresh frozen plasma (FFP) in 89 TPE. A total of two hundred and eleven SE were reported in 53 patients (84.1 per cent) during 173 TPE (24.1 per cent). Forty-six TPE were temporarily stopped because of SE (6.4 per cent). The mean volumes of removed plasma (ml/kg/TPE) were: 60.7 +/- 8.7 ml/kg when CFC was used 54.5 +/- 20 ml/kg with F and 52.5 +/- 9.6 ml/kg with IFC (n.s.) Main SE were: technical difficulties in 80 TPE, moderate or severe hypotension in 47, allergy to replacement fluid in 39. Hepatitis B antigen appeared in one patient. No death occurred during TPE and SE were usually minor and transient.(ABSTRACT TRUNCATED AT 250 WORDS)
{"title":"Side effects of therapeutic plasma exchange during treatment of polyarteritis nodosa. Comparison of filtration and centrifugation. 718 sessions in 63 patients.","authors":"F Lhote, L Guillevin, A Bussel, A Leon, C Lok, D Toledano, A Sobel, J Baudelot","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Between 1981 and 1984, 72 patients (22-75 years) were included in a prospective study for treatment of Polyarteritis Nodosa (PN) which associated therapeutic plasma exchanges (TPE), corticosteroids (CS) 1 mg/kg/day, and a randomized trial of cyclophosphamide (CP) 2 mg/kg/day. We observed the incidence and analysed side effects (SE) occurring during TPE considering the technology of plasma removal. Full data were available for 63 patients. Seven hundred and eighteen TPE were performed. Centrifugation was used in 594 PE (82.7 per cent) with intermittent flow centrifugation (IFC) 320 times (44.5 per cent) and continuous flow centrifugation (CFC) 274 times (38.2 per cent). Filtration (F) was used in 124 sessions (17.3 per cent). Replacement fluid was 4 per cent albumin in 650 TPE and fresh frozen plasma (FFP) in 89 TPE. A total of two hundred and eleven SE were reported in 53 patients (84.1 per cent) during 173 TPE (24.1 per cent). Forty-six TPE were temporarily stopped because of SE (6.4 per cent). The mean volumes of removed plasma (ml/kg/TPE) were: 60.7 +/- 8.7 ml/kg when CFC was used 54.5 +/- 20 ml/kg with F and 52.5 +/- 9.6 ml/kg with IFC (n.s.) Main SE were: technical difficulties in 80 TPE, moderate or severe hypotension in 47, allergy to replacement fluid in 39. Hepatitis B antigen appeared in one patient. No death occurred during TPE and SE were usually minor and transient.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":77869,"journal":{"name":"Life support systems : the journal of the European Society for Artificial Organs","volume":"5 4","pages":"359-66"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14030120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J R Monties, P Havlik, T Mesana, J Trinkl, F Aucomte, T Gauthier
{"title":"Rotary pump artificial heart: a new system for circulatory assistance or heart replacement.","authors":"J R Monties, P Havlik, T Mesana, J Trinkl, F Aucomte, T Gauthier","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77869,"journal":{"name":"Life support systems : the journal of the European Society for Artificial Organs","volume":"5 3","pages":"251-7"},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14815295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Forêt, F Kuentz, R Milongo, C Alibeu, T Hachache, H Meftahi, M Christollet, E Dechelette, D Cordonnier
{"title":"New advances in cuprophan membranes: steam-sterilization modified cellulose.","authors":"M Forêt, F Kuentz, R Milongo, C Alibeu, T Hachache, H Meftahi, M Christollet, E Dechelette, D Cordonnier","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77869,"journal":{"name":"Life support systems : the journal of the European Society for Artificial Organs","volume":"5 3","pages":"199-202"},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14624641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Choice of replacement fluid for plasma exchange.","authors":"U E Nydegger","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77869,"journal":{"name":"Life support systems : the journal of the European Society for Artificial Organs","volume":"5 3","pages":"279-82"},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14816200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Forêt, T Hachache, H Meftahi, R Milongo, F Kuentz, M Christollet, C Alibeu, D J Cordonnier
{"title":"The long-term evaluation of the biocompatibility of nine different haemodialysis membranes.","authors":"M Forêt, T Hachache, H Meftahi, R Milongo, F Kuentz, M Christollet, C Alibeu, D J Cordonnier","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77869,"journal":{"name":"Life support systems : the journal of the European Society for Artificial Organs","volume":"5 3","pages":"203-6"},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14815289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Experimental and clinical experience with the Pennsylvania State University total artificial heart.","authors":"W E Pae, G Rosenberg, W S Pierce","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77869,"journal":{"name":"Life support systems : the journal of the European Society for Artificial Organs","volume":"5 3","pages":"259-65"},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14448811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
U Fischer, E Salzsieder, P Abel, E J Freyse, I Hüttl
{"title":"The artificial beta cell: control of the milieu interieur.","authors":"U Fischer, E Salzsieder, P Abel, E J Freyse, I Hüttl","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77869,"journal":{"name":"Life support systems : the journal of the European Society for Artificial Organs","volume":"5 3","pages":"207-21"},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14448809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T Yshioka, T Tani, T Oka, K Hanasawa, Y Endo, K Matsuda, M Kodama
{"title":"Importance of body temperature in preclinical studies of blood-perfused artificial organ.","authors":"T Yshioka, T Tani, T Oka, K Hanasawa, Y Endo, K Matsuda, M Kodama","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77869,"journal":{"name":"Life support systems : the journal of the European Society for Artificial Organs","volume":"5 3","pages":"195-8"},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14815290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We report here an experimental investigation of the effects of inlet blood pressure and rotation speed on the performance of a rotating membrane device for plasmapheresis commercialized by Hemascience. The good performance of this device can be explained by a combination of high shear rate, centrifugation of red cells and platelets away from the membrane and large secondary flows.
{"title":"High efficiency plasmapheresis using rotating membrane device.","authors":"G Beaudoin, M Y Jaffrin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report here an experimental investigation of the effects of inlet blood pressure and rotation speed on the performance of a rotating membrane device for plasmapheresis commercialized by Hemascience. The good performance of this device can be explained by a combination of high shear rate, centrifugation of red cells and platelets away from the membrane and large secondary flows.</p>","PeriodicalId":77869,"journal":{"name":"Life support systems : the journal of the European Society for Artificial Organs","volume":"5 3","pages":"273-8"},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14816201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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