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Implications of using a prognostic index to select therapy for patients with aggressive histology lymphoma. 应用预后指标选择侵袭性组织学淋巴瘤治疗的意义。
The Canadian journal of oncology
Pub Date : 1995-03-01
R M Meyer, G P Browman

The International Non-Hodgkin's Lymphoma Prognostic Factor Index (INHLPF-Index) is a validated method of determining prognosis for patients with aggressive histology lymphoma and is now being used to identify those who might benefit most from new investigative therapies. This review assesses its usefulness and potential clinical utility in this context, and shows that several factors will determine the clinical utility of using this index, including the inherent accuracy of the index, the effect of mislabelling and the efficacy and toxicity of experimental treatment.

国际非霍奇金淋巴瘤预后因子指数(INHLPF-Index)是一种确定侵袭性组织学淋巴瘤患者预后的有效方法，目前被用于确定那些可能从新的调查性治疗中获益最多的患者。这篇综述评估了它在这种情况下的有用性和潜在的临床应用，并表明几个因素将决定使用该指数的临床应用，包括指数的固有准确性、错误标记的影响以及实验治疗的疗效和毒性。
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引用次数: 0
Restructuring: meeting the challenges. 重组:迎接挑战。
The Canadian journal of oncology
Pub Date : 1995-03-01
J D Beatty
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引用次数: 0
Issues for interpreting external stakeholder feedback on restructuring NCIC's research programs. 解释外部利益相关者对NCIC研究项目重组反馈的问题。
The Canadian journal of oncology
Pub Date : 1995-03-01
F D Ashbury, D C Iverson, P J Shephard

The National Cancer Institute of Canada surveyed members of its stakeholder groups on a number of issues pertaining to restructuring research programs. While it was hoped that the survey would ensure input from its primary stakeholder groups and thereby facilitate decision-making on critical issues like distribution of funds and research awards, there is reason to believe this may not have occurred. Some of the stakeholder groups seemed to be over-represented in the respondent population and the effect of this on the results was therefore examined. Analysis revealed several important issues: 1) a clear definition of who constitutes a "stakeholder" needs to be developed when stakeholder input-gathering is being contemplated; 2) multi-faceted strategies need to be developed to gain input from stakeholders; 3) potential sources of bias can emerge from the various techniques used to gather feedback from stakeholders; and 4) a clear outline of how the feedback is to be used in the decision-making process needs to be determined.

加拿大国家癌症研究所调查了其利益相关者团体的成员关于重组研究项目的一些问题。虽然人们希望这项调查能确保主要利益相关者群体的投入，从而促进在资金分配和研究奖励等关键问题上的决策，但有理由相信这可能没有发生。一些利益相关者群体在被调查者中似乎代表过多，因此对这对结果的影响进行了检查。分析揭示了几个重要问题:1)在考虑收集利益相关者的意见时，需要明确定义谁是“利益相关者”;2)需要制定多方面的战略，以获得利益相关者的投入;3)从利益相关者那里收集反馈的各种技术可能会产生潜在的偏见来源;4)需要确定如何在决策过程中使用反馈的清晰大纲。
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引用次数: 0
NCIC perspective on cancer control. NCIC对癌症控制的看法。
The Canadian journal of oncology
Pub Date : 1994-11-01
J D Beatty
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引用次数: 0
Quality of life and prostate cancer treatment: decision-making and rehabilitative support. 生活质量与前列腺癌治疗:决策和康复支持。
The Canadian journal of oncology
Pub Date : 1994-11-01
P G Ritvo
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引用次数: 0
The European Screening Study for Prostate Cancer. 欧洲前列腺癌筛查研究。
The Canadian journal of oncology
Pub Date : 1994-11-01
F H Schröder
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引用次数: 0
What studies should be undertaken in Canada to determine the value of screening for prostate cancer? 加拿大应该进行哪些研究来确定前列腺癌筛查的价值?
The Canadian journal of oncology
Pub Date : 1994-11-01
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引用次数: 0
The need to measure quality of life in a prostate cancer screening trial. 在前列腺癌筛查试验中测量生活质量的必要性。
The Canadian journal of oncology
Pub Date : 1994-11-01
D Iverson
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引用次数: 0
Recommendations from the BC Office of Health Technology Assessment. 不列颠哥伦比亚省卫生技术评估办公室的建议。
The Canadian journal of oncology
Pub Date : 1994-11-01
K Bassett

The BCOHTA does not make recommendations or set policy; rather, we report on the evidence. Our message is clear: For asymptomatic men, there is no evidence that annual or semi-annual PSA testing will do any good. There is substantial evidence that PSA testing will lead to considerable harm.

BCOHTA不提出建议或制定政策;相反，我们报告的是证据。我们的信息很明确:对于无症状的男性，没有证据表明每年或半年一次的PSA检测会有任何好处。有大量证据表明，PSA检测将导致相当大的危害。
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引用次数: 0
E-cadherin, estrogens and cancer: is there a connection? e -钙粘蛋白，雌激素和癌症:有联系吗?
The Canadian journal of oncology
Pub Date : 1994-11-01
O W Blaschuk, S B Munro, R Farookhi

E-cadherin is a calcium-dependent, epithelial cell adhesion molecule. It has recently been implicated as a tumor suppressor. This review article contains a description of the structure, function, and regulation of E-cadherin and other members comprising the cadherin family. In particular, we discuss studies concerning the ability of estrogens to modulate E-cadherin levels in vivo. Finally, we consider the hypothesis that estrogens may promote breast, uterine and ovarian cancer by down-regulating E-cadherin levels in these tissues.

钙粘蛋白是一种钙依赖性的上皮细胞粘附分子。它最近被认为是一种肿瘤抑制因子。本文综述了e -钙粘蛋白及其他钙粘蛋白家族成员的结构、功能和调控。特别地，我们讨论了关于雌激素调节体内e -钙粘蛋白水平的能力的研究。最后，我们考虑了雌激素可能通过下调E-cadherin在这些组织中的水平而促进乳腺癌、子宫癌和卵巢癌的假设。
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引用次数: 0
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