The process of measuring health-related quality of life (HQL) in oncology is reviewed and the role of these results in clinical practice and clinical trials is discussed. It is determined that comparisons of HQL measurement instruments are needed to clarify which questionnaires are preferable in particular populations or situations. "Calibration" data are also needed, to help explain the meaning of HQL scores and to link them to external reality. In phase III clinical trials, HQL assessment is most important in trials involving disease sites and stages with a poor prognosis and when comparing treatments not expected to affect survival.
{"title":"Health-related quality of life: measurement and clinical application. A workshop report.","authors":"D Osoba, J E Till, J L Pater, J R Young","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The process of measuring health-related quality of life (HQL) in oncology is reviewed and the role of these results in clinical practice and clinical trials is discussed. It is determined that comparisons of HQL measurement instruments are needed to clarify which questionnaires are preferable in particular populations or situations. \"Calibration\" data are also needed, to help explain the meaning of HQL scores and to link them to external reality. In phase III clinical trials, HQL assessment is most important in trials involving disease sites and stages with a poor prognosis and when comparing treatments not expected to affect survival.</p>","PeriodicalId":79379,"journal":{"name":"The Canadian journal of oncology","volume":"5 1","pages":"338-43"},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19820576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The International Non-Hodgkin's Lymphoma Prognostic Factor Index (INHLPF-Index) is a validated method of determining prognosis for patients with aggressive histology lymphoma and is now being used to identify those who might benefit most from new investigative therapies. This review assesses its usefulness and potential clinical utility in this context, and shows that several factors will determine the clinical utility of using this index, including the inherent accuracy of the index, the effect of mislabelling and the efficacy and toxicity of experimental treatment.
{"title":"Implications of using a prognostic index to select therapy for patients with aggressive histology lymphoma.","authors":"R M Meyer, G P Browman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The International Non-Hodgkin's Lymphoma Prognostic Factor Index (INHLPF-Index) is a validated method of determining prognosis for patients with aggressive histology lymphoma and is now being used to identify those who might benefit most from new investigative therapies. This review assesses its usefulness and potential clinical utility in this context, and shows that several factors will determine the clinical utility of using this index, including the inherent accuracy of the index, the effect of mislabelling and the efficacy and toxicity of experimental treatment.</p>","PeriodicalId":79379,"journal":{"name":"The Canadian journal of oncology","volume":"5 1","pages":"344-54"},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19820577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Restructuring: meeting the challenges.","authors":"J D Beatty","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79379,"journal":{"name":"The Canadian journal of oncology","volume":"5 1","pages":"VII-IX"},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19821272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The National Cancer Institute of Canada surveyed members of its stakeholder groups on a number of issues pertaining to restructuring research programs. While it was hoped that the survey would ensure input from its primary stakeholder groups and thereby facilitate decision-making on critical issues like distribution of funds and research awards, there is reason to believe this may not have occurred. Some of the stakeholder groups seemed to be over-represented in the respondent population and the effect of this on the results was therefore examined. Analysis revealed several important issues: 1) a clear definition of who constitutes a "stakeholder" needs to be developed when stakeholder input-gathering is being contemplated; 2) multi-faceted strategies need to be developed to gain input from stakeholders; 3) potential sources of bias can emerge from the various techniques used to gather feedback from stakeholders; and 4) a clear outline of how the feedback is to be used in the decision-making process needs to be determined.
{"title":"Issues for interpreting external stakeholder feedback on restructuring NCIC's research programs.","authors":"F D Ashbury, D C Iverson, P J Shephard","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The National Cancer Institute of Canada surveyed members of its stakeholder groups on a number of issues pertaining to restructuring research programs. While it was hoped that the survey would ensure input from its primary stakeholder groups and thereby facilitate decision-making on critical issues like distribution of funds and research awards, there is reason to believe this may not have occurred. Some of the stakeholder groups seemed to be over-represented in the respondent population and the effect of this on the results was therefore examined. Analysis revealed several important issues: 1) a clear definition of who constitutes a \"stakeholder\" needs to be developed when stakeholder input-gathering is being contemplated; 2) multi-faceted strategies need to be developed to gain input from stakeholders; 3) potential sources of bias can emerge from the various techniques used to gather feedback from stakeholders; and 4) a clear outline of how the feedback is to be used in the decision-making process needs to be determined.</p>","PeriodicalId":79379,"journal":{"name":"The Canadian journal of oncology","volume":"5 1","pages":"328-37"},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19820575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"NCIC perspective on cancer control.","authors":"J D Beatty","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79379,"journal":{"name":"The Canadian journal of oncology","volume":"4 Suppl 1 ","pages":"2-3"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19820578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quality of life and prostate cancer treatment: decision-making and rehabilitative support.","authors":"P G Ritvo","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79379,"journal":{"name":"The Canadian journal of oncology","volume":"4 Suppl 1 ","pages":"43-5; discussion 46"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19820589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The European Screening Study for Prostate Cancer.","authors":"F H Schröder","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79379,"journal":{"name":"The Canadian journal of oncology","volume":"4 Suppl 1 ","pages":"102-5; discussion 106-9"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19822411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"What studies should be undertaken in Canada to determine the value of screening for prostate cancer?","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79379,"journal":{"name":"The Canadian journal of oncology","volume":"4 Suppl 1 ","pages":"119-24"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19822413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The need to measure quality of life in a prostate cancer screening trial.","authors":"D Iverson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":79379,"journal":{"name":"The Canadian journal of oncology","volume":"4 Suppl 1 ","pages":"76-7"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19822406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The BCOHTA does not make recommendations or set policy; rather, we report on the evidence. Our message is clear: For asymptomatic men, there is no evidence that annual or semi-annual PSA testing will do any good. There is substantial evidence that PSA testing will lead to considerable harm.
{"title":"Recommendations from the BC Office of Health Technology Assessment.","authors":"K Bassett","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The BCOHTA does not make recommendations or set policy; rather, we report on the evidence. Our message is clear: For asymptomatic men, there is no evidence that annual or semi-annual PSA testing will do any good. There is substantial evidence that PSA testing will lead to considerable harm.</p>","PeriodicalId":79379,"journal":{"name":"The Canadian journal of oncology","volume":"4 Suppl 1 ","pages":"86-8; discussion 89-95"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19822409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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