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Regulation of the transcription factor GATA-1 at the gene and protein level. 转录因子 GATA-1 在基因和蛋白质水平上的调控。
IF 6.2
Social work research & abstracts
Pub Date : 2001-12-01 DOI: 10.1007/PL00000833
X B Tang, D P Liu, C C Liang

GATA-1, an important hematopoietic transcription factor, plays a critical role in differentiation and maturation of erythroid and megakaryocytic cell lines. GATA-1 appears to serve as a factor for virtually all characterized erythroid and megakaryocytic-expressed genes. Thus, defining the mechanisms by which the GATA-1 gene and protein are regulated should provide important clues regarding the establishment of erythroid and megakaryocytic programs of gene expression in committed cells and their maintenance thereafter in maturing precursors. This review focuses on the regulation of GATA-1 expression and elucidates the regulation of GATA-1 at the gene and protein levels. Such research is expected to provide insights into the mechanisms involved in hematopoietic commitment.

GATA-1 是一种重要的造血转录因子，在红细胞和巨核细胞系的分化和成熟过程中发挥着关键作用。GATA-1 似乎是几乎所有特征性红细胞和巨核细胞表达基因的因子。因此，确定 GATA-1 基因和蛋白的调控机制将为红细胞和巨核细胞基因表达程序在成熟前体细胞中的建立和维持提供重要线索。本综述侧重于 GATA-1 的表达调控，并阐明了 GATA-1 在基因和蛋白水平上的调控。这些研究有望为造血承诺的相关机制提供深入见解。
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引用次数: 0
Social worker burnout: A longitudinal study 社工职业倦怠:一项纵向研究
Social work research & abstracts
Pub Date : 1993-12-01 DOI: 10.1093/SWRA/29.4.5
J. Poulin, C. Walter
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引用次数: 91
Measuring Attitudes toward Poverty: A New Scale 衡量对贫困的态度:一种新的尺度
Social work research & abstracts
Pub Date : 1993-12-01 DOI: 10.1093/SWRA/29.4.28
C. Atherton, Raymond J. Gemmel, S. Haagenstad, D. Holt, L. A. Jensen, David F. O'Hara, T. Rehner
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引用次数: 91
Counting the rural homeless population: Methodological dilemmas 农村无家可归人口的统计:方法上的困境
Social work research & abstracts
Pub Date : 1993-12-01 DOI: 10.1093/SWRA/29.4.23
B. Toomey, R. J. First, R. Greenlee, Linda K. Cummins
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引用次数: 9
Correction of workers' personal versus environmental bias in formulation of client problems 修正员工在制定客户问题时的个人与环境偏见
Social work research & abstracts
Pub Date : 1993-12-01 DOI: 10.1093/SWRA/29.4.12
A. Rosen
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引用次数: 22
Improving Research Writing 提高研究写作
Social work research & abstracts
Pub Date : 1993-12-01 DOI: 10.1093/SWRA/29.4.3
S. Kirk, R. Berger
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引用次数: 6
Coping strategies and the maintenance of change after inpatient alcoholism treatment 住院酒精中毒治疗后的应对策略及维持改变
Social work research & abstracts
Pub Date : 1993-12-01 DOI: 10.1093/SWRA/29.4.18
Sandra Munroe Wunschel, D. Rohsenow, J. Norcross, P. Monti
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引用次数: 22
Randomized controlled trials in the human services 人类服务的随机对照试验
Social work research & abstracts
Pub Date : 1993-09-01 DOI: 10.1093/SWRA/29.3.3
W. Epstein
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引用次数: 10
Emotional abuse: A study of interobserver reliability 情绪虐待:观察者间信度的研究
Social work research & abstracts
Pub Date : 1993-09-01 DOI: 10.1093/SWRA/29.3.22
J. R. Seaberg
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引用次数: 4
Models of helping and coping: A field experiment with natural and professional helpers 帮助和应对的模式:自然和专业帮助者的现场实验
Social work research & abstracts
Pub Date : 1993-09-01 DOI: 10.1093/SWRA/29.3.11
Jay L. Memmott
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引用次数: 7
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