{"title":"Parkinson’s disease and dance therapy—An Indian scenario: An initial experience","authors":"A. Mehta","doi":"10.4103/aomd.aomd_55_22","DOIUrl":"https://doi.org/10.4103/aomd.aomd_55_22","url":null,"abstract":"","PeriodicalId":7973,"journal":{"name":"Annals of Movement Disorders","volume":"16 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140222472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Qavi, Pradeep Maurya, A. K. Singh, D. Kulshreshtha, A. Thacker, Triman S Sikand
{"title":"Tongue tremor: A rare manifestation of disseminated central nervous system tuberculosis","authors":"A. Qavi, Pradeep Maurya, A. K. Singh, D. Kulshreshtha, A. Thacker, Triman S Sikand","doi":"10.4103/aomd.aomd_34_23","DOIUrl":"https://doi.org/10.4103/aomd.aomd_34_23","url":null,"abstract":"","PeriodicalId":7973,"journal":{"name":"Annals of Movement Disorders","volume":"230 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140222557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Gomathy, Arti Saini, Anu Gupta, V. Vishnu, Mamta B. Singh, R. Bhatia, P. Srivastava, Divya Radhakrishnan, A. Srivastava, R. Rajan
{"title":"A rare yet treatable case of paroxysmal kinesigenic dyskinesia","authors":"S. Gomathy, Arti Saini, Anu Gupta, V. Vishnu, Mamta B. Singh, R. Bhatia, P. Srivastava, Divya Radhakrishnan, A. Srivastava, R. Rajan","doi":"10.4103/aomd.aomd_28_23","DOIUrl":"https://doi.org/10.4103/aomd.aomd_28_23","url":null,"abstract":"","PeriodicalId":7973,"journal":{"name":"Annals of Movement Disorders","volume":" 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140221726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quadrupedal locomotion in Uner Tan syndrome: A neurological viewpoint","authors":"Gurusidheshwar M. Wali, Gautam Wali","doi":"10.4103/aomd.aomd_13_23","DOIUrl":"https://doi.org/10.4103/aomd.aomd_13_23","url":null,"abstract":"","PeriodicalId":7973,"journal":{"name":"Annals of Movement Disorders","volume":"8 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140222659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shreyashi Jha, Mona Tiwari, Debarshi Chatterjee, Ashis Datta, Shobhana A
Movement disorders associated with tubercular meningitis have been reported, ranging from tremors to chorea. Stereotypy is a rare manifestation following tubercular meningitis. Here we report a rare case of a 29-year-old man who developed stereotypy and parkinsonism following tubercular meningitis. The stereotypy was in the form of rotatory movements of the right upper limb, which were repetitive, purposeless, non-goal directed, present for most of the day, and partially suppressible. In addition, it was associated with severe generalized parkinsonism. This report expands the spectrum of movement disorders seen in tubercular meningitis.
{"title":"Stereotypy and Parkinsonism in tubercular meningitis: Expanding the spectrum","authors":"Shreyashi Jha, Mona Tiwari, Debarshi Chatterjee, Ashis Datta, Shobhana A","doi":"10.4103/aomd.aomd_20_23","DOIUrl":"https://doi.org/10.4103/aomd.aomd_20_23","url":null,"abstract":"\u0000 Movement disorders associated with tubercular meningitis have been reported, ranging from tremors to chorea. Stereotypy is a rare manifestation following tubercular meningitis. Here we report a rare case of a 29-year-old man who developed stereotypy and parkinsonism following tubercular meningitis. The stereotypy was in the form of rotatory movements of the right upper limb, which were repetitive, purposeless, non-goal directed, present for most of the day, and partially suppressible. In addition, it was associated with severe generalized parkinsonism. This report expands the spectrum of movement disorders seen in tubercular meningitis.","PeriodicalId":7973,"journal":{"name":"Annals of Movement Disorders","volume":"208 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140222985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"“EYES ON CEILING” sign: A new ocular sign in progressive supranuclear palsy","authors":"Mohan Madhusudanan","doi":"10.4103/aomd.aomd_5_23","DOIUrl":"https://doi.org/10.4103/aomd.aomd_5_23","url":null,"abstract":"","PeriodicalId":7973,"journal":{"name":"Annals of Movement Disorders","volume":"127 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140223349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Poornam N Venkateswaran, Balaji Gopalan, Hariharan S.
Anti-leucine-rich, glioma-inactivated (LGI1) autoimmune encephalitis is one of the autoimmune encephalitides with a distinct movement abnormality – faciobrachial dystonic seizures (FBDS). FBDS, being the clinching sign towards a clinical diagnosis, is known to occur at disease onset, and if left untreated, can lead to disabling cognitive impairment. In this case series, we describe three cases of LGI1 encephalitis presenting with behavioral abnormalities at onset for a significant period, compelling an alternative diagnosis preceding the onset of FBDS. In addition, it highlights that imaging could be normal in the initial stages of the disease, further making the diagnosis a challenge at an initial stage.
{"title":"LGI1 encephalitis–Behaviors predate movements: A case series","authors":"Poornam N Venkateswaran, Balaji Gopalan, Hariharan S.","doi":"10.4103/aomd.aomd_37_23","DOIUrl":"https://doi.org/10.4103/aomd.aomd_37_23","url":null,"abstract":"\u0000 Anti-leucine-rich, glioma-inactivated (LGI1) autoimmune encephalitis is one of the autoimmune encephalitides with a distinct movement abnormality – faciobrachial dystonic seizures (FBDS). FBDS, being the clinching sign towards a clinical diagnosis, is known to occur at disease onset, and if left untreated, can lead to disabling cognitive impairment. In this case series, we describe three cases of LGI1 encephalitis presenting with behavioral abnormalities at onset for a significant period, compelling an alternative diagnosis preceding the onset of FBDS. In addition, it highlights that imaging could be normal in the initial stages of the disease, further making the diagnosis a challenge at an initial stage.","PeriodicalId":7973,"journal":{"name":"Annals of Movement Disorders","volume":" 31","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140222346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RohanR Mahale, Sandeep M, Anita Mahadevan, N. Kamble, V. Holla, R. Mundlamuri, S. Vengalil, N. M, A. Nalini, P. Pal, Ravi Yadav
Anti-glutamate decarboxylase 65 antibody-associated cerebellar ataxia (anti-GAD65Ab-associated CA) is the most widely studied immune-mediated CA. There are few case series evaluating the clinical, radiological, treatment profile, and outcome of anti-GAD65Ab-associated CA. To study the clinical, radiological profile, associated neoplasm, treatment outcome, and prognosis in patients diagnosed with anti-GAD65Ab-associated CA. A retrospective descriptive analysis of a cohort of patients diagnosed with anti-GAD65Ab-associated CA was performed and analyzed. Thirteen patients were selected for the analysis with female predominance (70%). The mean age at presentation was 47.5 ± 11.1 years (range, 29–65 years), and the median duration of the symptoms was 4 months. All 13 patients (100%) had gait ataxia. Ten patients had limb ataxia along with gait ataxia (75%). Seven patients had cerebellar dysarthria (54%). Four patients (31%) had gaze-evoked jerky nystagmus. Five patients (39%) were diagnosed with type 2 diabetes mellitus, and one patient had hypothyroidism in addition to type 2 diabetes mellitus. Brain magnetic resonance imaging was normal in seven (54%) patients, and pure cerebellar atrophy was observed in six patients. One patient was detected with a colon neoplasm. All 13 patients received intravenous methylprednisolone, followed by oral steroids over 3 months. Six patients (50%) received plasma exchange along with intravenous methylprednisolone. Favorable outcomes (modified Rankin scale score ≤2) were observed in five patients and poor outcomes in two; six patients were lost to follow-up after the first admission. Anti-GAD65Ab-associated CA presents as subacute to chronic progressive CA with a favorable outcome with immunotherapy. Anti-GAD antibodies should be assessed in serum or cerebrospinal fluid in patients presenting subacute to chronic sporadic CA. The occurrence of a systemic neoplasm is rare in anti-GAD65Ab-associated CA.
{"title":"Anti-glutamic acid decarboxylase antibodies-associated cerebellar ataxia: A treatable ataxia","authors":"RohanR Mahale, Sandeep M, Anita Mahadevan, N. Kamble, V. Holla, R. Mundlamuri, S. Vengalil, N. M, A. Nalini, P. Pal, Ravi Yadav","doi":"10.4103/aomd.aomd_23_23","DOIUrl":"https://doi.org/10.4103/aomd.aomd_23_23","url":null,"abstract":"\u0000 \u0000 \u0000 Anti-glutamate decarboxylase 65 antibody-associated cerebellar ataxia (anti-GAD65Ab-associated CA) is the most widely studied immune-mediated CA. There are few case series evaluating the clinical, radiological, treatment profile, and outcome of anti-GAD65Ab-associated CA.\u0000 \u0000 \u0000 \u0000 To study the clinical, radiological profile, associated neoplasm, treatment outcome, and prognosis in patients diagnosed with anti-GAD65Ab-associated CA.\u0000 \u0000 \u0000 \u0000 A retrospective descriptive analysis of a cohort of patients diagnosed with anti-GAD65Ab-associated CA was performed and analyzed.\u0000 \u0000 \u0000 \u0000 Thirteen patients were selected for the analysis with female predominance (70%). The mean age at presentation was 47.5 ± 11.1 years (range, 29–65 years), and the median duration of the symptoms was 4 months. All 13 patients (100%) had gait ataxia. Ten patients had limb ataxia along with gait ataxia (75%). Seven patients had cerebellar dysarthria (54%). Four patients (31%) had gaze-evoked jerky nystagmus. Five patients (39%) were diagnosed with type 2 diabetes mellitus, and one patient had hypothyroidism in addition to type 2 diabetes mellitus. Brain magnetic resonance imaging was normal in seven (54%) patients, and pure cerebellar atrophy was observed in six patients. One patient was detected with a colon neoplasm. All 13 patients received intravenous methylprednisolone, followed by oral steroids over 3 months. Six patients (50%) received plasma exchange along with intravenous methylprednisolone. Favorable outcomes (modified Rankin scale score ≤2) were observed in five patients and poor outcomes in two; six patients were lost to follow-up after the first admission.\u0000 \u0000 \u0000 \u0000 Anti-GAD65Ab-associated CA presents as subacute to chronic progressive CA with a favorable outcome with immunotherapy. Anti-GAD antibodies should be assessed in serum or cerebrospinal fluid in patients presenting subacute to chronic sporadic CA. The occurrence of a systemic neoplasm is rare in anti-GAD65Ab-associated CA.\u0000","PeriodicalId":7973,"journal":{"name":"Annals of Movement Disorders","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140223832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Baikuntha Panigrahi, Divya Radhakrishnan, R. Rajan, Ayush Agarwal, A. Pandit, A. Srivastava
Pramipexole, a dopaminergic agonist, has rarely been implicated as a cause of hyponatremia in patients with Parkinson’s disease (PD). Pramipexole-induced stimulation of anti-diuretic hormone results in euvolemic hyponatremia. This is often neglected, and hyponatremia may lead to worsening of the motor symptoms with PD and an unnecessary increase in dopaminergic medications, causing disabling dyskinesias. This case report describes a patient with young-onset PD who developed new-onset hyponatremia due to pramipexole-induced syndrome of inappropriate anti-diuretic hormone within 3 months of starting the drug.
{"title":"Pramipexole-induced syndrome of inappropriate antidiuretic hormone secretion in a patient with young-onset Parkinson’s disease","authors":"Baikuntha Panigrahi, Divya Radhakrishnan, R. Rajan, Ayush Agarwal, A. Pandit, A. Srivastava","doi":"10.4103/aomd.aomd_58_22","DOIUrl":"https://doi.org/10.4103/aomd.aomd_58_22","url":null,"abstract":"\u0000 Pramipexole, a dopaminergic agonist, has rarely been implicated as a cause of hyponatremia in patients with Parkinson’s disease (PD). Pramipexole-induced stimulation of anti-diuretic hormone results in euvolemic hyponatremia. This is often neglected, and hyponatremia may lead to worsening of the motor symptoms with PD and an unnecessary increase in dopaminergic medications, causing disabling dyskinesias. This case report describes a patient with young-onset PD who developed new-onset hyponatremia due to pramipexole-induced syndrome of inappropriate anti-diuretic hormone within 3 months of starting the drug.","PeriodicalId":7973,"journal":{"name":"Annals of Movement Disorders","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140222062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BACKGROUND: In the 1960s, levodopa was first administered to treat the symptoms of Parkinson’s disease (PD), and it has since become the “gold standard” in its treatment. Since then, many classes of drugs have been made available to treat PD; however, these drugs are associated with considerable adverse effects. OBJECTIVE: The objective of this review is to highlight the most important and clinically relevant side effects of the medications used to treat the motor symptoms of PD. MATERIAL AND METHODS: We used PubMed and Google scholar to search for articles from January 1975 to January 2021. RESULTS: The medications used to treat PD vary in their mechanisms of action. The major classes of drugs that are used include levodopa and dopamine agonists. Nausea, vomiting, sleepiness, and neuropsychiatric and cardiovascular problems are some of the most common adverse effects observed. In addition, class-specific adverse effects of various drugs are observed and are important. CONCLUSIONS: The drugs used to treat PD are associated with considerable adverse effects, which may be mild, severe, or even life threatening. Most adverse effects are reversible and disappear with drug withdrawal. However, discontinuation of the drugs may not always be possible. Education of the patient and caregiver and awareness among clinicians is essential for early recognition and to prevent impairment of the quality of life. In addition, the development of new drugs with a favorable side effect profile should be prioritized.
{"title":"Adverse effects of medications used to treat motor symptoms of Parkinson′s disease: A narrative review","authors":"Bhushan Mishal, Akash Shetty, P. Wadia","doi":"10.4103/aomd.aomd_37_22","DOIUrl":"https://doi.org/10.4103/aomd.aomd_37_22","url":null,"abstract":"BACKGROUND: In the 1960s, levodopa was first administered to treat the symptoms of Parkinson’s disease (PD), and it has since become the “gold standard” in its treatment. Since then, many classes of drugs have been made available to treat PD; however, these drugs are associated with considerable adverse effects. OBJECTIVE: The objective of this review is to highlight the most important and clinically relevant side effects of the medications used to treat the motor symptoms of PD. MATERIAL AND METHODS: We used PubMed and Google scholar to search for articles from January 1975 to January 2021. RESULTS: The medications used to treat PD vary in their mechanisms of action. The major classes of drugs that are used include levodopa and dopamine agonists. Nausea, vomiting, sleepiness, and neuropsychiatric and cardiovascular problems are some of the most common adverse effects observed. In addition, class-specific adverse effects of various drugs are observed and are important. CONCLUSIONS: The drugs used to treat PD are associated with considerable adverse effects, which may be mild, severe, or even life threatening. Most adverse effects are reversible and disappear with drug withdrawal. However, discontinuation of the drugs may not always be possible. Education of the patient and caregiver and awareness among clinicians is essential for early recognition and to prevent impairment of the quality of life. In addition, the development of new drugs with a favorable side effect profile should be prioritized.","PeriodicalId":7973,"journal":{"name":"Annals of Movement Disorders","volume":"6 1","pages":"45 - 57"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44317760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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