Cardiovascular radiation medicine最新文献

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Abstract 摘要

Cardiovascular radiation medicine

Pub Date : 2002-07-01 DOI: 10.1016/S1522-1865(03)00048-9

引用次数: 0

Keyword Index to Volume 3 关键词索引卷3

Cardiovascular radiation medicine

Pub Date : 2002-07-01 DOI: 10.1016/S1522-1865(03)00135-5

引用次数: 0

Geographical miss and restenosis during catheter-based intracoronary β-radiation for de novo lesions 基于导管的冠状动脉内β放射治疗新发病变时的地理遗漏和再狭窄

Cardiovascular radiation medicine

Pub Date : 2002-07-01 DOI: 10.1016/S1522-1865(03)00101-X

Georgios Sianos , William Wijns , Pim J de Feyter , Ron van Domburg , Patrick W Serruys

Objectives: We sought to determine the impact of geographical miss (GM) on restenosis rates after intracoronary β-radiation therapy for de novo lesions. Background: GM is the situation in which injured vessel segments (VSs) are receiving low-dose radiation and is accounted for edge restenosis. Its impact on the overall restenosis rates remains to be determined. Methods: We analyzed 330 patients (356 vessels) treated according to the Beta Radiation in Europe (BRIE) and the Dose Finding study protocols. Using quantitative coronary angiography (QCA), the effective irradiated segment (EIRS), its edges and the total VS were analysed. The edges of the EIRS that were injured constituted the GM edges. Restenosis was defined as diameter stenosis >50% at follow-up. GM was determined by the simultaneous electrocardiographic-matched, side-by-side projection of the source and balloons deflated and surrounded by contrast, at the site of injury, in identical angiographic projections. Results: In 20.5% of the vessels, GM was non-interpretable due to inadequate filming. GM occurred at 30.4% of the interpretable edges and 53% of the interpretable vessels that were analysed. Edge restenosis was significantly increased in the GM compared to non-GM edges (13.16% vs. 4.17%, respectively, P=.001), both in the proximal (P=.03) and the distal (P=.001) edges. GM associated with stent injury significantly increased edge restenosis (P=.006). GM related to balloon injury tended to be associated with increment in edge restenosis (P=.07). The restenosis in the EIRS was similar between vessels with and without GM (17.78% and 14.85%, respectively, P=.6). GM was associated with significant increment in the restenosis at the analyzed VS (31.85% vs. 21.48%, P=.05). Conclusions: GM is strongly associated with edges and restenosis in the analysed VS. GM does not increase restenosis in the EIRS.

目的:我们试图确定地理缺失(GM)对新发病变冠状动脉内β放射治疗后再狭窄率的影响。背景:GM是受损血管段(VSs)接受低剂量辐射的情况，并被认为是边缘再狭窄的原因。其对总体再狭窄率的影响仍有待确定。方法:我们分析了330例(356条血管)根据欧洲β辐射(BRIE)和剂量寻找研究方案治疗的患者。应用定量冠状动脉造影(QCA)对有效辐照段(EIRS)、边缘及总VS进行分析。损伤的EIRS边缘构成GM边缘。随访时，再狭窄定义为直径狭窄50%。GM是通过同时心电图匹配，源和气球并排投影确定的，在损伤部位，在相同的血管造影投影中放气并被造影剂包围。结果:在20.5%的血管中，GM因拍摄不充分而无法解释。GM发生在30.4%的可解释边缘和53%的可解释血管中。在近端边缘(P= 0.03)和远端边缘(P= 0.001)，与非GM边缘相比，GM边缘再狭窄显著增加(分别为13.16%和4.17%，P= 0.001)。与支架损伤相关的GM显著增加边缘再狭窄(P= 0.006)。球囊损伤相关的GM倾向于与边缘再狭窄增加相关(P=.07)。合并和未合并GM的血管EIRS再狭窄发生率相似(分别为17.78%和14.85%，P= 0.6)。GM与VS再狭窄显著增加相关(31.85% VS . 21.48%， P= 0.05)。结论:在分析的病例中，转基因与边缘和再狭窄密切相关，而转基因不会增加EIRS的再狭窄。

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引用次数: 7

VEGF analysis induced by endothelialized gas-plasma treated d,l-PLA scaffolds 内皮化气浆处理的d,l-PLA支架诱导VEGF分析

Cardiovascular radiation medicine

Pub Date : 2002-07-01 DOI: 10.1016/S1522-1865(03)00100-8

Jodie L. Polan , Brian Morse , Suzanne Wetherold , Rosa E. Villanueva-Vedia , Clyde Phelix , Edwin Barera-Roderiquiz , Douglas Waggoner , Nilesh Goswami , Oscar Munoz , C.Mauli Agrawal , Steve R. Bailey

Purpose: Vascular endothelial growth factor (VEGF) isoforms play different roles in the temporal sprouting of endothelial-lined vessels in a nude mouse peritoneal model as cells respond to nontreated control and gas-plasma-treated bioresorbable poly-d,l-lactide acid 3D scaffolds with human aortic endothelial cells (HAEC). Methods and materials: Nude mice peritoneums were incubated with HAEC (CW=control; TW=gas-plasma treated) or polymer scaffolds (C_p=control; T_p=treated) for 12, 24 and 72 days. Cytoplasmic and nuclear protein fractions were isolated using NER, electrophoresized using NuPAGE–MES and analyzed by WesternBreeze Chemiluminescent. Results: Prominent VEGF bands included 28, 45 and 62 kDa; 52-kDa VEGF observed in cytoplasmic TW fractions contributed about 18.6% at 12 days, 20.0% at 24 days and 13.1% at 72 days of the total VEGF signal. Yet, it was only noted in CW at 72 days where it accounted for 6.9%. A unique 32-kDa band appeared in both C_p (24.6%) and T_p (18.3%). Significant differences between band densities occurred for cytoplasmic nuclear CW24–TW24 (P=.022), CW72–TW72 (P=.011) and, also, cytoplasmic C_p24–T_p24 (P=.038). Conclusions: The temporal and spatial organization of the TW isoforms results in more angiogenesis.

目的:血管内皮生长因子(VEGF)异构体在裸鼠腹膜模型内皮血管的时间萌发中发挥不同的作用，因为细胞对未经处理的对照和经气-血浆处理的人主动脉内皮细胞(HAEC)生物可吸收聚d -l -乳酸3D支架有反应。方法与材料:用HAEC孵育裸鼠腹膜(CW=对照组;TW=气等离子体处理)或聚合物支架(Cp=对照;Tp=治疗组)12、24和72天。细胞质和核蛋白用NER分离，用NuPAGE-MES电泳，用WesternBreeze化学发光仪分析。结果:显著的VEGF条带包括28、45、62 kDa;细胞质TW组分中观察到的52-kDa VEGF在第12天、第24天和第72天分别占总VEGF信号的18.6%、20.0%和13.1%。然而，在CW中，它只在72天中被注意到，占6.9%。Cp(24.6%)和Tp(18.3%)均有一条独特的32 kda带。胞质核CW24-TW24 (P= 0.022)、胞质核CW72-TW72 (P= 0.011)和胞质核Cp24-Tp24 (P= 0.038)的带密度存在显著差异。结论:TW异构体的时空组织导致更多的血管生成。

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引用次数: 14

Abstract 摘要

Cardiovascular radiation medicine

Pub Date : 2002-07-01 DOI: 10.1016/S1522-1865(03)00013-1

引用次数: 0

Abstract 摘要

Cardiovascular radiation medicine

Pub Date : 2002-07-01 DOI: 10.1016/S1522-1865(03)00028-3

引用次数: 0

Abstract 摘要

Cardiovascular radiation medicine

Pub Date : 2002-07-01 DOI: 10.1016/S1522-1865(03)00003-9

引用次数: 0

Abstract 摘要

Cardiovascular radiation medicine

Pub Date : 2002-07-01 DOI: 10.1016/S1522-1865(03)00020-9

引用次数: 0

Abstract 摘要

Cardiovascular radiation medicine

Pub Date : 2002-07-01 DOI: 10.1016/S1522-1865(03)00039-8

引用次数: 0

Abstract 摘要

Cardiovascular radiation medicine

Pub Date : 2002-07-01 DOI: 10.1016/S1522-1865(03)00031-3

引用次数: 0

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