{"title":"Differential diagnosis of persistent nonallergic rhinitis and rhinosinusitis syndromes.","authors":"M. Staevska, J. Baraniuk","doi":"10.3109/9781420021172-7","DOIUrl":"https://doi.org/10.3109/9781420021172-7","url":null,"abstract":"","PeriodicalId":80264,"journal":{"name":"Clinical allergy and immunology","volume":"19 1","pages":"35-53"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69465157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-01-01DOI: 10.3109/9781420014020-10
R. Pawankar, Kun‐Hee Lee, M. Nonaka, R. Takizawa
Mast cells and basophils contribute to induction and/or maintenance of eosinophilic inflammation by a variety of mechanisms, including IgE-dependent and IgE-independent processes. The latter include a variety of stimuli that have only recently been elucidated, including mechanisms triggered by bacteria, virus, fungi, complement, or autoantibodies. MCs, and basophils contribute to inflammation both directly through the release of inflammatory mediators, cytokines and growth factors and indirectly through the activation of structural cells. Accumulating evidence places MCs (and most probably basophils) in a position of importance in the pathogenesis of CRS, particularly in the pathogenesis and progression of NP (Fig. 1). Mechanisms other than conventional IgE-dependent activation of MCs are intriguing as potential mechanisms of eosinophilic inflammation in non-allergic CRS/NP. Although it is not possible using current pharmacologic approaches to completely isolate the effects of MCs or basophils in CRS and NP pathogenesis, it seems most likely that such approaches will eventually be available. It might be expected that one or both of these cells will be shown to play important roles, particularly considering their potential for activation by IgE and non-IgE mechanisms, their production of a broad array of inflammatory mediators, cytokines and growth factors, and their unique assortment of proteases.
{"title":"Role of mast cells and basophils in chronic rhinosinusitis.","authors":"R. Pawankar, Kun‐Hee Lee, M. Nonaka, R. Takizawa","doi":"10.3109/9781420014020-10","DOIUrl":"https://doi.org/10.3109/9781420014020-10","url":null,"abstract":"Mast cells and basophils contribute to induction and/or maintenance of eosinophilic inflammation by a variety of mechanisms, including IgE-dependent and IgE-independent processes. The latter include a variety of stimuli that have only recently been elucidated, including mechanisms triggered by bacteria, virus, fungi, complement, or autoantibodies. MCs, and basophils contribute to inflammation both directly through the release of inflammatory mediators, cytokines and growth factors and indirectly through the activation of structural cells. Accumulating evidence places MCs (and most probably basophils) in a position of importance in the pathogenesis of CRS, particularly in the pathogenesis and progression of NP (Fig. 1). Mechanisms other than conventional IgE-dependent activation of MCs are intriguing as potential mechanisms of eosinophilic inflammation in non-allergic CRS/NP. Although it is not possible using current pharmacologic approaches to completely isolate the effects of MCs or basophils in CRS and NP pathogenesis, it seems most likely that such approaches will eventually be available. It might be expected that one or both of these cells will be shown to play important roles, particularly considering their potential for activation by IgE and non-IgE mechanisms, their production of a broad array of inflammatory mediators, cytokines and growth factors, and their unique assortment of proteases.","PeriodicalId":80264,"journal":{"name":"Clinical allergy and immunology","volume":"20 1","pages":"93-101"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69463538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-01-01DOI: 10.3109/9781420014020-17
C. Melroy, M. Dubin, B. Senior
{"title":"The role of nasal endoscopy in the diagnosis and medical management of chronic rhinosinusitis.","authors":"C. Melroy, M. Dubin, B. Senior","doi":"10.3109/9781420014020-17","DOIUrl":"https://doi.org/10.3109/9781420014020-17","url":null,"abstract":"","PeriodicalId":80264,"journal":{"name":"Clinical allergy and immunology","volume":"20 1","pages":"227-40"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69463601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Environmental and allergic factors in chronic rhinosinusitis.","authors":"J. Pinto, R. Naclerio","doi":"10.3109/9781420014020-7","DOIUrl":"https://doi.org/10.3109/9781420014020-7","url":null,"abstract":"","PeriodicalId":80264,"journal":{"name":"Clinical allergy and immunology","volume":"20 1","pages":"25-49"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69463711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aspirin-sensitive rhinosinusitis and asthma.","authors":"Marek L Kowalski","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":80264,"journal":{"name":"Clinical allergy and immunology","volume":"19 ","pages":"147-75"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26428401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Environmental and allergic factors in chronic rhinosinusitis.","authors":"Jayant M Pinto, Robert M Naclerio","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":80264,"journal":{"name":"Clinical allergy and immunology","volume":"20 ","pages":"25-49"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26747830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of inflammatory T cells and eosinophils in chronic rhinosinusitis.","authors":"Susan Foley, Qutayba Hamid","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":80264,"journal":{"name":"Clinical allergy and immunology","volume":"20 ","pages":"79-91"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26747832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We have outlined the myriad of roles, both proven and suspected, of epithelial cells in airway inflammation in general and CRS in particular. There is little doubt that these remarkable cells are essential for host defense, tissue responses to injury and threats, and inflammation that cause disease. We believe that many of these responses are likely to be amenable to the development of new therapies for CRS. As we acquire more information on the signaling processes that drive the protective responses in epithelial cells, we will improve our chances of developing approaches to enhance these responses without triggering deleterious inflammatory responses. Enhanced clearance of fungi and bacteria by local immune responses would likely be beneficial in reducing disease. As we better understand the signals that epithelial cells give and get from DCs, B and T lymphocytes, new opportunities for productive intervention will arise.
{"title":"Innate and acquired immunity and epithelial cell function in chronic rhinosinusitis.","authors":"R. Schleimer, A. Lane, Jennifer S. Kim","doi":"10.3109/9781420014020-8","DOIUrl":"https://doi.org/10.3109/9781420014020-8","url":null,"abstract":"We have outlined the myriad of roles, both proven and suspected, of epithelial cells in airway inflammation in general and CRS in particular. There is little doubt that these remarkable cells are essential for host defense, tissue responses to injury and threats, and inflammation that cause disease. We believe that many of these responses are likely to be amenable to the development of new therapies for CRS. As we acquire more information on the signaling processes that drive the protective responses in epithelial cells, we will improve our chances of developing approaches to enhance these responses without triggering deleterious inflammatory responses. Enhanced clearance of fungi and bacteria by local immune responses would likely be beneficial in reducing disease. As we better understand the signals that epithelial cells give and get from DCs, B and T lymphocytes, new opportunities for productive intervention will arise.","PeriodicalId":80264,"journal":{"name":"Clinical allergy and immunology","volume":"20 1","pages":"51-78"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69463719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-01-01DOI: 10.3109/9781420021172-24
N. Jones
{"title":"Midfacial segment pain: implications for rhinitis and rhinosinusitis.","authors":"N. Jones","doi":"10.3109/9781420021172-24","DOIUrl":"https://doi.org/10.3109/9781420021172-24","url":null,"abstract":"","PeriodicalId":80264,"journal":{"name":"Clinical allergy and immunology","volume":"19 1","pages":"323-33"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69464994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-01-01DOI: 10.3109/9781420021172-13
M. Kowalski
{"title":"Aspirin-sensitive rhinosinusitis and asthma.","authors":"M. Kowalski","doi":"10.3109/9781420021172-13","DOIUrl":"https://doi.org/10.3109/9781420021172-13","url":null,"abstract":"","PeriodicalId":80264,"journal":{"name":"Clinical allergy and immunology","volume":"19 1","pages":"147-75"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69465201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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