首页 > 最新文献

Annals of Pediatric Cardiology最新文献

英文 中文
Pleuropericardial cyst presenting as recurrent pneumonia: A diagnostic dilemma. 表现为复发性肺炎的胸膜心包囊肿:诊断难题。
IF 0.7 Q3 Medicine Pub Date : 2023-07-01 Epub Date: 2024-01-05 DOI: 10.4103/apc.apc_67_23
Bandya Sahoo, Anshika Garg, Asish Ranjan Mohakud, Reshmi Mishra
{"title":"Pleuropericardial cyst presenting as recurrent pneumonia: A diagnostic dilemma.","authors":"Bandya Sahoo, Anshika Garg, Asish Ranjan Mohakud, Reshmi Mishra","doi":"10.4103/apc.apc_67_23","DOIUrl":"https://doi.org/10.4103/apc.apc_67_23","url":null,"abstract":"","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10856601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful hybrid management of hypertensive patent ductus arteriosus with unilateral absence of the right pulmonary artery - A case report. 高血压性动脉导管未闭伴单侧右肺动脉缺失的成功混合治疗 - 病例报告。
IF 0.7 Q3 Medicine Pub Date : 2023-07-01 Epub Date: 2024-01-05 DOI: 10.4103/apc.apc_54_23
Jayitri Mazumder, Debasree Gangopadhyay, Mahua Roy, Anoop Singh, Somrita Laha, Joyeeta Dutta

Unilateral absence of pulmonary artery (UAPA) can be either isolated or associated with other congenital cardiac defects. It is a rare congenital lesion with a diverse clinical presentation. We present a case of absent right pulmonary artery and large patent ductus arteriosus (PDA) with severe unilateral pulmonary hypertension. We describe our strategy of staged ductus arteriosus closure in this patient and successful outcome on long term follow up.

单侧肺动脉缺失(UAPA)既可单独存在,也可与其他先天性心脏缺陷伴发。这是一种罕见的先天性病变,临床表现多种多样。我们介绍了一例右肺动脉缺失和大动脉导管未闭(PDA)并伴有严重单侧肺动脉高压的病例。我们介绍了为该患者分阶段关闭动脉导管的策略以及长期随访的成功结果。
{"title":"Successful hybrid management of hypertensive patent ductus arteriosus with unilateral absence of the right pulmonary artery - A case report.","authors":"Jayitri Mazumder, Debasree Gangopadhyay, Mahua Roy, Anoop Singh, Somrita Laha, Joyeeta Dutta","doi":"10.4103/apc.apc_54_23","DOIUrl":"https://doi.org/10.4103/apc.apc_54_23","url":null,"abstract":"<p><p>Unilateral absence of pulmonary artery (UAPA) can be either isolated or associated with other congenital cardiac defects. It is a rare congenital lesion with a diverse clinical presentation. We present a case of absent right pulmonary artery and large patent ductus arteriosus (PDA) with severe unilateral pulmonary hypertension. We describe our strategy of staged ductus arteriosus closure in this patient and successful outcome on long term follow up.</p>","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10856613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In silico prediction, molecular modeling, and dynamics studies on the targeted next-generation sequencing identified genes underlying congenital heart disease in Down syndrome patients. 通过对定向新一代测序进行硅学预测、分子建模和动力学研究,确定了唐氏综合征患者先天性心脏病的潜在基因。
IF 0.7 Q3 Medicine Pub Date : 2023-07-01 Epub Date: 2024-01-05 DOI: 10.4103/apc.apc_63_23
Fiona Hannah Carlus, L Balasubramaniam Sujatha, Anbazhagan Ganesh Kumar, Lakshmanan Loganathan, Karthikeyan Muthusamy, Silas Justin Carlus

Background: Individuals with Down syndrome (DS) have a 40%-60% chance of being born with congenital heart disease (CHD). This indicates that CHD in individuals with DS is not solely caused by trisomy 21, and there may be other genetic factors contributing to the development of CHD in these children. A study has identified variants in the specific genes that contribute to the pathogenesis of CHD in children with DS, isolated DS, and the CHD group. Computational studies on these identified variants, which, together with trisomy 21, determine the risk for CHD in DS cases, were limited. Here, we aimed to identify the impact of the identified variants that contribute to the pathogenesis of CHD in children with DS through in silico prediction, molecular modeling, and dynamics studies.

Methodology and results: The target single-nucleotide polymorphisms included in the study were examined for pathogenicity, residue conservation, and protein structural changes. The structural predictions were done using I-TASSER, Robetta, SWISS-MODEL, and Phyre2 tools. Further, the predicted models were validated through the PROCHECK server and molecular dynamics simulation using GROMACS software. The conservation analysis conducted on the identified variant highlights its significance in relation to the genetic disorders. Furthermore, a dynamics simulation study revealed the impact of the variant on protein structural stability (≤3 Å), providing valuable insights into its pathogenicity. We have also observed that the structure of the centrosomal protein of 290 kDa gene is relatively unstable, which may be attributed to its exclusive inclusion of helices within its secondary structural components.

Conclusions: This computational study explores, for the first time, the association between genes and CHD-DS, evaluating the identified specific frameshift variants. The observed pathogenic mutations in CHD-DS patients require further experimental validation and may contribute to the development of prospective drug design research. The insights gained from the structural and functional implications of these variants could potentially serve as a cornerstone in the development of effective treatments for this debilitating condition.

背景:唐氏综合征(DS)患儿出生后患先天性心脏病(CHD)的几率为 40%-60%。这表明,唐氏综合征患者的先天性心脏病并不完全是由 21 三体综合征引起的,可能还有其他遗传因素导致这些儿童患上先天性心脏病。一项研究发现了导致 DS 患儿、孤立 DS 患儿和 CHD 组 CHD 发病的特定基因变异。这些已确定的变异与 21 三体综合征共同决定了 DS 患儿发生先天性心脏病的风险,但有关这些变异的计算研究却很有限。在此,我们旨在通过硅预测、分子建模和动力学研究,确定已发现的变异对DS患儿CHD发病机制的影响:对研究中的目标单核苷酸多态性进行了致病性、残基保护和蛋白质结构变化方面的检查。使用 I-TASSER、Robetta、SWISS-MODEL 和 Phyre2 工具进行了结构预测。此外,还通过 PROCHECK 服务器和使用 GROMACS 软件进行的分子动力学模拟对预测模型进行了验证。对鉴定出的变异体进行的保护分析凸显了其与遗传性疾病相关的重要性。此外,动力学模拟研究还揭示了该变体对蛋白质结构稳定性(≤3 Å)的影响,为了解其致病性提供了有价值的见解。我们还观察到,290 kDa 基因的中心体蛋白结构相对不稳定,这可能是由于其二级结构成分中只包含螺旋:这项计算研究首次探讨了基因与 CHD-DS 之间的关联,评估了已确定的特定移帧变异。在 CHD-DS 患者中观察到的致病突变需要进一步的实验验证,并可能有助于前瞻性药物设计研究的发展。从这些变异的结构和功能影响中获得的见解有可能成为开发治疗这种衰弱病症的有效方法的基石。
{"title":"<i>In silico</i> prediction, molecular modeling, and dynamics studies on the targeted next-generation sequencing identified genes underlying congenital heart disease in Down syndrome patients.","authors":"Fiona Hannah Carlus, L Balasubramaniam Sujatha, Anbazhagan Ganesh Kumar, Lakshmanan Loganathan, Karthikeyan Muthusamy, Silas Justin Carlus","doi":"10.4103/apc.apc_63_23","DOIUrl":"https://doi.org/10.4103/apc.apc_63_23","url":null,"abstract":"<p><strong>Background: </strong>Individuals with Down syndrome (DS) have a 40%-60% chance of being born with congenital heart disease (CHD). This indicates that CHD in individuals with DS is not solely caused by trisomy 21, and there may be other genetic factors contributing to the development of CHD in these children. A study has identified variants in the specific genes that contribute to the pathogenesis of CHD in children with DS, isolated DS, and the CHD group. Computational studies on these identified variants, which, together with trisomy 21, determine the risk for CHD in DS cases, were limited. Here, we aimed to identify the impact of the identified variants that contribute to the pathogenesis of CHD in children with DS through in silico prediction, molecular modeling, and dynamics studies.</p><p><strong>Methodology and results: </strong>The target single-nucleotide polymorphisms included in the study were examined for pathogenicity, residue conservation, and protein structural changes. The structural predictions were done using I-TASSER, Robetta, SWISS-MODEL, and Phyre2 tools. Further, the predicted models were validated through the PROCHECK server and molecular dynamics simulation using GROMACS software. The conservation analysis conducted on the identified variant highlights its significance in relation to the genetic disorders. Furthermore, a dynamics simulation study revealed the impact of the variant on protein structural stability (≤3 Å), providing valuable insights into its pathogenicity. We have also observed that the structure of the centrosomal protein of 290 kDa gene is relatively unstable, which may be attributed to its exclusive inclusion of helices within its secondary structural components.</p><p><strong>Conclusions: </strong>This computational study explores, for the first time, the association between genes and CHD-DS, evaluating the identified specific frameshift variants. The observed pathogenic mutations in CHD-DS patients require further experimental validation and may contribute to the development of prospective drug design research. The insights gained from the structural and functional implications of these variants could potentially serve as a cornerstone in the development of effective treatments for this debilitating condition.</p>","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10856610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel use of the double kissing crush technique to stent complex pulmonary artery stenosis in a child with Alagille syndrome. 在一名患有阿拉吉尔综合征的儿童身上,新颖地使用双吻挤压技术对复杂的肺动脉狭窄进行支架置入。
IF 0.7 Q3 Medicine Pub Date : 2023-07-01 Epub Date: 2024-01-05 DOI: 10.4103/apc.apc_60_23
Danielle D Strah, Riley D Hellinger, Kwan S Lee, Michael D Seckeler

Coronary bifurcation lesions and treatment with two-stent techniques have been developed, including the double kissing (DK) crush technique. The use of this technique in children or noncoronary vessels, including pulmonary arteries, has not been described. We present a 12-year-old girl with Alagille syndrome, a ventricular septal defect (VSD), and complex bilateral pulmonary artery (PA) stenoses who is status post six catheterizations for PA angioplasty and stenting to improve her marked right ventricular hypertension. With collaboration between the congenital and structural teams, she successfully underwent the DK crush technique for a complex lesion in her PA. This improved pulmonary flow and allowed for successful surgical VSD closure.

冠状动脉分叉病变和双支架治疗技术已经发展起来,包括双吻(DK)粉碎技术。该技术在儿童或包括肺动脉在内的非冠状动脉血管中的应用尚未见报道。我们介绍了一名患有阿拉吉尔综合征、室间隔缺损(VSD)和复杂的双侧肺动脉(PA)狭窄的 12 岁女孩,为了改善她明显的右室高血压,她接受了六次导管插入术,进行了肺动脉成形术和支架植入术。在先天性和结构性团队的通力合作下,她成功地接受了 DK 压碎技术治疗 PA 的复杂病变。这改善了肺血流,并使手术成功关闭了 VSD。
{"title":"Novel use of the double kissing crush technique to stent complex pulmonary artery stenosis in a child with Alagille syndrome.","authors":"Danielle D Strah, Riley D Hellinger, Kwan S Lee, Michael D Seckeler","doi":"10.4103/apc.apc_60_23","DOIUrl":"https://doi.org/10.4103/apc.apc_60_23","url":null,"abstract":"<p><p>Coronary bifurcation lesions and treatment with two-stent techniques have been developed, including the double kissing (DK) crush technique. The use of this technique in children or noncoronary vessels, including pulmonary arteries, has not been described. We present a 12-year-old girl with Alagille syndrome, a ventricular septal defect (VSD), and complex bilateral pulmonary artery (PA) stenoses who is status post six catheterizations for PA angioplasty and stenting to improve her marked right ventricular hypertension. With collaboration between the congenital and structural teams, she successfully underwent the DK crush technique for a complex lesion in her PA. This improved pulmonary flow and allowed for successful surgical VSD closure.</p>","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10856602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective study of preoperative sildenafil in prolonged pleural effusion after Fontan. 术前西地那非治疗方坦术后长期胸腔积液的回顾性研究。
IF 0.7 Q3 Medicine Pub Date : 2023-07-01 Epub Date: 2024-01-05 DOI: 10.4103/apc.apc_76_23
Dicky Fakhri, Pribadi Wiranda Busro, Budi Rahmat, Salomo Purba, Oktavia Lilyasari, Toshihide Asou

Background: By rerouting the systemic venous return into the pulmonary circulation, the Fontan operation is perhaps the most effective palliative procedure in patients with complex congenital heart disease. The Fontan, however, still comes with several significant complications and morbidities, one of them being postoperative prolonged pleural effusion. In our center from 2017 to 2021, 10% of all our patients who underwent Fontan operation developed prolonged pleural effusion. With this study, we aimed to analyze the preoperative use of sildenafil for 6 months and its role in prolonged pleural effusion after the Fontan operation.

Materials and methods: In total, 158 patients were included in the analysis. The cohort was divided into patients who developed prolonged pleural effusion after Fontan surgery (n = 17) and those who did not (n = 141). We analyzed several risk factors and the history of sildenafil use in each group in the cohort. We found that patients who used sildenafil for at least 6 months prior to Fontan surgery versus those who did not use (n = 112 vs. n = 46) were found to be at lower risk of developing prolonged pleural effusion (odds ratio [OR]: 0.32 [confidence interval 95%: 0.11-0.88], P = 0.027).

Conclusion: Preoperative administration of sildenafil for at least 6 months before Fontan might reduce the risk of postoperative prolonged pleural effusion.

背景:通过将全身静脉回流改道进入肺循环,丰坦手术可能是复杂先天性心脏病患者最有效的姑息性手术。然而,丰坦手术仍伴随着一些重大并发症和发病率,其中之一就是术后长期胸腔积液。从2017年到2021年,在我们中心接受丰坦手术的所有患者中,有10%出现了胸腔积液时间延长的情况。通过这项研究,我们旨在分析术前使用西地那非6个月的情况及其在丰坦手术后胸腔积液时间延长中的作用:共有 158 名患者纳入分析。该组患者分为在丰坦手术后出现长期胸腔积液的患者(17 人)和未出现长期胸腔积液的患者(141 人)。我们分析了队列中每组患者的几个风险因素和西地那非使用史。我们发现,在丰坦手术前使用西地那非至少6个月的患者与未使用西地那非的患者(n = 112 vs. n = 46)相比,发生长期胸腔积液的风险较低(几率比[OR]:0.32[置信区间95%:0.11-0.88],P = 0.027):结论:在Fontan手术前服用西地那非至少6个月可降低术后长期胸腔积液的风险。
{"title":"Retrospective study of preoperative sildenafil in prolonged pleural effusion after Fontan.","authors":"Dicky Fakhri, Pribadi Wiranda Busro, Budi Rahmat, Salomo Purba, Oktavia Lilyasari, Toshihide Asou","doi":"10.4103/apc.apc_76_23","DOIUrl":"https://doi.org/10.4103/apc.apc_76_23","url":null,"abstract":"<p><strong>Background: </strong>By rerouting the systemic venous return into the pulmonary circulation, the Fontan operation is perhaps the most effective palliative procedure in patients with complex congenital heart disease. The Fontan, however, still comes with several significant complications and morbidities, one of them being postoperative prolonged pleural effusion. In our center from 2017 to 2021, 10% of all our patients who underwent Fontan operation developed prolonged pleural effusion. With this study, we aimed to analyze the preoperative use of sildenafil for 6 months and its role in prolonged pleural effusion after the Fontan operation.</p><p><strong>Materials and methods: </strong>In total, 158 patients were included in the analysis. The cohort was divided into patients who developed prolonged pleural effusion after Fontan surgery (<i>n</i> = 17) and those who did not (<i>n</i> = 141). We analyzed several risk factors and the history of sildenafil use in each group in the cohort. We found that patients who used sildenafil for at least 6 months prior to Fontan surgery versus those who did not use (<i>n</i> = 112 vs. <i>n</i> = 46) were found to be at lower risk of developing prolonged pleural effusion (odds ratio [OR]: 0.32 [confidence interval 95%: 0.11-0.88], <i>P</i> = 0.027).</p><p><strong>Conclusion: </strong>Preoperative administration of sildenafil for at least 6 months before Fontan might reduce the risk of postoperative prolonged pleural effusion.</p>","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10856614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spectrum and outcome of the use of noninvasive ventilation in a pediatric cardiac intensive care unit: A single-center experience. 儿科心脏重症监护室使用无创通气的范围和结果:单中心经验。
IF 0.7 Q3 Medicine Pub Date : 2023-07-01 Epub Date: 2024-01-05 DOI: 10.4103/apc.apc_57_23
Shubhadeep Das, Minal Desai, Debasis Das, Nilanjan Dutta, Shivani Gajpal, Manish Sharma

Background and aims: The pediatric cardiac intensive care unit (PCICU) frequently uses noninvasive ventilation (NIV). There are several reasons for its use, including prophylactic use right after the patient has been extubated. It is also used when patients are experiencing acute respiratory failure due to either cardiac or noncardiac reasons but are still able to maintain their airways. The objective of this study was to understand the spectrum of use of NIV following congenital cardiac surgery and analyze the outcome.

Methods and results: A retrospective observational study was conducted in a 14-bed PCICU, reviewing data from August 2019 to August 2022. Among 1750 congenital cardiac surgeries, 523 patients (29.9%) received NIV. The median age of the population was 2.5 months. Factors such as higher Risk-Adjusted Classification for Congenital Heart Surgery-1 category, longer intraoperative cardiopulmonary bypass time, and aortic cross-clamp time were associated with increased NIV use. Preoperative ventilator needs, infections, genetic syndromes, diaphragmatic paralysis, high vasoactive inotrope score (VIS) in the first 24 h, neonatal age, and weight <5 kg were independently associated with increased NIV need. The NIV group had a longer intensive care unit (ICU) stay compared to non-NIV patients. The success rate of NIV was 84%, with 440 successful cases and 83 failures. The mortality rate in the success and failure groups was not significantly different (5.27% vs. 6.0%).

Conclusions: NIV is widely used in PCICU, but it is associated with longer ICU stays. It proves beneficial after congenital cardiac surgery, especially for patients with specific risk factors. However, NIV may not directly impact mortality rates, suggesting that other factors contribute to patient survival.

背景和目的:儿科心脏重症监护病房(PCICU)经常使用无创通气(NIV)。使用无创通气有多种原因,包括患者拔管后的预防性使用。当患者因心脏或非心脏原因出现急性呼吸衰竭,但仍能维持呼吸道通畅时,也会使用 NIV。本研究旨在了解先天性心脏病手术后使用 NIV 的范围并分析其结果:在一家拥有 14 张病床的 PCICU 开展了一项回顾性观察研究,回顾了 2019 年 8 月至 2022 年 8 月期间的数据。在1750例先天性心脏手术中,有523名患者(29.9%)接受了NIV治疗。患者的中位年龄为 2.5 个月。先天性心脏病手术风险调整分类-1类别较高、术中心肺旁路时间较长、主动脉交叉钳夹时间较长等因素与NIV使用率增加有关。术前呼吸机需求、感染、遗传综合征、膈肌麻痹、头 24 小时内血管活性肌力剂评分(VIS)高、新生儿年龄和体重结论:NIV 被广泛应用于 PCICU,但会延长重症监护室的住院时间。事实证明,在先天性心脏病手术后使用 NIV 是有益的,尤其是对有特殊风险因素的患者。不过,NIV 可能不会直接影响死亡率,这表明其他因素也会影响患者的存活率。
{"title":"Spectrum and outcome of the use of noninvasive ventilation in a pediatric cardiac intensive care unit: A single-center experience.","authors":"Shubhadeep Das, Minal Desai, Debasis Das, Nilanjan Dutta, Shivani Gajpal, Manish Sharma","doi":"10.4103/apc.apc_57_23","DOIUrl":"https://doi.org/10.4103/apc.apc_57_23","url":null,"abstract":"<p><strong>Background and aims: </strong>The pediatric cardiac intensive care unit (PCICU) frequently uses noninvasive ventilation (NIV). There are several reasons for its use, including prophylactic use right after the patient has been extubated. It is also used when patients are experiencing acute respiratory failure due to either cardiac or noncardiac reasons but are still able to maintain their airways. The objective of this study was to understand the spectrum of use of NIV following congenital cardiac surgery and analyze the outcome.</p><p><strong>Methods and results: </strong>A retrospective observational study was conducted in a 14-bed PCICU, reviewing data from August 2019 to August 2022. Among 1750 congenital cardiac surgeries, 523 patients (29.9%) received NIV. The median age of the population was 2.5 months. Factors such as higher Risk-Adjusted Classification for Congenital Heart Surgery-1 category, longer intraoperative cardiopulmonary bypass time, and aortic cross-clamp time were associated with increased NIV use. Preoperative ventilator needs, infections, genetic syndromes, diaphragmatic paralysis, high vasoactive inotrope score (VIS) in the first 24 h, neonatal age, and weight <5 kg were independently associated with increased NIV need. The NIV group had a longer intensive care unit (ICU) stay compared to non-NIV patients. The success rate of NIV was 84%, with 440 successful cases and 83 failures. The mortality rate in the success and failure groups was not significantly different (5.27% vs. 6.0%).</p><p><strong>Conclusions: </strong>NIV is widely used in PCICU, but it is associated with longer ICU stays. It proves beneficial after congenital cardiac surgery, especially for patients with specific risk factors. However, NIV may not directly impact mortality rates, suggesting that other factors contribute to patient survival.</p>","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10856600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-dimensional/four-dimensional spatiotemporal image correlation morphology of the ductus arteriosus in fetuses with pulmonary atresia undergoing neonatal ductal stenting. 接受新生儿动脉导管支架术的肺动脉闭锁胎儿动脉导管的三维/四维时空图像相关形态。
IF 0.7 Q3 Medicine Pub Date : 2023-07-01 Epub Date: 2024-01-05 DOI: 10.4103/apc.apc_95_23
Sonia Karapurkar, Aishwarya Gurav, Abish Sudhakar, Navaneetha Sasikumar, Raman Krishna Kumar, Balu Vaidyanathan

Background: The value of prenatal identification of morphology of ductus arteriosus in fetuses with congenital heart defects (CHD) with pulmonary atresia and duct-dependent pulmonary circulation (DDPC) in planning neonatal ductal stenting procedure is untested. The aim of the study is to analyze the utility of three-dimensional/four-dimensional (3D/4D) spatiotemporal image correlation (STIC) fetal echocardiography in delineating the morphology of ductus arteriosus in fetuses with DDPC undergoing neonatal ductal stenting.

Methods: In this retrospective study (2017-22), prenatal imaging of pulmonary artery (PA) anatomy, aortic arch sidedness, and morphology of ductus arteriosus (ductal origin was classified as vertical/horizontal and ductal course as tortuous/straight) was done using 3D/4D STIC imaging and volume datasets. Prenatal findings were correlated with angiographic findings during stenting and the degree of agreement was calculated.

Results: We included 27 fetuses with a prenatal diagnosis of CHD with DDPC who underwent neonatal ductal stenting. The accuracy of prenatal assessment of PA anatomy, branch PA stenosis, and arch sidedness was 100%, 92.6%, and 88.9%, respectively. The accuracy of prenatal assessment of ductal origin and course, compared with angiography, was 85.2% and 88.9%, respectively. Prenatal imaging had a diagnostic accuracy of 100% for vertical straight and horizontal tortuous ducts, 84.6% for vertical tortuous, and 67% for horizontal straight ducts. Duct stenting was successful in 25 (92.6%) babies; two died after the procedure from stent occlusion.

Conclusion: Fetal echocardiography using 3D/4D STIC imaging enables accurate delineation of the morphology of ductus arteriosus in fetuses with DDPC, thereby aiding parental counseling and planning neonatal ductal stenting.

背景:先天性心脏缺陷(CHD)合并肺动脉闭锁和管道依赖性肺循环(DDPC)的胎儿在产前识别动脉导管形态对计划新生儿动脉导管支架植入术的价值尚未得到验证。该研究旨在分析三维/四维(3D/4D)时空图像相关(STIC)胎儿超声心动图在划分接受新生儿动脉导管支架术的DDPC胎儿动脉导管形态中的实用性:在这项回顾性研究(2017-22 年)中,利用三维/四维 STIC 成像和容积数据集对肺动脉(PA)解剖、主动脉弓两侧性和动脉导管形态(导管起源分为垂直/水平,导管走向分为迂曲/笔直)进行了产前成像。将产前检查结果与支架植入术中的血管造影结果进行关联,并计算两者的吻合程度:结果:我们共纳入了27名产前诊断为DDPC合并先天性心脏病的胎儿,他们都接受了新生儿导管支架植入术。产前评估PA解剖结构、PA分支狭窄和弓侧性的准确率分别为100%、92.6%和88.9%。与血管造影相比,产前评估导管起源和走向的准确率分别为 85.2% 和 88.9%。产前成像对垂直直管和水平迂曲导管的诊断准确率为 100%,对垂直迂曲导管的诊断准确率为 84.6%,对水平直管的诊断准确率为 67%。25名婴儿(92.6%)成功进行了导管支架植入术;两名婴儿在术后因支架闭塞而死亡:结论:使用三维/四维 STIC 成像进行胎儿超声心动图检查可准确划分 DDPC 胎儿动脉导管的形态,从而帮助父母进行咨询和计划新生儿动脉导管支架植入术。
{"title":"Three-dimensional/four-dimensional spatiotemporal image correlation morphology of the ductus arteriosus in fetuses with pulmonary atresia undergoing neonatal ductal stenting.","authors":"Sonia Karapurkar, Aishwarya Gurav, Abish Sudhakar, Navaneetha Sasikumar, Raman Krishna Kumar, Balu Vaidyanathan","doi":"10.4103/apc.apc_95_23","DOIUrl":"https://doi.org/10.4103/apc.apc_95_23","url":null,"abstract":"<p><strong>Background: </strong>The value of prenatal identification of morphology of ductus arteriosus in fetuses with congenital heart defects (CHD) with pulmonary atresia and duct-dependent pulmonary circulation (DDPC) in planning neonatal ductal stenting procedure is untested. The aim of the study is to analyze the utility of three-dimensional/four-dimensional (3D/4D) spatiotemporal image correlation (STIC) fetal echocardiography in delineating the morphology of ductus arteriosus in fetuses with DDPC undergoing neonatal ductal stenting.</p><p><strong>Methods: </strong>In this retrospective study (2017-22), prenatal imaging of pulmonary artery (PA) anatomy, aortic arch sidedness, and morphology of ductus arteriosus (ductal origin was classified as vertical/horizontal and ductal course as tortuous/straight) was done using 3D/4D STIC imaging and volume datasets. Prenatal findings were correlated with angiographic findings during stenting and the degree of agreement was calculated.</p><p><strong>Results: </strong>We included 27 fetuses with a prenatal diagnosis of CHD with DDPC who underwent neonatal ductal stenting. The accuracy of prenatal assessment of PA anatomy, branch PA stenosis, and arch sidedness was 100%, 92.6%, and 88.9%, respectively. The accuracy of prenatal assessment of ductal origin and course, compared with angiography, was 85.2% and 88.9%, respectively. Prenatal imaging had a diagnostic accuracy of 100% for vertical straight and horizontal tortuous ducts, 84.6% for vertical tortuous, and 67% for horizontal straight ducts. Duct stenting was successful in 25 (92.6%) babies; two died after the procedure from stent occlusion.</p><p><strong>Conclusion: </strong>Fetal echocardiography using 3D/4D STIC imaging enables accurate delineation of the morphology of ductus arteriosus in fetuses with DDPC, thereby aiding parental counseling and planning neonatal ductal stenting.</p>","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10856608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139725649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Zephyr stent in congenital heart diseases: A single-center study. 在先天性心脏病中使用 Zephyr 支架:单中心研究
IF 0.7 Q3 Medicine Pub Date : 2023-07-01 Epub Date: 2024-01-05 DOI: 10.4103/apc.apc_78_23
Sudipta Bandyopadhyay, Muthukumaran Chinnaswamy Sivaprakasam

Large vessel stenosis is currently successfully treated with percutaneous stent implantation. Zephyr stent is a cobalt-chromium peripheral stent specifically designed for large-vessel stenting. Its specific "S-" and "C-" shaped flexible polylinks prevent stent foreshortening and recoil. We report our experience of using Zephyr among the pediatric population and their medium-term outcome. The study included a total of 19 patients treated with 21 Zephyr stents. The indications for stenting included coarctation of the aorta (four patients), stenosed pulmonary artery (eight patients), stenosed right ventricular outflow tract (five patients) or conduit (one patient), and percutaneous Fontan (one patient). All the procedures were successful. None of the patients showed any stent-related complications. Stent fractures, foreshortening, or recoil were not seen during follow-up. Our medium-term (1-20 months) follow-up showed a favorable outcome. One patient developed restenosis. Zephyr stent is a good therapeutic option for large-vessel stenting. However, it needs large-scale studies for further confirmation.

目前,经皮支架植入术可成功治疗大血管狭窄。Zephyr 支架是一种钴铬外周支架,专为大血管支架植入术而设计。其特殊的 "S "形和 "C "形柔性聚乙烯可防止支架前缩和反冲。我们报告了在儿科人群中使用 Zephyr 的经验及其中期疗效。这项研究共纳入了 19 名使用 21 个 Zephyr 支架治疗的患者。支架植入的适应症包括主动脉共动脉瘤(四名患者)、狭窄的肺动脉(八名患者)、狭窄的右室流出道(五名患者)或导管(一名患者)以及经皮丰坦(一名患者)。所有手术均获得成功。没有一名患者出现与支架相关的并发症。随访期间未发现支架断裂、变形或反冲。中期(1-20 个月)随访显示结果良好。一名患者出现了再狭窄。Zephyr 支架是大血管支架置入术的良好治疗选择。不过,它还需要大规模的研究来进一步证实。
{"title":"Use of Zephyr stent in congenital heart diseases: A single-center study.","authors":"Sudipta Bandyopadhyay, Muthukumaran Chinnaswamy Sivaprakasam","doi":"10.4103/apc.apc_78_23","DOIUrl":"https://doi.org/10.4103/apc.apc_78_23","url":null,"abstract":"<p><p>Large vessel stenosis is currently successfully treated with percutaneous stent implantation. Zephyr stent is a cobalt-chromium peripheral stent specifically designed for large-vessel stenting. Its specific \"S-\" and \"C-\" shaped flexible polylinks prevent stent foreshortening and recoil. We report our experience of using Zephyr among the pediatric population and their medium-term outcome. The study included a total of 19 patients treated with 21 Zephyr stents. The indications for stenting included coarctation of the aorta (four patients), stenosed pulmonary artery (eight patients), stenosed right ventricular outflow tract (five patients) or conduit (one patient), and percutaneous Fontan (one patient). All the procedures were successful. None of the patients showed any stent-related complications. Stent fractures, foreshortening, or recoil were not seen during follow-up. Our medium-term (1-20 months) follow-up showed a favorable outcome. One patient developed restenosis. Zephyr stent is a good therapeutic option for large-vessel stenting. However, it needs large-scale studies for further confirmation.</p>","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10856609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Off-label use of KONAR-MF™ occluder for transcatheter closure of patent ductus arteriosus in unusual circumstances. 在特殊情况下标签外使用 KONAR-MF™ 封堵器经导管封堵动脉导管未闭。
IF 0.7 Q3 Medicine Pub Date : 2023-07-01 Epub Date: 2024-01-05 DOI: 10.4103/apc.apc_49_22
Ashishkumar Banpurkar, Nageswara Rao Koneti, Prashant Thakur, Snehal M Kulkarni, Atul Prabhu, Pavan Kumar Venkata Doniparti

Background: Transcatheter patent ductus arteriosus (PDA) closure with unusual morphology associated with multiple constrictions or unusual circumstances such as interruption of inferior vena cava (IVC) is still challenging. This study evaluates the use of KONAR-MF™ (Lifetech Scientific Co Ltd., Shenzhen) for transcatheter closure of PDA in such situations.

Materials and methods and results: Between January 2021 and October 2021, 24 patients from three different tertiary care centers underwent PDA device closure using the KONAR-MF™ device and are included in the study. Patient demographics, echocardiographic assessment, procedural details including the approach, device details, complications, and follow-up data were recorded. The median age and weight of the cohort were 2 years (0.5-41) and 10 kg (5-98), respectively. The indications for using KONAR-MF™ were (a) unusual morphology of PDA in 14, long tubular PDA in 8, and long tubular with multiple constrictions in 6 patients and (b) unusual circumstances such as interrupted IVC in 6 and inability to cross PDA antegradely in 4 due to dilated main pulmonary artery. The procedure was successful in all the patients and no procedure-related complications were noted in this cohort. Median follow-up of 9 months (range: 5-18) showed no residual shunt and only one patient had flow acceleration across the left pulmonary artery (peak Doppler gradient 16 mmHg).

Conclusions: KONAR-MF™ device can be used safely and effectively for transcatheter closure of PDA with unusual anatomy or in unusual circumstances.

背景:经导管动脉导管未闭(PDA)形态异常,伴有多处收缩或下腔静脉(IVC)中断等特殊情况,仍具有挑战性。本研究评估了在这种情况下使用 KONAR-MF™(深圳力合科技有限公司)经导管闭合 PDA 的情况:在 2021 年 1 月至 2021 年 10 月期间,来自三个不同三级医疗中心的 24 名患者使用 KONAR-MF™ 装置进行了 PDA 装置闭合术。研究记录了患者的人口统计学特征、超声心动图评估、手术细节(包括方法)、装置细节、并发症和随访数据。患者年龄和体重的中位数分别为 2 岁(0.5-41 岁)和 10 公斤(5-98 公斤)。使用 KONAR-MF™ 的适应症包括:(a) PDA 形态异常(14 例)、长管状 PDA(8 例)和长管状伴多处收缩(6 例);(b) 异常情况,如 IVC 中断(6 例)和主肺动脉扩张导致无法逆行穿越 PDA(4 例)。所有患者的手术都很成功,未发现与手术相关的并发症。中位随访 9 个月(范围:5-18),未发现残余分流,只有一名患者出现左肺动脉血流加速(多普勒梯度峰值为 16 mmHg):结论:KONAR-MF™ 装置可安全有效地用于解剖结构异常或特殊情况下的 PDA 经导管封堵。
{"title":"Off-label use of KONAR-MF™ occluder for transcatheter closure of patent ductus arteriosus in unusual circumstances.","authors":"Ashishkumar Banpurkar, Nageswara Rao Koneti, Prashant Thakur, Snehal M Kulkarni, Atul Prabhu, Pavan Kumar Venkata Doniparti","doi":"10.4103/apc.apc_49_22","DOIUrl":"https://doi.org/10.4103/apc.apc_49_22","url":null,"abstract":"<p><strong>Background: </strong>Transcatheter patent ductus arteriosus (PDA) closure with unusual morphology associated with multiple constrictions or unusual circumstances such as interruption of inferior vena cava (IVC) is still challenging. This study evaluates the use of KONAR-MF™ (Lifetech Scientific Co Ltd., Shenzhen) for transcatheter closure of PDA in such situations.</p><p><strong>Materials and methods and results: </strong>Between January 2021 and October 2021, 24 patients from three different tertiary care centers underwent PDA device closure using the KONAR-MF™ device and are included in the study. Patient demographics, echocardiographic assessment, procedural details including the approach, device details, complications, and follow-up data were recorded. The median age and weight of the cohort were 2 years (0.5-41) and 10 kg (5-98), respectively. The indications for using KONAR-MF™ were (a) unusual morphology of PDA in 14, long tubular PDA in 8, and long tubular with multiple constrictions in 6 patients and (b) unusual circumstances such as interrupted IVC in 6 and inability to cross PDA antegradely in 4 due to dilated main pulmonary artery. The procedure was successful in all the patients and no procedure-related complications were noted in this cohort. Median follow-up of 9 months (range: 5-18) showed no residual shunt and only one patient had flow acceleration across the left pulmonary artery (peak Doppler gradient 16 mmHg).</p><p><strong>Conclusions: </strong>KONAR-MF™ device can be used safely and effectively for transcatheter closure of PDA with unusual anatomy or in unusual circumstances.</p>","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10856615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful treatment of pulmonary arterial hypertension in a 2-month-old female infant with incontinentia pigmenti: A case report. 成功治疗一名 2 个月大的猪尿失禁女婴的肺动脉高压:病例报告。
IF 0.7 Q3 Medicine Pub Date : 2023-07-01 Epub Date: 2024-01-05 DOI: 10.4103/apc.apc_75_23
Marta Marcia, Paola Coppo, Giuseppe Alberto Annoni, Gaetana Ferraro, Gabriella Agnoletti, Giuseppe Antonio Mazza

Incontinentia pigmenti (IP) is a rare X-linked dominant neuroectodermal dysplasia affecting almost exclusively females. It is caused by loss-of-function mutations in the inhibitor of kappa light polypeptide gene enhancer in B cells, kinase gamma gene, formerly known as NF-κB essential modulator. The disorder is typically identified by peculiar skin findings that develop throughout the 1st year of life. Approximately one-third of patients has ocular and neurologic abnormalities causing severe disability. Defects of hair, nails, and teeth can also occur. Among systemic complications, pulmonary arterial hypertension (PAH) is uncommon but potentially life-threatening. Only six cases have been described in the literature so far, and four of them died before reaching 1 year of age. Herein, we report the case of a 2-month-old girl with IP and severe PAH, successfully treated with pulmonary antihypertensive and anti-inflammatory therapy.

猪尿失禁症(IP)是一种罕见的 X 连锁显性神经外胚层发育不良症,几乎只影响女性。它是由 B 细胞中的卡巴轻多肽基因增强子抑制剂、激酶伽马基因(以前称为 NF-κB 重要调节因子)的功能缺失突变引起的。这种疾病通常是通过出生后第一年出现的特殊皮肤症状来识别的。约三分之一的患者有眼部和神经系统异常,导致严重残疾。毛发、指甲和牙齿也可能出现缺陷。在全身并发症中,肺动脉高压(PAH)并不常见,但可能危及生命。迄今为止,文献中仅描述了六例,其中四例在一岁前死亡。在此,我们报告了一例 2 个月大的 IP 重度 PAH 女婴的病例,她在接受肺部降压和抗炎治疗后获得成功。
{"title":"Successful treatment of pulmonary arterial hypertension in a 2-month-old female infant with incontinentia pigmenti: A case report.","authors":"Marta Marcia, Paola Coppo, Giuseppe Alberto Annoni, Gaetana Ferraro, Gabriella Agnoletti, Giuseppe Antonio Mazza","doi":"10.4103/apc.apc_75_23","DOIUrl":"https://doi.org/10.4103/apc.apc_75_23","url":null,"abstract":"<p><p>Incontinentia pigmenti (IP) is a rare X-linked dominant neuroectodermal dysplasia affecting almost exclusively females. It is caused by loss-of-function mutations in the inhibitor of kappa light polypeptide gene enhancer in B cells, kinase gamma gene, formerly known as NF-κB essential modulator. The disorder is typically identified by peculiar skin findings that develop throughout the 1<sup>st</sup> year of life. Approximately one-third of patients has ocular and neurologic abnormalities causing severe disability. Defects of hair, nails, and teeth can also occur. Among systemic complications, pulmonary arterial hypertension (PAH) is uncommon but potentially life-threatening. Only six cases have been described in the literature so far, and four of them died before reaching 1 year of age. Herein, we report the case of a 2-month-old girl with IP and severe PAH, successfully treated with pulmonary antihypertensive and anti-inflammatory therapy.</p>","PeriodicalId":8026,"journal":{"name":"Annals of Pediatric Cardiology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10856604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Annals of Pediatric Cardiology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1