Annals of Iowa最新文献

Introduction: This study aimed to analyze and report findings from the sessions conducted with healthcare workers during the early phase of COVID-19 pandemic.

Method: The study sample consisted of 130 healthcare workers who have consecutively reached out to nationwide psychosocial support line within the first ten days of COVID-19 pandemic and had a 30-minute video session and received psychological first aid and were evaluated using a socio-demographic data form. Mental state severity and progress were assessed using CGI (clinical global impressions) at the first and follow-up interviews.

Results: 90.4% of the applicants were female, 50.4% were nurses, 34.4% were doctors, 68.8% were frontline workers, whereas second-line healthcare workers had significantly higher rates of psychiatric illness history. Contracting the virus (n=83, 66.4%), infecting others (n=72, 57.6%) were the situations that caused the highest level of anxiety. Most common psychiatric complaints were anxiety (n=107, 85.6%), restlessness (n=80, 64%), fear (n=72, 64.0%) and insomnia (n=68, 57.6%). A second session was conducted with 36.8% (n=46) of the callers, and it was detected that 93.48% (n=43) of them were able to manage their stress and 33 of them reported that the severity of their complaints decreased.

Conclusion: Our findings have shown that healthcare workers were significantly affected in the early stage of COVID-19 pandemic with a significant level of anxiety and insomnia symptoms. Healthcare workers with a history of psychiatric illness should be considered as a vulnerable group regardless of their position.

Objective: Previous research has suggested an association between physical activity (PA), joint function, and molecular biomarkers, but more studies are needed. The aim of this study was to explore the associations between PA or self-reported joint function and molecular biomarkers of cartilage and inflammation in individuals with hip and/or knee osteoarthritis (OA). Specific objectives were to explore the correlations between (1) the change over 3 months in self-reported PA/joint function and the change in molecular biomarkers (2) objectively measured PA and molecular biomarkers measured at 3-month follow-up.

Design: Working age participants (n = 91) were recruited from a cluster randomized controlled trial. Self-reported PA, joint function, and serum samples were collected at baseline and after 3 months. Serum concentrations of the inflammatory marker C-reactive protein (CRP) and the cartilage markers Alanine-Arginine-Glycine-Serine (ARGS)-aggrecan, cartilage oligomeric matrix protein (COMP), and type II collagen C2C were analyzed by immunoassays. Objectively measured PA (steps/day) was collected during 12 weeks from activity trackers used by 53 participants. Associations were analyzed with Spearman's rank correlation.

Results: There was a weak negative correlation between the change in self-reported PA and the change in COMP (r _s = -0.256, P = .040) but not for the other molecular biomarkers. There were no correlations between the change in self-reported joint function and the change in molecular biomarkers or between the average steps/day and the molecular biomarkers at follow-up (r _s ⩽ -0.206, P ⩾ .06).

Conclusion: In general, no or only weak associations were found between PA/joint function and molecular biomarkers. Future research recommends including participants with lower PA, extend the follow-up, and use a design that allows comparisons.